Infection-related ventilator-associated complications in ICU patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-16

AUTHORS

François Barbier, Sébastien Bailly, Carole Schwebel, Laurent Papazian, Élie Azoulay, Hatem Kallel, Shidasp Siami, Laurent Argaud, Guillaume Marcotte, Benoît Misset, Jean Reignier, Michaël Darmon, Jean-Ralph Zahar, Dany Goldgran-Toledano, Étienne de Montmollin, Bertrand Souweine, Bruno Mourvillier, Jean-François Timsit

ABSTRACT

PurposeTo investigate the clinical significance of infection-related ventilator-associated complications (IVAC) and their impact on carbapenem consumption in mechanically ventilated (MV) patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLE).MethodsInception cohort study from the French prospective multicenter OUTCOMEREA database (17 ICUs, 1997–2015) including all ESBLE carriers (systematic rectal swabbing at admission then weekly and/or urinary or superficial surgical site colonisation) with MV duration > 48 h and ≥ 1 episode of IVAC after carriage documentation. All ICU-acquired infections were microbiologically documented.ResultsThe 318 enrolled ESBLE carriers (median age 68 years; males 67%; medical admission 68%; imported carriage 53%) experienced a total of 576 IVAC comprising 361 episodes (63%) without documented infection, 124 (21%) related to infections other than ventilator-associated pneumonia (VAP), 73 (13%) related to non-ESBLE VAP and 18 (3%) related to ESBLE VAP. Overall, ESBLE infections accounted for only 43 episodes (7%). Carbapenem exposure within the preceding 3 days was the sole independent predictor of ESBLE infection as the causative event of IVAC, with a protective effect (adjusted odds ratio 0.2, 95% confidence interval 0.05–0.6; P < 0.01). Carbapenems were initiated in 9% of IVAC without infection, 15% of IVAC related to non-VAP infections, 42% of IVAC related to non-ESBLE VAP, and 56% of IVAC related to ESBLE VAP (ESBLE VAP versus non-ESBLE VAP: P = 0.43).ConclusionsIVAC in ESBLE carriers mostly reflect noninfectious events but act as a strong driver of empirical carbapenem consumption. ESBLE infections are scarce yet hard to predict, strengthening the need for novel diagnostic approaches and carbapenem-sparing alternatives. More... »

PAGES

616-626

References to SciGraph publications

  • 2017-06-12. Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae in ANNALS OF INTENSIVE CARE
  • 2015-08-12. Mechanisms of antimicrobial resistance in Gram-negative bacilli in ANNALS OF INTENSIVE CARE
  • 2016-10-24. Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis in CRITICAL CARE
  • 2016-12-20. Colonization pressure as a risk factor of ICU-acquired multidrug resistant bacteria: a prospective observational study in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2017-02-02. Relation between presence of extended-spectrum β-lactamase-producing Enterobacteriaceae in systematic rectal swabs and respiratory tract specimens in ICU patients in ANNALS OF INTENSIVE CARE
  • 2015-03-20. Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria in INTENSIVE CARE MEDICINE
  • 2012-08-15. Clinical impact and risk factors for colonization with extended-spectrum β-lactamase-producing bacteria in the intensive care unit in INTENSIVE CARE MEDICINE
  • 2014-04-13. Predictive factors for extended-spectrum beta-lactamase producing Enterobacteriaceae causing infection among intensive care unit patients with prior colonization in INFECTION
  • 2018-06-15. Correction to: Infection-related ventilator-associated complications in ICU patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae in INTENSIVE CARE MEDICINE
  • 2015-06-03. Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric) in INTENSIVE CARE MEDICINE
  • 2016-02-03. Does this patient have VAP? in INTENSIVE CARE MEDICINE
  • Journal

    TITLE

    Intensive Care Medicine

    ISSUE

    5

    VOLUME

    44

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-018-5154-4

    DOI

    http://dx.doi.org/10.1007/s00134-018-5154-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103383826

