Correlation between shrinkage and infection of implanted synthetic meshes using an animal model of mesh infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09-07

AUTHORS

Laurent Mamy, Vincent Letouzey, Jean-Philippe Lavigne, Xavier Garric, Jean Gondry, Pierre Mares, Renaud de Tayrac

ABSTRACT

Introduction and hypothesisThe aim of this study was to evaluate a link between mesh infection and shrinkage.MethodsTwenty-eight Wistar rats were implanted with synthetic meshes that were either non-absorbable (polypropylene (PP), n = 14) or absorbable (poly (d,l-lactic acid) (PLA94), n = 14). A validated animal incisionnal abdominal hernia model of mesh infection was used. Fourteen meshes (n = 7 PLA94 and n = 7 PP meshes) were infected intraoperatively with 10e6 CFU Escherichia coli, and compared with 14 non-infected meshes (n = 7 PLA94 and n = 7 PP meshes) (control groups). Explantations were performed on day 30. Shrinkage was evaluated by a reproducible numerical analysis of mesh area. Infection and histological study were evaluated on day 30.ResultsNon-infected meshes were less shrunk than infected meshes for both non-absorbable (5.0 ± 1.7% versus 21.6 ± 6.1%, p < 0.05) and absorbable meshes (2.4 ± 0.9% versus 11.0 ± 2.5%, p < 0.05).ConclusionThis study highlights a link between infection and shrinkage in the model used. More... »

PAGES

47-52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00192-010-1245-7

DOI

http://dx.doi.org/10.1007/s00192-010-1245-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032705510

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20821311


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