Design of the POSSIBLE US™ Study: postmenopausal women’s compliance and persistence with osteoporosis medications View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07-08

AUTHORS

E. Barrett-Connor, K. Ensrud, A. N. A. Tosteson, S. F. Varon, M. Anthony, N. Daizadeh, S. Wade

ABSTRACT

Failure to take prescribed medication is common. The POSSIBLE US™ study is evaluating the impact of physician and patient characteristics on patient-reported compliance and persistence with osteoporosis medications. We report our study design and the baseline characteristics of 4,994 postmenopausal women recruited from primary care physician offices in 33 states.IntroductionThe Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US™) is a longitudinal cohort study of osteoporosis therapy in primary care.MethodsBetween 2004 and 2007, 134 physicians (in 33 states) enrolled postmenopausal women initiating, changing, or continuing osteoporosis medications. After completing a baseline questionnaire, participants will provide data semi-annually for up to 3 years through 2008. Physicians provide patient data at baseline and routine follow-up visits. Participants from 23 sites also signed a release regarding administrative claims data for economic analyses and validation of self-reported data.Baseline resultsFour thousand nine hundred and ninety-four evaluable women were recruited from internal medicine (n = 1,784), family practice (n = 1,556), obstetrics/gynecology (n = 1,556), and from one rheumatology practice (n = 98). Mean participant age was 64.3 years (SD = 9.97); 89% were Caucasian; 59% had some college education. Sixty-three percent used a single osteoporosis agent, usually a bisphosphonate. For monotherapy patients, concordance between clinic- and patient-reported medication use was lowest for patients prescribed estrogen therapy (70%) or calcium/vitamin D (72%). Obstetrician/gynecologists enrolled younger women, who were more likely to use estrogen therapy than patients enrolled by other physicians. The 934 women (19%) prescribed only calcium/vitamin D were younger than women prescribed pharmacologic therapy.ConclusionsPOSSIBLE US™ provides a unique foundation for evaluating longitudinal use of osteoporosis medications and related outcomes. More... »

PAGES

463

References to SciGraph publications

  • 2006-03-15. Determinants of adherence to osteoporosis treatment in clinical practice in OSTEOPOROSIS INTERNATIONAL
  • 2005-11-09. Osteoporosis intervention in ambulatory patients with previous hip fracture: a multicentric, nationwide Italian survey in OSTEOPOROSIS INTERNATIONAL
  • 2006-07-22. Compliance with drug therapy for postmenopausal osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 2006-11-15. Effectiveness of bisphosphonates on nonvertebral and hip fractures in the first year of therapy: The risedronate and alendronate (REAL) cohort study in OSTEOPOROSIS INTERNATIONAL
  • 2007-02-17. A systematic review of persistence and compliance with bisphosphonates for osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 2003-09-19. Compliance with pharmacologic therapy for osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 2007-06-19. Osteoporosis practice patterns in 2006 among primary care physicians participating in the NORA study in OSTEOPOROSIS INTERNATIONAL
  • 2000-02. The Osteoporosis Assessment Questionnaire (OPAQ): A reliable and valid disease-targeted measure of health-related quality of life (HRQOL) in osteoporosis in QUALITY OF LIFE RESEARCH
  • 2004-05-27. The impact of compliance with osteoporosis therapy on fracture rates in actual practice in OSTEOPOROSIS INTERNATIONAL
  • 2004-02-26. Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2003-03. Tolerability and compliance with risedronate in clinical practice in OSTEOPOROSIS INTERNATIONAL
  • 2006-04-12. Persistence with weekly alendronate therapy among postmenopausal women in OSTEOPOROSIS INTERNATIONAL
  • 2006-05-19. Channeling and adherence with alendronate and risedronate among chronic glucocorticoid users in OSTEOPOROSIS INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00198-008-0674-3

    DOI

    http://dx.doi.org/10.1007/s00198-008-0674-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041206509

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18607669


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Density Conservation Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium, Dietary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Estrogen Replacement Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Medication Adherence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteoporosis, Postmenopausal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Physician-Patient Relations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Primary Health Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Research Design", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Self Administration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "United States", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vitamin D", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, 92093-0607, La Jolla, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, 92093-0607, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barrett-Connor", 
