Intermittent noninvasive ventilation after extubation in patients with chronic respiratory disorders: a multicenter randomized controlled trial (VHYPER) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-09

AUTHORS

Frédéric Vargas, Marc Clavel, Pascale Sanchez-Verlan, Sylvain Garnier, Alexandre Boyer, Hoang-Nam Bui, Benjamin Clouzeau, Charline Sazio, Aissa Kerchache, Olivier Guisset, Antoine Benard, Julien Asselineau, Bernard Gauche, Didier Gruson, Stein Silva, Philippe Vignon, Gilles Hilbert

ABSTRACT

PurposeEarly noninvasive ventilation (NIV) after extubation decreases the risk of respiratory failure and lowers 90-day mortality in patients with hypercapnia. Patients with chronic respiratory disease are at risk of extubation failure. Therefore, it could be useful to determine the role of NIV with a discontinuous approach, not limited to patients with hypercapnia. We assessed the efficacy of early NIV in decreasing respiratory failure after extubation in patients with chronic respiratory disorders.MethodsA prospective randomized controlled multicenter study was conducted. We enrolled 144 mechanically ventilated patients with chronic respiratory disorders who tolerated a spontaneous breathing trial. Patients were randomly allocated after extubation to receive either NIV (NIV group, n = 72), performed with a discontinuous approach, for the first 48 h, or conventional oxygen treatment (usual care group, n = 72). The primary endpoint was decreased respiratory failure within 48 h after extubation. Analysis was by intention to treat. This trial was registered with ClinicalTrials.gov (NCT01047852).ResultsRespiratory failure after extubation was less frequent in the NIV group: 6 (8.5%) versus 20 (27.8%); p = 0.0016. Six patients (8.5%) in the NIV group versus 13 (18.1%) in the usual care group were reintubated; p = 0.09. Intensive care unit (ICU) mortality and 90-day mortality did not differ significantly between the two groups (p = 0.28 and p = 0.33, respectively). Median postrandomization ICU length of stay was lower in the usual care group: 3 days (IQR 2–6) versus 4 days (IQR 2–7; p = 0.008). Patients with hypercapnia during a spontaneous breathing trial were at risk of developing postextubation respiratory failure [adjusted odds ratio (95% CI) = 4.56 (1.59–14.00); p = 0.006] and being intubated [adjusted odds ratio (95% CI) = 3.60 (1.07–13.31); p = 0.04].ConclusionsEarly NIV performed following a sequential protocol for the first 48 h after extubation decreased the risk of respiratory failure in patients with chronic respiratory disorders. Reintubation and mortality did not differ between NIV and conventional oxygen therapy. More... »

PAGES

1626-1636

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-017-4785-1

DOI

http://dx.doi.org/10.1007/s00134-017-4785-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084757746

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28393258


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Airway Extubation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypercapnia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intention to Treat Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Length of Stay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Noninvasive Ventilation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen Inhalation Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Insufficiency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventilator Weaning", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre de Recherche Cardio-Thoracique, INSERM 1045, CIC 0005, Universit\u00e9 de Bordeaux, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France", 
            "Centre de Recherche Cardio-Thoracique, INSERM 1045, CIC 0005, Universit\u00e9 de Bordeaux, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vargas", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "id": "sg:person.01236106016.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236106016.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, CHU de Limoges, H\u00f4pital Dupuytren, Limoges, France", 
          "id": "http://www.grid.ac/institutes/grid.411178.a", 
          "name": [
            "Service de R\u00e9animation Polyvalente, CHU de Limoges, H\u00f4pital Dupuytren, Limoges, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clavel", 
        "givenName": "Marc", 
        "id": "sg:person.0576433535.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576433535.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, CHU de Toulouse, H\u00f4pital Purpan, Toulouse, France", 
          "id": "http://www.grid.ac/institutes/grid.414282.9", 
          "name": [
            "Service de R\u00e9animation Polyvalente, CHU de Toulouse, H\u00f4pital Purpan, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanchez-Verlan", 
        "givenName": "Pascale", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, Centre Hospitalier d\u2019Albi, Albi, France", 
          "id": "http://www.grid.ac/institutes/grid.460734.2", 
          "name": [
            "Service de R\u00e9animation Polyvalente, Centre Hospitalier d\u2019Albi, Albi, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garnier", 
        "givenName": "Sylvain", 
        "id": "sg:person.01345616042.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345616042.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.414263.6", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boyer", 
        "givenName": "Alexandre", 
        "id": "sg:person.01146613615.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146613615.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.414263.6", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bui", 
