Emerging pharmacological therapies for ARDS: COVID-19 and beyond View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-07-11

AUTHORS

Shahd Horie, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, Ger Curley, Danny McAuley, Cecilia O’Kane, Alistair Nichol, Claudia dos Santos, Patricia R. M. Rocco, Giacomo Bellani, John G. Laffey

ABSTRACT

ARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biologic mechanisms of lung injury and repair, and advances in supportive care, particularly ventilatory management, there remains no effective pharmacological therapy for this syndrome. Hospital mortality at 40% remains unacceptably high underlining the need to continue to develop and test therapies for this devastating clinical condition. The purpose of the review is to critically appraise the current status of promising emerging pharmacological therapies for patients with ARDS and potential impact of these and other emerging therapies for COVID-19-induced ARDS. We focus on drugs that: (1) modulate the immune response, both via pleiotropic mechanisms and via specific pathway blockade effects, (2) modify epithelial and channel function, (3) target endothelial and vascular dysfunction, (4) have anticoagulant effects, and (5) enhance ARDS resolution. We also critically assess drugs that demonstrate potential in emerging reports from clinical studies in patients with COVID-19-induced ARDS. Several therapies show promise in earlier and later phase clinical testing, while a growing pipeline of therapies is in preclinical testing. The history of unsuccessful clinical trials of promising therapies underlines the challenges to successful translation. Given this, attention has been focused on the potential to identify biologically homogenous subtypes within ARDS, to enable us to target more specific therapies ‘precision medicines.’ It is hoped that the substantial number of studies globally investigating potential therapies for COVID-19 will lead to the rapid identification of effective therapies to reduce the mortality and morbidity of this devastating form of ARDS. More... »

PAGES

2265-2283

References to SciGraph publications

  • 2014-06-10. Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice in INFLAMMATION
  • 2015-02-27. Angiotensin-(1-7) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental Acute Respiratory Distress Syndrome in INTENSIVE CARE MEDICINE EXPERIMENTAL
  • 2013-01-17. Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis in CRITICAL CARE
  • 2019-06-25. Inhibition of the Receptor for Advanced Glycation End-Products in Acute Respiratory Distress Syndrome: A Randomised Laboratory Trial in Piglets in SCIENTIFIC REPORTS
  • 2020-02-05. Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism in INTENSIVE CARE MEDICINE EXPERIMENTAL
  • 2012-12-04. Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model in CELL RESEARCH
  • 2020-02-04. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro in CELL RESEARCH
  • 2010-10-11. Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial in CRITICAL CARE
  • 2017-07-27. Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial in CRITICAL CARE
  • 2002-05. Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2020-04-28. A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia in SIGNAL TRANSDUCTION AND TARGETED THERAPY
  • 2018-02-08. Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study in SCIENTIFIC REPORTS
  • 2016-03-02. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys in NATURE
  • 2019-08-22. Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition in RESPIRATORY RESEARCH
  • 2012-02-16. A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome in BMC PULMONARY MEDICINE
  • 2015-09-29. Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice in RESPIRATORY RESEARCH
  • 2017-09-07. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome in CRITICAL CARE
  • 2017-08-03. RAGE inhibition reduces acute lung injury in mice in SCIENTIFIC REPORTS
  • 2019-07-25. Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury in INTENSIVE CARE MEDICINE EXPERIMENTAL
  • Journal

    TITLE

    Intensive Care Medicine

    ISSUE

    12

    VOLUME

    46

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-020-06141-z

    DOI

    http://dx.doi.org/10.1007/s00134-020-06141-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1129298163

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32654006


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