A multicentre controlled pre–post trial of an implementation science intervention to improve venous thromboembolism prophylaxis in critically ill patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Henry T. Stelfox, Rebecca Brundin-Mather, Andrea Soo, Jeanna Parsons Leigh, Daniel J. Niven, Kirsten M. Fiest, Christopher James Doig, Danny J. Zuege, Barry Kushner, Fiona Clement, Sharon E. Straus, Deborah J. Cook, Sean M. Bagshaw, Khara M. Sauro

ABSTRACT

PURPOSE: To test whether a multicomponent intervention would increase the use of low molecular weight heparin (LMWH) over unfractionated heparin (UFH) for venous thromboembolism (VTE) prophylaxis in critically ill patients and change patient outcomes and healthcare utilization. METHODS: Controlled pre-post trial of 12,342 adults admitted to 11 ICUs (five intervention, six control) May 1, 2015 to April 30, 2017 with no contraindication to pharmacological prophylaxis and an ICU stay longer than 24 h. Models were developed to examine temporal changes in ICU VTE prophylaxis (primary outcome), VTE, major bleeding, heparin-induced thrombocytopenia (HIT), death and hospital costs. RESULTS: The use of LMWH increased from 45.9% to 78.3% of patient days in the intervention group and from 37.9% to 53.3% in the control group, an absolute increase difference of 17.0% (32.4% vs. 15.4%, p = 0.001). Changes in the administration of UFH were inversely related to those of LMWH. There were no significant differences in the adjusted odds of VTE (ratio of odds ratios [rOR] 1.13, 95% CI 0.51-2.46) or major bleeding (rOR 1.22, 95% CI 0.97-1.54) post-implementation of the intervention (compared to pre-implementation) between the intervention group and the control group. HIT was uncommon in both groups (n = 20 patients). There were no significant changes for ICU and hospital mortality, length of stay and costs. Results were similar when stratified according to reason for ICU admission, patient weight and kidney function. CONCLUSIONS: A multicomponent intervention changed practice, but not clinical and economic outcomes. The benefit of implementing LMWH for VTE prophylaxis under real-world conditions is uncertain. More... »

PAGES

1-12

References to SciGraph publications

  • 2014-04. Thromboprophylaxis patterns and determinants in critically ill patients: a multicenter audit in CRITICAL CARE
  • 2016-03. Critical care transition programs and the risk of readmission or death after discharge from ICU in INTENSIVE CARE MEDICINE
  • 2016-02. Prophylaxis of Venous Thrombosis in Neurocritical Care Patients: An Evidence-Based Guideline: A Statement for Healthcare Professionals from the Neurocritical Care Society in NEUROCRITICAL CARE
  • 2017-03. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 in INTENSIVE CARE MEDICINE
  • 2017-03. Practice guidelines as implementation science: the journal editorsʼ perspective in INTENSIVE CARE MEDICINE
  • 2012-12. Developing theory-informed behaviour change interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework in IMPLEMENTATION SCIENCE
  • 2019-04. Venous Thromboembolism Prophylaxis in Neurocritical Care Patients: Are Current Practices, Best Practices? in NEUROCRITICAL CARE
  • 2014-11. PROF-ETEV study: prophylaxis of venous thromboembolic disease in critical care units in Spain in INTENSIVE CARE MEDICINE
  • 2014-12. Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial in TRIALS
  • 2015-12. Towards understanding the de-adoption of low-value clinical practices: a scoping review in BMC MEDICINE
  • 2018-12. Reproducibility of clinical research in critical care: a scoping review in BMC MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-019-05532-1

    DOI

    http://dx.doi.org/10.1007/s00134-019-05532-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111836762

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30707246


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Alberta Health Services", 
              "id": "https://www.grid.ac/institutes/grid.413574.0", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada", 
                "Alberta Health Services, Calgary, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stelfox", 
            "givenName": "Henry T.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "W21C Research and Innovation Centre, University of Calgary, Calgary, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brundin-Mather", 
            "givenName": "Rebecca", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alberta Health Services", 
              "id": "https://www.grid.ac/institutes/grid.413574.0", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Alberta Health Services, Calgary, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soo", 
            "givenName": "Andrea", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parsons Leigh", 
            "givenName": "Jeanna", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niven", 
            "givenName": "Daniel J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fiest", 
            "givenName": "Kirsten M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alberta Health Services", 
              "id": "https://www.grid.ac/institutes/grid.413574.0", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada", 
                "Alberta Health Services, Calgary, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doig", 
            "givenName": "Christopher James", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alberta Health Services", 
              "id": "https://www.grid.ac/institutes/grid.413574.0", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Alberta Health Services, Calgary, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zuege", 
