Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04-24

AUTHORS

Jean-Francois Timsit, Carole Schwebel, Lenka Styfalova, Muriel Cornet, Philippe Poirier, Christiane Forrestier, Stéphane Ruckly, Marie-Christine Jacob, Bertrand Souweine

ABSTRACT

IntroductionRespiratory tract Candida spp. colonization is associated with more frequent bacterial ventilator-associated pneumonia (VAP). However, this colonization could be causally related to VAP or simply reflect the immune paralysis associated with multiple organ failure.ObjectiveTo prospectively evaluate the relationship between Candida spp. colonization and bacterial VAP in mechanically ventilated patients with multiple organ failure.InclusionPatients receiving mechanical ventilation for > 4 days and presenting multiple organ failure were included. Tracheal colonization with Candida spp. was evaluated at inclusion (day 0, D0) and every 4 days until extubation. Quantitative proximal and tracheal cultures were performed at each VAP episode. Monocyte human leukocyte antigen-DR isotype (mHLA-DR) expression and the ratio of polymononuclear leukocytes to lymphocytes were used to evaluate immunoparalysis at D0 and D7. The relationship between fungal colonization and VAP was modelled using cause-specific models for repeated events with adjustment for time-dependent confounders and immune factors.ResultsA total of 213 patients, with a median age of 64, simplified acute physiology score II (SAPS II) score 55 and sequential organ failure assessment (SOFA) score 10, mainly admitted for medical reasons (n = 197, 92%), were enrolled in 2012–2015. The median ICU stay was 24 days and the mortality rate was 32% (69 cases). Median mHLA-DR was 5916 Ab-bound/cell [3863–8934]; median lymphocyte count, 0.9Giga/L [0.6–1.3]; neutrophil-to-lymphocyte ratio, 10.9 [6.5–19.7]. Overall, 146 cases (68.5%) had tracheal colonization with Candida spp. An episode of VAP occurred (either for the first or only time) in 62 (29.1%) cases 5.5 days (median) after D0; a second episode occurred in 12 (5.6%) cases, 15.5 days (median) after D0. After adjustment, bronchial colonization with Candida was not associated with VAP [adjusted cause-specific hazard ratio = 0.98 (0.59–1.65), p = 0.95].ConclusionIn patients with mechanical ventilation for more than 4 days and multiple organ failure, bronchial colonization with Candida spp. was not associated with VAP, even after adjustment for immune function. More... »

PAGES

834-843

References to SciGraph publications

  • 2009-04-09. Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy study in INTENSIVE CARE MEDICINE
  • 2017-12-11. Advances in the understanding and treatment of sepsis-induced immunosuppression in NATURE REVIEWS NEPHROLOGY
  • 2004-05-18. Practices in non-neutropenic ICU patients with Candida-positive airway specimens in INTENSIVE CARE MEDICINE
  • 2006-11-08. Impact of antifungal treatment on Candida–Pseudomonas interaction: a preliminary retrospective case–control study in INTENSIVE CARE MEDICINE
  • 2013-10-11. Nebulised amphotericin B to eradicate Candida colonisation from the respiratory tract in critically ill patients receiving selective digestive decontamination: a cohort study in CRITICAL CARE
  • 2013-11-15. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy in NATURE REVIEWS IMMUNOLOGY
  • 2014-07-01. Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study) in INTENSIVE CARE MEDICINE
  • 2010-07-23. Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock in INTENSIVE CARE MEDICINE
  • 2017-11-22. Understanding the role of host immune responses in invasive candidiasis in INTENSIVE CARE MEDICINE
  • 2010-12-14. The relationship between Candida species cultured from the respiratory tract and systemic inflammation in critically ill patients with ventilator-associated pneumonia in JOURNAL CANADIEN D'ANESTHÉSIE
  • 1997-03. Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients in INTENSIVE CARE MEDICINE
  • 2010-11-19. Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma in CRITICAL CARE
  • 2017-03-17. Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission in ANNALS OF INTENSIVE CARE
  • 2012-06-15. Candida spp. airway colonization could promote antibiotic-resistant bacteria selection in patients with suspected ventilator-associated pneumonia in INTENSIVE CARE MEDICINE
  • 2011-06-20. Short term Candida albicans colonization reduces Pseudomonas aeruginosa-related lung injury and bacterial burden in a murine model in CRITICAL CARE
  • 2015-12-01. Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock in CRITICAL CARE
  • 2011-03-11. Immunity to fungal infections in NATURE REVIEWS IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-019-05622-0