        "givenName": "Hoang-Nam", 
        "id": "sg:person.01201312006.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201312006.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.414263.6", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clouzeau", 
        "givenName": "Benjamin", 
        "id": "sg:person.01306660172.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306660172.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.414263.6", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sazio", 
        "givenName": "Charline", 
        "id": "sg:person.012242166273.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012242166273.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, Centre Hospitalier d\u2019Agen, Agen, France", 
          "id": "http://www.grid.ac/institutes/grid.489897.3", 
          "name": [
            "Service de R\u00e9animation Polyvalente, Centre Hospitalier d\u2019Agen, Agen, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerchache", 
        "givenName": "Aissa", 
        "id": "sg:person.013037546673.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013037546673.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, CHU de Bordeaux, H\u00f4pital Saint-Andr\u00e9, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.414339.8", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, CHU de Bordeaux, H\u00f4pital Saint-Andr\u00e9, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guisset", 
        "givenName": "Olivier", 
        "id": "sg:person.0767512633.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767512633.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d\u2019Information M\u00e9dicale, CHU de Bordeaux, P\u00f4le de Sant\u00e9 Publique, USMR, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.42399.35", 
          "name": [
            "Service d\u2019Information M\u00e9dicale, CHU de Bordeaux, P\u00f4le de Sant\u00e9 Publique, USMR, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benard", 
        "givenName": "Antoine", 
        "id": "sg:person.01346320132.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346320132.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d\u2019Information M\u00e9dicale, CHU de Bordeaux, P\u00f4le de Sant\u00e9 Publique, USMR, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.42399.35", 
          "name": [
            "Service d\u2019Information M\u00e9dicale, CHU de Bordeaux, P\u00f4le de Sant\u00e9 Publique, USMR, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asselineau", 
        "givenName": "Julien", 
        "id": "sg:person.01222244757.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222244757.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, Centre Hospitalier de Libourne, Libourne, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de R\u00e9animation Polyvalente, Centre Hospitalier de Libourne, Libourne, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gauche", 
        "givenName": "Bernard", 
        "id": "sg:person.01017471224.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017471224.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.414263.6", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gruson", 
        "givenName": "Didier", 
        "id": "sg:person.01053512353.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053512353.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM, URM 1214, Universit\u00e9 de Toulouse, Toulouse, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de R\u00e9animation Polyvalente, CHU de Toulouse, H\u00f4pital Purpan, Toulouse, France", 
            "INSERM, URM 1214, Universit\u00e9 de Toulouse, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva", 
        "givenName": "Stein", 
        "id": "sg:person.01107247643.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107247643.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, CHU de Limoges, H\u00f4pital Dupuytren, Limoges, France", 
          "id": "http://www.grid.ac/institutes/grid.411178.a", 
          "name": [
            "Service de R\u00e9animation Polyvalente, CHU de Limoges, H\u00f4pital Dupuytren, Limoges, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vignon", 
        "givenName": "Philippe", 
        "id": "sg:person.0760775335.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760775335.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherche Cardio-Thoracique, INSERM 1045, CIC 0005, Universit\u00e9 de Bordeaux, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Am\u00e9lie Raba-L\u00e9on, 33076, Bordeaux, France", 
            "Centre de Recherche Cardio-Thoracique, INSERM 1045, CIC 0005, Universit\u00e9 de Bordeaux, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hilbert", 
        "givenName": "Gilles", 
        "id": "sg:person.0714117317.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714117317.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s13054-016-1228-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051062750", 
          "https://doi.org/10.1186/s13054-016-1228-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-002-1208-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027730669", 
          "https://doi.org/10.1007/s00134-002-1208-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012369249", 
          "https://doi.org/10.1186/cc12549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-002-1574-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006156595", 
          "https://doi.org/10.1007/s00134-002-1574-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340050927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027347765", 
          "https://doi.org/10.1007/s001340050927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340050438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001921680", 
