Surgery alters parameters of vitamin D status and other laboratory results View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-08

AUTHORS

N. Binkley, D. Coursin, D. Krueger, P. Iglar, J. Heiner, R. Illgen, M. Squire, J. Lappe, P. Watson, K. Hogan

ABSTRACT

Fracture liaison services often perform laboratory testing, but these results may be altered by surgery. In 40 hip arthroplasty patients, many laboratory parameters of bone health relevance were reduced by 8–22% on the first post-operative day. Laboratory results obtained in the immediate post-surgery interval do not reliably ascertain baseline status.IntroductionAs secondary causes of osteoporosis are common, fracture liaison services often perform laboratory testing in the immediate post-fracture interval. We hypothesized that laboratory results obtained shortly after surgery may not accurately ascertain baseline status. If true, such alterations might confound subsequent fracture prevention efforts.MethodsPatients undergoing elective total hip arthroplasty were studied as a surrogate for hip fracture patients. Blood and urine were obtained 2 weeks before surgery, before anesthetic induction, on post-operative day one, and 6 weeks after surgery. Serum total and free 25-hydroxyvitamin D (25(OH)D), vitamin D-binding protein (DBP), calcium, creatinine, albumin (Alb), alkaline phosphatase (ALP), plasma hemoglobin (Hgb) and urinary DBP/creatinine ratio (UDBP/Cr) were measured.ResultsForty volunteers (28 women; 12 men) with mean age of 65.7 [8.7] years were studied. Laboratory results were stable from 2 weeks before to the day of surgery. On the first day after surgery, total 25(OH)D, DBP, calcium, creatinine, ALP, and Alb declined 8–22% (p < 0.0001); free 25(OH)D and Hgb declined by 8 and 15% (p < 0.01), respectively; and UDBP/Cr increased 32% (p < 0.01). Using a 25(OH)D <30 ng/mL threshold, vitamin D inadequacy prevalence increased from 38% before surgery to 68% the day after (p < 0.001). All laboratory values returned to baseline at 6 weeks after surgery.ConclusionsLaboratory values are reduced immediately following elective total hip arthroplasty. Testing at that time does not accurately ascertain baseline status and may lead to elevated estimates of vitamin D inadequacy, incorrect interventions, and misallocation of healthcare resources. More... »

PAGES

1013-1020

References to SciGraph publications

  • 2015-01-15. Perioperative catabolism in JOURNAL CANADIEN D'ANESTHÉSIE
  • 2008-04-18. Rapid correction of low vitamin D status in nursing home residents in OSTEOPOROSIS INTERNATIONAL
  • 2013-10-24. A systematic review of models used in cost-effectiveness analyses of preventing osteoporotic fractures in OSTEOPOROSIS INTERNATIONAL
  • 2016-02-01. Perioperative risk factors in patients with a femoral neck fracture – influence of 25-hydroxyvitamin D and C-reactive protein on postoperative medical complications and 1-year mortality in BMC MUSCULOSKELETAL DISORDERS
  • 2013-10-11. Osteoporosis in the European Union: medical management, epidemiology and economic burden in ARCHIVES OF OSTEOPOROSIS
  • 2015-04-10. Perioperative fluid therapy: a statement from the international Fluid Optimization Group in PERIOPERATIVE MEDICINE
  • 2013-04-16. Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle in OSTEOPOROSIS INTERNATIONAL
  • 2014-02-22. A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions in OSTEOPOROSIS INTERNATIONAL
  • 2014-08-05. Fracture mortality: associations with epidemiology and osteoporosis treatment in NATURE REVIEWS ENDOCRINOLOGY
  • 2015-04-30. Vitamin D status and surgical outcomes: a systematic review in PATIENT SAFETY IN SURGERY
  • 2016-06-13. Is there an association between low serum 25-OH-D levels and the length of hospital stay in orthopaedic patients after arthroplasty? in JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
  • 2008-03-29. Vitamin D-deficiency and post-fracture changes in lower extremity function and falls in women with hip fractures in OSTEOPOROSIS INTERNATIONAL
  • 2003-12-23. Fracture risk following an osteoporotic fracture in OSTEOPOROSIS INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00198-016-3819-9

    DOI

    http://dx.doi.org/10.1007/s00198-016-3819-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037372044

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27826645


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Arthroplasty, Replacement, Hip", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "False Positive Reactions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hip Fractures", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteoarthritis, Hip", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteoporosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteoporotic Fractures", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Postoperative Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Postoperative Period", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vitamin D", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vitamin D Deficiency", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "University of Wisconsin Osteoporosis Clinical Research Program, 2870 University Ave, 53705, Madison, WI, USA", 