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29663045


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carbapenems", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier State", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enterobacteriaceae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enterobacteriaceae Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "France", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pneumonia, Ventilator-Associated", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "beta-Lactamases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Medical ICU, La Source Hospital, CHR Orl\u00e9ans, Orl\u00e9ans, France", 
              "id": "http://www.grid.ac/institutes/grid.413932.e", 
              "name": [
                "Medical ICU, La Source Hospital, CHR Orl\u00e9ans, Orl\u00e9ans, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barbier", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.0740065057.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740065057.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UMR 1137, IAME Team 5, DeSCID: Decision SCiences in Infectious Diseases, Control and Care, INSERM, Paris Diderot, Sorbonne Paris Cit\u00e9 University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.7429.8", 
              "name": [
                "UMR 1137, IAME Team 5, DeSCID: Decision SCiences in Infectious Diseases, Control and Care, INSERM, Paris Diderot, Sorbonne Paris Cit\u00e9 University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bailly", 
            "givenName": "S\u00e9bastien", 
            "id": "sg:person.01125634305.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125634305.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Albert Michallon University Hospital, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.410529.b", 
              "name": [
                "Medical ICU, Albert Michallon University Hospital, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schwebel", 
            "givenName": "Carole", 
            "id": "sg:person.01056561220.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056561220.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Respiratory and Infectious Diseases ICU, North Hospital, Marseille, France", 
              "id": "http://www.grid.ac/institutes/grid.414244.3", 
              "name": [
                "Respiratory and Infectious Diseases ICU, North Hospital, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Papazian", 
            "givenName": "Laurent", 
            "id": "sg:person.0632223703.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632223703.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Saint-Louis Hospital, APHP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Medical ICU, Saint-Louis Hospital, APHP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Azoulay", 
            "givenName": "\u00c9lie", 
            "id": "sg:person.01352577613.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352577613.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Surgical ICU, Andr\u00e9e Rosemon Hospital, Cayenne, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Medical Surgical ICU, Andr\u00e9e Rosemon Hospital, Cayenne, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kallel", 
            "givenName": "Hatem", 
            "id": "sg:person.01102024662.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102024662.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Surgical ICU, Corbeil-Essone Hospital, Corbeil-Essone, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Medical Surgical ICU, Corbeil-Essone Hospital, Corbeil-Essone, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siami", 
            "givenName": "Shidasp", 
            "id": "sg:person.0771074230.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771074230.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Edouard-Herriot University Hospital, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.412180.e", 
              "name": [
                "Medical ICU, Edouard-Herriot University Hospital, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Argaud", 
            "givenName": "Laurent", 
            "id": "sg:person.01021057652.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021057652.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Surgical ICU, Edouard-Herriot University Hospital, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.412180.e", 
              "name": [
                "Surgical ICU, Edouard-Herriot University Hospital, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marcotte", 
            "givenName": "Guillaume", 
            "id": "sg:person.0700066673.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700066673.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Charles Nicolle University Hospital, Rouen, France", 
              "id": "http://www.grid.ac/institutes/grid.417615.0", 
              "name": [
                "Medical ICU, Charles Nicolle University Hospital, Rouen, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Misset", 
            "givenName": "Beno\u00eet", 
