Ontology type: schema:ScholarlyArticle
2003-12
AUTHORSI. Fogelman, G. M. Blake, R. Blamey, M. Palmer, W. Sauerbrei, M. Schumacher, D. Serin, A. Stewart, W. Wilpshaar
ABSTRACTThe purpose of this study was to compare changes in bone mineral density (BMD) in premenopausal patients with node-positive early breast cancer treated with goserelin (Zoladex) or cyclophosphamide, methotrexate and 5-fluorouracil (CMF). Patients ( n=1640) were randomized to goserelin (3.6 mg every 28 days for 2 years) or CMF (sixx28-day cycles) treatment. In a protocoled sub-study involving 96 patients from eight centers (goserelin: n=53; CMF: n=43), lumbar spine (L2-L4) and femoral neck BMD were assessed by dual X-ray absorptiometry at baseline and then annually for 3 years. At the end of the 2-year goserelin-treatment period, mean BMD losses for goserelin-treated and CMF-treated patients were -10.5% and -6.5% ( P=0.0005) for lumbar spine and -6.4% and -4.5% ( P=0.04) for femoral neck, respectively. At 3 years, partial recovery of BMD was observed in goserelin recipients. In contrast, mean BMD losses for the CMF group indicated persistent BMD loss. No significant differences in BMD were observed between groups at the 3-year assessment of the spine or femoral neck. In the CMF group, based on amenorrhea status at 48 weeks, BMD losses at the lumbar spine were greater for amenorrheic than non-amenorrheic patients. Ovarian suppression resulting in amenorrhea was closely related to BMD loss in both treatment groups. Overall, patients who received CMF did not show recovery of BMD throughout follow-up, whereas partial recovery was observed 1 year after cessation of goserelin therapy, associated with the return of ovarian function in the majority of patients. More... »
PAGES1001-1006
http://scigraph.springernature.com/pub.10.1007/s00198-003-1508-y
DOIhttp://dx.doi.org/10.1007/s00198-003-1508-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1044150768
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/14530912
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amenorrhea",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents, Hormonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Combined Chemotherapy Protocols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Density",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclophosphamide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Administration Schedule",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Femur Neck",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorouracil",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Goserelin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lumbar Vertebrae",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methotrexate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Premenopause",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Department of Nuclear Medicine, Guy\u2019s, Kings and St Thomas\u2019 Hospital Medical School, SE1 9RT, London, UK"
],
"type": "Organization"
},
"familyName": "Fogelman",
"givenName": "I.",
"id": "sg:person.0655217537.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655217537.21"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Nuclear Medicine, Guy\u2019s, Kings and St Thomas\u2019 Hospital Medical School, SE1 9RT, London, UK"
],
"type": "Organization"
},
"familyName": "Blake",
"givenName": "G. M.",
"id": "sg:person.01102033437.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102033437.11"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Nottingham Hospital, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Blamey",
"givenName": "R.",
"id": "sg:person.015650304144.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "AstraZeneca (United Kingdom)",
"id": "https://www.grid.ac/institutes/grid.417815.e",
"name": [
"AstraZeneca, Macclesfield, UK"
],
"type": "Organization"
},
"familyName": "Palmer",
"givenName": "M.",
"id": "sg:person.0705212163.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705212163.54"
],
"type": "Person"
},
{
"familyName": "Sauerbrei",
"givenName": "W.",
"id": "sg:person.01026070224.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026070224.70"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Institute fur Medizinische Biometrie und Informatik, University Hospital, Freiburg, Germany"
],
"type": "Organization"
},
"familyName": "Schumacher",
"givenName": "M.",
"id": "sg:person.0646232763.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646232763.44"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Clinic Sainte Catherine, Avignon, France"
],
"type": "Organization"
},
"familyName": "Serin",
"givenName": "D.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Christie Hospital",
"id": "https://www.grid.ac/institutes/grid.415720.5",
"name": [
"Christie Hospital, Manchester, UK"
],
"type": "Organization"
},
"familyName": "Stewart",
"givenName": "A.",
"id": "sg:person.0647367524.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647367524.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "AstraZeneca (United Kingdom)",
"id": "https://www.grid.ac/institutes/grid.417815.e",
"name": [
"AstraZeneca, Macclesfield, UK"
],
"type": "Organization"
},
"familyName": "Wilpshaar",
"givenName": "W.",
"id": "sg:person.01021440563.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021440563.37"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1023/a:1005792830054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003671030",
"https://doi.org/10.1023/a:1005792830054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1067/mgn.2001.113534",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005950645"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(01)80148-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006522013"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0015-0282(16)58200-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007157689"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(97)10135-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012452075"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001980070062",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012689352",
