Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-02

AUTHORS

H. Dupont, H. Mentec, J.P. Sollet, G. Bleichner

ABSTRACT

OBJECTIVES: To evaluate the impact of appropriate initial antibiotic therapy (AB) on the outcome of ventilator-associated pneumonia (VAP). DESIGN: Retrospective study (1992-97). PATIENTS AND METHODS: Episodes of VAP diagnosed on both clinical and microbiological criteria after > or = 48 h of mechanical ventilation (MV). Initial AB was considered appropriate when all significant organisms were susceptible to at least one of the antibiotics started after distal bronchial sampling. Antibiotic treatment was modified within 48 h when susceptibility testing was available. Outcome was recorded at the ICU and hospital discharge. RESULTS: One hundred and eleven patients were included (SAPS II = 48 +/- 18, age = 62 +/- 14 years, mean duration of MV before VAP = 12 +/- 9 days). Initial AB was appropriate in 55 patients (49.5%). No difference between appropriate initial AB and inappropriate initial AB was found concerning severity indices at the time of VAP diagnosis. ICU length of stay was shorter with appropriate initial AB than with inappropriate initial AB for survivors (12 +/- 11 days vs 20 +/- 24 days, P = 0.01). Crude hospital mortality tended to be lower with appropriate initial AB than with inappropriate initial AB (47.3% vs 60.7%, odds ratio = 1.72, 95% CI = 0.81-3.7). Relative crude mortality reduction with appropriate initial AB was 22%, 95% CI = -10% to 45%. CONCLUSION: Inappropriate initial AB of VAP during the first 48 h increased ICU length of stay after VAP diagnosis and tended to increase crude hospital mortality despite equal severity of illness at the time of VAP diagnosis, when compared to appropriate initial AB in a population of 111 ICU patients. More... »

PAGES

355-362

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001340000640

DOI

http://dx.doi.org/10.1007/s001340000640

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012145259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11396279


