Marrow adiposity assessed on transiliac crest biopsy samples correlates with noninvasive measurement of marrow adiposity by proton magnetic resonance spectroscopy ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05-19

AUTHORS

A. Cohen, W. Shen, D. W. Dempster, H. Zhou, R. R. Recker, J. M. Lappe, A. Kepley, M. Kamanda-Kosseh, M. Bucovsky, E. M. Stein, T. L. Nickolas, E. Shane

ABSTRACT

Measurement of marrow fat (MF) is important to the study of bone fragility. We measured MF on iliac biopsies and by spine/hip magnetic resonance spectroscopy in the same subjects. Noninvasively assessed spine MF and histomorphometrically assessed MF correlated well. MF quantity and relationships with bone volume differed by measurement site.IntroductionExcess marrow fat has been implicated in the pathogenesis of osteoporosis in several populations. In the bone marrow, adipocytes and osteoblasts share a common precursor and are reciprocally regulated. In addition, adipocytes may secrete toxic fatty acids and adipokines that adversely affect osteoblasts. Measurement of marrow fat is important to the study of mechanisms of bone fragility. Marrow fat can be quantified on bone biopsy samples by histomorphometry and noninvasively by proton magnetic resonance spectroscopy (1H-MRS). In this study, we evaluate relationships between marrow fat assessed using both methods in the same subjects for the first time.MethodsSixteen premenopausal women, nine with idiopathic osteoporosis and seven normal controls, had marrow fat measured at the iliac crest by bone biopsy and at the lumbar spine (L3) and proximal femur by 1H-MRS.ResultsAt L3, fat fraction by 1H-MRS correlated directly and significantly with marrow fat variables on iliac crest biopsies (r = 0.5–0.8). In contrast, there were no significant correlations between fat fraction at the femur and marrow fat on biopsies. Marrow fat quantity (%) was greater at the femur than at L3 and the iliac crest and correlated inversely with total hip and femoral neck BMD by DXA.ConclusionsIn summary, measurement of marrow fat in transiliac crest biopsies correlates with marrow fat at the spine but not the proximal femur by 1H-MRS. There were site-specific differences in marrow fat quantity and in the relationships between marrow fat and bone volume. More... »

PAGES

2471-2478

References to SciGraph publications

  • 2014-03-07. Fat and Bone Interactions in CURRENT OSTEOPOROSIS REPORTS
  • 2006-01. Mechanisms of Disease: is osteoporosis the obesity of bone? in NATURE REVIEWS RHEUMATOLOGY
  • 2011-03-02. Premenopausal women with idiopathic low-trauma fractures and/or low bone mineral density in OSTEOPOROSIS INTERNATIONAL
  • 2012-04-11. MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2007-06-14. Glucocorticoid-induced osteoporosis: pathophysiology and therapy in OSTEOPOROSIS INTERNATIONAL
  • 2006-12-01. MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women in OSTEOPOROSIS INTERNATIONAL
  • 2009-05-20. Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy in OSTEOPOROSIS INTERNATIONAL
  • 1998-09. Magnetic resonance imaging of normal bone marrow in EUROPEAN RADIOLOGY
  • 2011-03-05. The Role of Bone Marrow and Visceral Fat on Bone Metabolism in CURRENT OSTEOPOROSIS REPORTS
  • 2011-12-16. Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationship in OSTEOPOROSIS INTERNATIONAL
  • 2008-02-15. Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women in OSTEOPOROSIS INTERNATIONAL
  • 2001-07-01. Troglitazone Treatment Increases Bone Marrow Adipose Tissue Volume but Does not Affect Trabecular Bone Volume in Mice in CALCIFIED TISSUE INTERNATIONAL
  • 2010-05-07. Bone and fat relationships in postadolescent black females: a pQCT study in OSTEOPOROSIS INTERNATIONAL
  • 2001-09. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis in BIOGERONTOLOGY
  • 2011-08-18. Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study in OSTEOPOROSIS INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00198-015-3161-7

    DOI

    http://dx.doi.org/10.1007/s00198-015-3161-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008878691

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25986383


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipose Tissue", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adiposity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biopsy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Density", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Examination", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Femur", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ilium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lumbar Vertebrae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Premenopause", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proton Magnetic Resonance Spectroscopy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cohen", 
            "givenName": "A.", 
            "id": "sg:person.010252053607.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010252053607.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shen", 