            "givenName": "E.", 
            "id": "sg:person.01346631166.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346631166.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Minnesota, Minneapolis, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.17635.36", 
              "name": [
                "University of Minnesota, Minneapolis, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ensrud", 
            "givenName": "K.", 
            "id": "sg:person.012311562057.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012311562057.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dartmouth Medical School, Hanover, NH, USA", 
              "id": "http://www.grid.ac/institutes/grid.254880.3", 
              "name": [
                "Dartmouth Medical School, Hanover, NH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tosteson", 
            "givenName": "A. N. A.", 
            "id": "sg:person.012234200657.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012234200657.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amgen, Inc., Thousand Oaks, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.417886.4", 
              "name": [
                "Amgen, Inc., Thousand Oaks, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Varon", 
            "givenName": "S. F.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amgen, Inc., Thousand Oaks, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.417886.4", 
              "name": [
                "Amgen, Inc., Thousand Oaks, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anthony", 
            "givenName": "M.", 
            "id": "sg:person.01165514160.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165514160.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amgen, Inc., Thousand Oaks, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.417886.4", 
              "name": [
                "Amgen, Inc., Thousand Oaks, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daizadeh", 
            "givenName": "N.", 
            "id": "sg:person.01140101245.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140101245.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wade Outcomes Research and Consulting, Salt Lake City, UT, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Wade Outcomes Research and Consulting, Salt Lake City, UT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wade", 
            "givenName": "S.", 
            "id": "sg:person.0617012057.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617012057.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00198-007-0408-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008726830", 
              "https://doi.org/10.1007/s00198-007-0408-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0274-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007298732", 
              "https://doi.org/10.1007/s00198-006-0274-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0322-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012288373", 
              "https://doi.org/10.1007/s00198-006-0322-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-002-1370-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021711183", 
              "https://doi.org/10.1007/s00198-002-1370-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7525-2-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039428500", 
              "https://doi.org/10.1186/1477-7525-2-12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0136-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031571579", 
              "https://doi.org/10.1007/s00198-006-0136-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-003-1502-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013179474", 
              "https://doi.org/10.1007/s00198-003-1502-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-005-0010-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022496022", 
              "https://doi.org/10.1007/s00198-005-0010-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0085-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019542455", 
              "https://doi.org/10.1007/s00198-006-0085-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0179-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038026469", 
              "https://doi.org/10.1007/s00198-006-0179-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1008934208764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038535451", 
              "https://doi.org/10.1023/a:1008934208764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-004-1652-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023624379", 
