Bone architecture, bone material properties, and bone turnover in non-osteoporotic post-menopausal women with fragility fracture View Full Text


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Article Info

DATE

2022-01-15

AUTHORS

D. B. Kimmel, S. Vennin, A. Desyatova, J. A. Turner, M. P. Akhter, J. M. Lappe, R. R. Recker

ABSTRACT

Summary Macro- and microarchitectural, bone material property, dynamic histomorphometric, and bone turnover marker data were studied in normal bone mineral density (BMD) post-menopausal women with fragility fracture. Women with fracture had thinner iliac cortices and more homogeneous bone material properties in cortical bone than age/BMD-matched non-fracture women. Low cortical thickness and bone tissue heterogeneity in normal BMD women are associated with prevalent fragility fracture.Introduction Bone mass (bone mineral density, (BMD)) of the spine and hip is today’s best single measurement for evaluating future fragility fracture risk. However, the majority of fragility fractures occur in women with BMD T-score above the WHO osteoporotic BMD threshold of − 2.5, indicating that non-BMD endpoints may play a role in their fragility fractures. We hypothesize that in non-osteoporotic women, bone micoarchitecture, bone material properties, dynamic histomorphometric endpoints, and bone turnover markers are related to fragility fracture.MethodsTwo groups (N = 60 each) of post-menopausal women with total hip BMD T-score ranging from + 0.3 to –2.49 were recruited: fragility fracture and age/BMD-matched, non-fragility fracture women. Normal (T-score > − 0.99) and osteopenic (T-score ≤ − 1.0) BMD cohorts were designated within both the fracture and non-fracture groups. Transiliac biopsy specimens were obtained to evaluate dynamic histomorphometric and microarchitectural endpoints and bone material properties by static and dynamic nanoindentation testing. All variables for fracture and non-fracture women within each BMD cohort were compared by the Wilcoxon signed-rank test (P < 0.01).ResultsCompared to non-fracture/normal BMD women, fracture/normal BMD women display lower iliac cortical thickness (− 12%, P = 0.0041) and lower heterogeneity of hardness (− 27%, P = 0.0068), elastic modulus (− 35%, P = 0.0009), and storage modulus (− 23%, P = 0.0054) in the cortical bone tissue, and lower heterogeneity of hardness (− 13%, P = 0.0088) in the trabecular bone tissue. Osteopenic women had no abnormalities related to fracture status.ConclusionPost-menopausal women with normal BMD and fragility fracture have low cortical thickness and heterogeneity of several bone material properties in cortical and trabecular mineralized bone tissue. These differences may explain a portion of the excess bone fragility in women with normal BMD and fragility fracture. More... »