            "givenName": "W.", 
            "id": "sg:person.01325412256.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325412256.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helen Hayes Hospital, West Haverstraw, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.413989.e", 
              "name": [
                "Helen Hayes Hospital, West Haverstraw, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dempster", 
            "givenName": "D. W.", 
            "id": "sg:person.0674413732.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674413732.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helen Hayes Hospital, West Haverstraw, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.413989.e", 
              "name": [
                "Helen Hayes Hospital, West Haverstraw, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "H.", 
            "id": "sg:person.01217622430.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217622430.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Creighton University, Omaha, NE, USA", 
              "id": "http://www.grid.ac/institutes/grid.254748.8", 
              "name": [
                "Creighton University, Omaha, NE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Recker", 
            "givenName": "R. R.", 
            "id": "sg:person.016325222544.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016325222544.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Creighton University, Omaha, NE, USA", 
              "id": "http://www.grid.ac/institutes/grid.254748.8", 
              "name": [
                "Creighton University, Omaha, NE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lappe", 
            "givenName": "J. M.", 
            "id": "sg:person.0714345342.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714345342.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kepley", 
            "givenName": "A.", 
            "id": "sg:person.0771606654.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771606654.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamanda-Kosseh", 
            "givenName": "M.", 
            "id": "sg:person.0621063370.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621063370.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bucovsky", 
            "givenName": "M.", 
            "id": "sg:person.01025437224.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025437224.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stein", 
            "givenName": "E. M.", 
            "id": "sg:person.0643466425.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643466425.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nickolas", 
            "givenName": "T. L.", 
            "id": "sg:person.01026030225.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026030225.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.21729.3f", 
              "name": [
                "Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shane", 
            "givenName": "E.", 
            "id": "sg:person.014504540137.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014504540137.21"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00198-006-0285-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040778246", 
              "https://doi.org/10.1007/s00198-006-0285-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncprheum0070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051899382", 
              "https://doi.org/10.1038/ncprheum0070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejcn.2012.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041444176", 
              "https://doi.org/10.1038/ejcn.2012.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11914-011-0051-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023817759", 
              "https://doi.org/10.1007/s11914-011-0051-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-011-1741-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035473401", 
              "https://doi.org/10.1007/s00198-011-1741-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-011-1873-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020913921", 
              "https://doi.org/10.1007/s00198-011-1873-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-010-1266-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019459943", 
              "https://doi.org/10.1007/s00198-010-1266-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s003300050547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038273943", 
              "https://doi.org/10.1007/s003300050547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-007-0394-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004282104", 
              "https://doi.org/10.1007/s00198-007-0394-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011513223894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018871641", 
              "https://doi.org/10.1023/a:1011513223894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-008-0574-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013999867", 
