Transcriptome and metabolome analyses reveal the interweaving of immune response and metabolic regulation in pelvic organ prolapse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-09-22

AUTHORS

Xia Yu, Ying Chen, Li He, Hong Liu, Zhenglin Yang, Yonghong Lin

ABSTRACT

Introduction and hypothesisThe pathogenesis of pelvic organ prolapse (POP) remains unknown. Herein, we aim to reveal the molecular profile of POP by transcriptomic and metabolomic analysis.MethodsWe selected 12 samples of uterosacral ligaments (USLs) from 6 POP patients and 6 controls for transcriptomic and metabolomic analyses. Differentially expressed genes (DEGs) were identified using the R package edgeR. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using clusterProfiler, and a protein–protein interaction (PPI) network was constructed using STRING and visualized in Cytoscape. Metabolomic profiling was performed by a liquid chromatography–tandem mass spectrometry system.ResultsTranscriptomic analysis identified 487 DEGs between the POP and control groups. Functional enrichment analysis revealed that they were mostly related to immune response terms, including “adaptive immune response,” “T cell differentiation,” and “T cell activation.” In addition, PTPRC, LCK, CD247, IL2RB, CD2, CXR5, JUN, CD3E, IL2RG, and PRF1 were the 10 nodes with the highest node degrees in the PPI network. Metabolomic profiling revealed 290 differentially expressed metabolites, which significantly enriched in “glycerophospholipid metabolism,” “nicotinate and nicotinamide metabolism,” “glycine, serine, and threonine metabolism,” “arginine and proline metabolism,” “pyrimidine metabolism,” and “purine metabolism.” Finally, integrated analysis revealed that the DEGs involved in these significantly enriched metabolic pathways included NT5C1A, GMPR, SDS, ALAS2, CARNS1, PYCR1, P4HA3, PGS1, and NMRK2.ConclusionsOur findings demonstrate that the immune response and metabolic regulatory pathways are intertwined in POP and might provide new therapeutic targets. More... »

PAGES

1-9

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URI

http://scigraph.springernature.com/pub.10.1007/s00192-022-05357-5

DOI

http://dx.doi.org/10.1007/s00192-022-05357-5

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https://app.dimensions.ai/details/publication/pub.1151222925

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/36136109


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