            "id": "sg:person.0714512043.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714512043.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, H\u00f4tel-Dieu University Hospital, Nantes, France", 
              "id": "http://www.grid.ac/institutes/grid.277151.7", 
              "name": [
                "Medical ICU, H\u00f4tel-Dieu University Hospital, Nantes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reignier", 
            "givenName": "Jean", 
            "id": "sg:person.01342156037.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342156037.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Saint-Louis Hospital, APHP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Medical ICU, Saint-Louis Hospital, APHP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Darmon", 
            "givenName": "Micha\u00ebl", 
            "id": "sg:person.01027641050.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027641050.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Infection Control Unit, Avicenne Hospital, Bobigny, France", 
              "id": "http://www.grid.ac/institutes/grid.413780.9", 
              "name": [
                "Infection Control Unit, Avicenne Hospital, Bobigny, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zahar", 
            "givenName": "Jean-Ralph", 
            "id": "sg:person.01354274353.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354274353.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical-Surgical ICU, General Hospital, Montfermeil, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Medical-Surgical ICU, General Hospital, Montfermeil, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goldgran-Toledano", 
            "givenName": "Dany", 
            "id": "sg:person.0760777664.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760777664.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical-Surgical ICU, Delafontaine Hospital, Saint-Denis, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Medical-Surgical ICU, Delafontaine Hospital, Saint-Denis, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Montmollin", 
            "givenName": "\u00c9tienne", 
            "id": "sg:person.0615463126.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615463126.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical ICU, Gabriel Montpied Hospital, Clermont-Ferrand, France", 
              "id": "http://www.grid.ac/institutes/grid.411163.0", 
              "name": [
                "Medical ICU, Gabriel Montpied Hospital, Clermont-Ferrand, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Souweine", 
            "givenName": "Bertrand", 
            "id": "sg:person.01324422064.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324422064.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, 46 Rue Henri-Huchard, 75877, Paris Cedex 18, France", 
              "id": "http://www.grid.ac/institutes/grid.411119.d", 
              "name": [
                "Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, 46 Rue Henri-Huchard, 75877, Paris Cedex 18, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mourvillier", 
            "givenName": "Bruno", 
            "id": "sg:person.01330764062.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330764062.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, 46 Rue Henri-Huchard, 75877, Paris Cedex 18, France", 
              "id": "http://www.grid.ac/institutes/grid.411119.d", 
              "name": [
                "UMR 1137, IAME Team 5, DeSCID: Decision SCiences in Infectious Diseases, Control and Care, INSERM, Paris Diderot, Sorbonne Paris Cit\u00e9 University, Paris, France", 
                "Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, 46 Rue Henri-Huchard, 75877, Paris Cedex 18, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Timsit", 
            "givenName": "Jean-Fran\u00e7ois", 
            "id": "sg:person.01215000253.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215000253.20"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-016-4239-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046594845", 
              "https://doi.org/10.1007/s00134-016-4239-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0283-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085983389", 
              "https://doi.org/10.1186/s13613-017-0283-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-3853-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053634336", 
              "https://doi.org/10.1007/s00134-015-3853-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-012-2675-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021880899", 
              "https://doi.org/10.1007/s00134-012-2675-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-016-2863-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018914178", 
              "https://doi.org/10.1007/s10096-016-2863-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-018-5277-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104611516", 
              "https://doi.org/10.1007/s00134-018-5277-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-015-0061-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023955136", 
