Effects of high dose of zoledronic acid on superficial vascular network of membranous bone sites: an intravital study on rat ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12-18

AUTHORS

M. H. Vieillard, J. Paccou, B. Cortet, E. Biver, J. Salleron, G. Falgayrac, G. Penel

ABSTRACT

We evaluated the impact of high dose of zoledronic acid on the superficial vascular network parameters of a membranous bone site. During a 5-day follow-up, significant reduction of the vascular density is observed only in the treated group.IntroductionThe superficial vascularization is of great importance in membranous bone-healing process. A new rat calvarium intravital model was developed to study the short-term effect of a single high dose of zoledronic acid infusion on the superficial vascularization.MethodsOptical bone chambers were implanted in the bone tissue surface of Sprague-Dawley rats' calvarium. Nine rats were injected i.v. with 400 µg/kg of zoledronic acid (Z group), and nine rats were injected with vehicle (PSS group). A 5-day follow-up of the vascular network was made by the use of pictures analysis method.ResultsThe vascular density significantly decreases only in Z group but there was no significant difference between groups at individual time points. The total length of the vascular network decreases significantly in Z group only (p = 0.003) with a significant higher decrease at D3 (p = 0.04) and D5 (p = 0.02) compared with control. The vascular density related to the smaller vessels (width, 5–10 µm) decreases significantly between T0 and D5 in Z group only (p = 0.002).ConclusionsWith the help of an original intravital animal model a significant modifications on the total length of the vascular network and the vascular density of small vessels are highlighted on a membranous bone site. More... »

PAGES

1919-1925

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00198-009-1146-0

DOI

http://dx.doi.org/10.1007/s00198-009-1146-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008213202

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20020279


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