          "https://doi.org/10.1007/s001340050438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1984-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024590799", 
          "https://doi.org/10.1007/s00134-010-1984-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-011-2179-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012991496", 
          "https://doi.org/10.1007/s00134-011-2179-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-002-1353-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000338397", 
          "https://doi.org/10.1007/s00134-002-1353-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-04-09", 
    "datePublishedReg": "2017-04-09", 
    "description": "PurposeEarly noninvasive ventilation (NIV) after extubation decreases the risk of respiratory failure and lowers 90-day mortality in patients with hypercapnia. Patients with chronic respiratory disease are at risk of extubation failure. Therefore, it could be useful to determine the role of NIV with a discontinuous approach, not limited to patients with hypercapnia. We assessed the efficacy of early NIV in decreasing respiratory failure after extubation in patients with chronic respiratory disorders.MethodsA prospective randomized controlled multicenter study was conducted. We enrolled 144 mechanically ventilated patients with chronic respiratory disorders who tolerated a spontaneous breathing trial. Patients were randomly allocated after extubation to receive either NIV (NIV group, n\u00a0=\u00a072), performed with a discontinuous approach, for the first 48\u00a0h, or conventional oxygen treatment (usual care group, n\u00a0=\u00a072). The primary endpoint was decreased respiratory failure within 48\u00a0h after extubation. Analysis was by intention to treat. This trial was registered with ClinicalTrials.gov (NCT01047852).ResultsRespiratory failure after extubation was less frequent in the NIV group: 6 (8.5%) versus 20 (27.8%); p\u00a0=\u00a00.0016. Six patients (8.5%) in the NIV group versus 13 (18.1%) in the usual care group were reintubated; p\u00a0=\u00a00.09. Intensive care unit (ICU) mortality and 90-day mortality did not differ significantly between the two groups (p\u00a0=\u00a00.28 and p\u00a0=\u00a00.33, respectively). Median postrandomization ICU length of stay was lower in the usual care group: 3\u00a0days (IQR 2\u20136) versus 4\u00a0days (IQR 2\u20137; p\u00a0=\u00a00.008). Patients with hypercapnia during a spontaneous breathing trial were at risk of developing postextubation respiratory failure [adjusted odds ratio (95% CI)\u00a0=\u00a04.56 (1.59\u201314.00); p\u00a0=\u00a00.006] and being intubated [adjusted odds ratio (95% CI)\u00a0=\u00a03.60 (1.07\u201313.31); p\u00a0=\u00a00.04].ConclusionsEarly NIV performed following a sequential protocol for the first 48\u00a0h after extubation decreased the risk of respiratory failure in patients with chronic respiratory disorders. Reintubation and mortality did not differ between NIV and conventional oxygen therapy.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00134-017-4785-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "43"
      }
    ], 
    "keywords": [
      "chronic respiratory disorders", 
      "noninvasive ventilation", 
      "spontaneous breathing trial", 
      "usual care group", 
      "respiratory failure", 
      "respiratory disorders", 
      "NIV group", 
      "breathing trial", 
      "care group", 
      "role of NIV", 
      "intensive care unit mortality", 
      "early noninvasive ventilation", 
      "conventional oxygen treatment", 
      "postextubation respiratory failure", 
      "intermittent noninvasive ventilation", 
      "conventional oxygen therapy", 
      "chronic respiratory disease", 
      "extubation failure", 
      "unit mortality", 
      "ICU length", 
      "primary endpoint", 
      "oxygen therapy", 
      "multicenter study", 
      "extubation", 
      "respiratory disease", 
      "patients", 
      "mortality", 
      "hypercapnia", 
      "oxygen treatment", 
      "trials", 
      "disorders", 
      "risk", 
      "ventilation", 
      "failure", 
      "sequential protocol", 
      "group", 
      "days", 
      "reintubation", 
      "multicenter", 
      "stay", 
      "therapy", 
      "methodsA", 
      "disease", 
      "endpoints", 
      "efficacy", 
      "treatment", 
      "study", 
      "role", 
      "protocol", 
      "intention", 
      "length", 
      "analysis", 
      "approach", 
      "discontinuous approach", 
      "ResultsRespiratory failure", 
      "care unit (ICU) mortality", 
      "Median postrandomization ICU length", 
      "postrandomization ICU length"
    ], 
    "name": "Intermittent noninvasive ventilation after extubation in patients with chronic respiratory disorders: a multicenter randomized controlled trial (VHYPER)", 
    "pagination": "1626-1636", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084757746"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-017-4785-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28393258"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-017-4785-1", 
      "https://app.dimensions.ai/details/publication/pub.1084757746"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_748.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00134-017-4785-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4785-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4785-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4785-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4785-1'


 

This table displays all metadata directly associated to this object as RDF triples.