                "Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Binkley", 
            "givenName": "N.", 
            "id": "sg:person.0762201325.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762201325.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, 53792-3272, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA", 
                "Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, 53792-3272, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coursin", 
            "givenName": "D.", 
            "id": "sg:person.01000310121.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000310121.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Wisconsin Osteoporosis Clinical Research Program, 2870 University Ave, 53705, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.28803.31", 
              "name": [
                "University of Wisconsin Osteoporosis Clinical Research Program, 2870 University Ave, 53705, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krueger", 
            "givenName": "D.", 
            "id": "sg:person.01056220020.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056220020.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 707 WARF Building, 610 North Walnut Street, 53726, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 707 WARF Building, 610 North Walnut Street, 53726, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iglar", 
            "givenName": "P.", 
            "id": "sg:person.0753477425.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753477425.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heiner", 
            "givenName": "J.", 
            "id": "sg:person.0676454034.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676454034.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Illgen", 
            "givenName": "R.", 
            "id": "sg:person.01240175733.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240175733.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Squire", 
            "givenName": "M.", 
            "id": "sg:person.0620306350.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620306350.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Creighton University Osteoporosis Research Center, 601 N. 30th Street, Suite 4820, 68131, Omaha, NE, USA", 
              "id": "http://www.grid.ac/institutes/grid.254748.8", 
              "name": [
                "Creighton University Osteoporosis Research Center, 601 N. 30th Street, Suite 4820, 68131, Omaha, NE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lappe", 
            "givenName": "J.", 
            "id": "sg:person.0714345342.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714345342.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Creighton University Osteoporosis Research Center, 601 N. 30th Street, Suite 4820, 68131, Omaha, NE, USA", 
              "id": "http://www.grid.ac/institutes/grid.254748.8", 
              "name": [
                "Creighton University Osteoporosis Research Center, 601 N. 30th Street, Suite 4820, 68131, Omaha, NE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watson", 
            "givenName": "P.", 
            "id": "sg:person.0654165000.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654165000.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, 53792-3272, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, 53792-3272, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hogan", 
            "givenName": "K.", 
            "id": "sg:person.01224717320.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224717320.99"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s12630-014-0274-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047563980", 
              "https://doi.org/10.1007/s12630-014-0274-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-013-2348-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041850502", 
              "https://doi.org/10.1007/s00198-013-2348-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-003-1514-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042859125", 
              "https://doi.org/10.1007/s00198-003-1514-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13037-015-0060-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006078707", 
              "https://doi.org/10.1186/s13037-015-0060-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12891-016-0906-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049489227", 
              "https://doi.org/10.1186/s12891-016-0906-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-013-2551-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038103420", 
              "https://doi.org/10.1007/s00198-013-2551-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-008-0582-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020722804", 
              "https://doi.org/10.1007/s00198-008-0582-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13741-015-0014-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019124807", 
              "https://doi.org/10.1186/s13741-015-0014-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2014.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004508818", 
