Oxygen tension in isolated transplanted rat islets and in islets of rat whole-pancreas transplants View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-11

AUTHORS

Per-Ola Carlsson, Fredrik Palm

ABSTRACT

Despite similar immunosuppressive protocols having been applied, the success rate of pancreatic islet transplantation has been much lower than that of whole-pancreas transplantation. We compared the oxygen tension in syngeneically transplanted isolated rat islets and islets of syngeneic rat whole-pancreatic grafts, with native islets, using Clark-type microelectrodes. An oxygen tension of ∼40 mmHg was recorded in both native islets and in islets of the whole-pancreas graft. Isolated islets transplanted under the renal capsule had a markedly lower oxygen tension (∼6 mmHg). The exocrine parenchyma of the native and of the transplanted pancreatic gland had an oxygen tension of ∼30 mmHg. The lower oxygen tension in transplanted isolated islets may be one explanation for the more frequent failures of transplanted islets compared with the outcome when the whole pancreatic gland is transplanted. More... »

PAGES

581-585

References to SciGraph publications

Journal

TITLE

Transplant International

ISSUE

11

VOLUME

15

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00147-002-0460-7

DOI

http://dx.doi.org/10.1007/s00147-002-0460-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026470102


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