              "https://doi.org/10.1186/s13613-015-0061-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0237-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083524416", 
              "https://doi.org/10.1186/s13613-017-0237-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-3719-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045916659", 
              "https://doi.org/10.1007/s00134-015-3719-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-016-1506-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039568477", 
              "https://doi.org/10.1186/s13054-016-1506-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s15010-014-0619-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024330306", 
              "https://doi.org/10.1007/s15010-014-0619-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-04-16", 
        "datePublishedReg": "2018-04-16", 
        "description": "PurposeTo investigate the clinical significance of infection-related ventilator-associated complications (IVAC) and their impact on carbapenem consumption in mechanically ventilated (MV) patients colonised with extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae (ESBLE).MethodsInception cohort study from the French prospective multicenter OUTCOMEREA database (17 ICUs, 1997\u20132015) including all ESBLE carriers (systematic rectal swabbing at admission then weekly and/or urinary or superficial surgical site colonisation) with MV duration\u2009>\u200948\u00a0h and\u2009\u2265\u20091 episode of IVAC after carriage documentation. All ICU-acquired infections were microbiologically documented.ResultsThe 318 enrolled ESBLE carriers (median age 68\u00a0years; males 67%; medical admission 68%; imported carriage 53%) experienced a total of 576 IVAC comprising 361 episodes (63%) without documented infection, 124 (21%) related to infections other than ventilator-associated pneumonia (VAP), 73 (13%) related to non-ESBLE VAP and 18 (3%) related to ESBLE VAP. Overall, ESBLE infections accounted for only 43 episodes (7%). Carbapenem exposure within the preceding 3\u00a0days was the sole independent predictor of ESBLE infection as the causative event of IVAC, with a protective effect (adjusted odds ratio 0.2, 95% confidence interval 0.05\u20130.6; P\u2009<\u20090.01). Carbapenems were initiated in 9% of IVAC without infection, 15% of IVAC related to non-VAP infections, 42% of IVAC related to non-ESBLE VAP, and 56% of IVAC related to ESBLE VAP (ESBLE VAP versus non-ESBLE VAP: P\u2009=\u20090.43).ConclusionsIVAC in ESBLE carriers mostly reflect noninfectious events but act as a strong driver of empirical carbapenem consumption. ESBLE infections are scarce yet hard to predict, strengthening the need for novel diagnostic approaches and carbapenem-sparing alternatives.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00134-018-5154-4", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1313639", 
            "issn": [
              "0342-4642", 
              "1432-1238"
            ], 
            "name": "Intensive Care Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "44"
          }
        ], 
        "keywords": [
          "infection-related ventilator-associated complications", 
          "ventilator-associated pneumonia", 
          "ventilator-associated complications", 
          "carbapenem consumption", 
          "carbapenem-sparing alternatives", 
          "sole independent predictor", 
          "novel diagnostic approach", 
          "carbapenem exposure", 
          "noninfectious events", 
          "MV duration", 
          "cohort study", 
          "independent predictors", 
          "ICU patients", 
          "Outcomerea database", 
          "clinical significance", 
          "protective effect", 
          "infection", 
          "diagnostic approach", 
          "causative event", 
          "complications", 
          "patients", 
          "episodes", 
          "Enterobacteriaceae", 
          "ICU", 
          "pneumonia", 
          "PurposeTo", 
          "carbapenems", 
          "total", 
          "predictors", 
          "exposure", 
          "duration", 
          "days", 
          "events", 
          "carriers", 
          "database", 
          "significance", 
          "study", 
          "consumption", 
          "effect", 
          "documentation", 
          "need", 
          "alternative", 
          "impact", 
          "approach", 
          "strong driver", 
          "drivers"
        ], 
        "name": "Infection-related ventilator-associated complications in ICU patients colonised with extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae", 
        "pagination": "616-626", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1103383826"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00134-018-5154-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29663045"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00134-018-5154-4", 
