Endocrine-mediated effects of 4,4’-(hexafluoroisopropylidene)diphenol in SD rats, based on a subacute oral toxicity study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01

AUTHORS

Takaaki Umano, Ryota Tanaka, Kanji Yamasaki

ABSTRACT

The purpose of this study was to investigate the endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol according to OECD test guideline no. 407. The estrogenic properties of this chemical have already been shown on uterotrophic assay, and this chemical is classified as a low-production volume chemical in REACH program. Rats were orally gavaged with 0, 10, 30, and 100 mg/kg/day of test chemical for at least 28 days, beginning at 8 weeks of age. In the 100 mg/kg group of male rats, endocrine-mediated effects, atrophic changes in the mammary glands and testicular Leydig cells, decreased accessory sex organ weights, and hypertrophy of the adrenal zona fasciculata with increased organ weights were seen; there was dysfunction of the estrous cycle in the 30 and 100 mg/kg groups, and increased serum T4 values were observed in the 100 mg/kg groups of both sexes. In addition, we also noted other findings, such as reduced body weight gains in the 30 and/or 100 mg/kg groups of both sexes, dilatation of the large intestinal lumen in the 100 mg/kg groups of both sexes, decreased hematopoiesis in the bone marrow and spleen, and decreased white blood cell counts in the 100 mg/kg group of male rats. Our results demonstrate that in a repeated-dose toxicity study, 4,4'-(hexafluoroisopropylidene)diphenol has various endocrine-mediated effects and its NOAEL (no observed adverse effect level) is 10 mg/kg/day. More... »

PAGES

151-157

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00204-011-0731-0

DOI

http://dx.doi.org/10.1007/s00204-011-0731-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043538927

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21713527


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzhydryl Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endocrine Disruptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endocrine System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estradiol Congeners", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrous Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "No-Observed-Adverse-Effect Level", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toxicity Tests, Subacute", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chemicals Evaluation and Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418471.f", 
          "name": [
            "Chemicals Evaluation and Research Institute, 1-4-25 Kouraku, Bunkyo-ku, 112-0004, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Umano", 
        "givenName": "Takaaki", 
        "id": "sg:person.0740636345.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740636345.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Biosafety Research Center Foods, Drugs and Pesticides, 582-2 Shiosinden, Iwata, 437-1213, Shizuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Ryota", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chemicals Evaluation and Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418471.f", 
          "name": [
            "Chemicals Evaluation and Research Institute, 1-4-25 Kouraku, Bunkyo-ku, 112-0004, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamasaki", 
        "givenName": "Kanji", 
        "id": "sg:person.0630456453.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630456453.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00204-002-0337-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001713073", 
          "https://doi.org/10.1007/s00204-002-0337-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-483x(02)00445-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002110542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-483x(02)00445-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002110542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/rtph.1997.1100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005250637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2009.10.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011430250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfq274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022729365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2010.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041814457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-001-0319-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049600325", 
          "https://doi.org/10.1007/s00204-001-0319-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/03601230600701866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058324605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.18.6.1165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071506495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077527478", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01", 
    "datePublishedReg": "2012-01-01", 
    "description": "The purpose of this study was to investigate the endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol according to OECD test guideline no. 407. The estrogenic properties of this chemical have already been shown on uterotrophic assay, and this chemical is classified as a low-production volume chemical in REACH program. Rats were orally gavaged with 0, 10, 30, and 100 mg/kg/day of test chemical for at least 28 days, beginning at 8 weeks of age. In the 100 mg/kg group of male rats, endocrine-mediated effects, atrophic changes in the mammary glands and testicular Leydig cells, decreased accessory sex organ weights, and hypertrophy of the adrenal zona fasciculata with increased organ weights were seen; there was dysfunction of the estrous cycle in the 30 and 100 mg/kg groups, and increased serum T4 values were observed in the 100 mg/kg groups of both sexes. In addition, we also noted other findings, such as reduced body weight gains in the 30 and/or 100 mg/kg groups of both sexes, dilatation of the large intestinal lumen in the 100 mg/kg groups of both sexes, decreased hematopoiesis in the bone marrow and spleen, and decreased white blood cell counts in the 100 mg/kg group of male rats. Our results demonstrate that in a repeated-dose toxicity study, 4,4'-(hexafluoroisopropylidene)diphenol has various endocrine-mediated effects and its NOAEL (no observed adverse effect level) is 10 mg/kg/day.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00204-011-0731-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019669", 
        "issn": [
          "0340-5761", 
          "1432-0738"
        ], 
        "name": "Archives of Toxicology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "86"
      }
    ], 
    "name": "Endocrine-mediated effects of 4,4\u2019-(hexafluoroisopropylidene)diphenol in SD rats, based on a subacute oral toxicity study", 
    "pagination": "151-157", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cf6474178995bae9187aad639022a8b3f8d3527a54c1284c24ec2bbe51caa064"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21713527"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0417615"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00204-011-0731-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043538927"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00204-011-0731-0", 
      "https://app.dimensions.ai/details/publication/pub.1043538927"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000515.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00204-011-0731-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00204-011-0731-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00204-011-0731-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00204-011-0731-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00204-011-0731-0'