              "https://doi.org/10.1007/s00198-004-1652-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0073-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020337646", 
              "https://doi.org/10.1007/s00198-006-0073-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008-07-08", 
        "datePublishedReg": "2008-07-08", 
        "description": "Failure to take prescribed medication is common. The POSSIBLE US\u2122 study is evaluating the impact of physician and patient characteristics on patient-reported compliance and persistence with osteoporosis medications. We report our study design and the baseline characteristics of 4,994 postmenopausal women recruited from primary care physician offices in 33 states.IntroductionThe Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US\u2122) is a longitudinal cohort study of osteoporosis therapy in primary care.MethodsBetween 2004 and 2007, 134 physicians (in 33 states) enrolled postmenopausal women initiating, changing, or continuing osteoporosis medications. After completing a baseline questionnaire, participants will provide data semi-annually for up to 3\u00a0years through 2008. Physicians provide patient data at baseline and routine follow-up visits. Participants from 23 sites also signed a release regarding administrative claims data for economic analyses and validation of self-reported data.Baseline resultsFour thousand nine hundred and ninety-four evaluable women were recruited from internal medicine (n\u2009=\u20091,784), family practice (n\u2009=\u20091,556), obstetrics/gynecology (n\u2009=\u20091,556), and from one rheumatology practice (n\u2009=\u200998). Mean participant age was 64.3\u00a0years (SD\u2009=\u20099.97); 89% were Caucasian; 59% had some college education. Sixty-three percent used a single osteoporosis agent, usually a bisphosphonate. For monotherapy patients, concordance between clinic- and patient-reported medication use was lowest for patients prescribed estrogen therapy (70%) or calcium/vitamin D (72%). Obstetrician/gynecologists enrolled younger women, who were more likely to use estrogen therapy than patients enrolled by other physicians. The 934 women (19%) prescribed only calcium/vitamin D were younger than women prescribed pharmacologic therapy.ConclusionsPOSSIBLE US\u2122 provides a unique foundation for evaluating longitudinal use of osteoporosis medications and related outcomes.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00198-008-0674-3", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1100834", 
            "issn": [
              "0937-941X", 
              "1433-2965"
            ], 
            "name": "Osteoporosis International", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "keywords": [
          "calcium/vitamin D", 
          "osteoporosis medications", 
          "postmenopausal women", 
          "estrogen therapy", 
          "vitamin D", 
          "Prospective Observational Scientific Study", 
          "patient-reported medication use", 
          "primary care physician's office", 
          "patient-reported compliance", 
          "Bone Loss Experience", 
          "longitudinal cohort study", 
          "administrative claims data", 
          "obstetricians/gynecologists", 
          "impact of physicians", 
          "obstetrics/gynecology", 
          "evaluable women", 
          "osteoporosis agents", 
          "monotherapy patients", 
          "baseline characteristics", 
          "routine follow", 
          "pharmacologic therapy", 
          "patient characteristics", 
          "cohort study", 
          "medication use", 
          "prescribed medications", 
          "MethodsBetween 2004", 
          "osteoporosis therapy", 
          "rheumatology practice", 
          "primary care", 
          "baseline questionnaire", 
          "claims data", 
          "physician's office", 
          "medications", 
          "internal medicine", 
          "therapy", 
          "women's compliance", 
          "young women", 
          "study design", 
          "patients", 
          "physicians", 
          "patient data", 
          "women", 
          "family practice", 
          "participant age", 
          "related outcomes", 
          "self-reported data", 
          "longitudinal use", 
          "compliance", 
          "loss experience", 
          "college education", 
          "participants", 
          "bisphosphonates", 
          "gynecologists", 
          "Gynecology", 
          "clinic", 
          "follow", 
          "years", 
          "study", 
          "baseline", 
          "visits", 
          "care", 
          "Caucasians", 
          "age", 
          "outcomes", 
          "questionnaire", 
          "concordance", 
          "persistence", 
          "medicine", 
          "percent", 
          "failure", 
          "data", 
          "agents", 
          "release", 
          "use", 
          "practice", 
          "scientific studies", 
          "uses", 
          "experience", 
          "characteristics", 
