Ontology type: schema:ScholarlyArticle
2000-04
AUTHORSI. C. van Riemsdijk-van Overbeeke, C. C. Baan, C. J. Knoop, P. J. M. J. Vantrimpont, A. H. M. M. Balk, A. P. W. M. Maat, W. Weimar
ABSTRACTAfter heart transplantation a high incidence of infections and malignancies is found. Not only immunosuppression, but also intrinsic cytokine systems with some unbalance, e. g. TNF-α and IL-2, can result in impaired immune competence and may have a role in these complications. The aim of this study was to assess the activity of the TNF-α and IL-2 systems after heart transplantation. In peripheral blood we measured expression of activation markers of TNF-α (TNF-R2) and IL-2 (IL-2Rα, IL-2Rβ-chain) on monocytes and lymphocytes using quantitative flow-cytometric analysis. TNF-R2 expression was significantly enhanced on monocytes and lymphocytes in patients after heart transplantation, while the expression of IL-2Rα and IL-2Rβ was not elevated. Increased TNF-R2 expression in peripheral blood after heart transplantation reflects an activated TNF-α system, leading to high levels of active sTNF-R, which impairs TNF-α bioavailibility and consequently leads to immune incompetence. More... »
PAGESs212-s215
http://scigraph.springernature.com/pub.10.1007/s001470050327
DOIhttp://dx.doi.org/10.1007/s001470050327
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