            "givenName": "Danny J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alberta Health Services", 
              "id": "https://www.grid.ac/institutes/grid.413574.0", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Alberta Health Services, Calgary, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kushner", 
            "givenName": "Barry", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clement", 
            "givenName": "Fiona", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, Toronto, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Straus", 
            "givenName": "Sharon E.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Deparment of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cook", 
            "givenName": "Deborah J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alberta", 
              "id": "https://www.grid.ac/institutes/grid.17089.37", 
              "name": [
                "Department of Critical Care Medicine, Faculty of Medicine and Dentistry, and the School of Public Health, University of Alberta, Edmonton, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bagshaw", 
            "givenName": "Sean M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada", 
                "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sauro", 
            "givenName": "Khara M.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.jclinepi.2013.03.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003156170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jclinepi.2013.03.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003156170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0000000000002255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003204236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0000000000002255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003204236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1014475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003502724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2016.0154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003581306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4683-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003731534", 
              "https://doi.org/10.1007/s00134-017-4683-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4683-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003731534", 
              "https://doi.org/10.1007/s00134-017-4683-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0006-341x.2001.00126.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005090909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0006-341x.2001.00126.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005090909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-014-3442-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005788532", 
              "https://doi.org/10.1007/s00134-014-3442-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-4173-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009025697", 
              "https://doi.org/10.1007/s00134-015-4173-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1745-6215-15-502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012768838", 
              "https://doi.org/10.1186/1745-6215-15-502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc13844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013074945", 
              "https://doi.org/10.1186/cc13844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.g1687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015461169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2016.3463", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016128238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamainternmed.2015.0157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016419787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4680-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017279745", 
              "https://doi.org/10.1007/s00134-017-4680-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4680-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017279745", 
              "https://doi.org/10.1007/s00134-017-4680-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1000098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021380586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamainternmed.2013.6521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026097386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.161.10.1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027301461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201608-1690st", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028077908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1748-5908-7-38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032986659", 
              "https://doi.org/10.1186/1748-5908-7-38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12916-015-0488-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033095397", 
