Long-term results of a prospective randomized study comparing two immunosuppressive regimens, one with and one without CsA, in low-risk renal ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-11

AUTHORS

Philippe Grimbert, Christophe Baron, Ghislaine Fruchaud, François Hemery, Dominique Desvaux, Claude Buisson, Dominique Chopin, Djamel Dahmane, Philippe Remy, Myriam Pastural, Claude Abbou, Bertrand Weil, Philippe Lang

ABSTRACT

. Due to the nephrotoxicity of cyclosporin A (CsA), its benefit on long-term graft survival remains controversial, especially in low-risk patients. Here we report the 12-year results of a calcineurin-inhibitor-free regimen. One hundred and seventeen low-risk kidney recipients were prospectively randomized to maintenance therapy with either a combination of azathioprine and prednisone (group NoCsA, n=58), or with cyclosporine, azathioprine, and prednisone (group CsA, n=59). Both groups received induction therapy with anti-lymphocyte globulins (ALG). Twelve-year patient survival was 75% and 82.5% in the CsA and NoCsA groups, respectively [P= not significant (NS)]. Twelve-year graft survival was 59% and 56% (P=NS) in the CsA and NoCsA groups, respectively (NS). Transplant rejection rates were similar in both groups. Mean serum creatinine levels after 10 years were 161 and 136 μmol/l in the CsA and NoCsA groups, respectively. Rejection-free patients of the CsA group had poorer renal function (168 μmol/l) than those of the NoCsA group (121 μmol/l; P=0.0060). We concluded that a 12-year graft survival of 56% and a graft half-life of 15 years can be achieved without the primary use of a calcineurin inhibitor in low-risk patients receiving ALG. Patients treated with CsA had poorer graft function at 12 years. More... »

PAGES

550-555

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00147-002-0494-x

DOI

http://dx.doi.org/10.1007/s00147-002-0494-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044132945


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