    DOI

    http://dx.doi.org/10.1007/s00134-019-05622-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113668390

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31020361


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bronchi", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Candida", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Candidiasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "France", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organ Dysfunction Scores", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pneumonia, Ventilator-Associated", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Simplified Acute Physiology Score", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "INSERM, IAME UMR 1137, Paris-Diderot Sorbonne-Paris Cit\u00e9 University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.7429.8", 
              "name": [
                "Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, Paris, France", 
                "INSERM, IAME UMR 1137, Paris-Diderot Sorbonne-Paris Cit\u00e9 University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Timsit", 
            "givenName": "Jean-Francois", 
            "id": "sg:person.01215000253.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215000253.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Albert Michallon University Hospital, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.410529.b", 
              "name": [
                "Medical ICU, Albert Michallon University Hospital, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schwebel", 
            "givenName": "Carole", 
            "id": "sg:person.01056561220.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056561220.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "OUTCOMEREA Network, Aulnay Sous Bois, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "OUTCOMEREA Network, Aulnay Sous Bois, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Styfalova", 
            "givenName": "Lenka", 
            "id": "sg:person.016467361041.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016467361041.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Engineering, Univ. Grenoble Alpes, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.450307.5", 
              "name": [
                "Univ. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP, TIMC-IMAG, 38000, Grenoble, France", 
                "Institute of Engineering, Univ. Grenoble Alpes, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cornet", 
            "givenName": "Muriel", 
            "id": "sg:person.01334256475.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334256475.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratoire de Parasitologie-Mycologie, CHU Clermont-Ferrand, CNRS, Universit\u00e9 Clermont Auvergne, 63000, Clermont-Ferrand, France", 
              "id": "http://www.grid.ac/institutes/grid.411163.0", 
              "name": [
                "Laboratoire de Parasitologie-Mycologie, CHU Clermont-Ferrand, CNRS, Universit\u00e9 Clermont Auvergne, 63000, Clermont-Ferrand, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poirier", 
            "givenName": "Philippe", 
            "id": "sg:person.0762720175.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762720175.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Clermont Auvergne, UMR CNRS 6023, Clermont-Ferrand, France", 
              "id": "http://www.grid.ac/institutes/grid.494717.8", 
              "name": [
                "Universit\u00e9 Clermont Auvergne, UMR CNRS 6023, Clermont-Ferrand, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Forrestier", 
            "givenName": "Christiane", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "OUTCOMEREA Network, Aulnay Sous Bois, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "INSERM, IAME UMR 1137, Paris-Diderot Sorbonne-Paris Cit\u00e9 University, Paris, France", 
                "OUTCOMEREA Network, Aulnay Sous Bois, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruckly", 
            "givenName": "St\u00e9phane", 
            "id": "sg:person.01013767315.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013767315.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences,, Universit\u00e9 Grenoble Alpes,, 38700, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.418110.d", 
              "name": [
                "Department of Immunology, Grenoble-Alpes University Hospital (CHUGA) 38700 Grenoble, France", 
                "INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences,, Universit\u00e9 Grenoble Alpes,, 38700, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jacob", 