          "possible uses", 
          "sites", 
          "education", 
          "impact", 
          "office", 
          "analysis", 
          "validation", 
          "economic analysis", 
          "design", 
          "unique foundation", 
          "state", 
          "foundation", 
          "care physician offices", 
          "IntroductionThe Prospective Observational Scientific Study", 
          "Observational Scientific Study", 
          "single osteoporosis agent", 
          "ConclusionsPOSSIBLE US", 
          "postmenopausal women\u2019s compliance"
        ], 
        "name": "Design of the POSSIBLE US\u2122 Study: postmenopausal women\u2019s compliance and persistence with osteoporosis medications", 
        "pagination": "463", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1041206509"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00198-008-0674-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "18607669"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00198-008-0674-3", 
          "https://app.dimensions.ai/details/publication/pub.1041206509"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_461.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00198-008-0674-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00198-008-0674-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00198-008-0674-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00198-008-0674-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00198-008-0674-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    328 TRIPLES      22 PREDICATES      152 URIs      131 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00198-008-0674-3 schema:about N21853967b2f448b3a056e6d66eb536e1
    2 N29f414f2d0e84d518abceb24dc0555ca
    3 N4de41913b10a4468891da0f7281ff8d1
    4 N50f0070a11d4428c8f16a65cb7104288
    5 N6521657f4ae54de6b88a996f8437c966
    6 N752d7ed27f1b40469fa4f9cc2023325e
    7 N77fb1ad514764733831848936683336a
    8 N8a47d23ba03d4296bfd36beba73850c2
    9 Na302977b2d8549d2b8027343055c26c2
    10 Na758f5537621410487d77b405916a3d3
    11 Naade29d7146d4932ae24522e406e5209
    12 Nb541092af4d94e6d868a91b6b570f09f
    13 Nbaa86febecd147f6a7e21b6a0d02a9af
    14 Nc3a4e96822e64b5e93b32e081f0c0e08
    15 Nccc0dcfb147340d4a92a3e2367a70b1a
    16 Nfcd6b69ba60144109baebb1439bbbbd2
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author N570e9af2d51e4f5b8a44a81afef9cf58
    20 schema:citation sg:pub.10.1007/s00198-002-1370-3
    21 sg:pub.10.1007/s00198-003-1502-4
    22 sg:pub.10.1007/s00198-004-1652-z
    23 sg:pub.10.1007/s00198-005-0010-0
    24 sg:pub.10.1007/s00198-006-0073-6
    25 sg:pub.10.1007/s00198-006-0085-2
    26 sg:pub.10.1007/s00198-006-0136-8
    27 sg:pub.10.1007/s00198-006-0179-x
    28 sg:pub.10.1007/s00198-006-0274-z
    29 sg:pub.10.1007/s00198-006-0322-8
    30 sg:pub.10.1007/s00198-007-0408-y
    31 sg:pub.10.1023/a:1008934208764
    32 sg:pub.10.1186/1477-7525-2-12
    33 schema:datePublished 2008-07-08
    34 schema:datePublishedReg 2008-07-08
    35 schema:description Failure to take prescribed medication is common. The POSSIBLE US™ study is evaluating the impact of physician and patient characteristics on patient-reported compliance and persistence with osteoporosis medications. We report our study design and the baseline characteristics of 4,994 postmenopausal women recruited from primary care physician offices in 33 states.IntroductionThe Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US™) is a longitudinal cohort study of osteoporosis therapy in primary care.MethodsBetween 2004 and 2007, 134 physicians (in 33 states) enrolled postmenopausal women initiating, changing, or continuing osteoporosis medications. After completing a baseline questionnaire, participants will provide data semi-annually for up to 3 years through 2008. Physicians provide patient data at baseline and routine follow-up visits. Participants from 23 sites also signed a release regarding administrative claims data for economic analyses and validation of self-reported data.Baseline resultsFour thousand nine hundred and ninety-four evaluable women were recruited from internal medicine (n = 1,784), family practice (n = 1,556), obstetrics/gynecology (n = 1,556), and from one rheumatology practice (n = 98). Mean participant age was 64.3 years (SD = 9.97); 89% were Caucasian; 59% had some college education. Sixty-three percent used a single osteoporosis agent, usually a bisphosphonate. For monotherapy patients, concordance between clinic- and patient-reported medication use was lowest for patients prescribed estrogen therapy (70%) or calcium/vitamin D (72%). Obstetrician/gynecologists enrolled younger women, who were more likely to use estrogen therapy than patients enrolled by other physicians. The 934 women (19%) prescribed only calcium/vitamin D were younger than women prescribed pharmacologic therapy.ConclusionsPOSSIBLE US™ provides a unique foundation for evaluating longitudinal use of osteoporosis medications and related outcomes.