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross Infection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Length of Stay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Bichat-Claude-Bernard", 
          "id": "https://www.grid.ac/institutes/grid.411119.d", 
          "name": [
            "Service de R\u00e9animation Chirurgicale, H\u00f4pital Bichat-Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dupont", 
        "givenName": "H.", 
        "id": "sg:person.016646675432.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016646675432.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Intensive Care Unit, Victor Dupouy Hospital, Argenteuil, France, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mentec", 
        "givenName": "H.", 
        "id": "sg:person.0654006344.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654006344.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Intensive Care Unit, Victor Dupouy Hospital, Argenteuil, France, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sollet", 
        "givenName": "J.P.", 
        "id": "sg:person.01066770631.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066770631.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Intensive Care Unit, Victor Dupouy Hospital, Argenteuil, France, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bleichner", 
        "givenName": "G.", 
        "id": "sg:person.0621526767.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621526767.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3109/00365549709008668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001607395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01712153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002298120", 
          "https://doi.org/10.1007/bf01712153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01712153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002298120", 
          "https://doi.org/10.1007/bf01712153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01712153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002298120", 
          "https://doi.org/10.1007/bf01712153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/139.4.877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002974268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01720528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005711113", 
          "https://doi.org/10.1007/bf01720528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01720528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005711113", 
          "https://doi.org/10.1007/bf01720528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.104.4.1230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006149329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clinids/23.3.486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011540543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01704699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016430301", 
          "https://doi.org/10.1007/bf01704699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01704699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016430301", 
          "https://doi.org/10.1007/bf01704699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01704699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016430301", 
          "https://doi.org/10.1007/bf01704699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.108.6.1655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022181405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.156.1.9607030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023538747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/142.3.523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024659358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.157.2.9705064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026195240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.81.5.556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027999318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.93.2.318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029435988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.159.4.9807050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031488863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(74)90440-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035944851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.115.2.462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038426973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.115.2.462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038426973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(93)90060-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041365201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.157.2.97-02039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041436850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1995.03530080055041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046987451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(91)90384-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047266825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.154.1.8680705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047986662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.102.5_supplement_1.553s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048128170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/143.4_pt_1.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049046875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/143.5_pt_1.1055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051519595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.111.3.676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053376115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199711000-00026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060172189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199711000-00026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060172189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199711000-00026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060172189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199802000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060172734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199802000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060172734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199802000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060172734"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-02", 
    "datePublishedReg": "2001-02-01", 
    "description": "OBJECTIVES: To evaluate the impact of appropriate initial antibiotic therapy (AB) on the outcome of ventilator-associated pneumonia (VAP).\nDESIGN: Retrospective study (1992-97).\nPATIENTS AND METHODS: Episodes of VAP diagnosed on both clinical and microbiological criteria after > or = 48 h of mechanical ventilation (MV). Initial AB was considered appropriate when all significant organisms were susceptible to at least one of the antibiotics started after distal bronchial sampling. Antibiotic treatment was modified within 48 h when susceptibility testing was available. Outcome was recorded at the ICU and hospital discharge.\nRESULTS: One hundred and eleven patients were included (SAPS II = 48 +/- 18, age = 62 +/- 14 years, mean duration of MV before VAP = 12 +/- 9 days). Initial AB was appropriate in 55 patients (49.5%). No difference between appropriate initial AB and inappropriate initial AB was found concerning severity indices at the time of VAP diagnosis. ICU length of stay was shorter with appropriate initial AB than with inappropriate initial AB for survivors (12 +/- 11 days vs 20 +/- 24 days, P = 0.01). Crude hospital mortality tended to be lower with appropriate initial AB than with inappropriate initial AB (47.3% vs 60.7%, odds ratio = 1.72, 95% CI = 0.81-3.7). Relative crude mortality reduction with appropriate initial AB was 22%, 95% CI = -10% to 45%.\nCONCLUSION: Inappropriate initial AB of VAP during the first 48 h increased ICU length of stay after VAP diagnosis and tended to increase crude hospital mortality despite equal severity of illness at the time of VAP diagnosis, when compared to appropriate initial AB in a population of 111 ICU patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s001340000640", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "name": "Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia", 