              "https://doi.org/10.1038/nrendo.2014.125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10195-016-0414-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015094957", 
              "https://doi.org/10.1007/s10195-016-0414-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-008-0619-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017008873", 
              "https://doi.org/10.1007/s00198-008-0619-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11657-013-0136-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040868574", 
              "https://doi.org/10.1007/s11657-013-0136-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-014-2636-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015615014", 
              "https://doi.org/10.1007/s00198-014-2636-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-11-08", 
        "datePublishedReg": "2016-11-08", 
        "description": "Fracture liaison services often perform laboratory testing, but these results may be altered by surgery. In 40 hip arthroplasty patients, many laboratory parameters of bone health relevance were reduced by 8\u201322% on the first post-operative day. Laboratory results obtained in the immediate post-surgery interval do not reliably ascertain baseline status.IntroductionAs secondary causes of osteoporosis are common, fracture liaison services often perform laboratory testing in the immediate post-fracture interval. We hypothesized that laboratory results obtained shortly after surgery may not accurately ascertain baseline status. If true, such alterations might confound subsequent fracture prevention efforts.MethodsPatients undergoing elective total hip arthroplasty were studied as a surrogate for hip fracture patients. Blood and urine were obtained 2\u00a0weeks before surgery, before anesthetic induction, on post-operative day one, and 6\u00a0weeks after surgery. Serum total and free 25-hydroxyvitamin D (25(OH)D), vitamin D-binding protein (DBP), calcium, creatinine, albumin (Alb), alkaline phosphatase (ALP), plasma hemoglobin (Hgb) and urinary DBP/creatinine ratio (UDBP/Cr) were measured.ResultsForty volunteers (28 women; 12 men) with mean age of 65.7 [8.7]\u00a0years were studied. Laboratory results were stable from 2\u00a0weeks before to the day of surgery. On the first day after surgery, total 25(OH)D, DBP, calcium, creatinine, ALP, and Alb declined 8\u201322% (p\u00a0<\u00a00.0001); free 25(OH)D and Hgb declined by 8 and 15% (p\u00a0<\u00a00.01), respectively; and UDBP/Cr increased 32% (p\u00a0<\u00a00.01). Using a 25(OH)D <30\u00a0ng/mL threshold, vitamin D inadequacy prevalence increased from 38% before surgery to 68% the day after (p\u00a0<\u00a00.001). All laboratory values returned to baseline at 6\u00a0weeks after surgery.ConclusionsLaboratory values are reduced immediately following elective total hip arthroplasty. Testing at that time does not accurately ascertain baseline status and may lead to elevated estimates of vitamin D inadequacy, incorrect interventions, and misallocation of healthcare resources.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00198-016-3819-9", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1100834", 
            "issn": [
              "0937-941X", 
              "1433-2965"
            ], 
            "name": "Osteoporosis International", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "28"
          }
        ], 
        "keywords": [
          "elective total hip arthroplasty", 
          "fracture liaison service", 
          "total hip arthroplasty", 
          "baseline status", 
          "hip arthroplasty", 
          "liaison service", 
          "post-operative day one", 
          "first post-operative day", 
          "fracture prevention efforts", 
          "vitamin D inadequacy", 
          "hip fracture patients", 
          "vitamin D status", 
          "day of surgery", 
          "post-operative day", 
          "hip arthroplasty patients", 
          "laboratory results", 
          "alkaline phosphatase", 
          "post-surgery interval", 
          "D status", 
          "fracture patients", 
          "laboratory parameters", 
          "serum total", 
          "creatinine ratio", 
          "arthroplasty patients", 
          "vitamin D", 
          "mean age", 
          "anesthetic induction", 
          "secondary causes", 
          "laboratory testing", 
          "laboratory values", 
          "surgery", 
          "healthcare resources", 
          "plasma hemoglobin", 
          "health relevance", 
          "prevention efforts", 
          "day one", 
          "weeks", 
          "first day", 
          "patients", 
          "creatinine", 
          "arthroplasty", 
          "such alterations", 
          "incorrect interventions", 
          "elevated estimates", 
          "days", 
          "status", 
          "calcium", 
          "MethodsPatients", 
          "osteoporosis", 
          "prevalence", 
          "blood", 
          "Hgb", 
          "baseline", 
          "volunteers", 
          "urine", 
          "hemoglobin", 
          "interval", 
          "age", 
          "intervention", 
          "DBP", 
