Relationship between baseline characteristics and response to risedronate treatment for osteoporosis: data from three Japanese phase III trials View Full Text


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Article Info

DATE

2017-04

AUTHORS

T. Mawatari, R. Muraoka, Y. Iwamoto

ABSTRACT

We evaluated the influence of baseline age, bone mineral density (BMD), and serum levels of vitamin D on the response to risedronate treatment. Risedronate consistently increased BMD, but our results suggest vitamin D supplementation may be necessary to achieve optimal treatment effect. Furthermore, early intervention may help prevent bone fractures. INTRODUCTION: We aimed to investigate the influence of baseline age, BMD, and vitamin D insufficiency on the response to risedronate treatment. METHODS: Data regarding 1447 patients was obtained from the registries of three phase III clinical trials of risedronate. The response to treatment was expressed in terms of BMD increase and occurrence of new vertebral fractures. The patients were stratified by baseline values for age (<65, 65-72, and ≥72 years), lumbar spine BMD T-score (osteoporotic, <-2.5; and non-osteoporotic, ≥- 2.5), and serum levels of 25-hydroxyvitamin D (deficient, <21 ng/mL; and non-deficient, ≥21 ng/mL). RESULTS: Risedronate consistently increased lumbar spine BMD in all the groups, with similar percentage and absolute increments in all the age tertiles. The percentage, but not absolute, increment in BMD was significantly higher (p = 0.0003) in the osteoporotic than that in the non-osteoporotic patients (baseline). Of the 1330 patients whose baseline serum levels of 25-hydroxyvitamin D were available, 44.7% had vitamin D deficiency (<20 ng/mL), while 89.2% had insufficiency (<30 ng/mL). The percentage and absolute increments in BMD were lower (p < 0.05 and p < 0.01, respectively) in the vitamin D-deficient than those in the non-deficient patients. New vertebral fractures occurred in 1.5 and 0.8% of the osteoporotic and non-osteoporotic patients, respectively (end of the treatment). CONCLUSIONS: Therapeutic response in elderly patients is consistent, but early initiation of risedronate treatment may help prevent fractures. Risedronate-induced increase in BMD is lower in patients with vitamin D deficiency, suggesting that vitamin D supplementation is important to achieve optimal treatment response. More... »

PAGES

1279-1286

References to SciGraph publications

  • 2002-12. Effect of vitamin D on bone mineral density of elderly patients with osteoporosis responding poorly to bisphosphonates in BMC MUSCULOSKELETAL DISORDERS
  • 2008-10. Assessing response to osteoporosis therapy in OSTEOPOROSIS INTERNATIONAL
  • 2012-10. The 25(OH)D level needed to maintain a favorable bisphosphonate response is ≥33 ng/ml in OSTEOPOROSIS INTERNATIONAL
  • 2004-09. A comparison of incidences of vertebral fracture in Japanese patients with involutional osteoporosis treated with risedronate and etidronate: a randomized, double-masked trial in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2011-01. Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D3 load in Japanese subjects in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2002-12. A Comparison of the Effect of Risedronate and Etidronate on Lumbar Bone Mineral Density in Japanese Patients with Osteoporosis: A Randomized Controlled Trial in OSTEOPOROSIS INTERNATIONAL
  • 2008-08. Osteoporosis treatment and fracture incidence: the ICARO longitudinal study in OSTEOPOROSIS INTERNATIONAL
  • 2000-01. Randomized Trial of the Effects of Risedronate on Vertebral Fractures in Women with Established Postmenopausal Osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 1998-08. Diagnostic criteria of primary osteoporosis in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2001-11. Diagnostic criteria for primary osteoporosis: year 2000 revision in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2009-02. Vitamin D status and response to treatment in post-menopausal osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 2009-11. Minimum Required Vitamin D Level for Optimal Increase in Bone Mineral Density with Alendronate Treatment in Osteoporotic Women in CALCIFIED TISSUE INTERNATIONAL
  • 2006-09. Efficacy and tolerability of once-weekly administration of 17.5 mg risedronate in Japanese patients with involutional osteoporosis: a comparison with 2.5-mg once-daily dosage regimen in JOURNAL OF BONE AND MINERAL METABOLISM
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00198-016-3848-4

    DOI

    http://dx.doi.org/10.1007/s00198-016-3848-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029132111

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27900428


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        "description": "We evaluated the influence of baseline age, bone mineral density (BMD), and serum levels of vitamin D on the response to risedronate treatment. Risedronate consistently increased BMD, but our results suggest vitamin D supplementation may be necessary to achieve optimal treatment effect. Furthermore, early intervention may help prevent bone fractures.\nINTRODUCTION: We aimed to investigate the influence of baseline age, BMD, and vitamin D insufficiency on the response to risedronate treatment.\nMETHODS: Data regarding 1447 patients was obtained from the registries of three phase III clinical trials of risedronate. The response to treatment was expressed in terms of BMD increase and occurrence of new vertebral fractures. The patients were stratified by baseline values for age (<65, 65-72, and \u226572\u00a0years), lumbar spine BMD T-score (osteoporotic, <-2.5; and non-osteoporotic, \u2265-\u20092.5), and serum levels of 25-hydroxyvitamin D (deficient, <21\u00a0ng/mL; and non-deficient, \u226521\u00a0ng/mL).\nRESULTS: Risedronate consistently increased lumbar spine BMD in all the groups, with similar percentage and absolute increments in all the age tertiles. The percentage, but not absolute, increment in BMD was significantly higher (p\u2009=\u20090.0003) in the osteoporotic than that in the non-osteoporotic patients (baseline). Of the 1330 patients whose baseline serum levels of 25-hydroxyvitamin D were available, 44.7% had vitamin D deficiency (<20\u00a0ng/mL), while 89.2% had insufficiency (<30\u00a0ng/mL). The percentage and absolute increments in BMD were lower (p\u2009<\u20090.05 and p\u2009<\u20090.01, respectively) in the vitamin D-deficient than those in the non-deficient patients. New vertebral fractures occurred in 1.5 and 0.8% of the osteoporotic and non-osteoporotic patients, respectively (end of the treatment).\nCONCLUSIONS: Therapeutic response in elderly patients is consistent, but early initiation of risedronate treatment may help prevent fractures. Risedronate-induced increase in BMD is lower in patients with vitamin D deficiency, suggesting that vitamin D supplementation is important to achieve optimal treatment response.", 
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