 

This table displays all metadata directly associated to this object as RDF triples.

187 TRIPLES      21 PREDICATES      57 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00204-011-0731-0 schema:about N1d40b8c8d3ac473ba5fafe603e4a0170
2 N2065afe9cd3c47edbe8e4d4dc4b461b4
3 N2308d669e1ee40c0b1229c9344d472c7
4 N24532dbadecc4a04825b56d022fa3395
5 N26f8d0de8e49499fa9791c3986ae5cb5
6 N357fc5f831e0495fbd5310ffce8179cb
7 N395e924057e042e39d0ba7921c55ebe7
8 N4a44d045e09646229aa0e9b99a95e745
9 N4be69961fb2a4cfbafbaaf61c97b0f71
10 N5265f7f322a14304a07e8dd270be3ed6
11 N55c947e842f7492f8c629659ca3944cb
12 N5b71c6a737484a17ab7de732eaf7131e
13 N8526d18ebac2441a9fe453abf4bfed63
14 N9aa4b51656834e079b56e0fee8ee285c
15 N9e42d342a1af464fb653759b94f450c8
16 Nc04aa888a26a46278f1421af954c56ca
17 Nd09cc2ab12e048b8ab34ff16bd4d23b4
18 Nf471c6abd6dd42e4a7f5e975caf3de7b
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N8edd7351a8a54d429b1cd3a548618d69
22 schema:citation sg:pub.10.1007/s00204-001-0319-1
23 sg:pub.10.1007/s00204-002-0337-7
24 https://app.dimensions.ai/details/publication/pub.1077527478
25 https://doi.org/10.1006/rtph.1997.1100
26 https://doi.org/10.1016/j.tox.2009.10.030
27 https://doi.org/10.1016/j.toxlet.2010.01.011
28 https://doi.org/10.1016/s0300-483x(02)00445-6
29 https://doi.org/10.1080/03601230600701866
30 https://doi.org/10.1093/toxsci/kfq274
31 https://doi.org/10.3892/ijmm.18.6.1165
32 schema:datePublished 2012-01
33 schema:datePublishedReg 2012-01-01
34 schema:description The purpose of this study was to investigate the endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol according to OECD test guideline no. 407. The estrogenic properties of this chemical have already been shown on uterotrophic assay, and this chemical is classified as a low-production volume chemical in REACH program. Rats were orally gavaged with 0, 10, 30, and 100 mg/kg/day of test chemical for at least 28 days, beginning at 8 weeks of age. In the 100 mg/kg group of male rats, endocrine-mediated effects, atrophic changes in the mammary glands and testicular Leydig cells, decreased accessory sex organ weights, and hypertrophy of the adrenal zona fasciculata with increased organ weights were seen; there was dysfunction of the estrous cycle in the 30 and 100 mg/kg groups, and increased serum T4 values were observed in the 100 mg/kg groups of both sexes. In addition, we also noted other findings, such as reduced body weight gains in the 30 and/or 100 mg/kg groups of both sexes, dilatation of the large intestinal lumen in the 100 mg/kg groups of both sexes, decreased hematopoiesis in the bone marrow and spleen, and decreased white blood cell counts in the 100 mg/kg group of male rats. Our results demonstrate that in a repeated-dose toxicity study, 4,4'-(hexafluoroisopropylidene)diphenol has various endocrine-mediated effects and its NOAEL (no observed adverse effect level) is 10 mg/kg/day.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf N4d2bbf9c16a0404badbac792fee56c14
39 N68a0e42636274a0cadac4496a76dcc25
40 sg:journal.1019669
41 schema:name Endocrine-mediated effects of 4,4’-(hexafluoroisopropylidene)diphenol in SD rats, based on a subacute oral toxicity study
42 schema:pagination 151-157
43 schema:productId N88ce71edc7f742f381c5722d9ea5ca3d
44 N9385ba0d5d9a4d499999337704759cbb
45 Ndb3cab63e91c4c09a1f4d8afc0b4910b
46 Ndd68c4d68ac64df789842e8652a833eb
47 Nfaebcfdb19dd4b09b65328a29babd1d7