              "https://doi.org/10.1186/s12916-015-0488-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3182982b03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035460606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3182982b03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035460606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2014.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037400485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0140141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038927560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.11-2296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039499818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31828cf104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039685186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31828cf104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039685186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2011/505373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041959260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2710.2002.00430.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044028133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-015-0221-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044239808", 
              "https://doi.org/10.1007/s12028-015-0221-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201407-1317st", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044838635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jth.13140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048045194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0000000000002256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048287045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0000000000002256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048287045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0160947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051501612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18637/jss.v015.i02", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068672224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2105/ajph.94.3.361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068879488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.i6795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084224501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.i6795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084224501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/hex.12576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085730495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12916-018-1018-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101116843", 
              "https://doi.org/10.1186/s12916-018-1018-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12916-018-1018-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101116843", 
              "https://doi.org/10.1186/s12916-018-1018-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12916-018-1018-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101116843", 
              "https://doi.org/10.1186/s12916-018-1018-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd008201.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103611750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2018.07.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105764663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamainternmed.2018.3675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106253953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-018-0614-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107333958", 
              "https://doi.org/10.1007/s12028-018-0614-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-018-0614-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107333958", 
              "https://doi.org/10.1007/s12028-018-0614-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-018-0614-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107333958", 
              "https://doi.org/10.1007/s12028-018-0614-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2018.11.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110259403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2018.11.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110259403"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-02", 
        "datePublishedReg": "2019-02-01", 
        "description": "PURPOSE: To test whether a multicomponent intervention would increase the use of low molecular weight heparin (LMWH) over unfractionated heparin (UFH) for venous thromboembolism (VTE) prophylaxis in critically ill patients and change patient outcomes and healthcare utilization.\nMETHODS: Controlled pre-post trial of 12,342 adults admitted to 11 ICUs (five intervention, six control) May 1, 2015 to April 30, 2017 with no contraindication to pharmacological prophylaxis and an ICU stay longer than 24\u00a0h. Models were developed to examine temporal changes in ICU VTE prophylaxis (primary outcome), VTE, major bleeding, heparin-induced thrombocytopenia (HIT), death and hospital costs.\nRESULTS: The use of LMWH increased from 45.9% to 78.3% of patient days in the intervention group and from 37.9% to 53.3% in the control group, an absolute increase difference of 17.0% (32.4% vs. 15.4%, p\u2009=\u20090.001). Changes in the administration of UFH were inversely related to those of LMWH. There were no significant differences in the adjusted odds of VTE (ratio of odds ratios [rOR] 1.13, 95% CI 0.51-2.46) or major bleeding (rOR 1.22, 95% CI 0.97-1.54) post-implementation of the intervention (compared to pre-implementation) between the intervention group and the control group. HIT was uncommon in both groups (n\u2009=\u200920 patients). There were no significant changes for ICU and hospital mortality, length of stay and costs. Results were similar when stratified according to reason for ICU admission, patient weight and kidney function.\nCONCLUSIONS: A multicomponent intervention changed practice, but not clinical and economic outcomes. The benefit of implementing LMWH for VTE prophylaxis under real-world conditions is uncertain.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00134-019-05532-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1313639", 
