Do proximal hip geometry, trabecular microarchitecture, and prevalent vertebral fractures differ in postmenopausal women with type 2 diabetes mellitus? A ... View Full Text


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Article Info

DATE

2021-01-27

AUTHORS

J. Paul, V. Devarapalli, J. T. Johnson, K. E. Cherian, F. K. Jebasingh, H. S. Asha, N. Kapoor, N. Thomas, T. V. Paul

ABSTRACT

This study from southern India showed that the trabecular microarchitecture and proximal hip geometry were significantly impaired in postmenopausal women with diabetes as compared to age and BMI matched non-diabetic controls. This is despite there being no significant difference in bone mineral density at the femoral neck and hip not between both groups. One-third of the study subjects with type 2 diabetes had prevalent vertebral fractures. Bone mineral density assessment as a standalone tool may not adequately reflect bone health in subjects with diabetes.IntroductionThere is limited information with regard to bone health in Indian postmenopausal women with type 2 diabetes. We studied the bone mineral density (BMD), trabecular bone score (TBS), prevalent vertebral fractures (VF), proximal hip geometry, and bone mineral biochemistry in ambulatory postmenopausal women with and without type 2 diabetes mellitus (T2DM).MethodsThis was a cross-sectional study conducted at a tertiary care center. BMD, TBS, prevalent vertebral fractures, and hip structural analysis (HSA) were assessed using a dual-energy X-ray absorptiometry (DXA) scanner. Bone mineral biochemical profiles were also studied.ResultsA total of 202 ambulatory postmenopausal women known to have type 2 diabetes mellitus with mean (SD) age of 65.6 (5.2) years and 200 age and BMI matched non-diabetic controls with mean (SD) age of 64.9 (4.7) years were recruited from the local community. Although the prevalence of lumbar spine osteoporosis was significantly lower among cases (30.7%) as compared to controls (42.9%), the prevalence of degraded bone microarchitecture (TBS < 1.200) was significantly higher among cases (51%) than in controls (23.5%); P < 0.001. Prevalent vertebral fractures were not significantly different in cases and controls. The various geometric indices of the proximal hip were significantly impaired in subjects with diabetes as compared to controls.ConclusionThis study may highlight the utility of the trabecular bone score and hip structural analysis in subjects with diabetes, where the bone mineral density tends to be paradoxically high, and may not adequately predict fracture risk. More... »

PAGES

1585-1593

References to SciGraph publications

  • 2019-03-09. Effect of diabetes on BMD and TBS values as determinants of bone health in the elderly: Bushehr Elderly Health program in JOURNAL OF DIABETES & METABOLIC DISORDERS
  • 2003-08-29. Measuring the structural strength of bones with dual-energy X-ray absorptiometry: principles, technical limitations, and future possibilities in OSTEOPOROSIS INTERNATIONAL
  • 2009-09-15. Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density? in OSTEOPOROSIS INTERNATIONAL
  • 2020-06-01. FRAX® with or without BMD and TBS predicts fragility fractures in community-dwelling rural southern Indian postmenopausal women in ARCHIVES OF OSTEOPOROSIS
  • 2013-07-20. Hip structural analysis: a comparison of DXA with CT in postmenopausal Japanese women in SPRINGERPLUS
  • 2009-07-08. Assessing the Susceptibility to Local Buckling at the Femoral Neck Cortex to Age-Related Bone Loss in ANNALS OF BIOMEDICAL ENGINEERING
  • 2006-10-27. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis in OSTEOPOROSIS INTERNATIONAL
  • 2020-02-24. Vertebral fracture assessment by dual-energy X-ray absorptiometry along with bone mineral density in the evaluation of postmenopausal osteoporosis in ARCHIVES OF OSTEOPOROSIS
  • 2019-06-18. Association between trabecular bone score and type 2 diabetes: a quantitative update of evidence in OSTEOPOROSIS INTERNATIONAL
  • 2006-03-22. Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture in OSTEOPOROSIS INTERNATIONAL
  • 2020-02-27. Insulin resistance negatively affects bone quality not quantity: the relationship between bone and adipose tissue in OSTEOPOROSIS INTERNATIONAL
  • 2017-10-07. The Trabecular Bone Score (TBS) Complements DXA and the FRAX as a Fracture Risk Assessment Tool in Routine Clinical Practice in CURRENT OSTEOPOROSIS REPORTS
  • 2018-07-31. Diagnosis and management of bone fragility in diabetes: an emerging challenge in OSTEOPOROSIS INTERNATIONAL
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    http://scigraph.springernature.com/pub.10.1007/s00198-021-05855-0

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    33 schema:description This study from southern India showed that the trabecular microarchitecture and proximal hip geometry were significantly impaired in postmenopausal women with diabetes as compared to age and BMI matched non-diabetic controls. This is despite there being no significant difference in bone mineral density at the femoral neck and hip not between both groups. One-third of the study subjects with type 2 diabetes had prevalent vertebral fractures. Bone mineral density assessment as a standalone tool may not adequately reflect bone health in subjects with diabetes.IntroductionThere is limited information with regard to bone health in Indian postmenopausal women with type 2 diabetes. We studied the bone mineral density (BMD), trabecular bone score (TBS), prevalent vertebral fractures (VF), proximal hip geometry, and bone mineral biochemistry in ambulatory postmenopausal women with and without type 2 diabetes mellitus (T2DM).MethodsThis was a cross-sectional study conducted at a tertiary care center. BMD, TBS, prevalent vertebral fractures, and hip structural analysis (HSA) were assessed using a dual-energy X-ray absorptiometry (DXA) scanner. Bone mineral biochemical profiles were also studied.ResultsA total of 202 ambulatory postmenopausal women known to have type 2 diabetes mellitus with mean (SD) age of 65.6 (5.2) years and 200 age and BMI matched non-diabetic controls with mean (SD) age of 64.9 (4.7) years were recruited from the local community. Although the prevalence of lumbar spine osteoporosis was significantly lower among cases (30.7%) as compared to controls (42.9%), the prevalence of degraded bone microarchitecture (TBS < 1.200) was significantly higher among cases (51%) than in controls (23.5%); P < 0.001. Prevalent vertebral fractures were not significantly different in cases and controls. The various geometric indices of the proximal hip were significantly impaired in subjects with diabetes as compared to controls.ConclusionThis study may highlight the utility of the trabecular bone score and hip structural analysis in subjects with diabetes, where the bone mineral density tends to be paradoxically high, and may not adequately predict fracture risk.
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