Relative antioxidant capacities of propofol and its main metabolites View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-07-10

AUTHORS

Sandrine Boisset, Jean-Paul Steghens, Patrick Favetta, Raphaël Terreux, Jérôme Guitton

ABSTRACT

The antioxidant activity of propofol, a widely used anesthetic, has previously been demonstrated, but no study has focused on propofol metabolites although propofol undergoes extensive metabolism. In the present study, the antioxidant properties of propofol and its metabolites were studied by measuring malondialdehyde (MDA) produced from lipid peroxidation by microsomes triggered with several free radical generating systems. True MDA determination was performed using a specific high performance liquid chromatography technique. Gas chromatography–isotope ratio mass spectrometry methodology was also used to assess the antioxidant action in a homogeneous aqueous environment. Propofol, 2,6-di-isopropyl-1,4-quinol (1,4-quinol) metabolite and 3,5-di-tert-butyl-4-hydroxytoluene markedly inhibit lipid peroxidation at concentrations lower than 5 µM. The binding of the glucuroconjugated moiety to either one of two hydroxyl groups of 1,4-quinol lowers the radical scavenging activity. Propofol glucuronide did not exert any radical scavenging activity except when peroxidation was induced with tert-butylhydroperoxide. Our data demonstrate that propofol and its metabolites inhibit lipid peroxidation at concentrations similar to those measured in human plasma during anesthesia. Their antioxidant efficiency is influenced by several factors, including the type of radical initiator involved and the site of radical production. More... »

PAGES

635-642

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00204-004-0585-9

DOI

http://dx.doi.org/10.1007/s00204-004-0585-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003324222

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15248045


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