          "total", 
          "testing", 
          "cause", 
          "alterations", 
          "induction", 
          "Alb", 
          "albumin", 
          "years", 
          "phosphatase", 
          "protein", 
          "results", 
          "surrogate", 
          "services", 
          "relevance", 
          "threshold", 
          "values", 
          "inadequacy", 
          "ratio", 
          "time", 
          "efforts", 
          "parameters", 
          "estimates", 
          "Cr", 
          "one", 
          "resources", 
          "misallocation"
        ], 
        "name": "Surgery alters parameters of vitamin D status and other laboratory results", 
        "pagination": "1013-1020", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037372044"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00198-016-3819-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27826645"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00198-016-3819-9", 
          "https://app.dimensions.ai/details/publication/pub.1037372044"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:34", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_686.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00198-016-3819-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00198-016-3819-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00198-016-3819-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00198-016-3819-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00198-016-3819-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    347 TRIPLES      21 PREDICATES      142 URIs      121 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00198-016-3819-9 schema:about N056c1060114143df80385aca1e99bdfb
    2 N087ef93ee52645d69e1ec43a0783c7b2
    3 N1713b060f5c94a8482448d6ef2796624
    4 N2b9f6e1be193402281f7fa51f39c7618
    5 N30c359f682bd4aa6b1e262f976069b74
    6 N33ebd19d9aa3451daac9529969e1a133
    7 N438fe89f461e47cdbbc7dd8de81b53e2
    8 N4c53298efa07453eb4fd24eae397aabb
    9 N5e631e1f581c4d8aacbee409d7b1e37c
    10 N66bf397ef28b4c5788ed959f1418e023
    11 N864f2697e07f46689c29118de0c85c63
    12 N97c7632f0af243f99778ec48d05aec02
    13 Nc9b82b567167478a96f699adeac40fd5
    14 Nca21e34058a74820bf3fbf7a62772fca
    15 Nd4edb11ed5ca4067974287eb527c1ad0
    16 Ne6054f1e94bd46bf99c06c065da430f0
    17 Nfc2b64912aae402ba1d218f4ffb5c5c5
    18 Nfc4e6d2139404cc9b4a0b4b7258d1688
    19 anzsrc-for:11
    20 anzsrc-for:1103
    21 schema:author N09c75e8e776d454ea12f2a396b5796ea
    22 schema:citation sg:pub.10.1007/s00198-003-1514-0
    23 sg:pub.10.1007/s00198-008-0582-6
    24 sg:pub.10.1007/s00198-008-0619-x
    25 sg:pub.10.1007/s00198-013-2348-z
    26 sg:pub.10.1007/s00198-013-2551-y
    27 sg:pub.10.1007/s00198-014-2636-2
    28 sg:pub.10.1007/s10195-016-0414-y
    29 sg:pub.10.1007/s11657-013-0136-1
    30 sg:pub.10.1007/s12630-014-0274-y
    31 sg:pub.10.1038/nrendo.2014.125
    32 sg:pub.10.1186/s12891-016-0906-1
    33 sg:pub.10.1186/s13037-015-0060-y
    34 sg:pub.10.1186/s13741-015-0014-z
    35 schema:datePublished 2016-11-08
    36 schema:datePublishedReg 2016-11-08
    37 schema:description Fracture liaison services often perform laboratory testing, but these results may be altered by surgery. In 40 hip arthroplasty patients, many laboratory parameters of bone health relevance were reduced by 8–22% on the first post-operative day. Laboratory results obtained in the immediate post-surgery interval do not reliably ascertain baseline status.IntroductionAs secondary causes of osteoporosis are common, fracture liaison services often perform laboratory testing in the immediate post-fracture interval. We hypothesized that laboratory results obtained shortly after surgery may not accurately ascertain baseline status. If true, such alterations might confound subsequent fracture prevention efforts.MethodsPatients undergoing elective total hip arthroplasty were studied as a surrogate for hip fracture patients. Blood and urine were obtained 2 weeks before surgery, before anesthetic induction, on post-operative day one, and 6 weeks after surgery. Serum total and free 25-hydroxyvitamin D (25(OH)D), vitamin D-binding protein (DBP), calcium, creatinine, albumin (Alb), alkaline phosphatase (ALP), plasma hemoglobin (Hgb) and urinary DBP/creatinine ratio (UDBP/Cr) were measured.ResultsForty volunteers (28 women; 12 men) with mean age of 65.7 [8.7] years were studied. Laboratory results were stable from 2 weeks before to the day of surgery. On the first day after surgery, total 25(OH)D, DBP, calcium, creatinine, ALP, and Alb declined 8–22% (p < 0.0001); free 25(OH)D and Hgb declined by 8 and 15% (p < 0.01), respectively; and UDBP/Cr increased 32% (p < 0.01). Using a 25(OH)D <30 ng/mL threshold, vitamin D inadequacy prevalence increased from 38% before surgery to 68% the day after (p < 0.001). All laboratory values returned to baseline at 6 weeks after surgery.ConclusionsLaboratory values are reduced immediately following elective total hip arthroplasty. Testing at that time does not accurately ascertain baseline status and may lead to elevated estimates of vitamin D inadequacy, incorrect interventions, and misallocation of healthcare resources.