              "https://doi.org/10.1007/s00198-008-0574-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11914-014-0199-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033292676", 
              "https://doi.org/10.1007/s11914-014-0199-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002230020018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050199198", 
              "https://doi.org/10.1007/s002230020018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-009-0945-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038536964", 
              "https://doi.org/10.1007/s00198-009-0945-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-011-1560-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051181048", 
              "https://doi.org/10.1007/s00198-011-1560-y"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-05-19", 
        "datePublishedReg": "2015-05-19", 
        "description": "Measurement of marrow fat (MF) is important to the study of bone fragility. We measured MF on iliac biopsies and by spine/hip magnetic resonance spectroscopy in the same subjects. Noninvasively assessed spine MF and histomorphometrically assessed MF correlated well. MF quantity and relationships with bone volume differed by measurement site.IntroductionExcess marrow fat has been implicated in the pathogenesis of osteoporosis in several populations. In the bone marrow, adipocytes and osteoblasts share a common precursor and are reciprocally regulated. In addition, adipocytes may secrete toxic fatty acids and adipokines that adversely affect osteoblasts. Measurement of marrow fat is important to the study of mechanisms of bone fragility. Marrow fat can be quantified on bone biopsy samples by histomorphometry and noninvasively by proton magnetic resonance spectroscopy (1H-MRS). In this study, we evaluate relationships between marrow fat assessed using both methods in the same subjects for the first time.MethodsSixteen premenopausal women, nine with idiopathic osteoporosis and seven normal controls, had marrow fat measured at the iliac crest by bone biopsy and at the lumbar spine (L3) and proximal femur by 1H-MRS.ResultsAt L3, fat fraction by 1H-MRS correlated directly and significantly with marrow fat variables on iliac crest biopsies (r\u2009=\u20090.5\u20130.8). In contrast, there were no significant correlations between fat fraction at the femur and marrow fat on biopsies. Marrow fat quantity (%) was greater at the femur than at L3 and the iliac crest and correlated inversely with total hip and femoral neck BMD by DXA.ConclusionsIn summary, measurement of marrow fat in transiliac crest biopsies correlates with marrow fat at the spine but not the proximal femur by 1H-MRS. There were site-specific differences in marrow fat quantity and in the relationships between marrow fat and bone volume.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00198-015-3161-7", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438976", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1100834", 
            "issn": [
              "0937-941X", 
              "1433-2965"
            ], 
            "name": "Osteoporosis International", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "26"
          }
        ], 
        "keywords": [
          "proton magnetic resonance spectroscopy", 
          "marrow fat", 
          "marrow adiposity", 
          "bone fragility", 
          "crest biopsies", 
          "iliac crest", 
          "biopsy samples", 
          "proximal femur", 
          "bone volume", 
          "fat quantity", 
          "femoral neck BMD", 
          "pathogenesis of osteoporosis", 
          "transiliac crest biopsies", 
          "iliac crest biopsies", 
          "fat fraction", 
          "bone biopsy samples", 
          "magnetic resonance spectroscopy", 
          "premenopausal women", 
          "idiopathic osteoporosis", 
          "iliac biopsies", 
          "total hip", 
          "neck BMD", 
          "bone biopsy", 
          "same subjects", 
          "lumbar spine", 
          "toxic fatty acids", 
          "normal controls", 
          "bone marrow", 
          "biopsy", 
          "fat variables", 
          "femur", 
          "ConclusionsIn summary", 
          "spine", 
          "adiposity", 
          "significant correlation", 
          "osteoporosis", 
          "fat", 
          "noninvasive measurement", 
          "resonance spectroscopy", 
          "fatty acids", 
          "study of mechanisms", 
          "adipocytes", 
          "subjects", 
          "osteoblasts", 
          "site-specific differences", 
          "adipokines", 
          "pathogenesis", 
          "BMD", 
          "DXA", 
          "marrow", 
          "hip", 
          "histomorphometry", 
          "study", 
          "women", 
          "L3", 
          "common precursor", 
          "crest", 
          "fragility", 
          "volume", 
          "population", 
          "relationship", 
          "samples", 
          "differences", 
          "control", 