          "https://app.dimensions.ai/details/publication/pub.1103383826"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_791.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00134-018-5154-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-018-5154-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-018-5154-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-018-5154-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-018-5154-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    364 TRIPLES      21 PREDICATES      95 URIs      76 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00134-018-5154-4 schema:about N110719f72e1441f9a553622453eec37f
    2 N19686d6362b74c489abb4596c6cc10b2
    3 N22ea574e6aa545558fdf51e11ac39615
    4 N288cbcc688b248318711510a6786edd4
    5 N35e0f39c126b4b0eae3ca1f2721d0578
    6 N39455e60b84b4c1ca3f1383b9ee8991c
    7 N616e23a6121d42eabbdf4174d9b8f376
    8 N917a94855af54068be3f8470faf167b1
    9 N92cbc7bb7ed5446fa7efd7b097f6957d
    10 Nc957d636525546438f44a1f7462f06b0
    11 Nc98c8535b84a42b9a05b1fd90a725663
    12 Ne892e7d8730f4fbd8de553312de8c0a0
    13 Ne9ff23db14334675aea6d1c897232cf9
    14 anzsrc-for:11
    15 anzsrc-for:1103
    16 schema:author N7877a684858d471695832aac45de9b6b
    17 schema:citation sg:pub.10.1007/s00134-012-2675-0
    18 sg:pub.10.1007/s00134-015-3719-z
    19 sg:pub.10.1007/s00134-015-3853-7
    20 sg:pub.10.1007/s00134-016-4239-1
    21 sg:pub.10.1007/s00134-018-5277-7
    22 sg:pub.10.1007/s10096-016-2863-x
    23 sg:pub.10.1007/s15010-014-0619-z
    24 sg:pub.10.1186/s13054-016-1506-z
    25 sg:pub.10.1186/s13613-015-0061-0
    26 sg:pub.10.1186/s13613-017-0237-x
    27 sg:pub.10.1186/s13613-017-0283-4
    28 schema:datePublished 2018-04-16
    29 schema:datePublishedReg 2018-04-16
    30 schema:description PurposeTo investigate the clinical significance of infection-related ventilator-associated complications (IVAC) and their impact on carbapenem consumption in mechanically ventilated (MV) patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLE).MethodsInception cohort study from the French prospective multicenter OUTCOMEREA database (17 ICUs, 1997–2015) including all ESBLE carriers (systematic rectal swabbing at admission then weekly and/or urinary or superficial surgical site colonisation) with MV duration > 48 h and ≥ 1 episode of IVAC after carriage documentation. All ICU-acquired infections were microbiologically documented.ResultsThe 318 enrolled ESBLE carriers (median age 68 years; males 67%; medical admission 68%; imported carriage 53%) experienced a total of 576 IVAC comprising 361 episodes (63%) without documented infection, 124 (21%) related to infections other than ventilator-associated pneumonia (VAP), 73 (13%) related to non-ESBLE VAP and 18 (3%) related to ESBLE VAP. Overall, ESBLE infections accounted for only 43 episodes (7%). Carbapenem exposure within the preceding 3 days was the sole independent predictor of ESBLE infection as the causative event of IVAC, with a protective effect (adjusted odds ratio 0.2, 95% confidence interval 0.05–0.6; P < 0.01). Carbapenems were initiated in 9% of IVAC without infection, 15% of IVAC related to non-VAP infections, 42% of IVAC related to non-ESBLE VAP, and 56% of IVAC related to ESBLE VAP (ESBLE VAP versus non-ESBLE VAP: P = 0.43).ConclusionsIVAC in ESBLE carriers mostly reflect noninfectious events but act as a strong driver of empirical carbapenem consumption. ESBLE infections are scarce yet hard to predict, strengthening the need for novel diagnostic approaches and carbapenem-sparing alternatives.
    31 schema:genre article
    32 schema:isAccessibleForFree true
    33 schema:isPartOf N9a3fbd8fe44f4dab9d4a302bd57370a2
    34 Nba21262fda1e457191dd2fae15f55405
    35 sg:journal.1313639
    36 schema:keywords Enterobacteriaceae
    37 ICU
    38 ICU patients
    39 MV duration
    40 Outcomerea database
    41 PurposeTo
    42 alternative
    43 approach
    44 carbapenem consumption
    45 carbapenem exposure
    46 carbapenem-sparing alternatives
    47 carbapenems
    48 carriers
    49 causative event
    50 clinical significance
    51 cohort study
    52 complications
    53 consumption
    54 database
    55 days
    56 diagnostic approach
    57 documentation
    58 drivers
    59 duration
    60 effect
    61 episodes
    62 events
    63 exposure
    64 impact
    65 independent predictors
    66 infection
    67 infection-related ventilator-associated complications
    68 need
    69 noninfectious events
    70 novel diagnostic approach
    71 patients
    72 pneumonia
    73 predictors
    74 protective effect
    75 significance
    76 sole independent predictor
    77 strong driver
    78 study
    79 total
    80 ventilator-associated complications
    81 ventilator-associated pneumonia
    82 schema:name Infection-related ventilator-associated complications in ICU patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae
    83 schema:pagination 616-626
    84 schema:productId Nc526778a9f9d4abeb11e28968a1d2654
    85 Ncddd0176691943e7a224831cea7fcd4a
    86 Nfc73546aaf26447b85ee9c6139842332
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103383826
    88 https://doi.org/10.1007/s00134-018-5154-4
    89 schema:sdDatePublished 2022-09-02T16:03
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher N2a42976f57114110a727bd6952b1abd4
    92 schema:url https://doi.org/10.1007/s00134-018-5154-4
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N110719f72e1441f9a553622453eec37f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Carbapenems
