Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the “Enhanced OECD Test Guideline no. 407” View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Katsumi Miyata, Keiji Shiraishi, Satsuki Houshuyama, Nobuya Imatanaka, Takaaki Umano, Yasushi Minobe, Kanji Yamasaki

ABSTRACT

We performed a 28-day repeated-dose toxicity study of di(2-ethylhexyl)adipate (DEHA) based on the draft protocol of the "Enhanced OECD Test Guideline 407" to investigate whether it has endocrine-mediated properties according to this assay. DEHA was orally administered to SD rats at doses of 0, 40, 200 and 1,000 mg/kg/day for at least 28 days, and disturbance of the estrous cycle and increased ovarian follicle atresia were detected in the 1,000 mg/kg group. More... »

PAGES

181-186

References to SciGraph publications

  • 2001-04. Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide in ARCHIVES OF TOXICOLOGY
  • 2002-09. Comparison of toxicity studies based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407' and the research protocol of 'Pubertal Development and Thyroid Function in Immature Male Rats' with 6-n-propyl-2-thiouracil in ARCHIVES OF TOXICOLOGY
  • 2001-11. A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • 2003-09. Tamoxifen: 28-day oral toxicity study in the rat based on the Enhanced OECD Test Guideline 407 to detect endocrine effects in ARCHIVES OF TOXICOLOGY
  • 2000-05. Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the `Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • 2002-01. A repeated 28-day oral dose toxicity study of 17α-methyltestosterone in rats, based on the 'Enhanced OECD Test Guideline 407' for screening the endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • 2002-03. Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407' in ARCHIVES OF TOXICOLOGY
  • 2002-10. A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00204-005-0030-8

    DOI

    http://dx.doi.org/10.1007/s00204-005-0030-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012509362

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16187103


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