Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-08-09

AUTHORS

A. L. Boskey, E. DiCarlo, E. Paschalis, Paul West, Richard Mendelsohn

ABSTRACT

Fourier-transform infrared microspectroscopy (FTIRM) allows analysis of mineral content, mineral crystal maturity and mineral composition at ~10-μ spatial resolution. Previous FTIRM analyses comparing 4-μ thick sections from non-decalcified iliac crest biopsies from women with post-menopausal osteoporosis, as contrasted with iliac crest tissue from individuals without evidence of metabolic bone disease, demonstrated significant differences in average mineral content (decreased in osteoporosis) and mineral crystal size/perfection (increased in osteoporosis). More importantly, these parameters, which vary throughout the tissue in relation to the tissue age in healthy bone, showed no such variation in bone biopsies from patients with osteoporosis. The present study compares the spatial and temporal variation in mineral quantity and properties in trabecular bone in high- and low-turnover osteoporosis. Specifically, six biopsies from women (n=5) and one man with high-turnover osteoporosis (age range 39–77) and four women and two men with low turnover osteoporosis (age range 37–63) were compared to ten “normal” biopsies from three men and seven woman (age range: 27–69). “High turnover” was defined as the presence of increased resorptive surface, higher than normal numbers of osteoclasts and greater than or equal to normal osteoblastic activity. “Low turnover” was defined as lower than normal resorptive surface, decreased osteoclast number and less than normal osteoblastic activity. Comparing variations in FTIR-derived values for each of the parameters measured at the surfaces of the trabecular bone to the maximum value observed in multiple trabeculae from each person, the high-turnover samples showed little change in the mineral: matrix ratio, carbonate: amide I ratio, crystallinity and acid phosphate content. The low-turnover samples also showed little change in these parameters, but in contrast to the high-turnover samples, the low-turnover samples showed a slight increase in these parameters, indicative of retarded, but existent resorption and formation. These data indicate that FTIR microspectroscopy can provide quantitative information on mineral changes in osteoporosis that are consistent with proposed mechanisms of bone loss. More... »

PAGES

2031-2038

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00198-005-1992-3

DOI

http://dx.doi.org/10.1007/s00198-005-1992-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001670755

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16088360


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113 osteoporosis
114 parameters
115 patients
116 perfection
117 persons
118 phosphate content
119 post-menopausal osteoporosis
120 presence
121 present study
122 properties
123 quality
124 quantitative information
125 quantity
126 ratio
127 relation
128 resolution
129 resorption
130 resorptive surface
131 samples
132 sections
133 significant differences
134 size/perfection
135 slight increase
136 spatial resolution
137 study
138 such variation
139 surface
140 temporal variation
141 thick sections
142 tissue
143 tissue age
144 trabeculae
145 trabecular bone
146 turnover
147 turnover osteoporosis
148 values
149 variation
150 women
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