Effects of inhaled salmeterol and salbutamol (albuterol) on morning dips compared in intensive care patients recovering from an acute severe ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-12

AUTHORS

M. Ritz, J. B. Thorens, J. C. Chevrolet, M. Arnold-Ketterer

ABSTRACT

Objective: To assess the effect of a long-acting inhaled β2-agonist, salmeterol (SM), compared to a short-acting inhaled β2-agonist, salbutamol (or albuterol, SB), on the occurrence of morning dip (MD) in patients recovering from an acute severe asthma attack (ASA).Design: Prospective study Setting: 18-bed, medical intensive care unit (ICU) in a university hospital.Patients: 19 patients suffering from an ASA.Interventions: Serial measurements of the peak expiratory flow rate (PEFR), arterial blood gases, vital capacity and forced expiratory volume in one second (FEV1) were performed from admission. All patients were first treated with i. v. methyl prednisolone and i.v. SB. Once the PEFR was stable and > 35 % of predicted value, i. v. SB was stopped while i. v. steroids were maintained, and patients were randomised to either inhaled SB (9 patients, 400 μg every 4 h) or inhaled SM (10 patients, 100 μg every 12 h).Results: The mean admission PEFR was 26.1 ± 11.7 % of the predicted value and was not different between the two groups. MD was more frequent with SB (6/9 patients) than with SM (4/10). The severity of MD, expressed in 1/min fall in PEFR, was higher in SB than in SM (106 ± 25 vs 55±37;p<0.05).Discussion: MD is frequent in ASA. In ASA, SM appears to reduce the frequency and the severity of MD more than SB. The clinical implications of this observation, particularly a lowering of mortality and a shortening of the ICU stay, remain to be investigated. More... »

PAGES

1225-1230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001340050490

DOI

http://dx.doi.org/10.1007/s001340050490

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041421538

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9470077


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205 schema:name Medical Clinic I, Hôpital Cantonal Universitaire de Genève, Geneva, Switzerland
206 Medical Intensive Care, University Hospital, Geneva, 24, rue Micheli-du-Crest, CH-1211, Geneva 14, Switzerland
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