            "issn": [
              "0342-4642", 
              "1432-1238"
            ], 
            "name": "Intensive Care Medicine", 
            "type": "Periodical"
          }
        ], 
        "name": "A multicentre controlled pre\u2013post trial of an implementation science intervention to improve venous thromboembolism prophylaxis in critically ill patients", 
        "pagination": "1-12", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6cd95d2f104af0951bb91d7c8d3ee0b9e33d4d6fb700773a3bf946d2822450c2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30707246"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7704851"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00134-019-05532-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111836762"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00134-019-05532-1", 
          "https://app.dimensions.ai/details/publication/pub.1111836762"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000327_0000000327/records_114973_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00134-019-05532-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05532-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05532-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05532-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-019-05532-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    293 TRIPLES      21 PREDICATES      69 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00134-019-05532-1 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author N89d403def4834cc39856f5b20ad97c9f
    4 schema:citation sg:pub.10.1007/s00134-014-3442-1
    5 sg:pub.10.1007/s00134-015-4173-7
    6 sg:pub.10.1007/s00134-017-4680-9
    7 sg:pub.10.1007/s00134-017-4683-6
    8 sg:pub.10.1007/s12028-015-0221-y
    9 sg:pub.10.1007/s12028-018-0614-9
    10 sg:pub.10.1186/1745-6215-15-502
    11 sg:pub.10.1186/1748-5908-7-38
    12 sg:pub.10.1186/cc13844
    13 sg:pub.10.1186/s12916-015-0488-z
    14 sg:pub.10.1186/s12916-018-1018-6
    15 https://doi.org/10.1001/archinte.161.10.1268
    16 https://doi.org/10.1001/jama.2016.0154
    17 https://doi.org/10.1001/jama.2016.3463
    18 https://doi.org/10.1001/jamainternmed.2013.6521
    19 https://doi.org/10.1001/jamainternmed.2015.0157
    20 https://doi.org/10.1001/jamainternmed.2018.3675
    21 https://doi.org/10.1002/14651858.cd008201.pub3
    22 https://doi.org/10.1016/j.jclinepi.2013.03.016
    23 https://doi.org/10.1016/j.jcrc.2014.01.017
    24 https://doi.org/10.1016/j.jcrc.2018.07.021
    25 https://doi.org/10.1016/j.jcrc.2018.11.023
    26 https://doi.org/10.1046/j.1365-2710.2002.00430.x
    27 https://doi.org/10.1056/nejmoa1014475
    28 https://doi.org/10.1097/ccm.0000000000002255
    29 https://doi.org/10.1097/ccm.0000000000002256
    30 https://doi.org/10.1097/ccm.0b013e31828cf104
    31 https://doi.org/10.1097/ccm.0b013e3182982b03
    32 https://doi.org/10.1111/hex.12576
    33 https://doi.org/10.1111/j.0006-341x.2001.00126.x
    34 https://doi.org/10.1111/jth.13140
    35 https://doi.org/10.1136/bmj.g1687
    36 https://doi.org/10.1136/bmj.i6795
    37 https://doi.org/10.1155/2011/505373
    38 https://doi.org/10.1164/rccm.201407-1317st
    39 https://doi.org/10.1164/rccm.201608-1690st
    40 https://doi.org/10.1371/journal.pmed.1000098
    41 https://doi.org/10.1371/journal.pone.0140141
    42 https://doi.org/10.1371/journal.pone.0160947
    43 https://doi.org/10.1378/chest.11-2296
    44 https://doi.org/10.18637/jss.v015.i02
    45 https://doi.org/10.2105/ajph.94.3.361
    46 schema:datePublished 2019-02
    47 schema:datePublishedReg 2019-02-01
    48 schema:description PURPOSE: To test whether a multicomponent intervention would increase the use of low molecular weight heparin (LMWH) over unfractionated heparin (UFH) for venous thromboembolism (VTE) prophylaxis in critically ill patients and change patient outcomes and healthcare utilization. METHODS: Controlled pre-post trial of 12,342 adults admitted to 11 ICUs (five intervention, six control) May 1, 2015 to April 30, 2017 with no contraindication to pharmacological prophylaxis and an ICU stay longer than 24 h. Models were developed to examine temporal changes in ICU VTE prophylaxis (primary outcome), VTE, major bleeding, heparin-induced thrombocytopenia (HIT), death and hospital costs. RESULTS: The use of LMWH increased from 45.9% to 78.3% of patient days in the intervention group and from 37.9% to 53.3% in the control group, an absolute increase difference of 17.0% (32.4% vs. 15.4%, p = 0.001). Changes in the administration of UFH were inversely related to those of LMWH. There were no significant differences in the adjusted odds of VTE (ratio of odds ratios [rOR] 1.13, 95% CI 0.51-2.46) or major bleeding (rOR 1.22, 95% CI 0.97-1.54) post-implementation of the intervention (compared to pre-implementation) between the intervention group and the control group. HIT was uncommon in both groups (n = 20 patients). There were no significant changes for ICU and hospital mortality, length of stay and costs. Results were similar when stratified according to reason for ICU admission, patient weight and kidney function. CONCLUSIONS: A multicomponent intervention changed practice, but not clinical and economic outcomes. The benefit of implementing LMWH for VTE prophylaxis under real-world conditions is uncertain.