"https://doi.org/10.1007/s001980070062"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1990.58",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015146238",
"https://doi.org/10.1038/bjc.1990.58"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1990.58",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015146238",
"https://doi.org/10.1038/bjc.1990.58"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650091002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017261313"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650091002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017261313"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/90.9.704",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018904729"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/07357909809039747",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019046058"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(97)10036-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019758885"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02555894",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020486492",
"https://doi.org/10.1007/bf02555894"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02555894",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020486492",
"https://doi.org/10.1007/bf02555894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1359/jbmr.1997.12.1.16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021846486"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm197602192940801",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022455515"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0140-6736(93)92555-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027878716"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0140-6736(93)92555-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027878716"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/00016349609033310",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032765154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0015-0282(16)54948-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037961107"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650101022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053074833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650101022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053074833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2002.05.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064202982"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2002.09.112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064203132"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2000.18.14.2718",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074667563"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082997667",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1997.15.4.1341",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083105853"
],
"type": "CreativeWork"
}
],
"datePublished": "2003-12",
"datePublishedReg": "2003-12-01",
"description": "The purpose of this study was to compare changes in bone mineral density (BMD) in premenopausal patients with node-positive early breast cancer treated with goserelin (Zoladex) or cyclophosphamide, methotrexate and 5-fluorouracil (CMF). Patients ( n=1640) were randomized to goserelin (3.6 mg every 28 days for 2 years) or CMF (sixx28-day cycles) treatment. In a protocoled sub-study involving 96 patients from eight centers (goserelin: n=53; CMF: n=43), lumbar spine (L2-L4) and femoral neck BMD were assessed by dual X-ray absorptiometry at baseline and then annually for 3 years. At the end of the 2-year goserelin-treatment period, mean BMD losses for goserelin-treated and CMF-treated patients were -10.5% and -6.5% ( P=0.0005) for lumbar spine and -6.4% and -4.5% ( P=0.04) for femoral neck, respectively. At 3 years, partial recovery of BMD was observed in goserelin recipients. In contrast, mean BMD losses for the CMF group indicated persistent BMD loss. No significant differences in BMD were observed between groups at the 3-year assessment of the spine or femoral neck. In the CMF group, based on amenorrhea status at 48 weeks, BMD losses at the lumbar spine were greater for amenorrheic than non-amenorrheic patients. Ovarian suppression resulting in amenorrhea was closely related to BMD loss in both treatment groups. Overall, patients who received CMF did not show recovery of BMD throughout follow-up, whereas partial recovery was observed 1 year after cessation of goserelin therapy, associated with the return of ovarian function in the majority of patients.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00198-003-1508-y",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1100834",
"issn": [
"0937-941X",
"1433-2965"
],
"name": "Osteoporosis International",
"type": "Periodical"
},
{
"issueNumber": "12",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "14"
}
],
"name": "Bone mineral density in premenopausal women treated for node-positive early breast cancer with 2 years of goserelin or 6 months of cyclophosphamide, methotrexate and 5-fluorouracil (CMF)",
"pagination": "1001-1006",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"d24e03ee1a1b3acf8c4c49d9c883c9a523b10d2e69a61c23255507aee2ebe21e"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"14530912"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9100105"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00198-003-1508-y"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1044150768"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00198-003-1508-y",
"https://app.dimensions.ai/details/publication/pub.1044150768"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T14:04",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000490.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s00198-003-1508-y"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00198-003-1508-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00198-003-1508-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00198-003-1508-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00198-003-1508-y'
This table displays all metadata directly associated to this object as RDF triples.
272 TRIPLES
21 PREDICATES
68 URIs
37 LITERALS
25 BLANK NODES