Ontology type: schema:ScholarlyArticle
2012-11-15
AUTHORSS. Gamsjaeger, B. Hofstetter, E. Zwettler, R. Recker, J. A. Gasser, E. F. Eriksen, K. Klaushofer, E. P. Paschalis
ABSTRACTOnce-yearly administration of intravenous zoledronic acid for 3 years in humans affects the kinetics of matrix filling in by mineral, independent of bone turnover.IntroductionYearly 5-mg infusions of zoledronic acid (ZOL) for 3 years have shown pronounced antifracture efficacy. The purpose of the present study was to test whether ZOL affects the kinetics of forming bone material properties maturation.MethodsIliac crest biopsies from the HORIZON-PFT clinical trial were analyzed by Raman microspectroscopy in actively bone-forming surfaces as a function of tissue age in trabecular and osteonal bone, to determine ZOL’s effect on bone material quality indices maturation kinetics.ResultsMineral/matrix ratio increased in both groups as a function of tissue age, at both osteonal- and trabecular-forming surfaces; ZOL exhibiting the greatest increase in the trabecular surfaces only. The proteoglycan content showed a dependency on tissue age in both trabecular and osteonal surfaces, with ZOL exhibiting lower values in the tissue age 8–22 days in the trabecular surfaces. Mineral crystallinity (crystallite length and thickness) showed a dependence on tissue age, with ZOL exhibiting lower crystallite length compared with placebo only in the 8- to 22-day-old tissue at trabecular surfaces, while crystal thickness was lower in the 1- to 5-day-old tissue at both osteonal and trabecular surfaces.ConclusionsThe results of the present study suggest that once-yearly administration of intravenous ZOL for 3 years in humans does not exert any adverse effects on the evolution of bone material properties at actively forming osteonal and trabecular surfaces, while it may have a beneficial effect on the progression of the mineral-to-matrix ratio and mineral maturity bone quality indices. More... »
PAGES339-347
http://scigraph.springernature.com/pub.10.1007/s00198-012-2202-8
DOIhttp://dx.doi.org/10.1007/s00198-012-2202-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1034930032
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23229465
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Engineering",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biomedical Engineering",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biopsy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Density",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Density Conservation Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Matrix",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diphosphonates",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Administration Schedule",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Imidazoles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infusions, Intravenous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Osteoporosis, Postmenopausal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proteoglycans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spectrum Analysis, Raman",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Zoledronic Acid",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.413662.4",
"name": [
"Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Gamsjaeger",
"givenName": "S.",
"id": "sg:person.01036120531.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036120531.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.413662.4",
"name": [
"Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Hofstetter",
"givenName": "B.",
"id": "sg:person.01017710376.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017710376.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.413662.4",
"name": [
"Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Zwettler",
"givenName": "E.",
"id": "sg:person.01070522126.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070522126.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, Creighton University, Omaha, NE, USA",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center, Creighton University, Omaha, NE, USA"
],
"type": "Organization"
},
"familyName": "Recker",
"givenName": "R.",
"id": "sg:person.016325222544.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016325222544.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Novartis Institutes for BioMedical Research, Basel, Switzerland",
"id": "http://www.grid.ac/institutes/grid.419481.1",
"name": [
"Novartis Institutes for BioMedical Research, Basel, Switzerland"
],
"type": "Organization"
},
"familyName": "Gasser",
"givenName": "J. A.",
"id": "sg:person.01321177126.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321177126.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hormonlaboratoriet, AUS Aker Universitetssykehus Trondheimsveien, Oslo, Norway",
"id": "http://www.grid.ac/institutes/grid.55325.34",
"name": [
"Hormonlaboratoriet, AUS Aker Universitetssykehus Trondheimsveien, Oslo, Norway"
],
"type": "Organization"
},
"familyName": "Eriksen",
"givenName": "E. F.",
"id": "sg:person.0664446311.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664446311.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.413662.4",
"name": [
"Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Klaushofer",
"givenName": "K.",
"id": "sg:person.01030065520.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030065520.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.413662.4",
"name": [
"Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, 1140, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Paschalis",
"givenName": "E. P.",
"id": "sg:person.01041761631.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041761631.00"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s002239900372",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006153796",
"https://doi.org/10.1007/s002239900372"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00223-006-0011-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050793651",
"https://doi.org/10.1007/s00223-006-0011-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00198-009-0857-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034390788",
"https://doi.org/10.1007/s00198-009-0857-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00198-005-1992-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001670755",