    49 schema:genre research_article
    50 schema:inLanguage en
    51 schema:isAccessibleForFree false
    52 schema:isPartOf sg:journal.1313639
    53 schema:name A multicentre controlled pre–post trial of an implementation science intervention to improve venous thromboembolism prophylaxis in critically ill patients
    54 schema:pagination 1-12
    55 schema:productId N3d8dee5098b949b496b924470cd413c9
    56 N57117946c8d64d379ff2f7fde64287ac
    57 Nd4f6ac4f6ba94b21ab5f93b3ea6141be
    58 Nf146456e402147008cf4cdbb0a60b929
    59 Nf850d316c7dc47968453442302724e5e
    60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111836762
    61 https://doi.org/10.1007/s00134-019-05532-1
    62 schema:sdDatePublished 2019-04-11T08:59
    63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    64 schema:sdPublisher N57ead8024d804dbea690adfdde4f3930
    65 schema:url https://link.springer.com/10.1007%2Fs00134-019-05532-1
    66 sgo:license sg:explorer/license/
    67 sgo:sdDataset articles
    68 rdf:type schema:ScholarlyArticle
    69 N0e616a18f1d44f12ac5bf6bd587ce3cf schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    70 schema:familyName Straus
    71 schema:givenName Sharon E.
    72 rdf:type schema:Person
    73 N0fb6cad33edb4ee3b7e23613a987c3ff rdf:first N778d2b0897d24308952ac51e1d758019
    74 rdf:rest Naf68958c1b0043829268ebe942cd47c5
    75 N1428574f15e543f9886e4026692372c0 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    76 schema:familyName Clement
    77 schema:givenName Fiona
    78 rdf:type schema:Person
    79 N16a92e5ac8754758968fdc1d754f9879 rdf:first Ndfef33273e8d488aa325ba24123ba360
    80 rdf:rest Nf478389064f548c192710c2452b9b6c6
    81 N3d8dee5098b949b496b924470cd413c9 schema:name pubmed_id
    82 schema:value 30707246
    83 rdf:type schema:PropertyValue
    84 N43d0864edace46a588c282ffe21e05ed rdf:first Ne9a0562c846c41f98591d71aafcd7f42
    85 rdf:rest N0fb6cad33edb4ee3b7e23613a987c3ff
    86 N509420e442db46cbb4a8db33eaa11ba7 rdf:first Nf3893258bddb466c98283ad5e1458596
    87 rdf:rest rdf:nil
    88 N57117946c8d64d379ff2f7fde64287ac schema:name nlm_unique_id
    89 schema:value 7704851
    90 rdf:type schema:PropertyValue
    91 N57ead8024d804dbea690adfdde4f3930 schema:name Springer Nature - SN SciGraph project
    92 rdf:type schema:Organization
    93 N582d097c45aa4eb2a48c131cc24e51d6 rdf:first Nce4899e1652647319d21b5fdf7a2025a
    94 rdf:rest N43d0864edace46a588c282ffe21e05ed
    95 N5a36a9d2f2f74130a13c556aa91eebfc schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    96 schema:familyName Cook
    97 schema:givenName Deborah J.
    98 rdf:type schema:Person
    99 N5ad5afd6eda743bab596ffb05f4d323f schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    100 schema:familyName Fiest
    101 schema:givenName Kirsten M.
    102 rdf:type schema:Person
    103 N5eb88da929554a9c82f7f3f90535303e rdf:first Nc28c6ca4e3e841278417026c98c47fcb
    104 rdf:rest N16a92e5ac8754758968fdc1d754f9879
    105 N778d2b0897d24308952ac51e1d758019 schema:affiliation https://www.grid.ac/institutes/grid.413574.0
    106 schema:familyName Kushner
    107 schema:givenName Barry
    108 rdf:type schema:Person
    109 N82e3cff80c3e4705a625ede12c0de9ee rdf:first N5a36a9d2f2f74130a13c556aa91eebfc
    110 rdf:rest Nf152e530f51941028eeee4b58295b7af
    111 N89d403def4834cc39856f5b20ad97c9f rdf:first Ndce28a359f34482aa47d4acb7aaff992
    112 rdf:rest Nb4ce468ee7e242cdb676b4d01ce44093
    113 Nae287775a48a4c87a4cdc1869074af5f schema:affiliation https://www.grid.ac/institutes/grid.413574.0
    114 schema:familyName Soo
    115 schema:givenName Andrea
    116 rdf:type schema:Person
    117 Naf68958c1b0043829268ebe942cd47c5 rdf:first N1428574f15e543f9886e4026692372c0
    118 rdf:rest Nb76fe51583054cc89fda1edda2daf9be
    119 Nafdf8f995fa04ecaa5b3a277e24f8170 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    120 schema:familyName Brundin-Mather
    121 schema:givenName Rebecca
    122 rdf:type schema:Person
    123 Nb459ac09064247259569a99a0450c681 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
    124 schema:familyName Bagshaw
    125 schema:givenName Sean M.