PAGES

1125-1136

References to SciGraph publications

  • 2007-05-21. Nanoscale heterogeneity promotes energy dissipation in bone in NATURE MATERIALS
  • 2002-11. Emerging views about “osteoporosis”, bone health, strength, fragility, and their determinants in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2016-08-08. The nanocomposite nature of bone drives its strength and damage resistance in NATURE MATERIALS
  • 2014-06-08. In situ micropillar compression reveals superior strength and ductility but an absence of damage in lamellar bone in NATURE MATERIALS
  • 2013-10-11. Osteoporosis in the European Union: medical management, epidemiology and economic burden in ARCHIVES OF OSTEOPOROSIS
  • 2010-05-13. Development and use of FRAX® in osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 2012-02-21. Intrinsic Material Properties of Trabecular Bone by Nanoindentation Testing of Biopsies Taken from Healthy Women Before and After Menopause in CALCIFIED TISSUE INTERNATIONAL
  • 1993-05. Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women in OSTEOPOROSIS INTERNATIONAL
  • 2013-05-30. Distribution of bone density and cortical thickness in the proximal femur and their association with hip fracture in postmenopausal women: a quantitative computed tomography study in OSTEOPOROSIS INTERNATIONAL
  • 2008-01-10. Bone quality: the material and structural basis of bone strength in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2006-05-13. The population burden of fractures originates in women with osteopenia, not osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 2015-03-18. The Role of Water Compartments in the Material Properties of Cortical Bone in CALCIFIED TISSUE INTERNATIONAL
  • 2015-01-07. Contributions of Raman spectroscopy to the understanding of bone strength in BONEKEY REPORTS
  • 1992-06. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments in JOURNAL OF MATERIALS RESEARCH
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        "description": "Abstract\nSummary\nMacro- and microarchitectural, bone material property, dynamic histomorphometric, and bone turnover marker data were studied in normal bone mineral density (BMD) post-menopausal women with fragility fracture. Women with fracture had thinner iliac cortices and more homogeneous bone material properties in cortical bone than age/BMD-matched non-fracture women. Low cortical thickness and bone tissue heterogeneity in normal BMD women are associated with prevalent fragility fracture.Introduction\nBone mass (bone mineral density, (BMD)) of the spine and hip is today\u2019s best single measurement for evaluating future fragility fracture risk. However, the majority of fragility fractures occur in women with BMD T-score above the WHO osteoporotic BMD threshold of\u2009\u2212\u20092.5, indicating that non-BMD endpoints may play a role in their fragility fractures. We hypothesize that in non-osteoporotic women, bone micoarchitecture, bone material properties, dynamic histomorphometric endpoints, and bone turnover markers are related to fragility fracture.MethodsTwo groups (N\u2009=\u200960 each) of post-menopausal women with total hip BMD T-score ranging from\u2009+\u20090.3 to \u20132.49 were recruited: fragility fracture and age/BMD-matched, non-fragility fracture women. Normal (T-score\u2009>\u2009\u2009\u2212\u20090.99) and osteopenic (T-score\u2009\u2264\u2009\u2009\u2212\u20091.0) BMD cohorts were designated within both the fracture and non-fracture groups. Transiliac biopsy specimens were obtained to evaluate dynamic histomorphometric and microarchitectural endpoints and bone material properties by static and dynamic nanoindentation testing. All variables for fracture and non-fracture women within each BMD cohort were compared by the Wilcoxon signed-rank test (P\u2009<\u20090.01).ResultsCompared to non-fracture/normal BMD women, fracture/normal BMD women display lower iliac cortical thickness (\u2212\u200912%, P\u2009=\u20090.0041) and lower heterogeneity of hardness (\u2212\u200927%, P\u2009=\u20090.0068), elastic modulus (\u2212\u200935%, P\u2009=\u20090.0009), and storage modulus (\u2212\u200923%, P\u2009=\u20090.0054) in the cortical bone tissue, and lower heterogeneity of hardness (\u2212\u200913%, P\u2009=\u20090.0088) in the trabecular bone tissue. Osteopenic women had no abnormalities related to fracture status.ConclusionPost-menopausal women with normal BMD and fragility fracture have low cortical thickness and heterogeneity of several bone material properties in cortical and trabecular mineralized bone tissue. These differences may explain a portion of the excess bone fragility in women with normal BMD and fragility fracture.", 
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    29 schema:description Abstract Summary Macro- and microarchitectural, bone material property, dynamic histomorphometric, and bone turnover marker data were studied in normal bone mineral density (BMD) post-menopausal women with fragility fracture. Women with fracture had thinner iliac cortices and more homogeneous bone material properties in cortical bone than age/BMD-matched non-fracture women. Low cortical thickness and bone tissue heterogeneity in normal BMD women are associated with prevalent fragility fracture.Introduction Bone mass (bone mineral density, (BMD)) of the spine and hip is today’s best single measurement for evaluating future fragility fracture risk. However, the majority of fragility fractures occur in women with BMD T-score above the WHO osteoporotic BMD threshold of − 2.5, indicating that non-BMD endpoints may play a role in their fragility fractures. We hypothesize that in non-osteoporotic women, bone micoarchitecture, bone material properties, dynamic histomorphometric endpoints, and bone turnover markers are related to fragility fracture.MethodsTwo groups (N = 60 each) of post-menopausal women with total hip BMD T-score ranging from + 0.3 to –2.49 were recruited: fragility fracture and age/BMD-matched, non-fragility fracture women. Normal (T-score >  − 0.99) and osteopenic (T-score ≤  − 1.0) BMD cohorts were designated within both the fracture and non-fracture groups. Transiliac biopsy specimens were obtained to evaluate dynamic histomorphometric and microarchitectural endpoints and bone material properties by static and dynamic nanoindentation testing. All variables for fracture and non-fracture women within each BMD cohort were compared by the Wilcoxon signed-rank test (P < 0.01).ResultsCompared to non-fracture/normal BMD women, fracture/normal BMD women display lower iliac cortical thickness (− 12%, P = 0.0041) and lower heterogeneity of hardness (− 27%, P = 0.0068), elastic modulus (− 35%, P = 0.0009), and storage modulus (− 23%, P = 0.0054) in the cortical bone tissue, and lower heterogeneity of hardness (− 13%, P = 0.0088) in the trabecular bone tissue. Osteopenic women had no abnormalities related to fracture status.ConclusionPost-menopausal women with normal BMD and fragility fracture have low cortical thickness and heterogeneity of several bone material properties in cortical and trabecular mineralized bone tissue. These differences may explain a portion of the excess bone fragility in women with normal BMD and fragility fracture.
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    35 schema:keywords BMD
    36 BMD T-score
    37 BMD threshold
    38 Histomorphometric
    39 MethodsTwo groups
    40 ResultsCompared
    41 T-score
    42 Wilcoxon signed-rank test
    43 abnormalities
    44 age
    45 architecture
    46 best single measurement
    47 biopsy specimens
    48 bone
    49 bone architecture
    50 bone fragility
    51 bone mass
    52 bone material properties
    53 bone tissue
    54 bone tissue heterogeneity
    55 bone turnover
    56 bone turnover markers
    57 cohort
    58 cortex
    59 cortical bone
    60 cortical bone tissue
    61 cortical thickness
    62 data
    63 differences
    64 dynamic nanoindentation testing
    65 elastic modulus
    66 endpoint
    67 excess bone fragility
    68 fracture risk
    69 fracture status
    70 fractures
    71 fragility
    72 fragility fracture risk
    73 fragility fractures
    74 future fragility fracture risk
    75 group
    76 hardness
    77 heterogeneity
    78 hip
    79 hip BMD T-score
    80 histomorphometric endpoints
    81 iliac cortex
    82 introduction
    83 low heterogeneity
    84 lower cortical thickness
    85 macro
    86 majority
    87 marker data
    88 markers
    89 mass
    90 material properties
    91 measurements
    92 microarchitectural
    93 mineralized bone tissue
    94 modulus
    95 nanoindentation testing
    96 non-fracture group
    97 non-fracture women
    98 non-osteoporotic women
    99 normal BMD
    100 osteopenic women
    101 portion
    102 post-menopausal women
    103 prevalent fragility fractures
    104 properties
    105 risk
    106 role
    107 signed-rank test
    108 single measurement
    109 specimens
    110 spine
    111 status
    112 storage modulus
    113 summary
    114 test
    115 testing
    116 thickness
    117 threshold
    118 tissue
    119 tissue heterogeneity
    120 total hip BMD T-score
    121 trabecular bone tissue
    122 transiliac biopsy specimens
    123 turnover
    124 turnover markers
    125 variables
    126 women
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