    98 rdf:type schema:DefinedTerm
    99 N13f8dc49db8f42dca5e0740d3a88ca52 rdf:first sg:person.0714512043.66
    100 rdf:rest Nf11cd74925614485b15c9461a7f370f0
    101 N19686d6362b74c489abb4596c6cc10b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Male
    103 rdf:type schema:DefinedTerm
    104 N22ea574e6aa545558fdf51e11ac39615 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Aged
    106 rdf:type schema:DefinedTerm
    107 N288cbcc688b248318711510a6786edd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name France
    109 rdf:type schema:DefinedTerm
    110 N2a42976f57114110a727bd6952b1abd4 schema:name Springer Nature - SN SciGraph project
    111 rdf:type schema:Organization
    112 N30415b55520041c28d837c42640e6c79 rdf:first sg:person.0700066673.74
    113 rdf:rest N13f8dc49db8f42dca5e0740d3a88ca52
    114 N35e0f39c126b4b0eae3ca1f2721d0578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Intensive Care Units
    116 rdf:type schema:DefinedTerm
    117 N39455e60b84b4c1ca3f1383b9ee8991c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name beta-Lactamases
    119 rdf:type schema:DefinedTerm
    120 N3dea9f6c896e474bb0a77698996af33c rdf:first sg:person.01125634305.00
    121 rdf:rest N73e90c46bc174e9e9ac694f9ea4cedea
    122 N616e23a6121d42eabbdf4174d9b8f376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Enterobacteriaceae
    124 rdf:type schema:DefinedTerm
    125 N6712f20afb8a494b8896c43edb93e322 rdf:first sg:person.01352577613.57
    126 rdf:rest N93191c648e9e46459461ff18b6af6baf
    127 N69c528986974438eb81142e3ef0cfe0d rdf:first sg:person.01330764062.25
    128 rdf:rest Nc6e8671c9347443a8e79ab566438e634
    129 N73e90c46bc174e9e9ac694f9ea4cedea rdf:first sg:person.01056561220.01
    130 rdf:rest Nf4b17548f28f43bd93bde37491d7bc0a
    131 N7877a684858d471695832aac45de9b6b rdf:first sg:person.0740065057.57
    132 rdf:rest N3dea9f6c896e474bb0a77698996af33c
    133 N8636f0cfb174457dbc89974f38e46692 rdf:first sg:person.0771074230.67
    134 rdf:rest Need96f420a08478ab113c21b8669bc72
    135 N8fd303ac92564c7fae70f85eef55eb13 rdf:first sg:person.0760777664.40
    136 rdf:rest Nded69a7147874ff68ab4b11d699d974d
    137 N917a94855af54068be3f8470faf167b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Prospective Studies
    139 rdf:type schema:DefinedTerm
    140 N92cbc7bb7ed5446fa7efd7b097f6957d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Enterobacteriaceae Infections
    142 rdf:type schema:DefinedTerm
    143 N93191c648e9e46459461ff18b6af6baf rdf:first sg:person.01102024662.88
    144 rdf:rest N8636f0cfb174457dbc89974f38e46692
    145 N9a3fbd8fe44f4dab9d4a302bd57370a2 schema:issueNumber 5
    146 rdf:type schema:PublicationIssue
    147 Nba21262fda1e457191dd2fae15f55405 schema:volumeNumber 44
    148 rdf:type schema:PublicationVolume
    149 Nc113798544924ca2ada314a705a28d61 rdf:first sg:person.01324422064.31
    150 rdf:rest N69c528986974438eb81142e3ef0cfe0d
    151 Nc526778a9f9d4abeb11e28968a1d2654 schema:name pubmed_id
    152 schema:value 29663045
    153 rdf:type schema:PropertyValue
    154 Nc6e8671c9347443a8e79ab566438e634 rdf:first sg:person.01215000253.20
    155 rdf:rest rdf:nil
    156 Nc957d636525546438f44a1f7462f06b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Female
    158 rdf:type schema:DefinedTerm
    159 Nc98c8535b84a42b9a05b1fd90a725663 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Carrier State
    161 rdf:type schema:DefinedTerm
    162 Ncddd0176691943e7a224831cea7fcd4a schema:name dimensions_id
    163 schema:value pub.1103383826
    164 rdf:type schema:PropertyValue
    165 Nd6ef7080fec74ad8be8c0715e070a7f3 rdf:first sg:person.01027641050.35
    166 rdf:rest Nee5e68d4941a48008f3a9158b8c36042
    167 Nded69a7147874ff68ab4b11d699d974d rdf:first sg:person.0615463126.53
    168 rdf:rest Nc113798544924ca2ada314a705a28d61
    169 Ne892e7d8730f4fbd8de553312de8c0a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Pneumonia, Ventilator-Associated
    171 rdf:type schema:DefinedTerm
    172 Ne9ff23db14334675aea6d1c897232cf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Humans
    174 rdf:type schema:DefinedTerm
    175 Nee5e68d4941a48008f3a9158b8c36042 rdf:first sg:person.01354274353.38
    176 rdf:rest N8fd303ac92564c7fae70f85eef55eb13
    177 Need96f420a08478ab113c21b8669bc72 rdf:first sg:person.01021057652.80
    178 rdf:rest N30415b55520041c28d837c42640e6c79
    179 Nf11cd74925614485b15c9461a7f370f0 rdf:first sg:person.01342156037.26
    180 rdf:rest Nd6ef7080fec74ad8be8c0715e070a7f3
    181 Nf4b17548f28f43bd93bde37491d7bc0a rdf:first sg:person.0632223703.37
    182 rdf:rest N6712f20afb8a494b8896c43edb93e322
    183 Nfc73546aaf26447b85ee9c6139842332 schema:name doi
    184 schema:value 10.1007/s00134-018-5154-4
    185 rdf:type schema:PropertyValue
    186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Medical and Health Sciences
    188 rdf:type schema:DefinedTerm
    189 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    190 schema:name Clinical Sciences
    191 rdf:type schema:DefinedTerm
    192 sg:journal.1313639 schema:issn 0342-4642
    193 1432-1238
    194 schema:name Intensive Care Medicine
