Clinical utility of bone turnover markers in monitoring the withdrawal of treatment with oral bisphosphonates in postmenopausal osteoporosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-06

AUTHORS

K.E. Naylor, E.V. McCloskey, R.M. Jacques, N.F.A. Peel, M.A. Paggiosi, F. Gossiel, J.S. Walsh, R. Eastell

ABSTRACT

Bone markers may be useful to monitor response to treatment withdrawal in osteoporosis. We used two criteria for investigating the change in BTMs after withdrawal of bisphosphonate treatment. A larger increase in BTMs was associated with greater bone loss. Bone markers may be useful in monitoring of patients taking a pause from treatment. INTRODUCTION: Measurement of bone turnover markers (BTMs) may be useful to monitor offset of treatment with bisphosphonates (BP) in osteoporosis. We assessed the effect of withdrawal of BP treatment by comparing the changes in BTMs and total hip (TH) bone density (BMD). METHODS: We studied postmenopausal osteoporotic women who had completed a randomised study of three oral BPs. After 2 years of treatment, participants with BMD T-score > - 2.5 and in whom it was considered clinically appropriate to discontinue treatment, were invited to participate in a further 2-year observational study. Biochemical response was assessed using BTMs (CTX and PINP) with offset being defined by two criteria: (1) an increase greater than the least significant change (LSC) and (2) an increase above the reference mean value. RESULTS: Fifty women completed the study. At 48 weeks after stopping BPs, CTX was greater than the LSC for 66% of women and PINP 72%; CTX was above the reference mean for 64% of women and PINP 42%. The decrease in THBMD was greater for women with the largest increase in BTM compared to those with continued suppression (mean difference for CTX was - 2.98%, 95%CI - 4.75 to - 1.22, P < 0.001, PINP - 2.25%, 95% CI - 4.46 to - 0.032, P = 0.046). CONCLUSION: The measurement of BTM after withdrawal of BPs is potentially useful to evaluate patients that are taking a pause from treatment. An increase in BTMs more than the LSC and/or reference mean reflects loss of treatment effect and identifies patients that are likely to have a decrease in BMD. Such changes could provide an indication for reintroduction of treatment. More... »

PAGES

1-6

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00198-018-04823-5

DOI

http://dx.doi.org/10.1007/s00198-018-04823-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111192399

