The relation of the Xbal and Pvull polymorphisms of the estrogen receptor gene and the CAG repeat polymorphism of the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-04-13

AUTHORS

Ville-Valtteri Välimäki, Kirsi Piippo, Stiina Välimäki, Eliisa Löyttyniemi, Kimmo Kontula, Matti J. Välimäki

ABSTRACT

The genes coding for estrogen receptor-α (ER-α) and androgen receptors (AR) are potential candidates for the regulation of bone mass and turnover, which may contribute to both the achievement of peak bone mass and bone loss after completion of growth. The present study was aimed at elucidating the role of two restriction fragment lengths (XbaI and PvuII) polymorphisms of the ER gene and the CAG repeat polymorphism of the AR gene as determinants of peak bone mass in men; special attention was paid to the interaction between serum free estradiol (E2) levels and the XbaI and PvuII genotypes. A cross-sectional study, with data on lifestyle factors collected retrospectively, was performed in 234 young men, aged 18.3 to 20.6 years. Of the men, 184 were recruits of the Finnish Army and 50 were men of similar age who had postponed their military service for reasons not related to health. Bone mineral content (BMC), density (BMD) and scan area were measured in the lumbar spine and upper femur by dual-energy X-ray absorptiometry (DXA). The bone turnover rate was assessed by measuring serum type I procollagen aminoterminal propeptide (PINP) and tartrate-resistant acid phosphatase 5b (TRACP5b) as well as urinary excretion of type I collagen aminoterminal telopeptide (NTX). After adjusting for age, height, weight, exercise, smoking, calcium and alcohol intake, BMC, scan area and BMD at all measurement sites were similar for the different XbaI and PvuII genotypes of the ER and independent of the number of the CAG repeats of the AR gene. No association was found between free E2 levels and bone parameters among any genotype group of the XbaI and PvuII polymorphisms. Except for urinary NTX, which showed a tendency to higher values for the xx ( P =0.08) and pp ( P =0.10) genotypes of the ER, bone turnover markers were not related to the genotypes studied. Our study does not support the view that the XbaI and PvuII polymorphisms of the ER gene and the CAG polymorphism of the AR gene would have a substantial impact on the development of peak bone mass in young Finnish men. More... »

PAGES

1633-1640

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00198-005-1889-1

DOI

http://dx.doi.org/10.1007/s00198-005-1889-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039636456

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15827868


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102 growth
103 health
104 healthy men
105 height
106 higher values
107 impact
108 intake
109 interaction
110 length polymorphism
111 levels
112 lifestyle factors
113 loss
114 lumbar spine
115 markers
116 mass
117 measurement sites
118 men
119 military service
120 mineral content
121 number
122 parameters
123 peak bone mass
124 phosphatase 5b
125 polymorphism
126 potential candidate
127 present study
128 propeptide
129 rate
130 ray absorptiometry
131 reasons
132 receptor gene
133 receptors
134 recruits
135 regulation
136 relation
137 repeat polymorphism
138 repeats
139 resistant acid phosphatase 5b
140 restriction fragment length polymorphism
141 role
142 scan area
143 serum free estradiol (E2) levels
144 serum type I
145 services
146 similar age
147 sites
148 smoking
149 special attention
150 spine
151 study
152 substantial impact
153 telopeptide
154 tendency
155 turnover
156 turnover markers
157 turnover rate
158 type I
159 upper femur
160 urinary NTx
161 urinary excretion
162 values
163 view
164 weight
165 years
166 young Finnish men
167 young healthy men
168 young men
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