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043538927
49 https://doi.org/10.1007/s00204-011-0731-0
50 schema:sdDatePublished 2019-04-11T01:08
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher N8745877ec9fd4d13b7966b875b7f915e
53 schema:url http://link.springer.com/10.1007%2Fs00204-011-0731-0
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N1d40b8c8d3ac473ba5fafe603e4a0170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Estrous Cycle
59 rdf:type schema:DefinedTerm
60 N2065afe9cd3c47edbe8e4d4dc4b461b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Estradiol Congeners
62 rdf:type schema:DefinedTerm
63 N2308d669e1ee40c0b1229c9344d472c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name No-Observed-Adverse-Effect Level
65 rdf:type schema:DefinedTerm
66 N24532dbadecc4a04825b56d022fa3395 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Female
68 rdf:type schema:DefinedTerm
69 N26f8d0de8e49499fa9791c3986ae5cb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Benzhydryl Compounds
71 rdf:type schema:DefinedTerm
72 N357fc5f831e0495fbd5310ffce8179cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Endocrine Disruptors
74 rdf:type schema:DefinedTerm
75 N395e924057e042e39d0ba7921c55ebe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Endocrine System
77 rdf:type schema:DefinedTerm
78 N4a44d045e09646229aa0e9b99a95e745 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Administration, Oral
80 rdf:type schema:DefinedTerm
81 N4be69961fb2a4cfbafbaaf61c97b0f71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Organ Size
83 rdf:type schema:DefinedTerm
84 N4d2bbf9c16a0404badbac792fee56c14 schema:issueNumber 1
85 rdf:type schema:PublicationIssue
86 N5265f7f322a14304a07e8dd270be3ed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Drug Administration Schedule
88 rdf:type schema:DefinedTerm
89 N55c947e842f7492f8c629659ca3944cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Dose-Response Relationship, Drug
91 rdf:type schema:DefinedTerm
92 N5b71c6a737484a17ab7de732eaf7131e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Toxicity Tests, Subacute
94 rdf:type schema:DefinedTerm
95 N60cdaa9ca2c9449b991566549d89c380 schema:affiliation N8397aea9de5f44b9806d5a7edb10574b
96 schema:familyName Tanaka
97 schema:givenName Ryota
98 rdf:type schema:Person
99 N68a0e42636274a0cadac4496a76dcc25 schema:volumeNumber 86
100 rdf:type schema:PublicationVolume
101 N8397aea9de5f44b9806d5a7edb10574b schema:name Biosafety Research Center Foods, Drugs and Pesticides, 582-2 Shiosinden, Iwata, 437-1213, Shizuoka, Japan
102 rdf:type schema:Organization
103 N8526d18ebac2441a9fe453abf4bfed63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Male
105 rdf:type schema:DefinedTerm
106 N8745877ec9fd4d13b7966b875b7f915e schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N88ce71edc7f742f381c5722d9ea5ca3d schema:name doi
109 schema:value 10.1007/s00204-011-0731-0
110 rdf:type schema:PropertyValue
111 N8edd7351a8a54d429b1cd3a548618d69 rdf:first sg:person.0740636345.43
112 rdf:rest N93f9777838f842e3861f6b0627e87632
113 N9385ba0d5d9a4d499999337704759cbb schema:name dimensions_id
114 schema:value pub.1043538927
115 rdf:type schema:PropertyValue
116 N93f9777838f842e3861f6b0627e87632 rdf:first N60cdaa9ca2c9449b991566549d89c380
117 rdf:rest Nb76dbf956e2b4bf8ac24a854ff987fed