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30613868


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Bone Metabolism, The Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naylor", 
        "givenName": "K.E.", 
        "id": "sg:person.01046775141.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046775141.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Bone Metabolism, The Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK", 
            "Centre for Integrated Research into Musculoskeletal Ageing, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCloskey", 
        "givenName": "E.V.", 
        "id": "sg:person.0766756074.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766756074.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "School of Health and Related Research, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacques", 
        "givenName": "R.M.", 
        "id": "sg:person.0661004305.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661004305.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sheffield Teaching Hospitals NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.31410.37", 
          "name": [
            "Metabolic Bone Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peel", 
        "givenName": "N.F.A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Bone Metabolism, The Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paggiosi", 
        "givenName": "M.A.", 
        "id": "sg:person.01145737717.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145737717.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Bone Metabolism, The Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gossiel", 
        "givenName": "F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Bone Metabolism, The Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walsh", 
        "givenName": "J.S.", 
        "id": "sg:person.01077624517.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077624517.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Bone Metabolism, The Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eastell", 
        "givenName": "R.", 
        "id": "sg:person.0100521534.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100521534.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bone.2008.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010244282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.296.24.2927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015996674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028094726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-010-1274-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030784902", 
          "https://doi.org/10.1007/s00198-010-1274-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-010-1274-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030784902", 
          "https://doi.org/10.1007/s00198-010-1274-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cca.2016.06.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037462055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-015-3145-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038798784", 
          "https://doi.org/10.1007/s00198-015-3145-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-017-3906-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040942415", 
          "https://doi.org/10.1007/s00198-017-3906-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-010-1501-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044145841", 
          "https://doi.org/10.1007/s00198-010-1501-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.040326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044221652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/cclm.2011.602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045745468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-014-2817-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046047996", 
          "https://doi.org/10.1007/s00198-014-2817-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc062792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046528061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1346.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049084665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.2708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053708671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2011-0412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.acc.2017.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083902202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11657-017-0324-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084956458", 
          "https://doi.org/10.1007/s11657-017-0324-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11657-017-0324-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084956458", 
          "https://doi.org/10.1007/s11657-017-0324-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-017-4026-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085091615", 
          "https://doi.org/10.1007/s00198-017-4026-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-017-4082-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086098844", 
          "https://doi.org/10.1007/s00198-017-4082-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-017-4082-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086098844", 
          "https://doi.org/10.1007/s00198-017-4082-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-017-4082-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086098844", 
          "https://doi.org/10.1007/s00198-017-4082-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-018-4460-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101408655", 
          "https://doi.org/10.1007/s00198-018-4460-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-018-4460-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101408655", 
          "https://doi.org/10.1007/s00198-018-4460-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-018-4460-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101408655", 
          "https://doi.org/10.1007/s00198-018-4460-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-018-4460-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101408655", 
          "https://doi.org/10.1007/s00198-018-4460-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-06", 
    "datePublishedReg": "2019-01-06", 
    "description": "Bone markers may be useful to monitor response to treatment withdrawal in osteoporosis. We used two criteria for investigating the change in BTMs after withdrawal of bisphosphonate treatment. A larger increase in BTMs was associated with greater bone loss. Bone markers may be useful in monitoring of patients taking a pause from treatment.\nINTRODUCTION: Measurement of bone turnover markers (BTMs) may be useful to monitor offset of treatment with bisphosphonates (BP) in osteoporosis. We assessed the effect of withdrawal of BP treatment by comparing the changes in BTMs and total hip (TH) bone density (BMD).\nMETHODS: We studied postmenopausal osteoporotic women who had completed a randomised study of three oral BPs. After 2\u00a0years of treatment, participants with BMD T-score\u2009>\u2009-\u20092.5 and in whom it was considered clinically appropriate to discontinue treatment, were invited to participate in a further 2-year observational study. Biochemical response was assessed using BTMs (CTX and PINP) with offset being defined by two criteria: (1) an increase greater than the least significant change (LSC) and (2) an increase above the reference mean value.\nRESULTS: Fifty women completed the study. At 48\u00a0weeks after stopping BPs, CTX was greater than the LSC for 66% of women and PINP 72%; CTX was above the reference mean for 64% of women and PINP 42%. The decrease in THBMD was greater for women with the largest increase in BTM compared to those with continued suppression (mean difference for CTX was -\u20092.98%, 95%CI -\u20094.75 to -\u20091.22, P\u2009<\u20090.001, PINP -\u20092.25%, 95% CI -\u20094.46 to -\u20090.032, P\u2009=\u20090.046).\nCONCLUSION: The measurement of BTM after withdrawal of BPs is potentially useful to evaluate patients that are taking a pause from treatment. An increase in BTMs more than the LSC and/or reference mean reflects loss of treatment effect and identifies patients that are likely to have a decrease in BMD. Such changes could provide an indication for reintroduction of treatment.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00198-018-04823-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2770073", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1100834", 
        "issn": [
          "0937-941X", 
          "1433-2965"
        ], 
        "name": "Osteoporosis International", 
        "type": "Periodical"
      }
    ], 
    "name": "Clinical utility of bone turnover markers in monitoring the withdrawal of treatment with oral bisphosphonates in postmenopausal osteoporosis", 
    "pagination": "1-6", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "12089e25f8773317e3de98467ddb6d90bb8bb10e0567c08a7487dd97099f51bb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30613868"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9100105"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00198-018-04823-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111192399"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00198-018-04823-5", 
      "https://app.dimensions.ai/details/publication/pub.1111192399"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78959_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00198-018-04823-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00198-018-04823-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00198-018-04823-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00198-018-04823-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00198-018-04823-5'


 

This table displays all metadata directly associated to this object as RDF triples.