    "pagination": "355-362", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "39dd104f2a72c5da8ac98c9d9b649e4d8fc88f0a7c35faf15058cb1b23b34940"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11396279"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704851"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001340000640"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012145259"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001340000640", 
      "https://app.dimensions.ai/details/publication/pub.1012145259"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000486.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s001340000640"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001340000640'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001340000640'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001340000640'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001340000640'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      21 PREDICATES      71 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001340000640 schema:about N006c4033a6e448fe877161e2fd89c5ca
2 N2c03590c08fa4d13a29ad2864d27737b
3 N3a682f1b8ec34d2c84042519510b6e3e
4 N3afc5d80b56a4e2b9fdf4a7f49ee4fa1
5 N405fb25b02934b9cb408f1d3967c98ca
6 N45be3999e0b4444b852bb96223945c35
7 N5a66efa846ce4ccbbda250b3150880a3
8 N5d3a07b06368499bb72bf5c592fac9d1
9 N7031e4e4767248fe8393449382e7b7e4
10 N70bf415f838d46f881b78a6fd7a0801d
11 N7ad23ad9aaf54aec8f0fa7cb7abfe132
12 Nb13565a249924dd9ad48b9de3a4b525c
13 Nd028fafb3ccb44ba9d39cdfc5b383bff
14 Nd31db663d49d4ebda3cbdfb78ed4c7b3
15 Nf57d74e92ac94559b6918773ec321175
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N6b7f5c5b401d4935b353dcc7f3ff62b7
19 schema:citation sg:pub.10.1007/bf01704699
20 sg:pub.10.1007/bf01712153
21 sg:pub.10.1007/bf01720528
22 https://doi.org/10.1001/jama.1995.03530080055041
23 https://doi.org/10.1016/0002-9343(74)90440-9
24 https://doi.org/10.1016/0002-9343(91)90384-a
25 https://doi.org/10.1016/0002-9343(93)90060-3
26 https://doi.org/10.1093/clinids/23.3.486
27 https://doi.org/10.1097/00003246-199711000-00026
28 https://doi.org/10.1097/00003246-199802000-00017
29 https://doi.org/10.1164/ajrccm.154.1.8680705
30 https://doi.org/10.1164/ajrccm.156.1.9607030
31 https://doi.org/10.1164/ajrccm.157.2.97-02039
32 https://doi.org/10.1164/ajrccm.157.2.9705064
33 https://doi.org/10.1164/ajrccm.159.4.9807050
34 https://doi.org/10.1164/ajrccm/139.4.877
35 https://doi.org/10.1164/ajrccm/142.3.523
36 https://doi.org/10.1164/ajrccm/143.4_pt_1.855
37 https://doi.org/10.1164/ajrccm/143.5_pt_1.1055
38 https://doi.org/10.1378/chest.102.5_supplement_1.553s
39 https://doi.org/10.1378/chest.104.4.1230
40 https://doi.org/10.1378/chest.108.6.1655
41 https://doi.org/10.1378/chest.111.3.676
42 https://doi.org/10.1378/chest.115.2.462
43 https://doi.org/10.1378/chest.81.5.556
44 https://doi.org/10.1378/chest.93.2.318
45 https://doi.org/10.3109/00365549709008668
46 schema:datePublished 2001-02
47 schema:datePublishedReg 2001-02-01
48 schema:description OBJECTIVES: To evaluate the impact of appropriate initial antibiotic therapy (AB) on the outcome of ventilator-associated pneumonia (VAP). DESIGN: Retrospective study (1992-97). PATIENTS AND METHODS: Episodes of VAP diagnosed on both clinical and microbiological criteria after > or = 48 h of mechanical ventilation (MV). Initial AB was considered appropriate when all significant organisms were susceptible to at least one of the antibiotics started after distal bronchial sampling. Antibiotic treatment was modified within 48 h when susceptibility testing was available. Outcome was recorded at the ICU and hospital discharge. RESULTS: One hundred and eleven patients were included (SAPS II = 48 +/- 18, age = 62 +/- 14 years, mean duration of MV before VAP = 12 +/- 9 days). Initial AB was appropriate in 55 patients (49.5%). No difference between appropriate initial AB and inappropriate initial AB was found concerning severity indices at the time of VAP diagnosis. ICU length of stay was shorter with appropriate initial AB than with inappropriate initial AB for survivors (12 +/- 11 days vs 20 +/- 24 days, P = 0.01). Crude hospital mortality tended to be lower with appropriate initial AB than with inappropriate initial AB (47.3% vs 60.7%, odds ratio = 1.72, 95% CI = 0.81-3.7). Relative crude mortality reduction with appropriate initial AB was 22%, 95% CI = -10% to 45%. CONCLUSION: Inappropriate initial AB of VAP during the first 48 h increased ICU length of stay after VAP diagnosis and tended to increase crude hospital mortality despite equal severity of illness at the time of VAP diagnosis, when compared to appropriate initial AB in a population of 111 ICU patients.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N5272f93990ab4df4bcee6ec714609903
53 Nf8bcc2b63a2947f58c650caa981ac344
54 sg:journal.1313639
55 schema:name Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia
56 schema:pagination 355-362
57 schema:productId N2684007d592a4b25b1749521c9727f51
58 N2e0ace0c7dac407eb781cbb3fde1c6a4
59 N326641ad94364915a9a7b04dc7da2a0a
60 N95b23efd8302491f9678cbbec5ded9bf
61 Nea96852a0a4e40c1a21ca486d2f8461a
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012145259
63 https://doi.org/10.1007/s001340000640
64 schema:sdDatePublished 2019-04-10T14:02
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Na847655ff6a84dada2dfe532e118d4a7
67 schema:url http://link.springer.com/10.1007/s001340000640
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N006c4033a6e448fe877161e2fd89c5ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Cross Infection
73 rdf:type schema:DefinedTerm
74 N026761fbc0564381bda198f54e8e0c7c rdf:first sg:person.01066770631.69
75 rdf:rest Nbedf9435108f4fe7b4c17679170fc0e0
76 N224894c78aab4be3823e632a5c1ff048 schema:name Intensive Care Unit, Victor Dupouy Hospital, Argenteuil, France, France
77 rdf:type schema:Organization
78 N23996c73e9104b26be35fa9e12ad1033 schema:name Intensive Care Unit, Victor Dupouy Hospital, Argenteuil, France, France
79 rdf:type schema:Organization
80 N2684007d592a4b25b1749521c9727f51 schema:name nlm_unique_id
81 schema:value 7704851
82 rdf:type schema:PropertyValue
83 N2c03590c08fa4d13a29ad2864d27737b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Humans
85 rdf:type schema:DefinedTerm
86 N2e0ace0c7dac407eb781cbb3fde1c6a4 schema:name doi
87 schema:value 10.1007/s001340000640
88 rdf:type schema:PropertyValue
89 N326641ad94364915a9a7b04dc7da2a0a schema:name readcube_id
90 schema:value 39dd104f2a72c5da8ac98c9d9b649e4d8fc88f0a7c35faf15058cb1b23b34940
91 rdf:type schema:PropertyValue
92 N3a682f1b8ec34d2c84042519510b6e3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Hospital Mortality
94 rdf:type schema:DefinedTerm
95 N3afc5d80b56a4e2b9fdf4a7f49ee4fa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Intensive Care Units
97 rdf:type schema:DefinedTerm
