Tissue response to a new type of biomaterial implanted subcutaneously in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09-14

AUTHORS

Marie Boennelycke, Lise Christensen, Lene Feldskov Nielsen, Hanne Everland, Gunnar Lose

ABSTRACT

Introduction and hypothesisA new type of resorbable biomaterial intended for pelvic reconstruction was tested with respect to tissue regeneration and biocompatibility in rats. The biomaterial consisted of methoxypolyethyleneglycol-poly(lactic-co-glycolic acid) (MPEG-PLGA). Implants were pure, enriched with extra-cellular matrix (ECM) or estrogen.MethodsTen implants of each type were tested for 3 and 8 weeks, respectively. Histological assessment of connective tissue organization, inflammation, vascularization, and thickness of regenerated tissue was undertaken.ResultsAll implants had a high degree of biocompatibility. ECM-enriched implants had significantly higher inflammatory scores compared to pure implants at 3 weeks. At 8 weeks, neither of the parameters differed significantly. No trace of the implants remained.ConclusionsThe MPEG-PLGA is highly biocompatible, degrades quickly, and seems inert in the process of tissue regeneration. Thus, it is hardly a candidate per se in reinforcement of pelvic reconstruction, but it could have a future role as carrier for stem cells. More... »

PAGES

191-196

References to SciGraph publications

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  • 2008-04-17. Cartilage repair with chondrocytes in fibrin hydrogel and MPEG polylactide scaffold: an in vivo study in goats in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2008-01-05. Biomechanical properties of vaginal tissue: preliminary results in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • 2006-04. The biology behind fascial defects and the use of implants in pelvic organ prolapse repair in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • 2009-03-28. Tensile properties of commonly used prolapse meshes in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • 2009-08-28. Do the anatomical defects associated with cystocoele affect the outcome of anterior repair? A clinical and radiological study in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • 2008-03-20. Impact of the structure of polypropylene meshes in local tissue reaction: in vivo stereological study in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • 2006-10-10. Tensile strength and host response towards different polypropylene implant materials used for augmentation of fascial repair in a rat model in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • 2009-08-29. Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • 2001-06. Influence of Different Sling Materials on Connective Tissue Metabolism in Stress Urinary Incontinent Women in INTERNATIONAL UROGYNECOLOGY JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00192-010-1257-3

    DOI

    http://dx.doi.org/10.1007/s00192-010-1257-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052791227

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20838988


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