367 TRIPLES      22 PREDICATES      111 URIs      94 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-017-4785-1 schema:about N0f5cafbe51e943cea51a299cec44fe81
2 N18ec0515fd13407689ca2b2551fd2530
3 N1fe65830901e43bda03175d7de65ed8e
4 N41cc18558152481c98f76b16687ffcc6
5 N46fcc236a1df4651b2585fad707d7a4b
6 N50faa4a075c348fcb0ae796e0780f607
7 N67b7503761d544538410c18611662d65
8 N6f771f986e064274ba5b3e148e1309c1
9 N877665c2cc7646d4be549addf82969f7
10 N879f999a28b544de93fdaf138e891f99
11 N8882ac647a5846c2aab42c15d103abf2
12 N9e8f202045c44811a1dc33b58c482b38
13 N9f67a8a8c2b44c578785fd6cf521e5e6
14 Nbde010f81667462e826f5d19400f5fe4
15 Ne825f5dd865046fda50a8984feea7dab
16 Nef2964e0442a4719bcb60b63f803e2fa
17 Nf166d139461e4c5abe44b3ccd8656a0d
18 Nf4fe83b200854923851302f1dd5abe38
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author Nd4433f717c82451ca850a6d41435eaf9
22 schema:citation sg:pub.10.1007/s00134-002-1208-7
23 sg:pub.10.1007/s00134-002-1353-z
24 sg:pub.10.1007/s00134-002-1574-1
25 sg:pub.10.1007/s00134-010-1984-4
26 sg:pub.10.1007/s00134-011-2179-3
27 sg:pub.10.1007/s001340050438
28 sg:pub.10.1007/s001340050927
29 sg:pub.10.1186/cc12549
30 sg:pub.10.1186/s13054-016-1228-2
31 schema:datePublished 2017-04-09
32 schema:datePublishedReg 2017-04-09
33 schema:description PurposeEarly noninvasive ventilation (NIV) after extubation decreases the risk of respiratory failure and lowers 90-day mortality in patients with hypercapnia. Patients with chronic respiratory disease are at risk of extubation failure. Therefore, it could be useful to determine the role of NIV with a discontinuous approach, not limited to patients with hypercapnia. We assessed the efficacy of early NIV in decreasing respiratory failure after extubation in patients with chronic respiratory disorders.MethodsA prospective randomized controlled multicenter study was conducted. We enrolled 144 mechanically ventilated patients with chronic respiratory disorders who tolerated a spontaneous breathing trial. Patients were randomly allocated after extubation to receive either NIV (NIV group, n = 72), performed with a discontinuous approach, for the first 48 h, or conventional oxygen treatment (usual care group, n = 72). The primary endpoint was decreased respiratory failure within 48 h after extubation. Analysis was by intention to treat. This trial was registered with ClinicalTrials.gov (NCT01047852).ResultsRespiratory failure after extubation was less frequent in the NIV group: 6 (8.5%) versus 20 (27.8%); p = 0.0016. Six patients (8.5%) in the NIV group versus 13 (18.1%) in the usual care group were reintubated; p = 0.09. Intensive care unit (ICU) mortality and 90-day mortality did not differ significantly between the two groups (p = 0.28 and p = 0.33, respectively). Median postrandomization ICU length of stay was lower in the usual care group: 3 days (IQR 2–6) versus 4 days (IQR 2–7; p = 0.008). Patients with hypercapnia during a spontaneous breathing trial were at risk of developing postextubation respiratory failure [adjusted odds ratio (95% CI) = 4.56 (1.59–14.00); p = 0.006] and being intubated [adjusted odds ratio (95% CI) = 3.60 (1.07–13.31); p = 0.04].ConclusionsEarly NIV performed following a sequential protocol for the first 48 h after extubation decreased the risk of respiratory failure in patients with chronic respiratory disorders. Reintubation and mortality did not differ between NIV and conventional oxygen therapy.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree false
37 schema:isPartOf N829c7f5a116840ccbd63e6fdbe0009ea
38 Nee4a001550c84a9791e0648e0c61b6db
39 sg:journal.1313639
40 schema:keywords ICU length
41 Median postrandomization ICU length
42 NIV group
43 ResultsRespiratory failure
44 analysis
45 approach
46 breathing trial
47 care group
48 care unit (ICU) mortality
49 chronic respiratory disease
