Beneficial effect of preoperative mycophenolate mofetil in murine corneal transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-10

AUTHORS

A. Reis, Helga Spelsberg, Thomas Reinhard, Stefan Braunstein, Erhard Godehardt, Rainer Sundmacher

ABSTRACT

To investigate the effect of preoperative mycophenolate mofetil (MMF) on allograft survival in a murine corneal transplantation model. Corneal grafting was performed from Brown Norway to Lewis rats. Groups were divided as follows: Rats that received syngeneic or allogeneic grafts without therapy served as controls. MMF treatment was either started 7 days prior to transplantation and continued for 14 postoperative days (POD) or started at the day of corneal grafting until POD 14. MMF (20 mg/kg) administered postoperatively had no significant beneficial effect on corneal graft survival when compared with controls. However, the group receiving 40 mg/kg MMF postoperatively showed a statistically significant prolonged graft survival. A 1-week preoperative administration of 20 mg/kg MMF allowed superior graft survival. Priming the immune system of corneal transplant recipients preoperatively with MMF proved to be a beneficial therapeutic regimen for prolonging corneal allograft survival in rats. More... »

PAGES

341-345

References to SciGraph publications

  • 1996-08. Systemic ciclosporin A in high-risk keratoplasties in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 1997-08. Preliminary Risk-Benefit Assessment of Mycophenolate Mofetil in Transplant Rejection in DRUG SAFETY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s001470050237

    DOI

    http://dx.doi.org/10.1007/s001470050237

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001864077

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10551999


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