    36 schema:genre article
    37 schema:inLanguage en
    38 schema:isAccessibleForFree false
    39 schema:isPartOf Nd28596882a184b3288035c4aae053b90
    40 Nfd2b4b8b74ed405196bdd2c88e265fcf
    41 sg:journal.1100834
    42 schema:keywords Bone Loss Experience
    43 Caucasians
    44 ConclusionsPOSSIBLE US
    45 Gynecology
    46 IntroductionThe Prospective Observational Scientific Study
    47 MethodsBetween 2004
    48 Observational Scientific Study
    49 Prospective Observational Scientific Study
    50 administrative claims data
    51 age
    52 agents
    53 analysis
    54 baseline
    55 baseline characteristics
    56 baseline questionnaire
    57 bisphosphonates
    58 calcium/vitamin D
    59 care
    60 care physician offices
    61 characteristics
    62 claims data
    63 clinic
    64 cohort study
    65 college education
    66 compliance
    67 concordance
    68 data
    69 design
    70 economic analysis
    71 education
    72 estrogen therapy
    73 evaluable women
    74 experience
    75 failure
    76 family practice
    77 follow
    78 foundation
    79 gynecologists
    80 impact
    81 impact of physicians
    82 internal medicine
    83 longitudinal cohort study
    84 longitudinal use
    85 loss experience
    86 medication use
    87 medications
    88 medicine
    89 monotherapy patients
    90 obstetricians/gynecologists
    91 obstetrics/gynecology
    92 office
    93 osteoporosis agents
    94 osteoporosis medications
    95 osteoporosis therapy
    96 outcomes
    97 participant age
    98 participants
    99 patient characteristics
    100 patient data
    101 patient-reported compliance
    102 patient-reported medication use
    103 patients
    104 percent
    105 persistence
    106 pharmacologic therapy
    107 physician's office
    108 physicians
    109 possible uses
    110 postmenopausal women
    111 postmenopausal women’s compliance
    112 practice
    113 prescribed medications
    114 primary care
    115 primary care physician's office
    116 questionnaire
    117 related outcomes
    118 release
    119 rheumatology practice
    120 routine follow
    121 scientific studies
    122 self-reported data
    123 single osteoporosis agent
    124 sites
    125 state
    126 study
    127 study design
    128 therapy
    129 unique foundation
    130 use
    131 uses
    132 validation
    133 visits
    134 vitamin D
    135 women
    136 women's compliance
    137 years
    138 young women
    139 schema:name Design of the POSSIBLE US™ Study: postmenopausal women’s compliance and persistence with osteoporosis medications
    140 schema:pagination 463
    141 schema:productId N49f8dab66d264266b7436fcce3ca691c
    142 N76416d0f3e474f3babe14742f290246a
    143 Nff24b64799064bd98177e29a6b9a8d05
    144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041206509
    145 https://doi.org/10.1007/s00198-008-0674-3
    146 schema:sdDatePublished 2021-12-01T19:20
    147 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    148 schema:sdPublisher Nce61db81586d4b46b5e1bec76b7a506a
    149 schema:url https://doi.org/10.1007/s00198-008-0674-3
    150 sgo:license sg:explorer/license/
    151 sgo:sdDataset articles
    152 rdf:type schema:ScholarlyArticle
    153 N21853967b2f448b3a056e6d66eb536e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Research Design
    155 rdf:type schema:DefinedTerm
    156 N29f414f2d0e84d518abceb24dc0555ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Vitamin D
    158 rdf:type schema:DefinedTerm
    159 N33e05ca54b1344698c8d8c9ce336ac4b rdf:first sg:person.01140101245.54
    160 rdf:rest N5caa0ba990464c4d8da11a09177544fa
    161 N49f8dab66d264266b7436fcce3ca691c schema:name pubmed_id
    162 schema:value 18607669
    163 rdf:type schema:PropertyValue
    164 N4de41913b10a4468891da0f7281ff8d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Humans
    166 rdf:type schema:DefinedTerm
    167 N50f0070a11d4428c8f16a65cb7104288 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Aged
