Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-27

AUTHORS

Marcus J. Schultz, Martin W. Dunser, Arjen M. Dondorp, Neill K. J. Adhikari, Shivakumar Iyer, Arthur Kwizera, Yoel Lubell, Alfred Papali, Luigi Pisani, Beth D. Riviello, Derek C. Angus, Luciano C. Azevedo, Tim Baker, Janet V. Diaz, Emir Festic, Rashan Haniffa, Randeep Jawa, Shevin T. Jacob, Niranjan Kissoon, Rakesh Lodha, Ignacio Martin-Loeches, Ganbold Lundeg, David Misango, Mervyn Mer, Sanjib Mohanty, Srinivas Murthy, Ndidiamaka Musa, Jane Nakibuuka, Ary Serpa Neto, Mai Nguyen Thi Hoang, Binh Nguyen Thien, Rajyabardhan Pattnaik, Jason Phua, Jacobus Preller, Pedro Povoa, Suchitra Ranjit, Daniel Talmor, Jonarthan Thevanayagam, C. Louise Thwaites,

ABSTRACT

BackgroundSepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome.AimTo describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics and research aspects of sepsis. We restricted this manuscript to the ICU setting even knowing that many sepsis patients in LMICs are treated outside an ICU.FindingsAlthough many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can sometimes be more important than the response of the host. There are substantial and persisting differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs, but with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and the important differences in resources.ConclusionsAddressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for severe sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both at a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement. More... »

PAGES

612-624

References to SciGraph publications

  • 2010-10-15. Cost and mortality prediction using polymerase chain reaction pathogen detection in sepsis: evidence from three observational trials in CRITICAL CARE
  • 2016-11-29. Intensive Care Medicine in 2050: global perspectives in INTENSIVE CARE MEDICINE
  • 2012-09-01. National intensive care unit bed capacity and ICU patient characteristics in a low income country in BMC RESEARCH NOTES
  • 2016-07-29. Ebola virus disease and critical illness in CRITICAL CARE
  • 2012-07-10. The variability of critical care bed numbers in Europe in INTENSIVE CARE MEDICINE
  • 1997-08. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate in NATURE MEDICINE
  • 2010-12-09. Cost-effectiveness of the Surviving Sepsis Campaign protocol for severe sepsis: a prospective nation-wide study in Spain in INTENSIVE CARE MEDICINE
  • 2015-09-28. Ventilatory support of patients with sepsis or septic shock in resource-limited settings in INTENSIVE CARE MEDICINE
  • 2016-06-21. Recommendations for infection management in patients with sepsis and septic shock in resource-limited settings in INTENSIVE CARE MEDICINE
  • 2016-01-29. What’s new in sepsis recognition in resource-limited settings? in INTENSIVE CARE MEDICINE
  • 2016-05-23. Pediatric sepsis and septic shock management in resource-limited settings in INTENSIVE CARE MEDICINE
  • 2016-06-08. Healthcare Costs to Poor Families: An Agonising Burden in THE INDIAN JOURNAL OF PEDIATRICS
  • 2016-04-11. Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance in NATURE GENETICS
  • 2008-10-01. Differences in critical care practice between an industrialized and a developing country in WIENER KLINISCHE WOCHENSCHRIFT
  • 2011-01-10. Availability of critical care resources to treat patients with severe sepsis or septic shock in Africa: a self-reported, continent-wide survey of anaesthesia providers in CRITICAL CARE
  • 2003-03-28. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference in INTENSIVE CARE MEDICINE
  • 2013-05-01. Malaria is an uncommon cause of adult sepsis in south-western Uganda in MALARIA JOURNAL
  • 2016-04-12. Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions in INTENSIVE CARE MEDICINE
  • 2013-04-16. Emergency and critical care services in Tanzania: a survey of ten hospitals in BMC HEALTH SERVICES RESEARCH
  • 2012-02-14. Recommendations for sepsis management in resource-limited settings in INTENSIVE CARE MEDICINE
  • 2013-12-13. Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities in INTENSIVE CARE MEDICINE
  • Journal

    TITLE

    Intensive Care Medicine

    ISSUE

    5

    VOLUME

    43

    Author Affiliations

  • Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
  • University College of London Hospital, London, UK
  • Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada
  • Bharati Vidyapeeth Deemed University Medical College, Pune, India
  • Mulago National Referral Hospital, Kampala, Uganda
  • University of Maryland School of Medicine, Baltimore, MD, USA
  • Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
  • University of Pittsburgh, Pittsburgh, PA, USA
  • Hospital Sirio-Libanes, Saõ Paulo, Brazil
  • Karolinska Institute, Stockholm, Sweden
  • California Pacific Medical Center, San Francisco, CA, USA
  • Mayo Clinic, Jacksonville, FL, USA
  • Mahidol University, Bangkok, Thailand
  • Stony Brook University Medical Center, Stony Brook, NY, USA
  • University of Washington, Seattle, WA, USA
  • British Columbia Children’s Hospital, Vancouver, Canada
  • All India Institute of Medical Science, Delhi, India
  • St. James’s University Hospital, Dublin, Ireland
  • Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Aga Khan University Hospital, Nairobi, Kenya
  • Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
  • Ispat General Hospital, Sundargarh, Rourkela, Odisha, India
  • Seattle Children’s Hospital and University of Washington, Seattle, WA, USA
  • Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  • Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
  • Trung Vuong Hospital, Ho Chi Minh City, Vietnam
  • National University Hospital, Singapore, Singapore
  • Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • Nova Medical School, CEDOC, New University of Lisbon and Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
  • Appolo Hospitals, Chennai, India
  • Mzuzu Central Hospital, Mzuzu, Malawi
  • Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-017-4750-z