            "givenName": "Marie-Christine", 
            "id": "sg:person.01300546406.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300546406.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Gabriel-Montpied University Hospital,, Clermont-Ferrand,, France", 
              "id": "http://www.grid.ac/institutes/grid.411163.0", 
              "name": [
                "Medical ICU, Gabriel-Montpied University Hospital,, Clermont-Ferrand,, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Souweine", 
            "givenName": "Bertrand", 
            "id": "sg:person.01324422064.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324422064.31"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-010-1962-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029269757", 
              "https://doi.org/10.1007/s00134-010-1962-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-015-1144-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021032710", 
              "https://doi.org/10.1186/s13054-015-1144-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0242-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252528", 
              "https://doi.org/10.1186/s13613-017-0242-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1482-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052801059", 
              "https://doi.org/10.1007/s00134-009-1482-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc13056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027484617", 
              "https://doi.org/10.1186/cc13056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12630-010-9439-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003835127", 
              "https://doi.org/10.1007/s12630-010-9439-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-012-2584-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001590750", 
              "https://doi.org/10.1007/s00134-012-2584-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc9331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042889631", 
              "https://doi.org/10.1186/cc9331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc10276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008807571", 
              "https://doi.org/10.1186/cc10276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032401309", 
              "https://doi.org/10.1038/nri3552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001340050334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029942748", 
              "https://doi.org/10.1007/s001340050334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneph.2017.165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099637595", 
              "https://doi.org/10.1038/nrneph.2017.165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-004-2316-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039674083", 
              "https://doi.org/10.1007/s00134-004-2316-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-014-3352-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001966514", 
              "https://doi.org/10.1007/s00134-014-3352-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4988-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092912436", 
              "https://doi.org/10.1007/s00134-017-4988-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010622156", 
              "https://doi.org/10.1038/nri2939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0422-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019331264", 
              "https://doi.org/10.1007/s00134-006-0422-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-24", 
        "datePublishedReg": "2019-04-24", 
        "description": "IntroductionRespiratory tract Candida spp. colonization is associated with more frequent bacterial ventilator-associated pneumonia (VAP). However, this colonization could be causally related to VAP or simply reflect the immune paralysis associated with multiple organ failure.ObjectiveTo prospectively evaluate the relationship between Candida spp. colonization and bacterial VAP in mechanically ventilated patients with multiple organ failure.InclusionPatients receiving mechanical ventilation for\u2009>\u20094\u00a0days and presenting multiple organ failure were included. Tracheal colonization with Candida spp. was evaluated at inclusion (day 0, D0) and every 4\u00a0days until extubation. Quantitative proximal and tracheal cultures were performed at each VAP episode. Monocyte human leukocyte antigen-DR isotype (mHLA-DR) expression and the ratio of polymononuclear leukocytes to lymphocytes were used to evaluate immunoparalysis