Molecular alterations of bone quality in sequesters of bisphosphonates-related osteonecrosis of the jaws View Full Text


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Article Info

DATE

2013-10-01

AUTHORS

C. Olejnik, G. Falgayrac, A. During, M. H. Vieillard, J. M. Maes, B. Cortet, G. Penel

ABSTRACT

Compared to healthy bone, the intrinsic bone materials properties in the pre-existing lamellar bone are altered in jaw bone sequesters of bisphosphonates (BP)-related osteonecrosis.IntroductionThe aim of this study was to evaluate the human jaw bone quality, especially intrinsic bone material properties among sequesters of osteonecrosis of the jaw (ONJ) induced by BP.MethodsBone sequesters were obtained from 24 patients suffering from ONJ following a BP treatment. Within BP-exposed bone samples, benign-BP and malignant-BP groups were distinguished in relation to the underlying disease: osteoporosis and bone metastases or multiple myeloma, respectively. Healthy cadaveric cortical jaw bone samples were used as controls. The physicochemical parameters of bone samples — mineral/organic ratio, relative proteoglycan content, crystallinity, monohydrogen phosphate content, and type-B carbonate substitution — were evaluated by Raman microspectroscopy. Representative Raman spectral features of bones control and BP-exposed bone sequesters were identified with the Partial-Least-Square Discriminant Analysis (PLS-DA).ResultsBP-exposed bone sequesters are characterized by a significant increase of mineral to organic ratio (+12 %) and a significant decrease of relative proteoglycan content (−35 %), thus regulating initial collagen matrix mineral deposition. Structural changes on mineral components are revealed by a significant decrease of both crystallinity (−2 %) and mineral maturation (−41 %) in the BP-exposed bone sequesters compared to healthy bones. These modifications were also observed distinctly in both benign-BP and malignant-BP groups. In addition, a shift of the phosphate ν1 band was highlighted by PLS-DA between bones control and BP-exposed bone sequesters, revealing a disruption of the apatitic phosphate environment in the jaw bone sequesters.ConclusionsThe present data show that jaw bone quality can be altered with an overmineralization and ultrastructural modifications of apatitic mineral in bone sequesters of BP-related ONJ. More... »

PAGES

747-756

References to SciGraph publications

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00198-013-2514-3

    DOI

    http://dx.doi.org/10.1007/s00198-013-2514-3

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24081510


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    30 schema:description Compared to healthy bone, the intrinsic bone materials properties in the pre-existing lamellar bone are altered in jaw bone sequesters of bisphosphonates (BP)-related osteonecrosis.IntroductionThe aim of this study was to evaluate the human jaw bone quality, especially intrinsic bone material properties among sequesters of osteonecrosis of the jaw (ONJ) induced by BP.MethodsBone sequesters were obtained from 24 patients suffering from ONJ following a BP treatment. Within BP-exposed bone samples, benign-BP and malignant-BP groups were distinguished in relation to the underlying disease: osteoporosis and bone metastases or multiple myeloma, respectively. Healthy cadaveric cortical jaw bone samples were used as controls. The physicochemical parameters of bone samples — mineral/organic ratio, relative proteoglycan content, crystallinity, monohydrogen phosphate content, and type-B carbonate substitution — were evaluated by Raman microspectroscopy. Representative Raman spectral features of bones control and BP-exposed bone sequesters were identified with the Partial-Least-Square Discriminant Analysis (PLS-DA).ResultsBP-exposed bone sequesters are characterized by a significant increase of mineral to organic ratio (+12 %) and a significant decrease of relative proteoglycan content (−35 %), thus regulating initial collagen matrix mineral deposition. Structural changes on mineral components are revealed by a significant decrease of both crystallinity (−2 %) and mineral maturation (−41 %) in the BP-exposed bone sequesters compared to healthy bones. These modifications were also observed distinctly in both benign-BP and malignant-BP groups. In addition, a shift of the phosphate ν1 band was highlighted by PLS-DA between bones control and BP-exposed bone sequesters, revealing a disruption of the apatitic phosphate environment in the jaw bone sequesters.ConclusionsThe present data show that jaw bone quality can be altered with an overmineralization and ultrastructural modifications of apatitic mineral in bone sequesters of BP-related ONJ.
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    37 BP treatment
    38 IntroductionThe aim
    39 ONJ
    40 PLS-DA
    41 Raman microspectroscopy
    42 Raman spectral features
    43 addition
    44 aim
    45 alterations
    46 analysis
    47 apatitic mineral
    48 band
    49 bisphosphonate-related osteonecrosis
    50 bisphosphonates
    51 bone
    52 bone controls
    53 bone material properties
    54 bone metastases
    55 bone quality
    56 bone samples
    57 bone sequesters
    58 carbonate substitution
    59 changes
    60 components
    61 content
    62 control
    63 crystallinity
    64 data show
    65 decrease
    66 deposition
    67 discriminant analysis
    68 disease
    69 disruption
    70 environment
    71 features
    72 group
    73 healthy bone
    74 increase
    75 intrinsic bone material properties
    76 jaw
    77 jaw bone quality
    78 jaw bone samples
    79 lamellar bone
    80 material properties
    81 maturation
    82 metastasis
    83 microspectroscopy
    84 mineral components
    85 mineral deposition
    86 mineral maturation
    87 minerals
    88 modification
    89 molecular alterations
    90 multiple myeloma
    91 myeloma
    92 organic ratio
    93 osteonecrosis
    94 osteoporosis
    95 parameters
    96 partials
    97 patients
    98 phosphate content
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    100 physicochemical parameters
    101 present data show
    102 properties
    103 proteoglycan content
    104 quality
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    106 relation
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    108 samples
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