Identification of fitness determinants in Enterococcus faecalis by differential proteomics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

Angela G. Lindenstrauß, Jürgen Behr, Matthias A. Ehrmann, Dirk Haller, Rudi F. Vogel

ABSTRACT

Enterococcus (E.) faecalis is found as commensal in healthy humans, in a variety of fermented foods. It can serve as probiotic but also as pathogen causing endocarditis, bacteremia and urinary tract infections. We have employed a proteomic study with E. faecalis strain OG1RF under different growth conditions and in contact to mouse intestinal cells to identify novel latent and adaptive fitness determinants. These relate to changes in catabolic pathways (BudA), protein biosynthesis (AsnS), cellular surface biosynthesis (RmlA) and regulatory mechanisms (OmpR). This knowledge can be used to derive novel evidence-based targets, which can be used to further elucidate gene expression changes enhancing pathogenicity or fitness in a commensal strain and possibly delineate this species into groups of higher and lower risk for applications in a food or a medical context versus improved treatment strategies of the so far hard to cure diseases. More... »

PAGES

121-130

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00203-012-0857-3

DOI

http://dx.doi.org/10.1007/s00203-012-0857-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046067757

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23239053


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