at D0 and D7. The relationship between fungal colonization and VAP was modelled using cause-specific models for repeated events with adjustment for time-dependent confounders and immune factors.ResultsA total of 213 patients, with a median age of 64, simplified acute physiology score II (SAPS II) score 55 and sequential organ failure assessment (SOFA) score 10, mainly admitted for medical reasons (n\u2009=\u2009197, 92%), were enrolled in 2012\u20132015. The median ICU stay was 24\u00a0days and the mortality rate was 32% (69 cases). Median mHLA-DR was 5916 Ab-bound/cell [3863\u20138934]; median lymphocyte count, 0.9Giga/L [0.6\u20131.3]; neutrophil-to-lymphocyte ratio, 10.9 [6.5\u201319.7]. Overall, 146 cases (68.5%) had tracheal colonization with Candida spp. An episode of VAP occurred (either for the first or only time) in 62 (29.1%) cases 5.5\u00a0days (median) after D0; a second episode occurred in 12 (5.6%) cases, 15.5\u00a0days (median) after D0. After adjustment, bronchial colonization with Candida was not associated with VAP [adjusted cause-specific hazard ratio\u2009=\u20090.98 (0.59\u20131.65), p\u2009=\u20090.95].ConclusionIn patients with mechanical ventilation for more than 4\u00a0days and multiple organ failure, bronchial colonization with Candida spp. was not associated with VAP, even after adjustment for immune function.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00134-019-05622-0", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1313639", 
            "issn": [
              "0342-4642", 
              "1432-1238"
            ], 
            "name": "Intensive Care Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "keywords": [
          "ventilator-associated pneumonia", 
          "multiple organ failure", 
          "bacterial ventilator-associated pneumonia", 
          "organ failure", 
          "bronchial colonization", 
          "Candida spp", 
          "mechanical ventilation", 
          "tracheal colonization", 
          "episodes of VAP", 
          "Acute Physiology Score II", 
          "median ICU stay", 
          "median lymphocyte count", 
          "prospective cohort study", 
          "cause-specific model", 
          "time-dependent confounders", 
          "ICU stay", 
          "mHLA-DR", 
          "Score II", 
          "ConclusionIn patients", 
          "immune paralysis", 
          "lymphocyte count", 
          "cohort study", 
          "VAP episodes", 
          "median age", 
          "lymphocyte ratio", 
          "ResultsA total", 
          "immune factors", 
          "score 10", 
          "immune function", 
          "tracheal cultures", 
          "medical reasons", 
          "mortality rate", 
          "isotype expression", 
          "patients", 
          "second episode", 
          "pneumonia", 
          "episodes", 
          "days", 
          "ventilation", 
          "failure", 
          "polymononuclear leukocytes", 
          "extubation", 
          "immunoparalysis", 
          "ICU", 
          "stay", 
          "confounders", 
          "adjustment", 
          "lymphocytes", 
          "ObjectiveTo", 
          "neutrophils", 
          "paralysis", 
          "leukocytes", 
          "colonization", 
          "age", 
          "total", 
          "risk", 
          "cases", 
          "spp", 
          "count", 
          "D7", 
          "Candida", 
          "cells", 
          "expression", 
          "fungal colonization", 
          "Ab", 
          "factors", 
          "relationship", 
          "study", 
          "ratio", 
          "rate", 
          "events", 
          "D0", 
          "culture", 
          "function", 
          "inclusion", 
          "reasons", 
          "impact", 
          "model"
        ], 
        "name": "Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study", 
        "pagination": "834-843", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113668390"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00134-019-05622-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31020361"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00134-019-05622-0", 
          "https://app.dimensions.ai/details/publication/pub.1113668390"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-06-01T22:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_803.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00134-019-05622-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05622-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05622-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05622-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05622-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    351 TRIPLES      22 PREDICATES      137 URIs      112 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00134-019-05622-0 schema:about N1b70f627c5d34f73a83938398bf9a7d3