          "summary", 
          "measurement sites", 
          "fraction", 
          "contrast", 
          "correlation", 
          "acid", 
          "first time", 
          "mechanism", 
          "addition", 
          "measurements", 
          "sites", 
          "variables", 
          "time", 
          "quantity", 
          "precursors", 
          "method", 
          "spectroscopy"
        ], 
        "name": "Marrow adiposity assessed on transiliac crest biopsy samples correlates with noninvasive measurement of marrow adiposity by proton magnetic resonance spectroscopy (1H-MRS) at the spine but not the femur", 
        "pagination": "2471-2478", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1008878691"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00198-015-3161-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25986383"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00198-015-3161-7", 
          "https://app.dimensions.ai/details/publication/pub.1008878691"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_658.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00198-015-3161-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00198-015-3161-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00198-015-3161-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00198-015-3161-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00198-015-3161-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    367 TRIPLES      21 PREDICATES      141 URIs      118 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00198-015-3161-7 schema:about N1c9127cafa0f4d7d8350f93459b5a841
    2 N21734dcc230d4a07b79f209987050d1b
    3 N31e4eedba6bd476892ec981a5ae09464
    4 N4d93c647a78e4862b5cd70e817b10a86
    5 N4e057f6f26c5462198b7c4db4417c07a
    6 N5a0e56f0e5c64b0ba37d497ed57e885d
    7 N5e5e131d5683427b9edb4c60925085d6
    8 N7217de4a44f84ea89c19395240181b90
    9 N9fc4ca9e532743b98465c736a6cb7492
    10 Nb9ee5c76c32641e6ac418743efae958e
    11 Nbd391c875f294367b2fa1a89293356e6
    12 Nc1082687193b432084758dcb60009e5f
    13 Nca4135c3990a436186d74435c8577b40
    14 Nd409c12c7d2b426484f91fc08b6f286d
    15 Nd53d2525b5f841b5937a42e46f5911d9
    16 Nf05eb0ffcaa94c19b7a585a7ee22e122
    17 Nf2ed03118eec4af2a2ea6b3149eb134d
    18 Nf513b1e8b1ea4bc3b2ffccbe7472bdee
    19 Nf7e0c13f453646f88ed0bab7f65cab4d
    20 Nfd55248e57e7436393f7812ee1e86d1b
    21 anzsrc-for:11
    22 anzsrc-for:1103
    23 schema:author N5c7257093e014970af6a823c52f8689c
    24 schema:citation sg:pub.10.1007/s00198-006-0285-9
    25 sg:pub.10.1007/s00198-007-0394-0
    26 sg:pub.10.1007/s00198-008-0574-6
    27 sg:pub.10.1007/s00198-009-0945-7
    28 sg:pub.10.1007/s00198-010-1266-6
    29 sg:pub.10.1007/s00198-011-1560-y
    30 sg:pub.10.1007/s00198-011-1741-8
    31 sg:pub.10.1007/s00198-011-1873-x
    32 sg:pub.10.1007/s002230020018
    33 sg:pub.10.1007/s003300050547
    34 sg:pub.10.1007/s11914-011-0051-6
    35 sg:pub.10.1007/s11914-014-0199-y
    36 sg:pub.10.1023/a:1011513223894
    37 sg:pub.10.1038/ejcn.2012.35
    38 sg:pub.10.1038/ncprheum0070
    39 schema:datePublished 2015-05-19
    40 schema:datePublishedReg 2015-05-19
    41 schema:description Measurement of marrow fat (MF) is important to the study of bone fragility. We measured MF on iliac biopsies and by spine/hip magnetic resonance spectroscopy in the same subjects. Noninvasively assessed spine MF and histomorphometrically assessed MF correlated well. MF quantity and relationships with bone volume differed by measurement site.IntroductionExcess marrow fat has been implicated in the pathogenesis of osteoporosis in several populations. In the bone marrow, adipocytes and osteoblasts share a common precursor and are reciprocally regulated. In addition, adipocytes may secrete toxic fatty acids and adipokines that adversely affect osteoblasts. Measurement of marrow fat is important to the study of mechanisms of bone fragility. Marrow fat can be quantified on bone biopsy samples by histomorphometry and noninvasively by proton magnetic resonance spectroscopy (1H-MRS). In this study, we evaluate relationships between marrow fat assessed using both methods in the same subjects for the first time.MethodsSixteen premenopausal women, nine with idiopathic osteoporosis and seven normal controls, had marrow fat measured at the iliac crest by bone biopsy and at the lumbar spine (L3) and proximal femur by 1H-MRS.ResultsAt L3, fat fraction by 1H-MRS correlated directly and significantly with marrow fat variables on iliac crest biopsies (r = 0.5–0.8). In contrast, there were no significant correlations between fat fraction at the femur and marrow fat on biopsies. Marrow fat quantity (%) was greater at the femur than at L3 and the iliac crest and correlated inversely with total hip and femoral neck BMD by DXA.ConclusionsIn summary, measurement of marrow fat in transiliac crest biopsies correlates with marrow fat at the spine but not the proximal femur by 1H-MRS. There were site-specific differences in marrow fat quantity and in the relationships between marrow fat and bone volume.