    169 rdf:type schema:DefinedTerm
    170 N570e9af2d51e4f5b8a44a81afef9cf58 rdf:first sg:person.01346631166.35
    171 rdf:rest Nb17bb17ceddf4c4ebb10db3f94a20c7f
    172 N5caa0ba990464c4d8da11a09177544fa rdf:first sg:person.0617012057.00
    173 rdf:rest rdf:nil
    174 N6521657f4ae54de6b88a996f8437c966 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name United States
    176 rdf:type schema:DefinedTerm
    177 N752d7ed27f1b40469fa4f9cc2023325e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Middle Aged
    179 rdf:type schema:DefinedTerm
    180 N76416d0f3e474f3babe14742f290246a schema:name dimensions_id
    181 schema:value pub.1041206509
    182 rdf:type schema:PropertyValue
    183 N77fb1ad514764733831848936683336a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Primary Health Care
    185 rdf:type schema:DefinedTerm
    186 N8a47d23ba03d4296bfd36beba73850c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Osteoporosis, Postmenopausal
    188 rdf:type schema:DefinedTerm
    189 Na302977b2d8549d2b8027343055c26c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Self Administration
    191 rdf:type schema:DefinedTerm
    192 Na758f5537621410487d77b405916a3d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Medication Adherence
    194 rdf:type schema:DefinedTerm
    195 Naade29d7146d4932ae24522e406e5209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Physician-Patient Relations
    197 rdf:type schema:DefinedTerm
    198 Nab91c337d0f64d64b5c3fc75a814b909 rdf:first sg:person.01165514160.38
    199 rdf:rest N33e05ca54b1344698c8d8c9ce336ac4b
    200 Nb17bb17ceddf4c4ebb10db3f94a20c7f rdf:first sg:person.012311562057.08
    201 rdf:rest Nfe9cccc958b94c4aa32cd4f48d8b3b3b
    202 Nb541092af4d94e6d868a91b6b570f09f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Estrogen Replacement Therapy
    204 rdf:type schema:DefinedTerm
    205 Nbaa86febecd147f6a7e21b6a0d02a9af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Calcium, Dietary
    207 rdf:type schema:DefinedTerm
    208 Nc3a4e96822e64b5e93b32e081f0c0e08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Prospective Studies
    210 rdf:type schema:DefinedTerm
    211 Nccc0dcfb147340d4a92a3e2367a70b1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Bone Density Conservation Agents
    213 rdf:type schema:DefinedTerm
    214 Nce61db81586d4b46b5e1bec76b7a506a schema:name Springer Nature - SN SciGraph project
    215 rdf:type schema:Organization
    216 Nd28596882a184b3288035c4aae053b90 schema:volumeNumber 20
    217 rdf:type schema:PublicationVolume
    218 Ne3d50e6092d54549abff396052489f8b rdf:first Nf24d0a06ee1f4d448bedff23f205c21d
    219 rdf:rest Nab91c337d0f64d64b5c3fc75a814b909
    220 Nf24d0a06ee1f4d448bedff23f205c21d schema:affiliation grid-institutes:grid.417886.4
    221 schema:familyName Varon
    222 schema:givenName S. F.
    223 rdf:type schema:Person
    224 Nfcd6b69ba60144109baebb1439bbbbd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Female
    226 rdf:type schema:DefinedTerm
    227 Nfd2b4b8b74ed405196bdd2c88e265fcf schema:issueNumber 3
    228 rdf:type schema:PublicationIssue
    229 Nfe9cccc958b94c4aa32cd4f48d8b3b3b rdf:first sg:person.012234200657.45
    230 rdf:rest Ne3d50e6092d54549abff396052489f8b
    231 Nff24b64799064bd98177e29a6b9a8d05 schema:name doi
    232 schema:value 10.1007/s00198-008-0674-3
    233 rdf:type schema:PropertyValue
    234 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    235 schema:name Medical and Health Sciences
    236 rdf:type schema:DefinedTerm
    237 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    238 schema:name Clinical Sciences
    239 rdf:type schema:DefinedTerm
    240 sg:journal.1100834 schema:issn 0937-941X
    241 1433-2965
    242 schema:name Osteoporosis International
    243 schema:publisher Springer Nature
    244 rdf:type schema:Periodical
    245 sg:person.01140101245.54 schema:affiliation grid-institutes:grid.417886.4
    246 schema:familyName Daizadeh
    247 schema:givenName N.