    38 schema:genre article
    39 schema:isAccessibleForFree false
    40 schema:isPartOf N6a4542bedd7344e8a12a1fa4904ec401
    41 Ndeb03afba1b14124a3ec87c711ba7afa
    42 sg:journal.1100834
    43 schema:keywords Alb
    44 Cr
    45 D status
    46 DBP
    47 Hgb
    48 MethodsPatients
    49 age
    50 albumin
    51 alkaline phosphatase
    52 alterations
    53 anesthetic induction
    54 arthroplasty
    55 arthroplasty patients
    56 baseline
    57 baseline status
    58 blood
    59 calcium
    60 cause
    61 creatinine
    62 creatinine ratio
    63 day of surgery
    64 day one
    65 days
    66 efforts
    67 elective total hip arthroplasty
    68 elevated estimates
    69 estimates
    70 first day
    71 first post-operative day
    72 fracture liaison service
    73 fracture patients
    74 fracture prevention efforts
    75 health relevance
    76 healthcare resources
    77 hemoglobin
    78 hip arthroplasty
    79 hip arthroplasty patients
    80 hip fracture patients
    81 inadequacy
    82 incorrect interventions
    83 induction
    84 interval
    85 intervention
    86 laboratory parameters
    87 laboratory results
    88 laboratory testing
    89 laboratory values
    90 liaison service
    91 mean age
    92 misallocation
    93 one
    94 osteoporosis
    95 parameters
    96 patients
    97 phosphatase
    98 plasma hemoglobin
    99 post-operative day
    100 post-operative day one
    101 post-surgery interval
    102 prevalence
    103 prevention efforts
    104 protein
    105 ratio
    106 relevance
    107 resources
    108 results
    109 secondary causes
    110 serum total
    111 services
    112 status
    113 such alterations
    114 surgery
    115 surrogate
    116 testing
    117 threshold
    118 time
    119 total
    120 total hip arthroplasty
    121 urine
    122 values
    123 vitamin D
    124 vitamin D inadequacy
    125 vitamin D status
    126 volunteers
    127 weeks
    128 years
    129 schema:name Surgery alters parameters of vitamin D status and other laboratory results
    130 schema:pagination 1013-1020
    131 schema:productId Na049a4eff532437b80665f3f344d019e
    132 Nd71dbe1b6e8a486cbce78fdb3ef14932
    133 Ne2dd764506624f838456b43fd732e401
    134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037372044
    135 https://doi.org/10.1007/s00198-016-3819-9
    136 schema:sdDatePublished 2022-12-01T06:34
    137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    138 schema:sdPublisher N7e9fc9c0ac1944cfb4c589aa814a16ba
    139 schema:url https://doi.org/10.1007/s00198-016-3819-9
    140 sgo:license sg:explorer/license/
    141 sgo:sdDataset articles
    142 rdf:type schema:ScholarlyArticle
    143 N056c1060114143df80385aca1e99bdfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Vitamin D Deficiency
    145 rdf:type schema:DefinedTerm
    146 N08741d925e8e44bba2b7663fc93cfddb rdf:first sg:person.0654165000.17
    147 rdf:rest N3e97c8dde54740ac91d9a4f11191ee61
    148 N087ef93ee52645d69e1ec43a0783c7b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Vitamin D
    150 rdf:type schema:DefinedTerm
    151 N09c75e8e776d454ea12f2a396b5796ea rdf:first sg:person.0762201325.44
    152 rdf:rest N0d28c4d842c84343a9ceae57b6fa8cca
    153 N0d28c4d842c84343a9ceae57b6fa8cca rdf:first sg:person.01000310121.08
    154 rdf:rest Ned4538031cf947dbae0fc279bcbb2abb
    155 N1713b060f5c94a8482448d6ef2796624 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Hip Fractures
    157 rdf:type schema:DefinedTerm
    158 N2b9f6e1be193402281f7fa51f39c7618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Aged
    160 rdf:type schema:DefinedTerm
    161 N30c359f682bd4aa6b1e262f976069b74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Osteoporosis
    163 rdf:type schema:DefinedTerm
    164 N30d01fa69d8a4e0dae134912c5468e70 rdf:first sg:person.0676454034.38
    165 rdf:rest Nca825a3c5eba4731a9d3211540c10b6f
    166 N33ebd19d9aa3451daac9529969e1a133 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Middle Aged
    168 rdf:type schema:DefinedTerm
    169 N3e97c8dde54740ac91d9a4f11191ee61 rdf:first sg:person.01224717320.99
    170 rdf:rest rdf:nil
