Premenopausal women with idiopathic low-trauma fractures and/or low bone mineral density View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03-02

AUTHORS

A. Cohen, R. R. Recker, J. Lappe, D. W. Dempster, S. Cremers, D. J. McMahon, E. M. Stein, J. Fleischer, C. J. Rosen, H. Rogers, R. B. Staron, J. LeMaster, E. Shane

ABSTRACT

IntroductionIn men, idiopathic osteoporosis (IOP) is often associated with low serum insulin-like growth factor (IGF-1) and reduced bone formation. The characteristics of premenopausal women with IOP are not well defined. We aimed to define the clinical, reproductive, and biochemical characteristics of premenopausal women with unexplained osteoporosis.MethodsThis is a cross-sectional study of 64 women with unexplained osteoporosis, 45 with fragility fractures, 19 with low bone mineral density (BMD; Z-score less than or equal to −2.0) and 40 normal controls. The following are the main outcome measures: clinical and anthropometric characteristics, reproductive history, BMD, gonadal and calciotropic hormones, IGF-1, and bone turnover markers (BTMs).ResultsSubjects had lower BMI and BMD than controls, but serum and urinary calcium, serum estradiol, vitamin D metabolites, IGF-1, and most BTMs were similar. Serum parathyroid hormone (PTH) and the resorption marker, tartrate-resistant acid phosphatase (TRAP5b), were significantly higher in both groups of subjects than controls and directly associated in all groups. Serum IGF-1 and all BTMs were directly associated in controls, but the association was not significant after controlling for age. There was no relationship between serum IGF-1 and BTMs in subjects. There were few differences between women with fractures and low BMD.ConclusionsHigher serum TRAP5b and PTH suggest that increased bone turnover, possibly related to subclinical secondary hyperparathyroidism could contribute to the pathogenesis of IOP. The absence of differences between women with fractures and those with very low BMD indicates that this distinction may not be clinically useful to categorize young women with osteoporosis. More... »

PAGES

171-182

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00198-011-1560-y

DOI

http://dx.doi.org/10.1007/s00198-011-1560-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051181048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21365462


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40 schema:description IntroductionIn men, idiopathic osteoporosis (IOP) is often associated with low serum insulin-like growth factor (IGF-1) and reduced bone formation. The characteristics of premenopausal women with IOP are not well defined. We aimed to define the clinical, reproductive, and biochemical characteristics of premenopausal women with unexplained osteoporosis.MethodsThis is a cross-sectional study of 64 women with unexplained osteoporosis, 45 with fragility fractures, 19 with low bone mineral density (BMD; Z-score less than or equal to −2.0) and 40 normal controls. The following are the main outcome measures: clinical and anthropometric characteristics, reproductive history, BMD, gonadal and calciotropic hormones, IGF-1, and bone turnover markers (BTMs).ResultsSubjects had lower BMI and BMD than controls, but serum and urinary calcium, serum estradiol, vitamin D metabolites, IGF-1, and most BTMs were similar. Serum parathyroid hormone (PTH) and the resorption marker, tartrate-resistant acid phosphatase (TRAP5b), were significantly higher in both groups of subjects than controls and directly associated in all groups. Serum IGF-1 and all BTMs were directly associated in controls, but the association was not significant after controlling for age. There was no relationship between serum IGF-1 and BTMs in subjects. There were few differences between women with fractures and low BMD.ConclusionsHigher serum TRAP5b and PTH suggest that increased bone turnover, possibly related to subclinical secondary hyperparathyroidism could contribute to the pathogenesis of IOP. The absence of differences between women with fractures and those with very low BMD indicates that this distinction may not be clinically useful to categorize young women with osteoporosis.
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49 IGF-1
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51 ResultsSubjects
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53 absence
54 absence of differences
55 acid phosphatase
56 age
57 anthropometric characteristics
58 association
59 biochemical characteristics
60 bone formation
61 bone mineral density
62 bone turnover
63 bone turnover markers
64 calciotropic hormones
65 calcium
66 characteristics
67 control
68 cross-sectional study
69 density
70 differences
71 distinction
72 estradiol
73 factors
74 formation
75 fractures
76 fragility fractures
77 gonadal
78 group
79 groups of subjects
80 growth factor
81 history
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83 hyperparathyroidism
84 idiopathic osteoporosis
85 insulin-like growth factor
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87 low bone mineral density
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89 low-trauma fractures
90 lower BMI
91 main outcome measures
92 markers
93 measures
94 men
95 metabolites
96 mineral density
97 most bone turnover markers
98 normal controls
99 osteoporosis
100 outcome measures
101 parathyroid hormone
102 pathogenesis
103 phosphatase
104 premenopausal women
105 relationship
106 reproductive history
107 resistant acid phosphatase
108 resorption markers
109 secondary hyperparathyroidism
110 serum IGF-1
111 serum TRAP5b
112 serum estradiol
113 serum insulin-like growth factor
114 serum parathyroid hormone
115 study
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