    2 N32644a9bfc7649a0acc513968e546146
    3 N337fcc2425524e4bb38dfb0a1b20d972
    4 N4b5bad292d014d4ab3d1f32fa71d6bdc
    5 N741e4ffafcb74a48986453ff69786e0f
    6 N8e815d9b9a4b4f56a2dbbdcc05f75e13
    7 Na33d1d2849ba44dfaf744effd7dfc5c2
    8 Na4eaf53a0aa84a77a1f1ebab7478b324
    9 Nab76a8553d674d91890ba89d3b4a5e40
    10 Nacd04ee6f0a344d9a21e124c83068dd8
    11 Nbc9a8d3bde90422d85466ded502999fe
    12 Nbd3f95ee577c4c9087a5454cd802a250
    13 Nbdfd51f80524405cb3e2d2d230810e7f
    14 Nfa896bf7881b46f589ccdf59c8e319e2
    15 Nfb91ce75785846fd932db24eb9193f98
    16 Nfcacb62cb31642c39e96c6f7afe79217
    17 anzsrc-for:11
    18 anzsrc-for:1107
    19 schema:author Nd17a1f07b5a848a2b78dabd55f6e466d
    20 schema:citation sg:pub.10.1007/s00134-004-2316-3
    21 sg:pub.10.1007/s00134-006-0422-0
    22 sg:pub.10.1007/s00134-009-1482-8
    23 sg:pub.10.1007/s00134-010-1962-x
    24 sg:pub.10.1007/s00134-012-2584-2
    25 sg:pub.10.1007/s00134-014-3352-2
    26 sg:pub.10.1007/s00134-017-4988-5
    27 sg:pub.10.1007/s001340050334
    28 sg:pub.10.1007/s12630-010-9439-5
    29 sg:pub.10.1038/nri2939
    30 sg:pub.10.1038/nri3552
    31 sg:pub.10.1038/nrneph.2017.165
    32 sg:pub.10.1186/cc10276
    33 sg:pub.10.1186/cc13056
    34 sg:pub.10.1186/cc9331
    35 sg:pub.10.1186/s13054-015-1144-x
    36 sg:pub.10.1186/s13613-017-0242-0
    37 schema:datePublished 2019-04-24
    38 schema:datePublishedReg 2019-04-24
    39 schema:description IntroductionRespiratory tract Candida spp. colonization is associated with more frequent bacterial ventilator-associated pneumonia (VAP). However, this colonization could be causally related to VAP or simply reflect the immune paralysis associated with multiple organ failure.ObjectiveTo prospectively evaluate the relationship between Candida spp. colonization and bacterial VAP in mechanically ventilated patients with multiple organ failure.InclusionPatients receiving mechanical ventilation for > 4 days and presenting multiple organ failure were included. Tracheal colonization with Candida spp. was evaluated at inclusion (day 0, D0) and every 4 days until extubation. Quantitative proximal and tracheal cultures were performed at each VAP episode. Monocyte human leukocyte antigen-DR isotype (mHLA-DR) expression and the ratio of polymononuclear leukocytes to lymphocytes were used to evaluate immunoparalysis at D0 and D7. The relationship between fungal colonization and VAP was modelled using cause-specific models for repeated events with adjustment for time-dependent confounders and immune factors.ResultsA total of 213 patients, with a median age of 64, simplified acute physiology score II (SAPS II) score 55 and sequential organ failure assessment (SOFA) score 10, mainly admitted for medical reasons (n = 197, 92%), were enrolled in 2012–2015. The median ICU stay was 24 days and the mortality rate was 32% (69 cases). Median mHLA-DR was 5916 Ab-bound/cell [3863–8934]; median lymphocyte count, 0.9Giga/L [0.6–1.3]; neutrophil-to-lymphocyte ratio, 10.9 [6.5–19.7]. Overall, 146 cases (68.5%) had tracheal colonization with Candida spp. An episode of VAP occurred (either for the first or only time) in 62 (29.1%) cases 5.5 days (median) after D0; a second episode occurred in 12 (5.6%) cases, 15.5 days (median) after D0. After adjustment, bronchial colonization with Candida was not associated with VAP [adjusted cause-specific hazard ratio = 0.98 (0.59–1.65), p = 0.95].ConclusionIn patients with mechanical ventilation for more than 4 days and multiple organ failure, bronchial colonization with Candida spp. was not associated with VAP, even after adjustment for immune function.
    40 schema:genre article
    41 schema:inLanguage en
    42 schema:isAccessibleForFree true
    43 schema:isPartOf N249191bbfaf44de18755db197b065876
    44 N39970da83c3a43f89cd838f109f5df5e
    45 sg:journal.1313639
    46 schema:keywords Ab
    47 Acute Physiology Score II
    48 Candida
    49 Candida spp
    50 ConclusionIn patients
    51 D0
    52 D7
    53 ICU
    54 ICU stay
    55 ObjectiveTo
    56 ResultsA total
    57 Score II
    58 VAP episodes
    59 adjustment
    60 age
    61 bacterial ventilator-associated pneumonia
    62 bronchial colonization
    63 cases
    64 cause-specific model
    65 cells
    66 cohort study
    67 colonization
    68 confounders
    69 count
    70 culture
    71 days
    72 episodes
    73 episodes of VAP
    74 events
    75 expression
    76 extubation
    77 factors