    42 schema:genre article
    43 schema:isAccessibleForFree true
    44 schema:isPartOf N001a462659e24ba1b491903d0fcde580
    45 N3696cfec984948f7b11e19b23ffb1334
    46 sg:journal.1100834
    47 schema:keywords BMD
    48 ConclusionsIn summary
    49 DXA
    50 L3
    51 acid
    52 addition
    53 adipocytes
    54 adipokines
    55 adiposity
    56 biopsy
    57 biopsy samples
    58 bone biopsy
    59 bone biopsy samples
    60 bone fragility
    61 bone marrow
    62 bone volume
    63 common precursor
    64 contrast
    65 control
    66 correlation
    67 crest
    68 crest biopsies
    69 differences
    70 fat
    71 fat fraction
    72 fat quantity
    73 fat variables
    74 fatty acids
    75 femoral neck BMD
    76 femur
    77 first time
    78 fraction
    79 fragility
    80 hip
    81 histomorphometry
    82 idiopathic osteoporosis
    83 iliac biopsies
    84 iliac crest
    85 iliac crest biopsies
    86 lumbar spine
    87 magnetic resonance spectroscopy
    88 marrow
    89 marrow adiposity
    90 marrow fat
    91 measurement sites
    92 measurements
    93 mechanism
    94 method
    95 neck BMD
    96 noninvasive measurement
    97 normal controls
    98 osteoblasts
    99 osteoporosis
    100 pathogenesis
    101 pathogenesis of osteoporosis
    102 population
    103 precursors
    104 premenopausal women
    105 proton magnetic resonance spectroscopy
    106 proximal femur
    107 quantity
    108 relationship
    109 resonance spectroscopy
    110 same subjects
    111 samples
    112 significant correlation
    113 site-specific differences
    114 sites
    115 spectroscopy
    116 spine
    117 study
    118 study of mechanisms
    119 subjects
    120 summary
    121 time
    122 total hip
    123 toxic fatty acids
    124 transiliac crest biopsies
    125 variables
    126 volume
    127 women
    128 schema:name Marrow adiposity assessed on transiliac crest biopsy samples correlates with noninvasive measurement of marrow adiposity by proton magnetic resonance spectroscopy (1H-MRS) at the spine but not the femur
    129 schema:pagination 2471-2478
    130 schema:productId N996ac9f901b5437787271bcf2c61c107
    131 Nddc3515e0e154d289165faddfee05b57
    132 Nec5640a300cb4145818fe4b4b4f2c1e4
    133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008878691
    134 https://doi.org/10.1007/s00198-015-3161-7
    135 schema:sdDatePublished 2022-08-04T17:03
    136 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    137 schema:sdPublisher N5a354d61a22a4372931d79d31b9daea8
    138 schema:url https://doi.org/10.1007/s00198-015-3161-7
    139 sgo:license sg:explorer/license/
    140 sgo:sdDataset articles
    141 rdf:type schema:ScholarlyArticle
    142 N001a462659e24ba1b491903d0fcde580 schema:issueNumber 10
    143 rdf:type schema:PublicationIssue
    144 N03931dfac6b2423a9056d07db45bbfef rdf:first sg:person.0771606654.52
    145 rdf:rest N75c34f326f1d4c5d876780f4a1052d60
    146 N1c9127cafa0f4d7d8350f93459b5a841 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Bone Marrow Examination
    148 rdf:type schema:DefinedTerm
    149 N21734dcc230d4a07b79f209987050d1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Adult
    151 rdf:type schema:DefinedTerm
    152 N31e4eedba6bd476892ec981a5ae09464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Premenopause
    154 rdf:type schema:DefinedTerm
    155 N3696cfec984948f7b11e19b23ffb1334 schema:volumeNumber 26
    156 rdf:type schema:PublicationVolume
    157 N3f3cfbd9bf124cdd89a60227371a0f59 rdf:first sg:person.0643466425.41
    158 rdf:rest Neeb3e322e6d641ae9725239e5f6d02db
    159 N49d8a06cf9154a7999b00ca5f69e74ac rdf:first sg:person.0674413732.10
    160 rdf:rest N5e948ef10b4242229a04caecb56a47fa
    161 N4d93c647a78e4862b5cd70e817b10a86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Biopsy
    163 rdf:type schema:DefinedTerm
    164 N4e057f6f26c5462198b7c4db4417c07a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Proton Magnetic Resonance Spectroscopy
    166 rdf:type schema:DefinedTerm
    167 N5a0e56f0e5c64b0ba37d497ed57e885d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Lumbar Vertebrae
    169 rdf:type schema:DefinedTerm
    170 N5a354d61a22a4372931d79d31b9daea8 schema:name Springer Nature - SN SciGraph project
    171 rdf:type schema:Organization
    172 N5c7257093e014970af6a823c52f8689c rdf:first sg:person.010252053607.71