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140101245.54
    249 rdf:type schema:Person
    250 sg:person.01165514160.38 schema:affiliation grid-institutes:grid.417886.4
    251 schema:familyName Anthony
    252 schema:givenName M.
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165514160.38
    254 rdf:type schema:Person
    255 sg:person.012234200657.45 schema:affiliation grid-institutes:grid.254880.3
    256 schema:familyName Tosteson
    257 schema:givenName A. N. A.
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012234200657.45
    259 rdf:type schema:Person
    260 sg:person.012311562057.08 schema:affiliation grid-institutes:grid.17635.36
    261 schema:familyName Ensrud
    262 schema:givenName K.
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012311562057.08
    264 rdf:type schema:Person
    265 sg:person.01346631166.35 schema:affiliation grid-institutes:grid.266100.3
    266 schema:familyName Barrett-Connor
    267 schema:givenName E.
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346631166.35
    269 rdf:type schema:Person
    270 sg:person.0617012057.00 schema:affiliation grid-institutes:None
    271 schema:familyName Wade
    272 schema:givenName S.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617012057.00
    274 rdf:type schema:Person
    275 sg:pub.10.1007/s00198-002-1370-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021711183
    276 https://doi.org/10.1007/s00198-002-1370-3
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s00198-003-1502-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013179474
    279 https://doi.org/10.1007/s00198-003-1502-4
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s00198-004-1652-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023624379
    282 https://doi.org/10.1007/s00198-004-1652-z
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1007/s00198-005-0010-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022496022
    285 https://doi.org/10.1007/s00198-005-0010-0
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s00198-006-0073-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020337646
    288 https://doi.org/10.1007/s00198-006-0073-6
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1007/s00198-006-0085-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019542455
    291 https://doi.org/10.1007/s00198-006-0085-2
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s00198-006-0136-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031571579
    294 https://doi.org/10.1007/s00198-006-0136-8
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s00198-006-0179-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038026469
    297 https://doi.org/10.1007/s00198-006-0179-x
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1007/s00198-006-0274-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007298732
    300 https://doi.org/10.1007/s00198-006-0274-z
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1007/s00198-006-0322-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012288373
    303 https://doi.org/10.1007/s00198-006-0322-8
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s00198-007-0408-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1008726830
    306 https://doi.org/10.1007/s00198-007-0408-y
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1023/a:1008934208764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038535451
    309 https://doi.org/10.1023/a:1008934208764
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1186/1477-7525-2-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039428500
    312 https://doi.org/10.1186/1477-7525-2-12
    313 rdf:type schema:CreativeWork
    314 grid-institutes:None schema:alternateName Wade Outcomes Research and Consulting, Salt Lake City, UT, USA
    315 schema:name Wade Outcomes Research and Consulting, Salt Lake City, UT, USA
    316 rdf:type schema:Organization
    317 grid-institutes:grid.17635.36 schema:alternateName University of Minnesota, Minneapolis, MN, USA
    318 schema:name University of Minnesota, Minneapolis, MN, USA
    319 rdf:type schema:Organization
    320 grid-institutes:grid.254880.3 schema:alternateName Dartmouth Medical School, Hanover, NH, USA
    321 schema:name Dartmouth Medical School, Hanover, NH, USA
    322 rdf:type schema:Organization
    323 grid-institutes:grid.266100.3 schema:alternateName Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, 92093-0607, La Jolla, CA, USA
    324 schema:name Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, 92093-0607, La Jolla, CA, USA
    325 rdf:type schema:Organization
    326 grid-institutes:grid.417886.4 schema:alternateName Amgen, Inc., Thousand Oaks, CA, USA
    327 schema:name Amgen, Inc., Thousand Oaks, CA, USA
    328 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...