    126 rdf:type schema:Person
    127 Nb4ce468ee7e242cdb676b4d01ce44093 rdf:first Nafdf8f995fa04ecaa5b3a277e24f8170
    128 rdf:rest Nf49108190a214dfcb32dde07160382ac
    129 Nb76fe51583054cc89fda1edda2daf9be rdf:first N0e616a18f1d44f12ac5bf6bd587ce3cf
    130 rdf:rest N82e3cff80c3e4705a625ede12c0de9ee
    131 Nc28c6ca4e3e841278417026c98c47fcb schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    132 schema:familyName Parsons Leigh
    133 schema:givenName Jeanna
    134 rdf:type schema:Person
    135 Nce4899e1652647319d21b5fdf7a2025a schema:affiliation https://www.grid.ac/institutes/grid.413574.0
    136 schema:familyName Doig
    137 schema:givenName Christopher James
    138 rdf:type schema:Person
    139 Nd4f6ac4f6ba94b21ab5f93b3ea6141be schema:name readcube_id
    140 schema:value 6cd95d2f104af0951bb91d7c8d3ee0b9e33d4d6fb700773a3bf946d2822450c2
    141 rdf:type schema:PropertyValue
    142 Ndce28a359f34482aa47d4acb7aaff992 schema:affiliation https://www.grid.ac/institutes/grid.413574.0
    143 schema:familyName Stelfox
    144 schema:givenName Henry T.
    145 rdf:type schema:Person
    146 Ndfef33273e8d488aa325ba24123ba360 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    147 schema:familyName Niven
    148 schema:givenName Daniel J.
    149 rdf:type schema:Person
    150 Ne9a0562c846c41f98591d71aafcd7f42 schema:affiliation https://www.grid.ac/institutes/grid.413574.0
    151 schema:familyName Zuege
    152 schema:givenName Danny J.
    153 rdf:type schema:Person
    154 Nf146456e402147008cf4cdbb0a60b929 schema:name dimensions_id
    155 schema:value pub.1111836762
    156 rdf:type schema:PropertyValue
    157 Nf152e530f51941028eeee4b58295b7af rdf:first Nb459ac09064247259569a99a0450c681
    158 rdf:rest N509420e442db46cbb4a8db33eaa11ba7
    159 Nf3893258bddb466c98283ad5e1458596 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    160 schema:familyName Sauro
    161 schema:givenName Khara M.