50 chronic respiratory disorders
51 conventional oxygen therapy
52 conventional oxygen treatment
53 days
54 discontinuous approach
55 disease
56 disorders
57 early noninvasive ventilation
58 efficacy
59 endpoints
60 extubation
61 extubation failure
62 failure
63 group
64 hypercapnia
65 intensive care unit mortality
66 intention
67 intermittent noninvasive ventilation
68 length
69 methodsA
70 mortality
71 multicenter
72 multicenter study
73 noninvasive ventilation
74 oxygen therapy
75 oxygen treatment
76 patients
77 postextubation respiratory failure
78 postrandomization ICU length
79 primary endpoint
80 protocol
81 reintubation
82 respiratory disease
83 respiratory disorders
84 respiratory failure
85 risk
86 role
87 role of NIV
88 sequential protocol
89 spontaneous breathing trial
90 stay
91 study
92 therapy
93 treatment
94 trials
95 unit mortality
96 usual care group
97 ventilation
98 schema:name Intermittent noninvasive ventilation after extubation in patients with chronic respiratory disorders: a multicenter randomized controlled trial (VHYPER)
99 schema:pagination 1626-1636
100 schema:productId N4a81a2394a9c4b278c59c20249ebf4a5
101 N70b697a84c05446aa793db426f92c7e5
102 Ndfffc9aeee4948beb8a19e857f82f09b
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084757746
104 https://doi.org/10.1007/s00134-017-4785-1
105 schema:sdDatePublished 2021-12-01T19:40
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N1baaa0ace9e24392b5ed20ff662f0bc7
108 schema:url https://doi.org/10.1007/s00134-017-4785-1
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N06fbae92c0aa4bfb955450da033ae49b rdf:first sg:person.0767512633.63
113 rdf:rest N43ea98b528814cc4ab009131de871438
114 N0f5cafbe51e943cea51a299cec44fe81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Intensive Care Units
116 rdf:type schema:DefinedTerm
117 N1416ec62dcae4010ad790d986cc4084b rdf:first N1fa2bdc8830b40aebe3e06155e6ce111
118 rdf:rest Nd1d7a5b8a6214c76a1b6a659c01a5c23
119 N18ec0515fd13407689ca2b2551fd2530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 N1baaa0ace9e24392b5ed20ff662f0bc7 schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 N1fa2bdc8830b40aebe3e06155e6ce111 schema:affiliation grid-institutes:grid.414282.9
125 schema:familyName Sanchez-Verlan
126 schema:givenName Pascale
127 rdf:type schema:Person
128 N1fe65830901e43bda03175d7de65ed8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Chronic Disease
130 rdf:type schema:DefinedTerm
131 N41cc18558152481c98f76b16687ffcc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Male
133 rdf:type schema:DefinedTerm
134 N43ea98b528814cc4ab009131de871438 rdf:first sg:person.01346320132.54
135 rdf:rest N8c5e264e1a344976832bf24ae6201307
136 N46fcc236a1df4651b2585fad707d7a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Noninvasive Ventilation
138 rdf:type schema:DefinedTerm
139 N487731a3886a4d16804cea14d2649ecd rdf:first sg:person.0760775335.66
140 rdf:rest N7ebebd52a0a4471bac33a674c8bf5dab
141 N4a81a2394a9c4b278c59c20249ebf4a5 schema:name pubmed_id
142 schema:value 28393258
143 rdf:type schema:PropertyValue
144 N50faa4a075c348fcb0ae796e0780f607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 N5fb6e0e753644a638aab544a967fe629 rdf:first sg:person.012242166273.76
148 rdf:rest N6cd969ad29ab4d0eb11d28092cdb4e33
149 N64ee85deaf004d56b34477bf34093192 rdf:first sg:person.0576433535.50
150 rdf:rest N1416ec62dcae4010ad790d986cc4084b
151 N661bd3e422dc450d9082730f7972cc0f rdf:first sg:person.01017471224.87
152 rdf:rest Nb78f28ae29054c3c865dc49113413411
153 N67b7503761d544538410c18611662d65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Length of Stay
155 rdf:type schema:DefinedTerm
156 N6cd969ad29ab4d0eb11d28092cdb4e33 rdf:first sg:person.013037546673.24
157 rdf:rest N06fbae92c0aa4bfb955450da033ae49b
158 N6f771f986e064274ba5b3e148e1309c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Airway Extubation
