Regeneration artikulärer Knorpeldefekte am Kniegelenk View Full Text


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Article Info

DATE

2019-04-02

AUTHORS

F. Blanke, S. Vogt

ABSTRACT

Knorpelgewebe besitzt keine Fähigkeit zur Eigenregeneration, sodass die chirurgische Knorpeltherapie ein essenzielles Verfahren in der Behandlung von Knorpelschäden darstellt. Die Indikation richtet sich nicht nur nach der Größe und morphologischen Beschaffenheit des Schadens, sondern insbesondere nach der klinischen Symptomatik. Die Mikrofrakturierung stellt ein validiertes Verfahren für kleine Defekte dar, ist jedoch der autologen Chondrozytentransplantation (ACT/MACT) in der histologischen Qualität etwas unterlegen. Die ACT/MACT kann mittlerweile in offener und rein arthroskopischer Technik angewendet werden und ist der Mikrofrakturierung hinsichtlich der klinischen Behandlungsergebnisse ebenbürtig bzw. bei großen Defekten sogar überlegen. Nachteilig ist jedoch weiterhin das notwendige zweizeitige Verfahren. Zellfreie Behandlungsmethoden bieten daher als einzeitige Verfahren eine gute Alternative und zeigten in ersten Studien vielversprechende Ergebnisse. Systematische Langzeitstudien und randomisierte Studien sind jedoch notwendig, um das Potenzial dieser Behandlungsstrategien zu evaluieren und sie mit traditionellen Therapiealternativen suffizient vergleichen zu können. Begleitpathologien bzw. Risikofaktoren müssen in der chirurgischen Knorpeltherapie unbedingt beachtet und ggf. mit therapiert werden. More... »

PAGES

1-5

References to SciGraph publications

  • 2015-12. Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee in INTERNATIONAL ORTHOPAEDICS
  • 2017-11. Knorpelreparative Eingriffe am Kniegelenk in DER ORTHOPÄDE
  • 2010-04. Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2014-10. Clinical outcome after medial patellofemoral ligament reconstruction and autologous chondrocyte implantation following recurrent patella dislocation in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2012-10. Cell-free collagen type I matrix for repair of cartilage defects—clinical and magnetic resonance imaging results in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2007-06. Stadiengerechte operative Knorpeltherapie in DER ORTHOPÄDE
  • 2012-10. Treatment of isolated chondral and osteochondral defects in the knee by autologous matrix-induced chondrogenesis (AMIC) in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2010-11. Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2017-10. Die Meniskusläsion – ein präarthrotischer Zustand des Kniegelenks in DER ORTHOPÄDE
  • 2017-11. Aktuelle Übersicht knorpelregenerativer Verfahren in DER ORTHOPÄDE
  • 2011-04. Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 1999-01. The microfracture technique to treat full thickness articular cartilage defects of the knee in DER ORTHOPÄDE
  • Journal

    TITLE

    Arthroskopie

    ISSUE

    N/A

    VOLUME

    N/A

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00142-019-0277-3

    DOI

    http://dx.doi.org/10.1007/s00142-019-0277-3

    DIMENSIONS

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