    171 N438fe89f461e47cdbbc7dd8de81b53e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name False Positive Reactions
    173 rdf:type schema:DefinedTerm
    174 N4c53298efa07453eb4fd24eae397aabb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Aged, 80 and over
    176 rdf:type schema:DefinedTerm
    177 N5e631e1f581c4d8aacbee409d7b1e37c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Postoperative Period
    179 rdf:type schema:DefinedTerm
    180 N66bf397ef28b4c5788ed959f1418e023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Arthroplasty, Replacement, Hip
    182 rdf:type schema:DefinedTerm
    183 N6a4542bedd7344e8a12a1fa4904ec401 schema:issueNumber 3
    184 rdf:type schema:PublicationIssue
    185 N7e9fc9c0ac1944cfb4c589aa814a16ba schema:name Springer Nature - SN SciGraph project
    186 rdf:type schema:Organization
    187 N864f2697e07f46689c29118de0c85c63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Postoperative Care
    189 rdf:type schema:DefinedTerm
    190 N97c7632f0af243f99778ec48d05aec02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Male
    192 rdf:type schema:DefinedTerm
    193 N97e22f8f6be04c8ba4ef42b163db5b64 rdf:first sg:person.0753477425.83
    194 rdf:rest N30d01fa69d8a4e0dae134912c5468e70
    195 Na049a4eff532437b80665f3f344d019e schema:name dimensions_id
    196 schema:value pub.1037372044
    197 rdf:type schema:PropertyValue
    198 Na7fc8fac251646f0bd0012d902ba5c40 rdf:first sg:person.0620306350.24
    199 rdf:rest Ned4754e6e63a45c596278bae7c4c36e8
    200 Nc9b82b567167478a96f699adeac40fd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Osteoporotic Fractures
    202 rdf:type schema:DefinedTerm
    203 Nca21e34058a74820bf3fbf7a62772fca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Humans
    205 rdf:type schema:DefinedTerm
    206 Nca825a3c5eba4731a9d3211540c10b6f rdf:first sg:person.01240175733.42
    207 rdf:rest Na7fc8fac251646f0bd0012d902ba5c40
    208 Nd4edb11ed5ca4067974287eb527c1ad0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Female
    210 rdf:type schema:DefinedTerm
    211 Nd71dbe1b6e8a486cbce78fdb3ef14932 schema:name pubmed_id
    212 schema:value 27826645
    213 rdf:type schema:PropertyValue
    214 Ndeb03afba1b14124a3ec87c711ba7afa schema:volumeNumber 28
    215 rdf:type schema:PublicationVolume
    216 Ne2dd764506624f838456b43fd732e401 schema:name doi
    217 schema:value 10.1007/s00198-016-3819-9
    218 rdf:type schema:PropertyValue
    219 Ne6054f1e94bd46bf99c06c065da430f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Prospective Studies
    221 rdf:type schema:DefinedTerm
    222 Ned4538031cf947dbae0fc279bcbb2abb rdf:first sg:person.01056220020.44
    223 rdf:rest N97e22f8f6be04c8ba4ef42b163db5b64
    224 Ned4754e6e63a45c596278bae7c4c36e8 rdf:first sg:person.0714345342.23
    225 rdf:rest N08741d925e8e44bba2b7663fc93cfddb
    226 Nfc2b64912aae402ba1d218f4ffb5c5c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Biomarkers
    228 rdf:type schema:DefinedTerm
    229 Nfc4e6d2139404cc9b4a0b4b7258d1688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Osteoarthritis, Hip
    231 rdf:type schema:DefinedTerm
    232 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    233 schema:name Medical and Health Sciences
    234 rdf:type schema:DefinedTerm
    235 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    236 schema:name Clinical Sciences
    237 rdf:type schema:DefinedTerm
    238 sg:journal.1100834 schema:issn 0937-941X
    239 1433-2965
    240 schema:name Osteoporosis International
    241 schema:publisher Springer Nature
    242 rdf:type schema:Periodical
    243 sg:person.01000310121.08 schema:affiliation grid-institutes:grid.14003.36
    244 schema:familyName Coursin
    245 schema:givenName D.
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000310121.08
    247 rdf:type schema:Person
    248 sg:person.01056220020.44 schema:affiliation grid-institutes:grid.28803.31
    249 schema:familyName Krueger
    250 schema:givenName D.
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056220020.44
    252 rdf:type schema:Person
    253 sg:person.01224717320.99 schema:affiliation grid-institutes:grid.14003.36
    254 schema:familyName Hogan
    255 schema:givenName K.
