Ontology type: schema:ScholarlyArticle
2000-04
AUTHORSF. B. S. Oei, M. J. P. Welters, L. M. B. Vaessen, R. L. Marquet, P. E. Zondervan, W. Weimar, A. J. JC. Bogers
ABSTRACTStructural failure of heart valve allografts may be related to technical factors or immunological reactions. To circumvent nonimmunological factors a new rat implantation model was developed to study whether alloreactivity results in histopathological changes and valve dysfunction. Syngeneic (WAG-WAG, DA-DA) and allogeneic (WAG-BN, WAG-DA) transplantation was carried out using this new technique, and the function of explanted valves was assessed 21 days later by retrograde comptence testing. Additionally, grafts were examined using standard histological and immunohistochemical techniques. There was no leakage during retrograde injection in nine of tem syngeneic and two of ten allogeneic grafts. Microscopically, syngeneic valves appeared normal without fibrosis or intimal thickening, although CD8+ lymphocytes and macrophages were found in necrotic myocardial rim and adventitia. In contrast, allogeneic valves were deformed and noncellular, with extensive infiltration of CD4+, CD8+ and CD68+ cells in adventitia and media. Absence of fibrosis and intimal thickening in syngeneic transplanted valves indicated circumvention of nonimmunological factors. Allogeneic valve transplantation induces cellular infiltration in the graft with subsequent graft failure. More... »
PAGESs528-s531
http://scigraph.springernature.com/pub.10.1007/s001470050395
DOIhttp://dx.doi.org/10.1007/s001470050395
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1004458060
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Departments of Thoracic Surgery, Room Bd. 158, University Hospital Rotterdam-Dijkzigt, P. O. Box 2040, 3000 CA Rotterdam, The Netherlands e-mail: oei@inw1.azr.nl, Tel.: + 31\u201310\u20134635420, Fax: + 31\u201310\u20134 635430, NL"
],
"type": "Organization"
},
"familyName": "Oei",
"givenName": "F. B. S.",
"id": "sg:person.011624555554.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011624555554.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, 3000 CA Rotterdam, The Netherlands, NL"
],
"type": "Organization"
},
"familyName": "Welters",
"givenName": "M. J. P.",
"id": "sg:person.014371630744.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014371630744.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, 3000 CA Rotterdam, The Netherlands, NL"
],
"type": "Organization"
},
"familyName": "Vaessen",
"givenName": "L. M. B.",
"id": "sg:person.011314326734.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314326734.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Experimental Surgery, University Hospital Rotterdam-Dijkzigt, 3000 CA Rotterdam, The Netherlands, NL"
],
"type": "Organization"
},
"familyName": "Marquet",
"givenName": "R. L.",
"id": "sg:person.01001745714.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001745714.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Pathology, University Hospital Rotterdam-Dijkzigt, 3000 CA Rotterdam, The Netherlands, NL"
],
"type": "Organization"
},
"familyName": "Zondervan",
"givenName": "P. E.",
"id": "sg:person.0750121371.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750121371.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, 3000 CA Rotterdam, The Netherlands, NL"
],
"type": "Organization"
},
"familyName": "Weimar",
"givenName": "W.",
"id": "sg:person.01132463171.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132463171.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Departments of Thoracic Surgery, Room Bd. 158, University Hospital Rotterdam-Dijkzigt, P. O. Box 2040, 3000 CA Rotterdam, The Netherlands e-mail: oei@inw1.azr.nl, Tel.: + 31\u201310\u20134635420, Fax: + 31\u201310\u20134 635430, NL"
],
"type": "Organization"
},
"familyName": "Bogers",
"givenName": "A. J. JC.",
"id": "sg:person.010005012057.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010005012057.39"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1111/jocs.1991.6.4s.534",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002384249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-4975(94)91347-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004329138"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0041-1345(97)00029-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007937125"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-5223(97)70002-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009851344"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(62)90345-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026989625"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(62)90345-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026989625"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-5223(96)70130-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050619799"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bjs.1800521105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051861165"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1540-8191.1988.tb00247.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052727448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-199910150-00018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060281542"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-199910150-00018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060281542"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-199910150-00018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060281542"
],
"type": "CreativeWork"
}
],
"datePublished": "2000-04",
"datePublishedReg": "2000-04-01",
"description": "Structural failure of heart valve allografts may be related to technical factors or immunological reactions. To circumvent nonimmunological factors a new rat implantation model was developed to study whether alloreactivity results in histopathological changes and valve dysfunction. Syngeneic (WAG-WAG, DA-DA) and allogeneic (WAG-BN, WAG-DA) transplantation was carried out using this new technique, and the function of explanted valves was assessed 21 days later by retrograde comptence testing. Additionally, grafts were examined using standard histological and immunohistochemical techniques. There was no leakage during retrograde injection in nine of tem syngeneic and two of ten allogeneic grafts. Microscopically, syngeneic valves appeared normal without fibrosis or intimal thickening, although CD8+ lymphocytes and macrophages were found in necrotic myocardial rim and adventitia. In contrast, allogeneic valves were deformed and noncellular, with extensive infiltration of CD4+, CD8+ and CD68+ cells in adventitia and media. Absence of fibrosis and intimal thickening in syngeneic transplanted valves indicated circumvention of nonimmunological factors. Allogeneic valve transplantation induces cellular infiltration in the graft with subsequent graft failure.",
"genre": "research_article",
"id": "sg:pub.10.1007/s001470050395",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1099393",
"issn": [
"0934-0874",
"1432-2277"
],
"name": "Transplant International",
"type": "Periodical"
},
{
"issueNumber": "Suppl 1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"name": "Heart valve dysfunction resulting from cellular rejection in a novel heterotopic transplantation rat model",
"pagination": "s528-s531",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"153e01bbfb01572e9dec1dcd9dd2a357df0b964e03d94480be2c11c4679d4d38"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s001470050395"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1004458060"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s001470050395",
"https://app.dimensions.ai/details/publication/pub.1004458060"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T16:35",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000485.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s001470050395"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001470050395'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001470050395'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001470050395'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001470050395'
This table displays all metadata directly associated to this object as RDF triples.
133 TRIPLES
21 PREDICATES
36 URIs
19 LITERALS
7 BLANK NODES