160 rdf:type schema:DefinedTerm
161 N70b697a84c05446aa793db426f92c7e5 schema:name dimensions_id
162 schema:value pub.1084757746
163 rdf:type schema:PropertyValue
164 N7ebebd52a0a4471bac33a674c8bf5dab rdf:first sg:person.0714117317.55
165 rdf:rest rdf:nil
166 N829c7f5a116840ccbd63e6fdbe0009ea schema:volumeNumber 43
167 rdf:type schema:PublicationVolume
168 N877665c2cc7646d4be549addf82969f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Respiratory Insufficiency
170 rdf:type schema:DefinedTerm
171 N879f999a28b544de93fdaf138e891f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Oxygen Inhalation Therapy
173 rdf:type schema:DefinedTerm
174 N8882ac647a5846c2aab42c15d103abf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Intention to Treat Analysis
176 rdf:type schema:DefinedTerm
177 N8c5e264e1a344976832bf24ae6201307 rdf:first sg:person.01222244757.42
178 rdf:rest N661bd3e422dc450d9082730f7972cc0f
179 N93d9dbc1f5c44e9ea8c9aee984a9751e rdf:first sg:person.01107247643.17
180 rdf:rest N487731a3886a4d16804cea14d2649ecd
181 N9e8f202045c44811a1dc33b58c482b38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Hypercapnia
183 rdf:type schema:DefinedTerm
184 N9f67a8a8c2b44c578785fd6cf521e5e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Aged
186 rdf:type schema:DefinedTerm
187 Nb78f28ae29054c3c865dc49113413411 rdf:first sg:person.01053512353.85
188 rdf:rest N93d9dbc1f5c44e9ea8c9aee984a9751e
189 Nbde010f81667462e826f5d19400f5fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Prospective Studies
191 rdf:type schema:DefinedTerm
192 Nbe8ca9f902d1488c86de136261f8c578 rdf:first sg:person.01146613615.31
193 rdf:rest Nfb329d28b67340a2bb1fe3d9c0a0d8b1
194 Nc053f7e074fa499a8cea080cc96109b1 rdf:first sg:person.01306660172.66
195 rdf:rest N5fb6e0e753644a638aab544a967fe629
196 Nd1d7a5b8a6214c76a1b6a659c01a5c23 rdf:first sg:person.01345616042.14
197 rdf:rest Nbe8ca9f902d1488c86de136261f8c578
198 Nd4433f717c82451ca850a6d41435eaf9 rdf:first sg:person.01236106016.48
199 rdf:rest N64ee85deaf004d56b34477bf34093192
200 Ndfffc9aeee4948beb8a19e857f82f09b schema:name doi
201 schema:value 10.1007/s00134-017-4785-1
202 rdf:type schema:PropertyValue
203 Ne825f5dd865046fda50a8984feea7dab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Respiration Disorders
205 rdf:type schema:DefinedTerm
206 Nee4a001550c84a9791e0648e0c61b6db schema:issueNumber 11
207 rdf:type schema:PublicationIssue
208 Nef2964e0442a4719bcb60b63f803e2fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Risk Factors
210 rdf:type schema:DefinedTerm
211 Nf166d139461e4c5abe44b3ccd8656a0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Middle Aged
213 rdf:type schema:DefinedTerm
214 Nf4fe83b200854923851302f1dd5abe38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Ventilator Weaning
216 rdf:type schema:DefinedTerm
217 Nfb329d28b67340a2bb1fe3d9c0a0d8b1 rdf:first sg:person.01201312006.73
218 rdf:rest Nc053f7e074fa499a8cea080cc96109b1
219 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
220 schema:name Medical and Health Sciences
221 rdf:type schema:DefinedTerm
222 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
223 schema:name Clinical Sciences
224 rdf:type schema:DefinedTerm
225 sg:journal.1313639 schema:issn 0342-4642
226 1432-1238
227 schema:name Intensive Care Medicine
228 schema:publisher Springer Nature
229 rdf:type schema:Periodical
230 sg:person.01017471224.87 schema:affiliation grid-institutes:None
231 schema:familyName Gauche
232 schema:givenName Bernard
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017471224.87
234 rdf:type schema:Person
235 sg:person.01053512353.85 schema:affiliation grid-institutes:grid.414263.6
236 schema:familyName Gruson
237 schema:givenName Didier
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053512353.85
239 rdf:type schema:Person