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224717320.99
    257 rdf:type schema:Person
    258 sg:person.01240175733.42 schema:affiliation grid-institutes:grid.14003.36
    259 schema:familyName Illgen
    260 schema:givenName R.
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240175733.42
    262 rdf:type schema:Person
    263 sg:person.0620306350.24 schema:affiliation grid-institutes:grid.14003.36
    264 schema:familyName Squire
    265 schema:givenName M.
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620306350.24
    267 rdf:type schema:Person
    268 sg:person.0654165000.17 schema:affiliation grid-institutes:grid.254748.8
    269 schema:familyName Watson
    270 schema:givenName P.
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654165000.17
    272 rdf:type schema:Person
    273 sg:person.0676454034.38 schema:affiliation grid-institutes:grid.14003.36
    274 schema:familyName Heiner
    275 schema:givenName J.
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676454034.38
    277 rdf:type schema:Person
    278 sg:person.0714345342.23 schema:affiliation grid-institutes:grid.254748.8
    279 schema:familyName Lappe
    280 schema:givenName J.
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714345342.23
    282 rdf:type schema:Person
    283 sg:person.0753477425.83 schema:affiliation grid-institutes:grid.14003.36
    284 schema:familyName Iglar
    285 schema:givenName P.
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753477425.83
    287 rdf:type schema:Person
    288 sg:person.0762201325.44 schema:affiliation grid-institutes:grid.14003.36
    289 schema:familyName Binkley
    290 schema:givenName N.
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762201325.44
    292 rdf:type schema:Person
    293 sg:pub.10.1007/s00198-003-1514-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042859125
    294 https://doi.org/10.1007/s00198-003-1514-0
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s00198-008-0582-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020722804
    297 https://doi.org/10.1007/s00198-008-0582-6
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1007/s00198-008-0619-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017008873
    300 https://doi.org/10.1007/s00198-008-0619-x
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1007/s00198-013-2348-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041850502
    303 https://doi.org/10.1007/s00198-013-2348-z
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s00198-013-2551-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038103420
    306 https://doi.org/10.1007/s00198-013-2551-y
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1007/s00198-014-2636-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015615014
    309 https://doi.org/10.1007/s00198-014-2636-2
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1007/s10195-016-0414-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015094957
    312 https://doi.org/10.1007/s10195-016-0414-y
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1007/s11657-013-0136-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040868574
    315 https://doi.org/10.1007/s11657-013-0136-1
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1007/s12630-014-0274-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047563980
    318 https://doi.org/10.1007/s12630-014-0274-y
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nrendo.2014.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004508818
    321 https://doi.org/10.1038/nrendo.2014.125
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1186/s12891-016-0906-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049489227
    324 https://doi.org/10.1186/s12891-016-0906-1
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1186/s13037-015-0060-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1006078707
    327 https://doi.org/10.1186/s13037-015-0060-y
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1186/s13741-015-0014-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1019124807
    330 https://doi.org/10.1186/s13741-015-0014-z
    331 rdf:type schema:CreativeWork
    332 grid-institutes:grid.14003.36 schema:alternateName Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, 53792-3272, Madison, WI, USA
    333 Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    334 Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA
    335 Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 707 WARF Building, 610 North Walnut Street, 53726, Madison, WI, USA
    336 schema:name Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, 53792-3272, Madison, WI, USA
    337 Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    338 Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 53705-2281, Madison, WI, USA
    339 Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 707 WARF Building, 610 North Walnut Street, 53726, Madison, WI, USA
    340 University of Wisconsin Osteoporosis Clinical Research Program, 2870 University Ave, 53705, Madison, WI, USA
    341 rdf:type schema:Organization
    342 grid-institutes:grid.254748.8 schema:alternateName Creighton University Osteoporosis Research Center, 601 N. 30th Street, Suite 4820, 68131, Omaha, NE, USA
    343 schema:name Creighton University Osteoporosis Research Center, 601 N. 30th Street, Suite 4820, 68131, Omaha, NE, USA
    344 rdf:type schema:Organization
    345 grid-institutes:grid.28803.31 schema:alternateName University of Wisconsin Osteoporosis Clinical Research Program, 2870 University Ave, 53705, Madison, WI, USA
    346 schema:name University of Wisconsin Osteoporosis Clinical Research Program, 2870 University Ave, 53705, Madison, WI, USA
    347 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...