    78 failure
    79 function
    80 fungal colonization
    81 immune factors
    82 immune function
    83 immune paralysis
    84 immunoparalysis
    85 impact
    86 inclusion
    87 isotype expression
    88 leukocytes
    89 lymphocyte count
    90 lymphocyte ratio
    91 lymphocytes
    92 mHLA-DR
    93 mechanical ventilation
    94 median ICU stay
    95 median age
    96 median lymphocyte count
    97 medical reasons
    98 model
    99 mortality rate
    100 multiple organ failure
    101 neutrophils
    102 organ failure
    103 paralysis
    104 patients
    105 pneumonia
    106 polymononuclear leukocytes
    107 prospective cohort study
    108 rate
    109 ratio
    110 reasons
    111 relationship
    112 risk
    113 score 10
    114 second episode
    115 spp
    116 stay
    117 study
    118 time-dependent confounders
    119 total
    120 tracheal colonization
    121 tracheal cultures
    122 ventilation
    123 ventilator-associated pneumonia
    124 schema:name Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study
    125 schema:pagination 834-843
    126 schema:productId N445e7cb3021f48de9c14e613028d0ec5
    127 N66e9a8d0d6f14a5aa631d9315d455e23
    128 N7ea947d16d344c47a0607ca223b4be30
    129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113668390
    130 https://doi.org/10.1007/s00134-019-05622-0
    131 schema:sdDatePublished 2022-06-01T22:20
    132 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    133 schema:sdPublisher N0a9faea139824a15a4079f51dbe0ebb9
    134 schema:url https://doi.org/10.1007/s00134-019-05622-0
    135 sgo:license sg:explorer/license/
    136 sgo:sdDataset articles
    137 rdf:type schema:ScholarlyArticle
    138 N015a75cad3a64e3d967c8b3a91e140b7 schema:affiliation grid-institutes:grid.494717.8
    139 schema:familyName Forrestier
    140 schema:givenName Christiane
    141 rdf:type schema:Person
    142 N0a9faea139824a15a4079f51dbe0ebb9 schema:name Springer Nature - SN SciGraph project
    143 rdf:type schema:Organization
    144 N182c9647eb564847876c9ad942c535e1 rdf:first sg:person.016467361041.18
    145 rdf:rest N6a370da467f74461973943f1af730d70
    146 N1b70f627c5d34f73a83938398bf9a7d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Cohort Studies
    148 rdf:type schema:DefinedTerm
    149 N249191bbfaf44de18755db197b065876 schema:issueNumber 6
    150 rdf:type schema:PublicationIssue
    151 N32644a9bfc7649a0acc513968e546146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Bronchi
    153 rdf:type schema:DefinedTerm
    154 N337fcc2425524e4bb38dfb0a1b20d972 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Pneumonia, Ventilator-Associated
    156 rdf:type schema:DefinedTerm
    157 N39970da83c3a43f89cd838f109f5df5e schema:volumeNumber 45
    158 rdf:type schema:PublicationVolume
    159 N445e7cb3021f48de9c14e613028d0ec5 schema:name pubmed_id
    160 schema:value 31020361
    161 rdf:type schema:PropertyValue
    162 N4b5bad292d014d4ab3d1f32fa71d6bdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Candidiasis
    164 rdf:type schema:DefinedTerm
    165 N66e9a8d0d6f14a5aa631d9315d455e23 schema:name dimensions_id
    166 schema:value pub.1113668390
    167 rdf:type schema:PropertyValue
    168 N6a370da467f74461973943f1af730d70 rdf:first sg:person.01334256475.46
    169 rdf:rest Nf73d23cd41cc4accafd733f5b7c6bbd8
    170 N741e4ffafcb74a48986453ff69786e0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Intensive Care Units
    172 rdf:type schema:DefinedTerm
    173 N7ea947d16d344c47a0607ca223b4be30 schema:name doi
    174 schema:value 10.1007/s00134-019-05622-0
    175 rdf:type schema:PropertyValue
    176 N8e815d9b9a4b4f56a2dbbdcc05f75e13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Prospective Studies
    178 rdf:type schema:DefinedTerm
    179 N9194dc47b43349c390673c5bcd6a50a5 rdf:first sg:person.01300546406.72
    180 rdf:rest Nf8a6f743fd0743eb96a892d121d2ec2f
    181 Na33d1d2849ba44dfaf744effd7dfc5c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Simplified Acute Physiology Score
    183 rdf:type schema:DefinedTerm
    184 Na4eaf53a0aa84a77a1f1ebab7478b324 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Adult
    186 rdf:type schema:DefinedTerm
    187 Nab76a8553d674d91890ba89d3b4a5e40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Risk Factors
    189 rdf:type schema:DefinedTerm
    190 Nacd04ee6f0a344d9a21e124c83068dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Humans
    192 rdf:type schema:DefinedTerm
    193 Nadbeb87c54304f46b480f6a6f036287d rdf:first N015a75cad3a64e3d967c8b3a91e140b7
    194 rdf:rest Nc6e8952ce0fb465884b3024baa1e808b
    195 Nb2941a4703dd47308e566d8074b61a23 rdf:first sg:person.01056561220.01