118 N9aa4b51656834e079b56e0fee8ee285c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 N9e42d342a1af464fb653759b94f450c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Rats
123 rdf:type schema:DefinedTerm
124 Nb76dbf956e2b4bf8ac24a854ff987fed rdf:first sg:person.0630456453.50
125 rdf:rest rdf:nil
126 Nc04aa888a26a46278f1421af954c56ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Rats, Sprague-Dawley
128 rdf:type schema:DefinedTerm
129 Nd09cc2ab12e048b8ab34ff16bd4d23b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Phenols
131 rdf:type schema:DefinedTerm
132 Ndb3cab63e91c4c09a1f4d8afc0b4910b schema:name nlm_unique_id
133 schema:value 0417615
134 rdf:type schema:PropertyValue
135 Ndd68c4d68ac64df789842e8652a833eb schema:name readcube_id
136 schema:value cf6474178995bae9187aad639022a8b3f8d3527a54c1284c24ec2bbe51caa064
137 rdf:type schema:PropertyValue
138 Nf471c6abd6dd42e4a7f5e975caf3de7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Sex Factors
140 rdf:type schema:DefinedTerm
141 Nfaebcfdb19dd4b09b65328a29babd1d7 schema:name pubmed_id
142 schema:value 21713527
143 rdf:type schema:PropertyValue
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
148 schema:name Clinical Sciences
149 rdf:type schema:DefinedTerm
150 sg:journal.1019669 schema:issn 0340-5761
151 1432-0738
152 schema:name Archives of Toxicology
153 rdf:type schema:Periodical
154 sg:person.0630456453.50 schema:affiliation https://www.grid.ac/institutes/grid.418471.f
155 schema:familyName Yamasaki
156 schema:givenName Kanji
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630456453.50
158 rdf:type schema:Person
159 sg:person.0740636345.43 schema:affiliation https://www.grid.ac/institutes/grid.418471.f
160 schema:familyName Umano
161 schema:givenName Takaaki
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740636345.43
163 rdf:type schema:Person
164 sg:pub.10.1007/s00204-001-0319-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049600325
165 https://doi.org/10.1007/s00204-001-0319-1
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/s00204-002-0337-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001713073
168 https://doi.org/10.1007/s00204-002-0337-7
169 rdf:type schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1077527478 schema:CreativeWork
171 https://doi.org/10.1006/rtph.1997.1100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005250637
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.tox.2009.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011430250
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.toxlet.2010.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041814457
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/s0300-483x(02)00445-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002110542
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1080/03601230600701866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058324605
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1093/toxsci/kfq274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022729365
182 rdf:type schema:CreativeWork
183 https://doi.org/10.3892/ijmm.18.6.1165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071506495
184 rdf:type schema:CreativeWork
185 https://www.grid.ac/institutes/grid.418471.f schema:alternateName Chemicals Evaluation and Research Institute
186 schema:name Chemicals Evaluation and Research Institute, 1-4-25 Kouraku, Bunkyo-ku, 112-0004, Tokyo, Japan
187 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...