Ontology type: schema:ScholarlyArticle
1999-10
AUTHORSA. Reis, Helga Spelsberg, Thomas Reinhard, Stefan Braunstein, Erhard Godehardt, Rainer Sundmacher
ABSTRACTTo investigate the effect of preoperative mycophenolate mofetil (MMF) on allograft survival in a murine corneal transplantation model. Corneal grafting was performed from Brown Norway to Lewis rats. Groups were divided as follows: Rats that received syngeneic or allogeneic grafts without therapy served as controls. MMF treatment was either started 7 days prior to transplantation and continued for 14 postoperative days (POD) or started at the day of corneal grafting until POD 14. MMF (20 mg/kg) administered postoperatively had no significant beneficial effect on corneal graft survival when compared with controls. However, the group receiving 40 mg/kg MMF postoperatively showed a statistically significant prolonged graft survival. A 1-week preoperative administration of 20 mg/kg MMF allowed superior graft survival. Priming the immune system of corneal transplant recipients preoperatively with MMF proved to be a beneficial therapeutic regimen for prolonging corneal allograft survival in rats. More... »
PAGES341-345
http://scigraph.springernature.com/pub.10.1007/s001470050237
DOIhttp://dx.doi.org/10.1007/s001470050237
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1001864077
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10551999
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Ophthalmology and Optometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cornea",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Corneal Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Graft Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunosuppressive Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mycophenolic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Inbred BN",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Inbred Lew",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE"
],
"type": "Organization"
},
"familyName": "Reis",
"givenName": "A.",
"id": "sg:person.01047640762.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047640762.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE"
],
"type": "Organization"
},
"familyName": "Spelsberg",
"givenName": "Helga",
"id": "sg:person.0603075043.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603075043.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE"
],
"type": "Organization"
},
"familyName": "Reinhard",
"givenName": "Thomas",
"id": "sg:person.0644301223.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644301223.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Heinrich-Heine University, Duesseldorf, Germany, DE",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Department of Pathology, Heinrich-Heine University, Duesseldorf, Germany, DE"
],
"type": "Organization"
},
"familyName": "Braunstein",
"givenName": "Stefan",
"id": "sg:person.0746747734.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746747734.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department for Biometry in the Department of Cardiac and Thoracic Surgery, Heinrich-Heine University, Duesseldorf, Germany, DE",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Department for Biometry in the Department of Cardiac and Thoracic Surgery, Heinrich-Heine University, Duesseldorf, Germany, DE"
],
"type": "Organization"
},
"familyName": "Godehardt",
"givenName": "Erhard",
"id": "sg:person.01213465656.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213465656.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Eye Clinic, Heinrich-Heine University, Moorenstr. 5, D-40 225 Duesseldorf, Germany e-mail: reis@uni-duesseldorf.de, Tel.: + 49\u2013211\u20138117320, Fax: + 49\u2013211\u20138 116241, DE"
],
"type": "Organization"
},
"familyName": "Sundmacher",
"givenName": "Rainer",
"id": "sg:person.01335527273.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335527273.07"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf02343059",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030735881",
"https://doi.org/10.1007/bf02343059"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00002018-199717020-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004170410",
"https://doi.org/10.2165/00002018-199717020-00001"
],
"type": "CreativeWork"
}
],
"datePublished": "1999-10",
"datePublishedReg": "1999-10-01",
"description": "Abstract To investigate the effect of preoperative mycophenolate mofetil (MMF) on allograft survival in a murine corneal transplantation model. Corneal grafting was performed from Brown Norway to Lewis rats. Groups were divided as follows: Rats that received syngeneic or allogeneic grafts without therapy served as controls. MMF treatment was either started 7 days prior to transplantation and continued for 14 postoperative days (POD) or started at the day of corneal grafting until POD 14. MMF (20 mg/kg) administered postoperatively had no significant beneficial effect on corneal graft survival when compared with controls. However, the group receiving 40 mg/kg MMF postoperatively showed a statistically significant prolonged graft survival. A 1-week preoperative administration of 20 mg/kg MMF allowed superior graft survival. Priming the immune system of corneal transplant recipients preoperatively with MMF proved to be a beneficial therapeutic regimen for prolonging corneal allograft survival in rats.",
"genre": "article",
"id": "sg:pub.10.1007/s001470050237",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1099393",
"issn": [
"0934-0874",
"1432-2277"
],
"name": "Transplant International",
"publisher": "Frontiers",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "12"
}
],
"keywords": [
"mycophenolate mofetil",
"graft survival",
"allograft survival",
"postoperative day",
"significant prolonged graft survival",
"beneficial effects",
"corneal graft survival",
"superior graft survival",
"corneal transplant recipients",
"beneficial therapeutic regimen",
"corneal allograft survival",
"murine corneal transplantation",
"prolonged graft survival",
"corneal transplantation model",
"significant beneficial effect",
"preoperative administration",
"transplant recipients",
"MMF treatment",
"POD 14",
"therapeutic regimen",
"Lewis rats",
"allogeneic grafts",
"corneal transplantation",
"transplantation model",
"corneal grafting",
"Brown Norway",
"immune system",
"rats",
"survival",
"mofetil",
"transplantation",
"days",
"regimen",
"group",
"graft",
"therapy",
"administration",
"recipients",
"treatment",
"control",
"effect",
"grafting",
"Norway",
"model",
"system"
],
"name": "Beneficial effect of preoperative mycophenolate mofetil in murine corneal transplantation",
"pagination": "341-345",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1001864077"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s001470050237"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"10551999"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s001470050237",
"https://app.dimensions.ai/details/publication/pub.1001864077"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:21",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_326.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s001470050237"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001470050237'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001470050237'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001470050237'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001470050237'
This table displays all metadata directly associated to this object as RDF triples.
194 TRIPLES
22 PREDICATES
84 URIs
74 LITERALS
17 BLANK NODES