Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-11-14

AUTHORS

B. M. Obermayer-Pietsch, M. Gugatschka, S. Reitter, W. Plank, A. Strele, D. Walter, C. Bonelli, W. Goessler, H. Dobnig, C. Högenauer, W. Renner, A. Fahrleitner-Pammer

ABSTRACT

Adult-type hypolactasia, as mediated by a widespread genetic predisposition, not only reduces calcium intake but also calcium absorption in the presence of high amounts of lactose and may, therefore, promote osteoporosis. A lactose-reduced diet and lactose-free calcium supplements may reverse this imbalance.Introduction and hypothesisAdult-type hypolactasia (HL) defined by the LCT(−13910) polymorphism may reduce calcium intake by reducing dairy consumption and, therefore, promote osteoporosis. This study aimed to evaluate whether lactose also decreases intestinal calcium absorption in subjects with HL and whether lactose-reduced diet and lactose-free calcium supplementation as recommended could maintain bone mineral density (BMD).MethodsBased on LCT genotyping, 73 postmenopausal women with and without HL underwent a conventional H2 breath test with a concomitant oral strontium absorption test lasting 150 minutes, which closely reflects intestinal calcium absorption. In addition, we compared bone-specific laboratory parameters, lumbar and femoral BMD, and spinal radiographs to a similar bone assessment 5 years earlier.ResultsLCT genotyping and functional lactose malabsorption tests were highly correlated. Dairy product consumption was reduced by 80% in HL individuals. During concomitant lactose application, mean strontium absorption was blunted by 54% in HL subjects after 150 minutes (1272 ± 629 μg/L vs. 2020 ± 1130 μg/L in lactose tolerant subjects, p = 0.001). Nevertheless, BMD in HL subjects remained stable with lactose-free calcium supplements during the observation period.ConclusionBoth decreased calcium intake as well as lactose-associated impaired calcium absorption may predispose subjects with HL to osteoporosis. Lactose-free calcium supplementation may help to maintain BMD in HL subjects. More... »

PAGES

445-451

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00198-006-0251-6

DOI

http://dx.doi.org/10.1007/s00198-006-0251-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020509427

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17103297


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29 schema:description Adult-type hypolactasia, as mediated by a widespread genetic predisposition, not only reduces calcium intake but also calcium absorption in the presence of high amounts of lactose and may, therefore, promote osteoporosis. A lactose-reduced diet and lactose-free calcium supplements may reverse this imbalance.Introduction and hypothesisAdult-type hypolactasia (HL) defined by the LCT(−13910) polymorphism may reduce calcium intake by reducing dairy consumption and, therefore, promote osteoporosis. This study aimed to evaluate whether lactose also decreases intestinal calcium absorption in subjects with HL and whether lactose-reduced diet and lactose-free calcium supplementation as recommended could maintain bone mineral density (BMD).MethodsBased on LCT genotyping, 73 postmenopausal women with and without HL underwent a conventional H2 breath test with a concomitant oral strontium absorption test lasting 150 minutes, which closely reflects intestinal calcium absorption. In addition, we compared bone-specific laboratory parameters, lumbar and femoral BMD, and spinal radiographs to a similar bone assessment 5 years earlier.ResultsLCT genotyping and functional lactose malabsorption tests were highly correlated. Dairy product consumption was reduced by 80% in HL individuals. During concomitant lactose application, mean strontium absorption was blunted by 54% in HL subjects after 150 minutes (1272 ± 629 μg/L vs. 2020 ± 1130 μg/L in lactose tolerant subjects, p = 0.001). Nevertheless, BMD in HL subjects remained stable with lactose-free calcium supplements during the observation period.ConclusionBoth decreased calcium intake as well as lactose-associated impaired calcium absorption may predispose subjects with HL to osteoporosis. Lactose-free calcium supplementation may help to maintain BMD in HL subjects.
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36 H2 breath test
37 HL individuals
38 HL subjects
39 MethodsBased
40 absorption
41 absorption test
42 addition
43 adult-type hypolactasia
44 amount
45 applications
46 assessment 5
47 availability
48 bone mineral density
49 breath test
50 calcium absorption
51 calcium availability
52 calcium intake
53 calcium supplementation
54 calcium supplements
55 consumption
56 dairy consumption
57 dairy product consumption
58 density
59 diet
60 femoral bone mineral density
61 genetic predisposition
62 genotyping
63 high amounts
64 hypolactasia
65 imbalance
66 impaired calcium absorption
67 individuals
68 intake
69 intestinal calcium absorption
70 introduction
71 laboratory parameters
72 lactose
73 malabsorption tests
74 mineral density
75 minutes
76 observation period
77 osteoporosis
78 parameters
79 period
80 polymorphism
81 postmenopausal women
82 predisposition
83 presence
84 product consumption
85 radiographs
86 spinal radiographs
87 strontium absorption
88 strontium absorption test
89 study
90 subjects
91 supplementation
92 supplements
93 test
94 women
95 years
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