98 N405fb25b02934b9cb408f1d3967c98ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Statistics, Nonparametric
100 rdf:type schema:DefinedTerm
101 N45be3999e0b4444b852bb96223945c35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Anti-Bacterial Agents
103 rdf:type schema:DefinedTerm
104 N5272f93990ab4df4bcee6ec714609903 schema:volumeNumber 27
105 rdf:type schema:PublicationVolume
106 N5a66efa846ce4ccbbda250b3150880a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Retrospective Studies
108 rdf:type schema:DefinedTerm
109 N5d3a07b06368499bb72bf5c592fac9d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 N6b7f5c5b401d4935b353dcc7f3ff62b7 rdf:first sg:person.016646675432.92
113 rdf:rest Naf5ef13ebd234d00bdccdec858d60d67
114 N7031e4e4767248fe8393449382e7b7e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N70bf415f838d46f881b78a6fd7a0801d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Treatment Outcome
119 rdf:type schema:DefinedTerm
120 N7ad23ad9aaf54aec8f0fa7cb7abfe132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Respiration, Artificial
122 rdf:type schema:DefinedTerm
123 N95b23efd8302491f9678cbbec5ded9bf schema:name dimensions_id
124 schema:value pub.1012145259
125 rdf:type schema:PropertyValue
126 Na847655ff6a84dada2dfe532e118d4a7 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 Naf5ef13ebd234d00bdccdec858d60d67 rdf:first sg:person.0654006344.07
129 rdf:rest N026761fbc0564381bda198f54e8e0c7c
130 Nafbb5559374346c8803b12ce3300ef24 schema:name Intensive Care Unit, Victor Dupouy Hospital, Argenteuil, France, France
131 rdf:type schema:Organization
132 Nb13565a249924dd9ad48b9de3a4b525c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Middle Aged
134 rdf:type schema:DefinedTerm
135 Nbedf9435108f4fe7b4c17679170fc0e0 rdf:first sg:person.0621526767.12
136 rdf:rest rdf:nil
137 Nd028fafb3ccb44ba9d39cdfc5b383bff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Length of Stay
139 rdf:type schema:DefinedTerm
140 Nd31db663d49d4ebda3cbdfb78ed4c7b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Logistic Models
142 rdf:type schema:DefinedTerm
143 Nea96852a0a4e40c1a21ca486d2f8461a schema:name pubmed_id
144 schema:value 11396279
145 rdf:type schema:PropertyValue
146 Nf57d74e92ac94559b6918773ec321175 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Pneumonia, Bacterial
148 rdf:type schema:DefinedTerm
149 Nf8bcc2b63a2947f58c650caa981ac344 schema:issueNumber 2
150 rdf:type schema:PublicationIssue
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
155 schema:name Clinical Sciences
156 rdf:type schema:DefinedTerm
157 sg:journal.1313639 schema:issn 0342-4642
158 1432-1238
159 schema:name Intensive Care Medicine
160 rdf:type schema:Periodical
161 sg:person.01066770631.69 schema:affiliation N23996c73e9104b26be35fa9e12ad1033
162 schema:familyName Sollet
163 schema:givenName J.P.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066770631.69
165 rdf:type schema:Person
166 sg:person.016646675432.92 schema:affiliation https://www.grid.ac/institutes/grid.411119.d
167 schema:familyName Dupont
168 schema:givenName H.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016646675432.92
170 rdf:type schema:Person
171 sg:person.0621526767.12 schema:affiliation N224894c78aab4be3823e632a5c1ff048
172 schema:familyName Bleichner
173 schema:givenName G.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621526767.12
175 rdf:type schema:Person
176 sg:person.0654006344.07 schema:affiliation Nafbb5559374346c8803b12ce3300ef24
177 schema:familyName Mentec
178 schema:givenName H.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654006344.07
180 rdf:type schema:Person
181 sg:pub.10.1007/bf01704699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016430301
182 https://doi.org/10.1007/bf01704699
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/bf01712153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002298120
185 https://doi.org/10.1007/bf01712153
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/bf01720528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005711113
188 https://doi.org/10.1007/bf01720528
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1001/jama.1995.03530080055041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046987451
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0002-9343(74)90440-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035944851
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/0002-9343(91)90384-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1047266825
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/0002-9343(93)90060-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041365201
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1093/clinids/23.3.486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011540543
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/00003246-199711000-00026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060172189
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/00003246-199802000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060172734
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1164/ajrccm.154.1.8680705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047986662
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1164/ajrccm.156.1.9607030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023538747
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1164/ajrccm.157.2.97-02039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041436850
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1164/ajrccm.157.2.9705064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026195240
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1164/ajrccm.159.4.9807050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031488863
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1164/ajrccm/139.4.877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002974268
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1164/ajrccm/142.3.523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024659358
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1164/ajrccm/143.4_pt_1.855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049046875
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1164/ajrccm/143.5_pt_1.1055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051519595
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1378/chest.102.5_supplement_1.553s schema:sameAs https://app.dimensions.ai/details/publication/pub.1048128170
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1378/chest.104.4.1230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006149329
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1378/chest.108.6.1655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022181405
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1378/chest.111.3.676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053376115
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1378/chest.115.2.462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038426973
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1378/chest.81.5.556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027999318
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1378/chest.93.2.318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029435988
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3109/00365549709008668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001607395
237 rdf:type schema:CreativeWork
238 https://www.grid.ac/institutes/grid.411119.d schema:alternateName Hôpital Bichat-Claude-Bernard
239 schema:name Service de Réanimation Chirurgicale, Hôpital Bichat-Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France, France
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...