    173 rdf:rest Nf0bb183f58834f90b0090f6dede591cc
    174 N5e5e131d5683427b9edb4c60925085d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Ilium
    176 rdf:type schema:DefinedTerm
    177 N5e948ef10b4242229a04caecb56a47fa rdf:first sg:person.01217622430.07
    178 rdf:rest Nddf4d5343c9a4f6aa0f9eeb02f096cca
    179 N7217de4a44f84ea89c19395240181b90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Case-Control Studies
    181 rdf:type schema:DefinedTerm
    182 N75c34f326f1d4c5d876780f4a1052d60 rdf:first sg:person.0621063370.24
    183 rdf:rest N9edb2c80d18d477ebd598bd684d12fce
    184 N996ac9f901b5437787271bcf2c61c107 schema:name pubmed_id
    185 schema:value 25986383
    186 rdf:type schema:PropertyValue
    187 N9edb2c80d18d477ebd598bd684d12fce rdf:first sg:person.01025437224.06
    188 rdf:rest N3f3cfbd9bf124cdd89a60227371a0f59
    189 N9fc4ca9e532743b98465c736a6cb7492 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Adolescent
    191 rdf:type schema:DefinedTerm
    192 Nb9ee5c76c32641e6ac418743efae958e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Adiposity
    194 rdf:type schema:DefinedTerm
    195 Nbd391c875f294367b2fa1a89293356e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Femur
    197 rdf:type schema:DefinedTerm
    198 Nc1082687193b432084758dcb60009e5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Middle Aged
    200 rdf:type schema:DefinedTerm
    201 Nca4135c3990a436186d74435c8577b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Female
    203 rdf:type schema:DefinedTerm
    204 Nd409c12c7d2b426484f91fc08b6f286d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Humans
    206 rdf:type schema:DefinedTerm
    207 Nd53d2525b5f841b5937a42e46f5911d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Adipocytes
    209 rdf:type schema:DefinedTerm
    210 Nd9f484b4395849c8b47facf6f35f12d0 rdf:first sg:person.0714345342.23
    211 rdf:rest N03931dfac6b2423a9056d07db45bbfef
    212 Nddc3515e0e154d289165faddfee05b57 schema:name doi
    213 schema:value 10.1007/s00198-015-3161-7
    214 rdf:type schema:PropertyValue
    215 Nddf4d5343c9a4f6aa0f9eeb02f096cca rdf:first sg:person.016325222544.69
    216 rdf:rest Nd9f484b4395849c8b47facf6f35f12d0
    217 Nec5640a300cb4145818fe4b4b4f2c1e4 schema:name dimensions_id
    218 schema:value pub.1008878691
    219 rdf:type schema:PropertyValue
    220 Neeb3e322e6d641ae9725239e5f6d02db rdf:first sg:person.01026030225.99
    221 rdf:rest Nf68e3521ebb04608ad46c89fc99029db
    222 Nf05eb0ffcaa94c19b7a585a7ee22e122 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Bone Density
    224 rdf:type schema:DefinedTerm
    225 Nf0bb183f58834f90b0090f6dede591cc rdf:first sg:person.01325412256.05
    226 rdf:rest N49d8a06cf9154a7999b00ca5f69e74ac
    227 Nf2ed03118eec4af2a2ea6b3149eb134d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Young Adult
    229 rdf:type schema:DefinedTerm
    230 Nf513b1e8b1ea4bc3b2ffccbe7472bdee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Reproducibility of Results
    232 rdf:type schema:DefinedTerm
    233 Nf68e3521ebb04608ad46c89fc99029db rdf:first sg:person.014504540137.21
    234 rdf:rest rdf:nil
    235 Nf7e0c13f453646f88ed0bab7f65cab4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Adipose Tissue
    237 rdf:type schema:DefinedTerm
    238 Nfd55248e57e7436393f7812ee1e86d1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Bone Marrow
    240 rdf:type schema:DefinedTerm
    241 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    242 schema:name Medical and Health Sciences
    243 rdf:type schema:DefinedTerm
    244 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    245 schema:name Clinical Sciences
    246 rdf:type schema:DefinedTerm
    247 sg:grant.2438976 http://pending.schema.org/fundedItem sg:pub.10.1007/s00198-015-3161-7
    248 rdf:type schema:MonetaryGrant
    249 sg:journal.1100834 schema:issn 0937-941X
    250 1433-2965
    251 schema:name Osteoporosis International
    252 schema:publisher Springer Nature
    253 rdf:type schema:Periodical
    254 sg:person.010252053607.71 schema:affiliation grid-institutes:grid.21729.3f
    255 schema:familyName Cohen
    256 schema:givenName A.
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010252053607.71
    258 rdf:type schema:Person
    259 sg:person.01025437224.06 schema:affiliation grid-institutes:grid.21729.3f
    260 schema:familyName Bucovsky
    261 schema:givenName M.
