Self-reported calcium use in a cohort of postmenopausal women receiving osteoporosis therapy: results from POSSIBLE US™ View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04-16

AUTHORS

E. Barrett-Connor, S. W. Wade, R. W. Downs, T. Ganiats, M. Hochberg, R. R. Recker, B. S. Stolshek

ABSTRACT

Calcium use was common and remained high among women on osteoporosis therapy. Use of calcium-supplemented pharmacologic therapy increased from 65.1 to 76.0 % in these women (mean follow-up, 27.5 months). Over 12 months, calcium discontinuation was fairly similar among women using calcium only (23.7 %) and women supplementing pharmacologic therapy with calcium (22.5 %).IntroductionCalcium has an important role in bone health. This study describes calcium use and persistence in a postmenopausal osteoporosis treatment cohort.MethodsSubject-reported calcium use was analyzed for 3,722 participants of the Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE USTM) who used calcium either as their sole osteoporosis treatment (calcium only) or to supplement pharmacologic osteoporosis therapy (supplementers). Descriptive analyses were conducted. Kaplan-Meier methods were used to estimate the probability of discontinuing calcium therapy, and logistic regression was used to assess associations (age-adjusted odds ratios) between healthy behaviors and calcium use.ResultsAt entry, there were 711 calcium-only subjects and 1,960 of 3,011 subjects on pharmacologic osteoporosis therapy also supplementing with calcium (supplementers). The percentage of supplementers increased from 65.1 to 76.0 % during follow-up (mean, 27.5 months). During the first 12 months on study, the probability of calcium discontinuation was 23.7 % (95 % confidence interval [CI], 20.7 − 27.0) among calcium-only subjects and 22.5 % (95 % CI, 20.7–24.5) among supplementers. Supplementers who discontinued pharmacologic therapy were more likely to discontinue calcium than supplementers who continued pharmacologic therapy (34.9 versus 14.8 %). Overall 54.2 % of calcium-only subjects who discontinued calcium and 42.3 % of supplementers who discontinued calcium resumed calcium use during follow-up. Regular exercise was positively correlated with calcium use at study entry.ConclusionsCalcium supplementation in pharmacologically treated subjects increased over time. Persistence with calcium was high. Discontinuation of pharmacologic osteoporosis therapy was associated with an increased likelihood of discontinuing calcium use. More... »

PAGES

2175-2184

References to SciGraph publications

  • 2013-07-11. The Women’s Health Initiative: Hormone Therapy and Calcium/Vitamin D Supplementation Trials in CURRENT OSTEOPOROSIS REPORTS
  • 2006-03-15. Determinants of adherence to osteoporosis treatment in clinical practice in OSTEOPOROSIS INTERNATIONAL
  • 2008-07-08. Design of the POSSIBLE US™ Study: postmenopausal women’s compliance and persistence with osteoporosis medications in OSTEOPOROSIS INTERNATIONAL
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  • 2012-12-04. Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study in OSTEOPOROSIS INTERNATIONAL
  • 2010-01-26. Persistence and switching patterns among women with varied osteoporosis medication histories: 12-month results from POSSIBLE US™ in OSTEOPOROSIS INTERNATIONAL
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  • 2004-02-26. Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease in HEALTH AND QUALITY OF LIFE OUTCOMES
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  • 2010-04-07. Association of physical exercise and calcium intake with bone mass measured by quantitative ultrasound in BMC WOMEN'S HEALTH
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    35 schema:description Calcium use was common and remained high among women on osteoporosis therapy. Use of calcium-supplemented pharmacologic therapy increased from 65.1 to 76.0 % in these women (mean follow-up, 27.5 months). Over 12 months, calcium discontinuation was fairly similar among women using calcium only (23.7 %) and women supplementing pharmacologic therapy with calcium (22.5 %).IntroductionCalcium has an important role in bone health. This study describes calcium use and persistence in a postmenopausal osteoporosis treatment cohort.MethodsSubject-reported calcium use was analyzed for 3,722 participants of the Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE USTM) who used calcium either as their sole osteoporosis treatment (calcium only) or to supplement pharmacologic osteoporosis therapy (supplementers). Descriptive analyses were conducted. Kaplan-Meier methods were used to estimate the probability of discontinuing calcium therapy, and logistic regression was used to assess associations (age-adjusted odds ratios) between healthy behaviors and calcium use.ResultsAt entry, there were 711 calcium-only subjects and 1,960 of 3,011 subjects on pharmacologic osteoporosis therapy also supplementing with calcium (supplementers). The percentage of supplementers increased from 65.1 to 76.0 % during follow-up (mean, 27.5 months). During the first 12 months on study, the probability of calcium discontinuation was 23.7 % (95 % confidence interval [CI], 20.7 − 27.0) among calcium-only subjects and 22.5 % (95 % CI, 20.7–24.5) among supplementers. Supplementers who discontinued pharmacologic therapy were more likely to discontinue calcium than supplementers who continued pharmacologic therapy (34.9 versus 14.8 %). Overall 54.2 % of calcium-only subjects who discontinued calcium and 42.3 % of supplementers who discontinued calcium resumed calcium use during follow-up. Regular exercise was positively correlated with calcium use at study entry.ConclusionsCalcium supplementation in pharmacologically treated subjects increased over time. Persistence with calcium was high. Discontinuation of pharmacologic osteoporosis therapy was associated with an increased likelihood of discontinuing calcium use.
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    42 schema:keywords Bone Loss Experience
    43 ConclusionsCalcium supplementation
    44 IntroductionCalcium
    45 Kaplan-Meier method
    46 MethodsSubjects
    47 Observational Scientific Study
    48 Prospective Observational Scientific Study
    49 ResultsAt entry
    50 Self-reported calcium use
    51 analysis
    52 association
    53 behavior
    54 bone health
    55 calcium
    56 calcium discontinuation
    57 calcium therapy
    58 calcium use
    59 calcium-supplemented pharmacologic therapy
    60 cohort
    61 descriptive analysis
    62 discontinuation
    63 entry
    64 exercise
    65 experience
    66 health
    67 healthy behaviors
    68 important role
    69 likelihood
    70 logistic regression
    71 loss experience
    72 method
    73 months
    74 osteoporosis therapy
    75 osteoporosis treatment
    76 osteoporosis treatment cohort
    77 participants
    78 percentage
    79 percentage of supplementers
    80 persistence
    81 pharmacologic osteoporosis therapy
    82 pharmacologic therapy
    83 possible uses
    84 postmenopausal osteoporosis treatment cohort
    85 postmenopausal women
    86 probability
    87 regression
    88 regular exercise
    89 results
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    93 study
    94 study entry
    95 subjects
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