    195 schema:publisher Springer Nature
    196 rdf:type schema:Periodical
    197 sg:person.01021057652.80 schema:affiliation grid-institutes:grid.412180.e
    198 schema:familyName Argaud
    199 schema:givenName Laurent
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021057652.80
    201 rdf:type schema:Person
    202 sg:person.01027641050.35 schema:affiliation grid-institutes:grid.413328.f
    203 schema:familyName Darmon
    204 schema:givenName Michaël
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027641050.35
    206 rdf:type schema:Person
    207 sg:person.01056561220.01 schema:affiliation grid-institutes:grid.410529.b
    208 schema:familyName Schwebel
    209 schema:givenName Carole
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056561220.01
    211 rdf:type schema:Person
    212 sg:person.01102024662.88 schema:affiliation grid-institutes:None
    213 schema:familyName Kallel
    214 schema:givenName Hatem
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102024662.88
    216 rdf:type schema:Person
    217 sg:person.01125634305.00 schema:affiliation grid-institutes:grid.7429.8
    218 schema:familyName Bailly
    219 schema:givenName Sébastien
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125634305.00
    221 rdf:type schema:Person
    222 sg:person.01215000253.20 schema:affiliation grid-institutes:grid.411119.d
    223 schema:familyName Timsit
    224 schema:givenName Jean-François
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215000253.20
    226 rdf:type schema:Person
    227 sg:person.01324422064.31 schema:affiliation grid-institutes:grid.411163.0
    228 schema:familyName Souweine
    229 schema:givenName Bertrand
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324422064.31
    231 rdf:type schema:Person
    232 sg:person.01330764062.25 schema:affiliation grid-institutes:grid.411119.d
    233 schema:familyName Mourvillier
    234 schema:givenName Bruno
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330764062.25
    236 rdf:type schema:Person
    237 sg:person.01342156037.26 schema:affiliation grid-institutes:grid.277151.7
    238 schema:familyName Reignier
    239 schema:givenName Jean
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342156037.26
    241 rdf:type schema:Person
    242 sg:person.01352577613.57 schema:affiliation grid-institutes:grid.413328.f
    243 schema:familyName Azoulay
    244 schema:givenName Élie
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352577613.57
    246 rdf:type schema:Person
    247 sg:person.01354274353.38 schema:affiliation grid-institutes:grid.413780.9
    248 schema:familyName Zahar
    249 schema:givenName Jean-Ralph
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354274353.38
    251 rdf:type schema:Person
    252 sg:person.0615463126.53 schema:affiliation grid-institutes:None
    253 schema:familyName de Montmollin
    254 schema:givenName Étienne
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615463126.53
    256 rdf:type schema:Person
    257 sg:person.0632223703.37 schema:affiliation grid-institutes:grid.414244.3
    258 schema:familyName Papazian
    259 schema:givenName Laurent
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632223703.37
    261 rdf:type schema:Person
    262 sg:person.0700066673.74 schema:affiliation grid-institutes:grid.412180.e
    263 schema:familyName Marcotte
    264 schema:givenName Guillaume
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700066673.74
    266 rdf:type schema:Person
    267 sg:person.0714512043.66 schema:affiliation grid-institutes:grid.417615.0
    268 schema:familyName Misset
    269 schema:givenName Benoît
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714512043.66
    271 rdf:type schema:Person
    272 sg:person.0740065057.57 schema:affiliation grid-institutes:grid.413932.e
    273 schema:familyName Barbier
    274 schema:givenName François
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740065057.57
    276 rdf:type schema:Person
    277 sg:person.0760777664.40 schema:affiliation grid-institutes:None
    278 schema:familyName Goldgran-Toledano
    279 schema:givenName Dany
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760777664.40
    281 rdf:type schema:Person
    282 sg:person.0771074230.67 schema:affiliation grid-institutes:None
    283 schema:familyName Siami
    284 schema:givenName Shidasp
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771074230.67
    286 rdf:type schema:Person
    287 sg:pub.10.1007/s00134-012-2675-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021880899
    288 https://doi.org/10.1007/s00134-012-2675-0
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1007/s00134-015-3719-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1045916659
    291 https://doi.org/10.1007/s00134-015-3719-z
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s00134-015-3853-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053634336
    294 https://doi.org/10.1007/s00134-015-3853-7
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s00134-016-4239-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046594845
    297 https://doi.org/10.1007/s00134-016-4239-1
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1007/s00134-018-5277-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104611516