186 TRIPLES      21 PREDICATES      46 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00198-018-04823-5 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N3a8906a621ff48daa3c3fda9463df592
4 schema:citation sg:pub.10.1007/s00198-010-1274-6
5 sg:pub.10.1007/s00198-010-1501-1
6 sg:pub.10.1007/s00198-014-2817-z
7 sg:pub.10.1007/s00198-015-3145-7
8 sg:pub.10.1007/s00198-017-3906-6
9 sg:pub.10.1007/s00198-017-4026-z
10 sg:pub.10.1007/s00198-017-4082-4
11 sg:pub.10.1007/s00198-018-4460-6
12 sg:pub.10.1007/s11657-017-0324-5
13 https://doi.org/10.1001/jama.296.24.2927
14 https://doi.org/10.1002/jbmr.251
15 https://doi.org/10.1002/jbmr.2708
16 https://doi.org/10.1016/bs.acc.2017.01.003
17 https://doi.org/10.1016/j.bone.2008.04.007
18 https://doi.org/10.1016/j.cca.2016.06.036
19 https://doi.org/10.1056/nejmc062792
20 https://doi.org/10.1196/annals.1346.041
21 https://doi.org/10.1210/jc.2011-0412
22 https://doi.org/10.1359/jbmr.040326
23 https://doi.org/10.1515/cclm.2011.602
24 schema:datePublished 2019-01-06
25 schema:datePublishedReg 2019-01-06
26 schema:description Bone markers may be useful to monitor response to treatment withdrawal in osteoporosis. We used two criteria for investigating the change in BTMs after withdrawal of bisphosphonate treatment. A larger increase in BTMs was associated with greater bone loss. Bone markers may be useful in monitoring of patients taking a pause from treatment. INTRODUCTION: Measurement of bone turnover markers (BTMs) may be useful to monitor offset of treatment with bisphosphonates (BP) in osteoporosis. We assessed the effect of withdrawal of BP treatment by comparing the changes in BTMs and total hip (TH) bone density (BMD). METHODS: We studied postmenopausal osteoporotic women who had completed a randomised study of three oral BPs. After 2 years of treatment, participants with BMD T-score > - 2.5 and in whom it was considered clinically appropriate to discontinue treatment, were invited to participate in a further 2-year observational study. Biochemical response was assessed using BTMs (CTX and PINP) with offset being defined by two criteria: (1) an increase greater than the least significant change (LSC) and (2) an increase above the reference mean value. RESULTS: Fifty women completed the study. At 48 weeks after stopping BPs, CTX was greater than the LSC for 66% of women and PINP 72%; CTX was above the reference mean for 64% of women and PINP 42%. The decrease in THBMD was greater for women with the largest increase in BTM compared to those with continued suppression (mean difference for CTX was - 2.98%, 95%CI - 4.75 to - 1.22, P < 0.001, PINP - 2.25%, 95% CI - 4.46 to - 0.032, P = 0.046). CONCLUSION: The measurement of BTM after withdrawal of BPs is potentially useful to evaluate patients that are taking a pause from treatment. An increase in BTMs more than the LSC and/or reference mean reflects loss of treatment effect and identifies patients that are likely to have a decrease in BMD. Such changes could provide an indication for reintroduction of treatment.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf sg:journal.1100834
31 schema:name Clinical utility of bone turnover markers in monitoring the withdrawal of treatment with oral bisphosphonates in postmenopausal osteoporosis
32 schema:pagination 1-6
33 schema:productId Na499c549c7684e849222fb87595cde3c
34 Naef7abc977de4197bf6879e5b9d04fd7
35 Nc9700074e317459ab5064d8255614b2c
36 Ne428d7443ff14ce683000c08a40e89d1
37 Ne76ace4574b24cbeb17e1e593264d2f8
38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111192399
39 https://doi.org/10.1007/s00198-018-04823-5
40 schema:sdDatePublished 2019-04-11T13:19
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher N22023cee3b3941828e73a4692496566e
43 schema:url https://link.springer.com/10.1007%2Fs00198-018-04823-5
44 sgo:license sg:explorer/license/
45 sgo:sdDataset articles
46 rdf:type schema:ScholarlyArticle
47 N1635c281b6494465a371e574254da902 rdf:first sg:person.0100521534.43
48 rdf:rest rdf:nil
49 N22023cee3b3941828e73a4692496566e schema:name Springer Nature - SN SciGraph project
50 rdf:type schema:Organization
51 N3856a1f217854e3780f8bd575278c223 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
52 schema:familyName Gossiel
53 schema:givenName F.
54 rdf:type schema:Person
55 N3a8906a621ff48daa3c3fda9463df592 rdf:first sg:person.01046775141.46
56 rdf:rest N6a516d0cf67449209c9f22fc23feb573
57 N58b7159796c649348f4dbf1b049bfe5f rdf:first N8a0658b0f887411581747f1f5db94f0c
58 rdf:rest Nf53375d8b9cb4272a98d073c6a44760c
59 N6a516d0cf67449209c9f22fc23feb573 rdf:first sg:person.0766756074.39
60 rdf:rest Neac4971cda1845b881d74a8d16ce1b72
61 N810e02d883414795841f043271fcf672 rdf:first N3856a1f217854e3780f8bd575278c223
62 rdf:rest Nc47048ccb70e44d094d1c3977054a6bd
63 N8a0658b0f887411581747f1f5db94f0c schema:affiliation https://www.grid.ac/institutes/grid.31410.37
64 schema:familyName Peel
65 schema:givenName N.F.A.
66 rdf:type schema:Person
67 Na499c549c7684e849222fb87595cde3c schema:name dimensions_id
68 schema:value pub.1111192399
69 rdf:type schema:PropertyValue
70 Naef7abc977de4197bf6879e5b9d04fd7 schema:name doi
71 schema:value 10.1007/s00198-018-04823-5
72 rdf:type schema:PropertyValue
73 Nc47048ccb70e44d094d1c3977054a6bd rdf:first sg:person.01077624517.19
74 rdf:rest N1635c281b6494465a371e574254da902
75 Nc9700074e317459ab5064d8255614b2c schema:name readcube_id
76 schema:value 12089e25f8773317e3de98467ddb6d90bb8bb10e0567c08a7487dd97099f51bb
77 rdf:type schema:PropertyValue
78 Ne428d7443ff14ce683000c08a40e89d1 schema:name nlm_unique_id
79 schema:value 9100105
80 rdf:type schema:PropertyValue
81 Ne76ace4574b24cbeb17e1e593264d2f8 schema:name pubmed_id
82 schema:value 30613868
83 rdf:type schema:PropertyValue
84 Neac4971cda1845b881d74a8d16ce1b72 rdf:first sg:person.0661004305.45