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025437224.06
    263 rdf:type schema:Person
    264 sg:person.01026030225.99 schema:affiliation grid-institutes:grid.21729.3f
    265 schema:familyName Nickolas
    266 schema:givenName T. L.
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026030225.99
    268 rdf:type schema:Person
    269 sg:person.01217622430.07 schema:affiliation grid-institutes:grid.413989.e
    270 schema:familyName Zhou
    271 schema:givenName H.
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217622430.07
    273 rdf:type schema:Person
    274 sg:person.01325412256.05 schema:affiliation grid-institutes:grid.21729.3f
    275 schema:familyName Shen
    276 schema:givenName W.
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325412256.05
    278 rdf:type schema:Person
    279 sg:person.014504540137.21 schema:affiliation grid-institutes:grid.21729.3f
    280 schema:familyName Shane
    281 schema:givenName E.
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014504540137.21
    283 rdf:type schema:Person
    284 sg:person.016325222544.69 schema:affiliation grid-institutes:grid.254748.8
    285 schema:familyName Recker
    286 schema:givenName R. R.
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016325222544.69
    288 rdf:type schema:Person
    289 sg:person.0621063370.24 schema:affiliation grid-institutes:grid.21729.3f
    290 schema:familyName Kamanda-Kosseh
    291 schema:givenName M.
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621063370.24
    293 rdf:type schema:Person
    294 sg:person.0643466425.41 schema:affiliation grid-institutes:grid.21729.3f
    295 schema:familyName Stein
    296 schema:givenName E. M.
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643466425.41
    298 rdf:type schema:Person
    299 sg:person.0674413732.10 schema:affiliation grid-institutes:grid.413989.e
    300 schema:familyName Dempster
    301 schema:givenName D. W.
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674413732.10
    303 rdf:type schema:Person
    304 sg:person.0714345342.23 schema:affiliation grid-institutes:grid.254748.8
    305 schema:familyName Lappe
    306 schema:givenName J. M.
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714345342.23
    308 rdf:type schema:Person
    309 sg:person.0771606654.52 schema:affiliation grid-institutes:grid.21729.3f
    310 schema:familyName Kepley
    311 schema:givenName A.
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771606654.52
    313 rdf:type schema:Person
    314 sg:pub.10.1007/s00198-006-0285-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040778246
    315 https://doi.org/10.1007/s00198-006-0285-9
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1007/s00198-007-0394-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004282104
    318 https://doi.org/10.1007/s00198-007-0394-0
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1007/s00198-008-0574-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013999867
    321 https://doi.org/10.1007/s00198-008-0574-6
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1007/s00198-009-0945-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038536964
    324 https://doi.org/10.1007/s00198-009-0945-7
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1007/s00198-010-1266-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019459943
    327 https://doi.org/10.1007/s00198-010-1266-6
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1007/s00198-011-1560-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051181048
    330 https://doi.org/10.1007/s00198-011-1560-y
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1007/s00198-011-1741-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035473401
    333 https://doi.org/10.1007/s00198-011-1741-8
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1007/s00198-011-1873-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020913921
    336 https://doi.org/10.1007/s00198-011-1873-x
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1007/s002230020018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050199198
    339 https://doi.org/10.1007/s002230020018
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1007/s003300050547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038273943
    342 https://doi.org/10.1007/s003300050547
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1007/s11914-011-0051-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023817759
    345 https://doi.org/10.1007/s11914-011-0051-6
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1007/s11914-014-0199-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033292676
    348 https://doi.org/10.1007/s11914-014-0199-y
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1023/a:1011513223894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018871641
    351 https://doi.org/10.1023/a:1011513223894
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/ejcn.2012.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041444176
    354 https://doi.org/10.1038/ejcn.2012.35
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/ncprheum0070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051899382
    357 https://doi.org/10.1038/ncprheum0070
    358 rdf:type schema:CreativeWork
    359 grid-institutes:grid.21729.3f schema:alternateName Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA
    360 schema:name Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, 10032, New York, NY, USA
    361 rdf:type schema:Organization
    362 grid-institutes:grid.254748.8 schema:alternateName Creighton University, Omaha, NE, USA
    363 schema:name Creighton University, Omaha, NE, USA
    364 rdf:type schema:Organization
    365 grid-institutes:grid.413989.e schema:alternateName Helen Hayes Hospital, West Haverstraw, NY, USA
    366 schema:name Helen Hayes Hospital, West Haverstraw, NY, USA
    367 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...