Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4´-[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] based on the OECD draft protocols View Full Text


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Article Info

DATE

2007-11

AUTHORS

Kanji Yamasaki, Katumi Miyata, Takako Muroi, Hatsune Ehara, Nobuhiko Higashihara, Satsuki Houshuyama, Hiroshi Oshima, Yasushi Minobe

ABSTRACT

We performed an uterotrophic assay, the Hershberger assay, and a 28-day repeated-dose toxicity study (enhanced OECD test guideline No. 407) of 4,4 -[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] based on the OECD draft protocols. In the uterotrophic assay, female SD rats were subcutaneously injected with the chemical at doses of 0, 100, 300, and 1,000 mg/kg on each of 3 days from postnatal day 20 to day 22, and the uterine weight of rats given the 1,000 mg/kg dose of the test chemical plus ethinyl estradiol decreased. In the Hershberger assay, the test chemical was orally administered at doses of 0, 100, 300, and 1,000 mg/kg day to castrated male SD rats for ten consecutive days beginning on postnatal day 56, and no changes were observed. On the other hand, when the test chemical was orally administered at doses 0, 100, 300, and 1,000 mg/kg day for at least 28 days, a decrease in LH values in rats of both sexes and a decrease in FSH and estradiol values in female rats were detected in the 1,000 mg/kg group, and abnormal estrous cycles, uterine glandular atrophy, persistence of ovarian corpora lutea, vaginal epithelial mucification, and mammary glandular hyperplasia were also observed in one female rat in the 1,000 mg/kg group. Therefore, the uterotrophic assay used in this study showed that the chemical has the estrogen-antagonist properties, and some potentially endocrine-mediated effects were detected in growing rats based on the results of the enhanced OECD test guideline No. 407. However, the changes were observed in rats given a high dose of the chemical, 1,000 mg/kg day. More... »

PAGES

749-757

References to SciGraph publications

  • 2001-04. Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide in ARCHIVES OF TOXICOLOGY
  • 2002-09. Comparison of toxicity studies based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407' and the research protocol of 'Pubertal Development and Thyroid Function in Immature Male Rats' with 6-n-propyl-2-thiouracil in ARCHIVES OF TOXICOLOGY
  • 2006-01. Subacute oral toxicity study of diethylphthalate based on the draft protocol for “Enhanced OECD Test Guideline no. 407” in ARCHIVES OF TOXICOLOGY
  • 2006-04. Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the “Enhanced OECD Test Guideline no. 407” in ARCHIVES OF TOXICOLOGY
  • 2001-11. A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • 2006-09. Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the “Enhanced OECD Test Guideline No. 407” to detect endocrine effects in ARCHIVES OF TOXICOLOGY
  • 2003-09. Tamoxifen: 28-day oral toxicity study in the rat based on the Enhanced OECD Test Guideline 407 to detect endocrine effects in ARCHIVES OF TOXICOLOGY
  • 2000-05. Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the `Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • 2002-01. A repeated 28-day oral dose toxicity study of 17α-methyltestosterone in rats, based on the 'Enhanced OECD Test Guideline 407' for screening the endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • 2002-03. Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407' in ARCHIVES OF TOXICOLOGY
  • 2002-10. A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00204-007-0211-8

    DOI

    http://dx.doi.org/10.1007/s00204-007-0211-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037813924

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17508203


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