Age-related differences in the activity of arterial mineral deposition and regional bone metabolism: a 18F-sodium fluoride positron emission tomography study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

T. Derlin, T. Janssen, J. Salamon, S. Veldhoen, J. D. Busch, G. Schön, J. Herrmann, F. O. Henes, P. Bannas, G. Adam

ABSTRACT

Functional (18)F-fluoride PET demonstrated an inverse relationship between the activity of arterial mineral deposition and regional bone metabolism. While bone metabolism decreases with age, the activity of arterial mineral deposition increases. INTRODUCTION: The extent of arterial calcification increases with age, whereas bone mineral density decreases, evidencing a well-known inverse correlation on morphological basis. The aim of this study was to evaluate the functional relationship between the activity of arterial mineral deposition and regional bone metabolism as assessed by (18)F-sodium fluoride (NaF) PET/CT. METHODS: Three hundred four subjects were examined by (18)F-NaF PET/CT. Tracer accumulation in the femoral arteries was analyzed both qualitatively and semiquantitatively by measuring the blood-pool-corrected standardized uptake value (target-to-background ratio). Uptake was compared with cardiovascular risk factors (RFs), calcified plaque burden, and regional bone metabolism as assessed by PET/CT. RESULTS: The activity of arterial mineral deposition significantly increased with age (p < 0.001), whereas regional bone metabolism significantly decreased (p < 0.001). There was a significant inverse correlation between bone metabolism and arterial mineral deposition (unadjusted, p < 0.001); that association was not significant (p = 0.79) when controlled for age and other RFs. Both high activity of arterial mineral deposition and low bone metabolism were significantly associated with cardiovascular events and other RFs. CONCLUSION: (18)F-NaF PET/CT provides a tool to visualize and quantify the activity of arterial mineral deposition and regional bone metabolism. In this study, we observed an inverse correlation between the activity of arterial mineral deposition and regional bone metabolism. While the activity of arterial mineral deposition significantly increases with age, regional bone metabolism decreases. More... »

PAGES

199-207

References to SciGraph publications

  • 2008-03. FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2012-08. Age-related changes in pre- and postmenopausal women investigated with 18F-fluoride PET—a preliminary study in SKELETAL RADIOLOGY
  • 1997-11. Mutation of the mouse klotho gene leads to a syndrome resembling ageing in NATURE
  • 2007-03. Vascular calcification and osteoporosis—from clinical observation towards molecular understanding in OSTEOPOROSIS INTERNATIONAL
  • 2013-02. Differences in regional bone metabolism at the spine and hip: a quantitative study using 18F-fluoride positron emission tomography in OSTEOPOROSIS INTERNATIONAL
  • 1997-03. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein in NATURE
  • 2001-05. Bone loss and the progression of abdominal aortic calcification over a 25 year period: The Framingham heart study in CALCIFIED TISSUE INTERNATIONAL
  • 2007-02-28. Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se? in OSTEOPOROSIS INTERNATIONAL
  • 1994-12. Comparison of the bone mineral content of the lower limbs in men with ischaemic atherosclerotic disease in CLINICAL RHEUMATOLOGY
  • 2014-04. Delayed sodium 18F-fluoride PET/CT imaging does not improve quantification of vascular calcification metabolism: Results from the CAMONA study in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2013-08. Association of linear 18F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: A PET/CT study in JOURNAL OF NUCLEAR CARDIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00198-014-2839-6

    DOI

    http://dx.doi.org/10.1007/s00198-014-2839-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013532921

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25124219


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