Statistical analysis of the intermediate filament network in cells of mesenchymal lineage by greyvalue-oriented image segmentation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

Sebastian Lück, Alois Fichtl, Michaela Sailer, Helga Joos, Rolf E. Brenner, Paul Walther, Volker Schmidt

ABSTRACT

Intermediate filament networks are part of the cytoskeleton and protect cellular integrity during large deformations. In cells from mesenchymal lineage the cytoskeleton is centrally involved in signal transduction, thereby influencing differentiation. We study the ultrastructure of IF networks in three human mesenchymal cell types, namely undifferentiated mesenchymal stem cells, chondrocytes, and osteoblasts. In order to capture the high morphological variability of IF networks we apply techniques from image analysis to extract the network graph from 2D scanning electron microscopy (SEM) images in a fully automatic way, which allows for a high-throughput analysis of SEM data. The extracted network graphs are analyzed by techniques from spatial statistics to detect differences in network morphology between different cell types and infer strategies of network remodeling used by the cells to adapt their mechanical properties during migration and differentiation. More... »

PAGES

139-160

Journal

TITLE

Computational Statistics

ISSUE

1

VOLUME

28

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00180-011-0265-1

DOI

http://dx.doi.org/10.1007/s00180-011-0265-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013669178


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00180-011-0265-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00180-011-0265-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00180-011-0265-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00180-011-0265-1'


 

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