"https://doi.org/10.1007/s00198-005-1992-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00216-006-0638-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023233440",
"https://doi.org/10.1007/s00216-006-0638-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/b:jmsm.0000036270.68200.97",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040191972",
"https://doi.org/10.1023/b:jmsm.0000036270.68200.97"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002239900339",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014076264",
"https://doi.org/10.1007/s002239900339"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00774-009-0146-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041292267",
"https://doi.org/10.1007/s00774-009-0146-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10544-007-9139-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031772546",
"https://doi.org/10.1007/s10544-007-9139-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02555847",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017527016",
"https://doi.org/10.1007/bf02555847"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00223-010-9404-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007306453",
"https://doi.org/10.1007/s00223-010-9404-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02509540",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024124933",
"https://doi.org/10.1007/bf02509540"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1746-160x-5-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036694594",
"https://doi.org/10.1186/1746-160x-5-13"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00369214",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032896559",
"https://doi.org/10.1007/bf00369214"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-11-15",
"datePublishedReg": "2012-11-15",
"description": "Once-yearly administration of intravenous zoledronic acid for 3\u00a0years in humans affects the kinetics of matrix filling in by mineral, independent of bone turnover.IntroductionYearly 5-mg infusions of zoledronic acid (ZOL) for 3\u00a0years have shown pronounced antifracture efficacy. The purpose of the present study was to test whether ZOL affects the kinetics of forming bone material properties maturation.MethodsIliac crest biopsies from the HORIZON-PFT clinical trial were analyzed by Raman microspectroscopy in actively bone-forming surfaces as a function of tissue age in trabecular and osteonal bone, to determine ZOL\u2019s effect on bone material quality indices maturation kinetics.ResultsMineral/matrix ratio increased in both groups as a function of tissue age, at both osteonal- and trabecular-forming surfaces; ZOL exhibiting the greatest increase in the trabecular surfaces only. The proteoglycan content showed a dependency on tissue age in both trabecular and osteonal surfaces, with ZOL exhibiting lower values in the tissue age 8\u201322\u00a0days in the trabecular surfaces. Mineral crystallinity (crystallite length and thickness) showed a dependence on tissue age, with ZOL exhibiting lower crystallite length compared with placebo only in the 8- to 22-day-old tissue at trabecular surfaces, while crystal thickness was lower in the 1- to 5-day-old tissue at both osteonal and trabecular surfaces.ConclusionsThe results of the present study suggest that once-yearly administration of intravenous ZOL for 3\u00a0years in humans does not exert any adverse effects on the evolution of bone material properties at actively forming osteonal and trabecular surfaces, while it may have a beneficial effect on the progression of the mineral-to-matrix ratio and mineral maturity bone quality indices.",
"genre": "article",
"id": "sg:pub.10.1007/s00198-012-2202-8",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1100834",
"issn": [
"0937-941X",
"1433-2965"
],
"name": "Osteoporosis International",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "24"
}
],
"keywords": [
"intravenous zoledronic acid",
"zoledronic acid",
"yearly administration",
"trabecular surface",
"yearly zoledronic acid",
"bone quality index",
"bone material quality",
"osteonal surfaces",
"antifracture efficacy",
"bone turnover",
"present study",
"bone-forming surfaces",
"osteoporotic patients",
"clinical trials",
"bone matrix maturation",
"crest biopsies",
"bone material properties",
"year treatment",
"ZOL effects",
"beneficial effects",
"adverse effects",
"age",
"age 8",
"greater increase",
"ConclusionsThe results",
"administration",
"tissue age",
"proteoglycan content",
"matrix ratio",
"tissue",
"matrix maturation",
"years",
"maturation",
"placebo",
"osteonal bone",
"patients",
"humans",
"biopsy",
"infusion",
"Quality Index",
"trials",
"progression",
"efficacy",
"maturation kinetics",
"effect",
"treatment",
"mineral crystallinity",
"bone",
"study",
"acid",
"days",
"group",
"function",
"index",
"ratio",
"increase",
"turnover",
"purpose",
"lower values",
"quality",
"length",
"results",
"kinetics",
"Raman microspectroscopy",
"values",
"content",
"thickness",
"surface",
"microspectroscopy",
"dependency",
"minerals",
"properties",
"matrix",
"dependence",
"evolution",
"material quality",
"crystallite length",
"material properties",
"crystallinity",
"crystal thickness"
],
"name": "Effects of 3 years treatment with once-yearly zoledronic acid on the kinetics of bone matrix maturation in osteoporotic patients",
"pagination": "339-347",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1034930032"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00198-012-2202-8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23229465"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00198-012-2202-8",
"https://app.dimensions.ai/details/publication/pub.1034930032"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_573.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00198-012-2202-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00198-012-2202-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00198-012-2202-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00198-012-2202-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00198-012-2202-8'
This table displays all metadata directly associated to this object as RDF triples.
331 TRIPLES
21 PREDICATES
138 URIs
114 LITERALS
24 BLANK NODES