Influence of perioperative sHLA I concentrations on the histological development of the liver graft View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

J. Müller, M. Schenk, A. Zipfel, W. Lauchart, R. Viebahn

ABSTRACT

Soluble HLA I (sHLA I) in human serum are ascribed an immunoregulatory role in the context of organ transplantation. Based on histological findings, the objective of the current study was to evaluate the protective influence of sHLA I in liver transplantation from the time point of reperfusion. The sHLA I concentrations in serum samples derived from the liver vein immediately after reperfusion (flush catheter) of 38 patients with liver transplantations were determined by ELISA. The postoperative histological findings of the transplant biopsies were categorized according to rejection, endothelialitis, cholestasis, and necrosis, as well as fatty degeneration. An evaluation according to Kaplan-Meier showed a lower incidence for all of these factors in liver grafts with high sHLA concentrations (P < 0.05). We conclude that low sHLA I concentrations during reperfusion correlate with later complications, thus indicating that sHLA I may have protective potential in liver transplantation. More... »

PAGES

s449-s451

References to SciGraph publications

Journal

TITLE

Transplant International

ISSUE

Suppl 1

VOLUME

13

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001470050380

DOI

http://dx.doi.org/10.1007/s001470050380

DIMENSIONS

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