240 sg:person.01107247643.17 schema:affiliation grid-institutes:None
241 schema:familyName Silva
242 schema:givenName Stein
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107247643.17
244 rdf:type schema:Person
245 sg:person.01146613615.31 schema:affiliation grid-institutes:grid.414263.6
246 schema:familyName Boyer
247 schema:givenName Alexandre
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146613615.31
249 rdf:type schema:Person
250 sg:person.01201312006.73 schema:affiliation grid-institutes:grid.414263.6
251 schema:familyName Bui
252 schema:givenName Hoang-Nam
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201312006.73
254 rdf:type schema:Person
255 sg:person.01222244757.42 schema:affiliation grid-institutes:grid.42399.35
256 schema:familyName Asselineau
257 schema:givenName Julien
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222244757.42
259 rdf:type schema:Person
260 sg:person.012242166273.76 schema:affiliation grid-institutes:grid.414263.6
261 schema:familyName Sazio
262 schema:givenName Charline
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012242166273.76
264 rdf:type schema:Person
265 sg:person.01236106016.48 schema:affiliation grid-institutes:grid.412041.2
266 schema:familyName Vargas
267 schema:givenName Frédéric
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236106016.48
269 rdf:type schema:Person
270 sg:person.013037546673.24 schema:affiliation grid-institutes:grid.489897.3
271 schema:familyName Kerchache
272 schema:givenName Aissa
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013037546673.24
274 rdf:type schema:Person
275 sg:person.01306660172.66 schema:affiliation grid-institutes:grid.414263.6
276 schema:familyName Clouzeau
277 schema:givenName Benjamin
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306660172.66
279 rdf:type schema:Person
280 sg:person.01345616042.14 schema:affiliation grid-institutes:grid.460734.2
281 schema:familyName Garnier
282 schema:givenName Sylvain
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345616042.14
284 rdf:type schema:Person
285 sg:person.01346320132.54 schema:affiliation grid-institutes:grid.42399.35
286 schema:familyName Benard
287 schema:givenName Antoine
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346320132.54
289 rdf:type schema:Person
290 sg:person.0576433535.50 schema:affiliation grid-institutes:grid.411178.a
291 schema:familyName Clavel
292 schema:givenName Marc
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576433535.50
294 rdf:type schema:Person
295 sg:person.0714117317.55 schema:affiliation grid-institutes:grid.412041.2
296 schema:familyName Hilbert
297 schema:givenName Gilles
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714117317.55
299 rdf:type schema:Person
300 sg:person.0760775335.66 schema:affiliation grid-institutes:grid.411178.a
301 schema:familyName Vignon
302 schema:givenName Philippe
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760775335.66
304 rdf:type schema:Person
305 sg:person.0767512633.63 schema:affiliation grid-institutes:grid.414339.8
306 schema:familyName Guisset
307 schema:givenName Olivier
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767512633.63
309 rdf:type schema:Person
310 sg:pub.10.1007/s00134-002-1208-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027730669
311 https://doi.org/10.1007/s00134-002-1208-7
312 rdf:type schema:CreativeWork
313 sg:pub.10.1007/s00134-002-1353-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000338397
314 https://doi.org/10.1007/s00134-002-1353-z
315 rdf:type schema:CreativeWork
316 sg:pub.10.1007/s00134-002-1574-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006156595
317 https://doi.org/10.1007/s00134-002-1574-1
318 rdf:type schema:CreativeWork
319 sg:pub.10.1007/s00134-010-1984-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024590799
320 https://doi.org/10.1007/s00134-010-1984-4
321 rdf:type schema:CreativeWork
