Subacute oral toxicity study of diethylphthalate based on the draft protocol for “Enhanced OECD Test Guideline no. 407” View Full Text


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Article Info

DATE

2006-01

AUTHORS

Keiji Shiraishi, Katusi Miyata, Satsuki Houshuyama, Nobuya Imatanaka, Takaaki Umano, Yasushi Minobe, Kanji Yamasaki

ABSTRACT

We performed a 28-day repeated-dose toxicity study of diethylphthalate based on the draft protocol of the "Enhanced OECD Test Guideline 407" to investigate whether it has endocrine-mediated properties according to this assay. Diethylphthalate was orally administered to SD rats at doses of 0, 40, 200, and 1,000 mg/kg/day for at least 28 days, but no endocrine-mediated effects were detected based on any of the parameters examined, suggesting that diethylphthalate does not possess endocrine properties according to this assay. More... »

PAGES

10-16

References to SciGraph publications

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  • 2002-10. A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals in ARCHIVES OF TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00204-005-0008-6

    DOI

    http://dx.doi.org/10.1007/s00204-005-0008-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040753551

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16059724


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