Effect of vitamin D3 on bone turnover markers in critical illness: post hoc analysis from the VITdAL-ICU study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-25

AUTHORS

V. Schwetz, C. Schnedl, T. Urbanic-Purkart, C. Trummer, H. P. Dimai, A. Fahrleitner-Pammer, C. Putz-Bankuti, K. B. Christopher, B. Obermayer-Pietsch, T. R. Pieber, H. Dobnig, K. Amrein

ABSTRACT

In this post hoc analysis of the VITdAL-ICU study, an RCT in critically ill adults with 25-hydroxyvitamin D levels ≤20 ng/ml, vitamin D3 did not have a significant effect on β-Crosslaps and osteocalcin.IntroductionObservational studies have shown accelerated bone loss in ICU survivors. A reversible contributor is vitamin D deficiency. In a post hoc analysis of the VITdAL-ICU study, we evaluated the effect of high-dose vitamin D3 on the bone turnover markers (BTM) β-Crosslaps (CTX) and osteocalcin (OC).MethodsThe VITdAL-ICU study was a randomized, double-blind, placebo-controlled trial in critically ill adults with 25-hydroxyvitamin D levels ≤20 ng/ml who received placebo or high-dose vitamin D3 (a loading dose of 540,000 IU and starting 1 month after the loading dose five monthly maintenance doses of 90,000 IU). In this analysis on 289 survivors (209 telephone, 80 personal follow-up visits), BTM were analyzed on days 0, 3, 7, 28, and 180; self-reported falls and fractures were assessed. Bone mineral density (BMD) was measured after 6 months.ResultsAt baseline, CTX was elevated; OC was low in both groups—after 6 months, both had returned to normal. There were no differences between groups concerning BTM, BMD, falls, or fractures. In linear mixed effects models, CTX and OC showed a significant change over time (p < 0.001, respectively), but there was no difference between the vitamin D and placebo group (p = 0.688 and p = 0.972, respectively).ConclusionsVitamin D supplementation did not have a significant effect on BTM. Further studies should assess the effectiveness of vitamin D on musculoskeletal outcomes in ICU survivors. More... »

PAGES

3347-3354

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00198-017-4190-1

DOI

http://dx.doi.org/10.1007/s00198-017-4190-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091353450

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28842727


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33 schema:description In this post hoc analysis of the VITdAL-ICU study, an RCT in critically ill adults with 25-hydroxyvitamin D levels ≤20 ng/ml, vitamin D3 did not have a significant effect on β-Crosslaps and osteocalcin.IntroductionObservational studies have shown accelerated bone loss in ICU survivors. A reversible contributor is vitamin D deficiency. In a post hoc analysis of the VITdAL-ICU study, we evaluated the effect of high-dose vitamin D3 on the bone turnover markers (BTM) β-Crosslaps (CTX) and osteocalcin (OC).MethodsThe VITdAL-ICU study was a randomized, double-blind, placebo-controlled trial in critically ill adults with 25-hydroxyvitamin D levels ≤20 ng/ml who received placebo or high-dose vitamin D3 (a loading dose of 540,000 IU and starting 1 month after the loading dose five monthly maintenance doses of 90,000 IU). In this analysis on 289 survivors (209 telephone, 80 personal follow-up visits), BTM were analyzed on days 0, 3, 7, 28, and 180; self-reported falls and fractures were assessed. Bone mineral density (BMD) was measured after 6 months.ResultsAt baseline, CTX was elevated; OC was low in both groups—after 6 months, both had returned to normal. There were no differences between groups concerning BTM, BMD, falls, or fractures. In linear mixed effects models, CTX and OC showed a significant change over time (p < 0.001, respectively), but there was no difference between the vitamin D and placebo group (p = 0.688 and p = 0.972, respectively).ConclusionsVitamin D supplementation did not have a significant effect on BTM. Further studies should assess the effectiveness of vitamin D on musculoskeletal outcomes in ICU survivors.
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39 schema:keywords BTM
40 CTX
41 ConclusionsVitamin D supplementation
42 D deficiency
43 D levels
44 D supplementation
45 D3
46 Further studies
47 ICU survivors
48 RCTs
49 ResultsAt baseline
50 adults
51 analysis
52 baseline
53 bone loss
54 bone mineral density
55 bone turnover markers
56 changes
57 contributor
58 critical illness
59 day 0
60 deficiency
61 density
62 differences
63 effect
64 effectiveness
65 effects model
66 fall
67 fractures
68 group
69 high-dose vitamin D3
70 ill adults
71 illness
72 levels
73 linear mixed effects models
74 loss
75 markers
76 mineral density
77 mixed effects models
78 model
79 months
80 musculoskeletal outcomes
81 osteocalcin
82 outcomes
83 placebo
84 placebo group
85 placebo-controlled trial
86 post
87 reversible contributors
88 self-reported falls
89 significant changes
90 significant effect
91 study
92 supplementation
93 survivors
94 time
95 trials
96 turnover markers
97 vitamin D
98 vitamin D deficiency
99 vitamin D3
100 β-crosslaps
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