    300 https://doi.org/10.1007/s00134-018-5277-7
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1007/s10096-016-2863-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018914178
    303 https://doi.org/10.1007/s10096-016-2863-x
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s15010-014-0619-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024330306
    306 https://doi.org/10.1007/s15010-014-0619-z
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1186/s13054-016-1506-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039568477
    309 https://doi.org/10.1186/s13054-016-1506-z
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1186/s13613-015-0061-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023955136
    312 https://doi.org/10.1186/s13613-015-0061-0
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1186/s13613-017-0237-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1083524416
    315 https://doi.org/10.1186/s13613-017-0237-x
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1186/s13613-017-0283-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085983389
    318 https://doi.org/10.1186/s13613-017-0283-4
    319 rdf:type schema:CreativeWork
    320 grid-institutes:None schema:alternateName Medical Surgical ICU, Andrée Rosemon Hospital, Cayenne, France
    321 Medical Surgical ICU, Corbeil-Essone Hospital, Corbeil-Essone, France
    322 Medical-Surgical ICU, Delafontaine Hospital, Saint-Denis, France
    323 Medical-Surgical ICU, General Hospital, Montfermeil, France
    324 schema:name Medical Surgical ICU, Andrée Rosemon Hospital, Cayenne, France
    325 Medical Surgical ICU, Corbeil-Essone Hospital, Corbeil-Essone, France
    326 Medical-Surgical ICU, Delafontaine Hospital, Saint-Denis, France
    327 Medical-Surgical ICU, General Hospital, Montfermeil, France
    328 rdf:type schema:Organization
    329 grid-institutes:grid.277151.7 schema:alternateName Medical ICU, Hôtel-Dieu University Hospital, Nantes, France
    330 schema:name Medical ICU, Hôtel-Dieu University Hospital, Nantes, France
    331 rdf:type schema:Organization
    332 grid-institutes:grid.410529.b schema:alternateName Medical ICU, Albert Michallon University Hospital, Grenoble, France
    333 schema:name Medical ICU, Albert Michallon University Hospital, Grenoble, France
    334 rdf:type schema:Organization
    335 grid-institutes:grid.411119.d schema:alternateName Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, 46 Rue Henri-Huchard, 75877, Paris Cedex 18, France
    336 schema:name Medical and Infectious Diseases ICU, Bichat-Claude Bernard Hospital, APHP, 46 Rue Henri-Huchard, 75877, Paris Cedex 18, France
    337 UMR 1137, IAME Team 5, DeSCID: Decision SCiences in Infectious Diseases, Control and Care, INSERM, Paris Diderot, Sorbonne Paris Cité University, Paris, France
    338 rdf:type schema:Organization
    339 grid-institutes:grid.411163.0 schema:alternateName Medical ICU, Gabriel Montpied Hospital, Clermont-Ferrand, France
    340 schema:name Medical ICU, Gabriel Montpied Hospital, Clermont-Ferrand, France
    341 rdf:type schema:Organization
    342 grid-institutes:grid.412180.e schema:alternateName Medical ICU, Edouard-Herriot University Hospital, Lyon, France
    343 Surgical ICU, Edouard-Herriot University Hospital, Lyon, France
    344 schema:name Medical ICU, Edouard-Herriot University Hospital, Lyon, France
    345 Surgical ICU, Edouard-Herriot University Hospital, Lyon, France
    346 rdf:type schema:Organization
    347 grid-institutes:grid.413328.f schema:alternateName Medical ICU, Saint-Louis Hospital, APHP, Paris, France
    348 schema:name Medical ICU, Saint-Louis Hospital, APHP, Paris, France
    349 rdf:type schema:Organization
    350 grid-institutes:grid.413780.9 schema:alternateName Infection Control Unit, Avicenne Hospital, Bobigny, France
    351 schema:name Infection Control Unit, Avicenne Hospital, Bobigny, France
    352 rdf:type schema:Organization
    353 grid-institutes:grid.413932.e schema:alternateName Medical ICU, La Source Hospital, CHR Orléans, Orléans, France
    354 schema:name Medical ICU, La Source Hospital, CHR Orléans, Orléans, France
    355 rdf:type schema:Organization
    356 grid-institutes:grid.414244.3 schema:alternateName Respiratory and Infectious Diseases ICU, North Hospital, Marseille, France
    357 schema:name Respiratory and Infectious Diseases ICU, North Hospital, Marseille, France
    358 rdf:type schema:Organization
    359 grid-institutes:grid.417615.0 schema:alternateName Medical ICU, Charles Nicolle University Hospital, Rouen, France
    360 schema:name Medical ICU, Charles Nicolle University Hospital, Rouen, France
    361 rdf:type schema:Organization
    362 grid-institutes:grid.7429.8 schema:alternateName UMR 1137, IAME Team 5, DeSCID: Decision SCiences in Infectious Diseases, Control and Care, INSERM, Paris Diderot, Sorbonne Paris Cité University, Paris, France
    363 schema:name UMR 1137, IAME Team 5, DeSCID: Decision SCiences in Infectious Diseases, Control and Care, INSERM, Paris Diderot, Sorbonne Paris Cité University, Paris, France
    364 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...