    162 rdf:type schema:Person
    163 Nf478389064f548c192710c2452b9b6c6 rdf:first N5ad5afd6eda743bab596ffb05f4d323f
    164 rdf:rest N582d097c45aa4eb2a48c131cc24e51d6
    165 Nf49108190a214dfcb32dde07160382ac rdf:first Nae287775a48a4c87a4cdc1869074af5f
    166 rdf:rest N5eb88da929554a9c82f7f3f90535303e
    167 Nf850d316c7dc47968453442302724e5e schema:name doi
    168 schema:value 10.1007/s00134-019-05532-1
    169 rdf:type schema:PropertyValue
    170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Medical and Health Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Clinical Sciences
    175 rdf:type schema:DefinedTerm
    176 sg:journal.1313639 schema:issn 0342-4642
    177 1432-1238
    178 schema:name Intensive Care Medicine
    179 rdf:type schema:Periodical
    180 sg:pub.10.1007/s00134-014-3442-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005788532
    181 https://doi.org/10.1007/s00134-014-3442-1
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/s00134-015-4173-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009025697
    184 https://doi.org/10.1007/s00134-015-4173-7
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s00134-017-4680-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017279745
    187 https://doi.org/10.1007/s00134-017-4680-9
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s00134-017-4683-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003731534
    190 https://doi.org/10.1007/s00134-017-4683-6
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1007/s12028-015-0221-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1044239808
    193 https://doi.org/10.1007/s12028-015-0221-y
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1007/s12028-018-0614-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107333958
    196 https://doi.org/10.1007/s12028-018-0614-9
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1186/1745-6215-15-502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012768838
    199 https://doi.org/10.1186/1745-6215-15-502
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1186/1748-5908-7-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032986659
    202 https://doi.org/10.1186/1748-5908-7-38
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1186/cc13844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013074945
    205 https://doi.org/10.1186/cc13844
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1186/s12916-015-0488-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033095397
    208 https://doi.org/10.1186/s12916-015-0488-z
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1186/s12916-018-1018-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101116843
    211 https://doi.org/10.1186/s12916-018-1018-6
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1001/archinte.161.10.1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027301461
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1001/jama.2016.0154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003581306
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1001/jama.2016.3463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016128238
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1001/jamainternmed.2013.6521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026097386
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1001/jamainternmed.2015.0157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016419787
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1001/jamainternmed.2018.3675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106253953
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1002/14651858.cd008201.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103611750
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/j.jclinepi.2013.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003156170
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/j.jcrc.2014.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037400485
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/j.jcrc.2018.07.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105764663
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.jcrc.2018.11.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110259403
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1046/j.1365-2710.2002.00430.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044028133
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1056/nejmoa1014475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003502724
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1097/ccm.0000000000002255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003204236
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1097/ccm.0000000000002256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048287045
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1097/ccm.0b013e31828cf104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039685186
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1097/ccm.0b013e3182982b03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035460606
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1111/hex.12576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085730495
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1111/j.0006-341x.2001.00126.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005090909
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1111/jth.13140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048045194
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1136/bmj.g1687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015461169
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1136/bmj.i6795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084224501
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1155/2011/505373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041959260
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1164/rccm.201407-1317st schema:sameAs https://app.dimensions.ai/details/publication/pub.1044838635
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1164/rccm.201608-1690st schema:sameAs https://app.dimensions.ai/details/publication/pub.1028077908
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1371/journal.pmed.1000098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021380586
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1371/journal.pone.0140141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038927560
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1371/journal.pone.0160947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051501612
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1378/chest.11-2296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039499818
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.18637/jss.v015.i02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068672224
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.2105/ajph.94.3.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068879488
    274 rdf:type schema:CreativeWork
    275 https://www.grid.ac/institutes/grid.17089.37 schema:alternateName University of Alberta
    276 schema:name Department of Critical Care Medicine, Faculty of Medicine and Dentistry, and the School of Public Health, University of Alberta, Edmonton, AB, Canada
    277 rdf:type schema:Organization
    278 https://www.grid.ac/institutes/grid.22072.35 schema:alternateName University of Calgary
    279 schema:name Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
    280 Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada
    281 W21C Research and Innovation Centre, University of Calgary, Calgary, AB, Canada
    282 rdf:type schema:Organization
    283 https://www.grid.ac/institutes/grid.25073.33 schema:alternateName McMaster University
    284 schema:name Deparment of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    285 rdf:type schema:Organization
    286 https://www.grid.ac/institutes/grid.413574.0 schema:alternateName Alberta Health Services
    287 schema:name Alberta Health Services, Calgary, Canada
    288 Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
    289 Department of Critical Care Medicine, University of Calgary, 3280 Hospital Drive NW, T2N 4Z6, Calgary, Canada
    290 rdf:type schema:Organization
    291 https://www.grid.ac/institutes/grid.415502.7 schema:alternateName St. Michael's Hospital
    292 schema:name Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada
    293 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...