Mycophenolic acid trough levels after kidney transplantation in a cyclosporine-free protocol View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

P. J. H. Smak Gregoor, T. van Gelder, N. M. van Besouw, B. J. van der Mast, C. J. Hesse, J. N. M. IJzermans, W. Weimar

ABSTRACT

Twenty-seven stable kidney transplant recipients treated with cyclosporine and prednisone were converted to mycophenolate mofetil (MMF) and prednisone 1 year after transplantation. After conversion the patients were treated with a standard daily dose of 1 g MMF b. i. d. and 10 mg prednisone for 4 months. Thereafter, two MMF dose reductions were performed with a 4-month interval. Mycophenolic acid (MPA) trough levels were measured at regular intervals. A relation was found between MPA trough levels and MMF dose. The median MPA trough level for patients treated with 1 g MMF b. i. d. was 4.3 μg/ml (0.95–15.5) and 3.0 μg/ml (0.73–7.8) for patients treated with 750 mg b. i. d. (P = 0.0002). The MPA trough levels further decreased from 3.0 to 2.3 μg/ml (0.6–6.63) in patients treated with 500 mg MMF b. i. d. (P = 0.01). Dose reduction of MMF from 1 g to 750 mg b. i. d. could be performed without acute rejections. A further dose reduction to 500 mg b. i. d. elicited 3 rejections. Patients experiencing an acute rejection had a median MPA trough level of 2.3 μg/ml (1.26–3.38) compared to 3.8 μg/ml (1.48–6.52) in patients without an acute rejection (P = 0.25). We conclude that there is a significant relation between MPA trough levels and MMF dose. MPA trough levels were not predictive of rejection in the present study. More... »

PAGES

s333-s335

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001470050355

DOI

http://dx.doi.org/10.1007/s001470050355

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011686691


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