    196 rdf:rest N182c9647eb564847876c9ad942c535e1
    197 Nbc9a8d3bde90422d85466ded502999fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Male
    199 rdf:type schema:DefinedTerm
    200 Nbd3f95ee577c4c9087a5454cd802a250 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Candida
    202 rdf:type schema:DefinedTerm
    203 Nbdfd51f80524405cb3e2d2d230810e7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name France
    205 rdf:type schema:DefinedTerm
    206 Nc6e8952ce0fb465884b3024baa1e808b rdf:first sg:person.01013767315.45
    207 rdf:rest N9194dc47b43349c390673c5bcd6a50a5
    208 Nd17a1f07b5a848a2b78dabd55f6e466d rdf:first sg:person.01215000253.20
    209 rdf:rest Nb2941a4703dd47308e566d8074b61a23
    210 Nf73d23cd41cc4accafd733f5b7c6bbd8 rdf:first sg:person.0762720175.41
    211 rdf:rest Nadbeb87c54304f46b480f6a6f036287d
    212 Nf8a6f743fd0743eb96a892d121d2ec2f rdf:first sg:person.01324422064.31
    213 rdf:rest rdf:nil
    214 Nfa896bf7881b46f589ccdf59c8e319e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Middle Aged
    216 rdf:type schema:DefinedTerm
    217 Nfb91ce75785846fd932db24eb9193f98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Female
    219 rdf:type schema:DefinedTerm
    220 Nfcacb62cb31642c39e96c6f7afe79217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Organ Dysfunction Scores
    222 rdf:type schema:DefinedTerm
    223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    224 schema:name Medical and Health Sciences
    225 rdf:type schema:DefinedTerm
    226 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    227 schema:name Immunology
    228 rdf:type schema:DefinedTerm
    229 sg:journal.1313639 schema:issn 0342-4642
    230 1432-1238
    231 schema:name Intensive Care Medicine
    232 schema:publisher Springer Nature
    233 rdf:type schema:Periodical
    234 sg:person.01013767315.45 schema:affiliation grid-institutes:None
    235 schema:familyName Ruckly
    236 schema:givenName Stéphane
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013767315.45
    238 rdf:type schema:Person
    239 sg:person.01056561220.01 schema:affiliation grid-institutes:grid.410529.b
    240 schema:familyName Schwebel
    241 schema:givenName Carole
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056561220.01
    243 rdf:type schema:Person
    244 sg:person.01215000253.20 schema:affiliation grid-institutes:grid.7429.8
    245 schema:familyName Timsit
    246 schema:givenName Jean-Francois
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215000253.20
    248 rdf:type schema:Person
    249 sg:person.01300546406.72 schema:affiliation grid-institutes:grid.418110.d
    250 schema:familyName Jacob
    251 schema:givenName Marie-Christine
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300546406.72
    253 rdf:type schema:Person
    254 sg:person.01324422064.31 schema:affiliation grid-institutes:grid.411163.0
    255 schema:familyName Souweine
    256 schema:givenName Bertrand
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324422064.31
    258 rdf:type schema:Person
    259 sg:person.01334256475.46 schema:affiliation grid-institutes:grid.450307.5
    260 schema:familyName Cornet
    261 schema:givenName Muriel
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334256475.46
    263 rdf:type schema:Person
    264 sg:person.016467361041.18 schema:affiliation grid-institutes:None
    265 schema:familyName Styfalova
    266 schema:givenName Lenka
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016467361041.18
    268 rdf:type schema:Person
    269 sg:person.0762720175.41 schema:affiliation grid-institutes:grid.411163.0
    270 schema:familyName Poirier
    271 schema:givenName Philippe
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762720175.41
    273 rdf:type schema:Person
    274 sg:pub.10.1007/s00134-004-2316-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039674083
    275 https://doi.org/10.1007/s00134-004-2316-3
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/s00134-006-0422-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019331264
    278 https://doi.org/10.1007/s00134-006-0422-0
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/s00134-009-1482-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052801059
    281 https://doi.org/10.1007/s00134-009-1482-8
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/s00134-010-1962-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029269757
    284 https://doi.org/10.1007/s00134-010-1962-x
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/s00134-012-2584-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001590750
