Ontology type: schema:ScholarlyArticle
2006-10
AUTHORSCorinna Weber-Sparenberg, Petra Pöplau, Heiner Brookman, Maike Rochón, Carolin Möckel, Monika Nietschke, Heinrich Jung
ABSTRACTTransport of flagellar structural proteins beyond the cytoplasmic membrane is accomplished by a type III secretory pathway [flagellar type III secretion system (fTTSS)]. The mechanism of substrate recognition by the fTTSS is still enigmatic. Using the hook scaffolding protein FlgD of Escherichia coli as a model substrate, it is demonstrated that the export signal is contained within the N-terminal 71 amino acids of FlgD. Analysis of frame-shift mutations and alterations of the nucleotide sequence suggest a proteinaceous nature of the signal. Furthermore, the physicochemical properties of the first about eight amino acids are crucial for export. More... »
PAGES307-316
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