85 rdf:rest N58b7159796c649348f4dbf1b049bfe5f
86 Nf53375d8b9cb4272a98d073c6a44760c rdf:first sg:person.01145737717.60
87 rdf:rest N810e02d883414795841f043271fcf672
88 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
89 schema:name Medical and Health Sciences
90 rdf:type schema:DefinedTerm
91 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
92 schema:name Clinical Sciences
93 rdf:type schema:DefinedTerm
94 sg:grant.2770073 http://pending.schema.org/fundedItem sg:pub.10.1007/s00198-018-04823-5
95 rdf:type schema:MonetaryGrant
96 sg:journal.1100834 schema:issn 0937-941X
97 1433-2965
98 schema:name Osteoporosis International
99 rdf:type schema:Periodical
100 sg:person.0100521534.43 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
101 schema:familyName Eastell
102 schema:givenName R.
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100521534.43
104 rdf:type schema:Person
105 sg:person.01046775141.46 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
106 schema:familyName Naylor
107 schema:givenName K.E.
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046775141.46
109 rdf:type schema:Person
110 sg:person.01077624517.19 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
111 schema:familyName Walsh
112 schema:givenName J.S.
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077624517.19
114 rdf:type schema:Person
115 sg:person.01145737717.60 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
116 schema:familyName Paggiosi
117 schema:givenName M.A.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145737717.60
119 rdf:type schema:Person
120 sg:person.0661004305.45 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
121 schema:familyName Jacques
122 schema:givenName R.M.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661004305.45
124 rdf:type schema:Person
125 sg:person.0766756074.39 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
126 schema:familyName McCloskey
127 schema:givenName E.V.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766756074.39
129 rdf:type schema:Person
130 sg:pub.10.1007/s00198-010-1274-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030784902
131 https://doi.org/10.1007/s00198-010-1274-6
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s00198-010-1501-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044145841
134 https://doi.org/10.1007/s00198-010-1501-1
135 rdf:type schema:CreativeWork
136 sg:pub.10.1007/s00198-014-2817-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1046047996
137 https://doi.org/10.1007/s00198-014-2817-z
138 rdf:type schema:CreativeWork
139 sg:pub.10.1007/s00198-015-3145-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038798784
140 https://doi.org/10.1007/s00198-015-3145-7
141 rdf:type schema:CreativeWork
142 sg:pub.10.1007/s00198-017-3906-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040942415
143 https://doi.org/10.1007/s00198-017-3906-6
144 rdf:type schema:CreativeWork
145 sg:pub.10.1007/s00198-017-4026-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1085091615
146 https://doi.org/10.1007/s00198-017-4026-z
147 rdf:type schema:CreativeWork
148 sg:pub.10.1007/s00198-017-4082-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086098844
149 https://doi.org/10.1007/s00198-017-4082-4
150 rdf:type schema:CreativeWork
151 sg:pub.10.1007/s00198-018-4460-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101408655
152 https://doi.org/10.1007/s00198-018-4460-6
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/s11657-017-0324-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084956458
155 https://doi.org/10.1007/s11657-017-0324-5
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1001/jama.296.24.2927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015996674
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1002/jbmr.251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028094726
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1002/jbmr.2708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053708671
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/bs.acc.2017.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083902202
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.bone.2008.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010244282
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.cca.2016.06.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037462055
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1056/nejmc062792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046528061
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1196/annals.1346.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049084665
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1210/jc.2011-0412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292743
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1359/jbmr.040326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044221652
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1515/cclm.2011.602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045745468
178 rdf:type schema:CreativeWork
179 https://www.grid.ac/institutes/grid.11835.3e schema:alternateName University of Sheffield
180 schema:name Academic Unit of Bone Metabolism, The Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK
181 Centre for Integrated Research into Musculoskeletal Ageing, Liverpool, UK
182 School of Health and Related Research, University of Sheffield, Sheffield, UK
183 rdf:type schema:Organization
184 https://www.grid.ac/institutes/grid.31410.37 schema:alternateName Sheffield Teaching Hospitals NHS Foundation Trust
185 schema:name Metabolic Bone Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital Sheffield, Sheffield, UK
186 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...