322 sg:pub.10.1007/s00134-011-2179-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012991496
323 https://doi.org/10.1007/s00134-011-2179-3
324 rdf:type schema:CreativeWork
325 sg:pub.10.1007/s001340050438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001921680
326 https://doi.org/10.1007/s001340050438
327 rdf:type schema:CreativeWork
328 sg:pub.10.1007/s001340050927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027347765
329 https://doi.org/10.1007/s001340050927
330 rdf:type schema:CreativeWork
331 sg:pub.10.1186/cc12549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012369249
332 https://doi.org/10.1186/cc12549
333 rdf:type schema:CreativeWork
334 sg:pub.10.1186/s13054-016-1228-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051062750
335 https://doi.org/10.1186/s13054-016-1228-2
336 rdf:type schema:CreativeWork
337 grid-institutes:None schema:alternateName INSERM, URM 1214, Université de Toulouse, Toulouse, France
338 Service de Réanimation Polyvalente, Centre Hospitalier de Libourne, Libourne, France
339 schema:name INSERM, URM 1214, Université de Toulouse, Toulouse, France
340 Service de Réanimation Polyvalente, CHU de Toulouse, Hôpital Purpan, Toulouse, France
341 Service de Réanimation Polyvalente, Centre Hospitalier de Libourne, Libourne, France
342 rdf:type schema:Organization
343 grid-institutes:grid.411178.a schema:alternateName Service de Réanimation Polyvalente, CHU de Limoges, Hôpital Dupuytren, Limoges, France
344 schema:name Service de Réanimation Polyvalente, CHU de Limoges, Hôpital Dupuytren, Limoges, France
345 rdf:type schema:Organization
346 grid-institutes:grid.412041.2 schema:alternateName Centre de Recherche Cardio-Thoracique, INSERM 1045, CIC 0005, Université de Bordeaux, Bordeaux, France
347 schema:name Centre de Recherche Cardio-Thoracique, INSERM 1045, CIC 0005, Université de Bordeaux, Bordeaux, France
348 Service de Réanimation Médicale, Hôpital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Amélie Raba-Léon, 33076, Bordeaux, France
349 rdf:type schema:Organization
350 grid-institutes:grid.414263.6 schema:alternateName Service de Réanimation Médicale, Hôpital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Amélie Raba-Léon, 33076, Bordeaux, France
351 schema:name Service de Réanimation Médicale, Hôpital Pellegrin-Tripode, Centre Hospitalier Universitaire (CHU) de Bordeaux, 1 Place Amélie Raba-Léon, 33076, Bordeaux, France
352 rdf:type schema:Organization
353 grid-institutes:grid.414282.9 schema:alternateName Service de Réanimation Polyvalente, CHU de Toulouse, Hôpital Purpan, Toulouse, France
354 schema:name Service de Réanimation Polyvalente, CHU de Toulouse, Hôpital Purpan, Toulouse, France
355 rdf:type schema:Organization
356 grid-institutes:grid.414339.8 schema:alternateName Service de Réanimation Médicale, CHU de Bordeaux, Hôpital Saint-André, Bordeaux, France
357 schema:name Service de Réanimation Médicale, CHU de Bordeaux, Hôpital Saint-André, Bordeaux, France
358 rdf:type schema:Organization
359 grid-institutes:grid.42399.35 schema:alternateName Service d’Information Médicale, CHU de Bordeaux, Pôle de Santé Publique, USMR, Bordeaux, France
360 schema:name Service d’Information Médicale, CHU de Bordeaux, Pôle de Santé Publique, USMR, Bordeaux, France
361 rdf:type schema:Organization
362 grid-institutes:grid.460734.2 schema:alternateName Service de Réanimation Polyvalente, Centre Hospitalier d’Albi, Albi, France
363 schema:name Service de Réanimation Polyvalente, Centre Hospitalier d’Albi, Albi, France
364 rdf:type schema:Organization
365 grid-institutes:grid.489897.3 schema:alternateName Service de Réanimation Polyvalente, Centre Hospitalier d’Agen, Agen, France
366 schema:name Service de Réanimation Polyvalente, Centre Hospitalier d’Agen, Agen, France
367 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...