    287 https://doi.org/10.1007/s00134-012-2584-2
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s00134-014-3352-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001966514
    290 https://doi.org/10.1007/s00134-014-3352-2
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s00134-017-4988-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092912436
    293 https://doi.org/10.1007/s00134-017-4988-5
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s001340050334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029942748
    296 https://doi.org/10.1007/s001340050334
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s12630-010-9439-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003835127
    299 https://doi.org/10.1007/s12630-010-9439-5
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nri2939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010622156
    302 https://doi.org/10.1038/nri2939
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/nri3552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032401309
    305 https://doi.org/10.1038/nri3552
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/nrneph.2017.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099637595
    308 https://doi.org/10.1038/nrneph.2017.165
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1186/cc10276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008807571
    311 https://doi.org/10.1186/cc10276
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1186/cc13056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027484617
    314 https://doi.org/10.1186/cc13056
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1186/cc9331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042889631
    317 https://doi.org/10.1186/cc9331
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1186/s13054-015-1144-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021032710
    320 https://doi.org/10.1186/s13054-015-1144-x
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1186/s13613-017-0242-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252528
    323 https://doi.org/10.1186/s13613-017-0242-0
    324 rdf:type schema:CreativeWork
    325 grid-institutes:None schema:alternateName OUTCOMEREA Network, Aulnay Sous Bois, France
    326 schema:name INSERM, IAME UMR 1137, Paris-Diderot Sorbonne-Paris Cité University, Paris, France
    327 OUTCOMEREA Network, Aulnay Sous Bois, France
    328 rdf:type schema:Organization
    329 grid-institutes:grid.410529.b schema:alternateName Medical ICU, Albert Michallon University Hospital, Grenoble, France
    330 schema:name Medical ICU, Albert Michallon University Hospital, Grenoble, France
    331 rdf:type schema:Organization
    332 grid-institutes:grid.411163.0 schema:alternateName Laboratoire de Parasitologie-Mycologie, CHU Clermont-Ferrand, CNRS, Université Clermont Auvergne, 63000, Clermont-Ferrand, France
    333 Medical ICU, Gabriel-Montpied University Hospital,, Clermont-Ferrand,, France
    334 schema:name Laboratoire de Parasitologie-Mycologie, CHU Clermont-Ferrand, CNRS, Université Clermont Auvergne, 63000, Clermont-Ferrand, France
    335 Medical ICU, Gabriel-Montpied University Hospital,, Clermont-Ferrand,, France
    336 rdf:type schema:Organization
    337 grid-institutes:grid.418110.d schema:alternateName INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences,, Université Grenoble Alpes,, 38700, Grenoble, France
    338 schema:name Department of Immunology, Grenoble-Alpes University Hospital (CHUGA) 38700 Grenoble, France
    339 INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences,, Université Grenoble Alpes,, 38700, Grenoble, France
    340 rdf:type schema:Organization
    341 grid-institutes:grid.450307.5 schema:alternateName Institute of Engineering, Univ. Grenoble Alpes, Grenoble, France
    342 schema:name Institute of Engineering, Univ. Grenoble Alpes, Grenoble, France
    343 Univ. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP, TIMC-IMAG, 38000, Grenoble, France
    344 rdf:type schema:Organization
    345 grid-institutes:grid.494717.8 schema:alternateName Université Clermont Auvergne, UMR CNRS 6023, Clermont-Ferrand, France
    346 schema:name Université Clermont Auvergne, UMR CNRS 6023, Clermont-Ferrand, France
    347 rdf:type schema:Organization
    348 grid-institutes:grid.7429.8 schema:alternateName INSERM, IAME UMR 1137, Paris-Diderot Sorbonne-Paris Cité University, Paris, France
    349 schema:name INSERM, IAME UMR 1137, Paris-Diderot Sorbonne-Paris Cité University, Paris, France
    350 Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, Paris, France
    351 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...