    DOI

    http://dx.doi.org/10.1007/s00134-017-4750-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084018945

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28349179


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomedical Research", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cost-Benefit Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Critical Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Developing Countries", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Global Burden of Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Health Care Costs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Health Resources", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant, Newborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Practice Guidelines as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quality of Health Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sepsis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Mahidol University, Bangkok, Thailand", 
                "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schultz", 
            "givenName": "Marcus J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College of London Hospital, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.439749.4", 
              "name": [
                "University College of London Hospital, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dunser", 
            "givenName": "Martin W.", 
            "id": "sg:person.0661420277.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661420277.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Mahidol University, Bangkok, Thailand", 
                "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dondorp", 
            "givenName": "Arjen M.", 
            "id": "sg:person.01162317707.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162317707.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.413104.3", 
              "name": [
                "Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adhikari", 
            "givenName": "Neill K. J.", 
            "id": "sg:person.01205364112.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205364112.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bharati Vidyapeeth Deemed University Medical College, Pune, India", 
              "id": "http://www.grid.ac/institutes/grid.411681.b", 
              "name": [
                "Bharati Vidyapeeth Deemed University Medical College, Pune, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iyer", 
            "givenName": "Shivakumar", 
            "id": "sg:person.01362157550.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362157550.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mulago National Referral Hospital, Kampala, Uganda", 
              "id": "http://www.grid.ac/institutes/grid.416252.6", 
              "name": [
                "Mulago National Referral Hospital, Kampala, Uganda"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kwizera", 
            "givenName": "Arthur", 
            "id": "sg:person.01100610423.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100610423.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lubell", 
            "givenName": "Yoel", 
            "id": "sg:person.0772543414.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772543414.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Maryland School of Medicine, Baltimore, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.411024.2", 
              "name": [
                "University of Maryland School of Medicine, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Papali", 
            "givenName": "Alfred", 
            "id": "sg:person.01343754225.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343754225.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Mahidol University, Bangkok, Thailand", 
                "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pisani", 
            "givenName": "Luigi", 
            "id": "sg:person.01055636325.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055636325.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riviello", 
            "givenName": "Beth D.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh, Pittsburgh, PA, USA", 
              "id": "http://www.grid.ac/institutes/grid.21925.3d", 
              "name": [
                "University of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Angus", 
            "givenName": "Derek C.", 
            "id": "sg:person.01013154627.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013154627.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Sirio-Libanes, Sa\u00f5 Paulo, Brazil", 
              "id": "http://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "Hospital Sirio-Libanes, Sa\u00f5 Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Azevedo", 
            "givenName": "Luciano C.", 
            "id": "sg:person.013070162407.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013070162407.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute, Stockholm, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Karolinska Institute, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baker", 
            "givenName": "Tim", 
            "id": "sg:person.01300325773.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300325773.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "California Pacific Medical Center, San Francisco, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.17866.3e", 
              "name": [
                "California Pacific Medical Center, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Diaz", 
            "givenName": "Janet V.", 
            "id": "sg:person.010522476441.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522476441.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic, Jacksonville, FL, USA", 
              "id": "http://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Mayo Clinic, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Festic", 
            "givenName": "Emir", 
            "id": "sg:person.0761337561.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761337561.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mahidol University, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.10223.32", 
              "name": [
                "Mahidol University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haniffa", 
            "givenName": "Rashan", 
            "id": "sg:person.01146723623.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146723623.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stony Brook University Medical Center, Stony Brook, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.412695.d", 
              "name": [
                "Stony Brook University Medical Center, Stony Brook, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jawa", 
            "givenName": "Randeep", 
            "id": "sg:person.0657017105.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657017105.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "University of Washington, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jacob", 
            "givenName": "Shevin T.", 
            "id": "sg:person.01074734123.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074734123.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "British Columbia Children\u2019s Hospital, Vancouver, Canada", 
              "id": "http://www.grid.ac/institutes/grid.414137.4", 
              "name": [
                "British Columbia Children\u2019s Hospital, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kissoon", 
            "givenName": "Niranjan", 
            "id": "sg:person.014150672735.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014150672735.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "All India Institute of Medical Science, Delhi, India", 
              "id": "http://www.grid.ac/institutes/grid.413618.9", 
              "name": [
                "All India Institute of Medical Science, Delhi, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lodha", 
            "givenName": "Rakesh", 
            "id": "sg:person.01075705652.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075705652.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. James\u2019s University Hospital, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "St. James\u2019s University Hospital, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin-Loeches", 
            "givenName": "Ignacio", 
            "id": "sg:person.01366266562.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366266562.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia", 
              "id": "http://www.grid.ac/institutes/grid.444534.6", 
              "name": [
                "Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lundeg", 
            "givenName": "Ganbold", 
            "id": "sg:person.01051057723.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051057723.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aga Khan University Hospital, Nairobi, Kenya", 
              "id": "http://www.grid.ac/institutes/grid.411192.e", 
              "name": [
                "Aga Khan University Hospital, Nairobi, Kenya"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Misango", 
            "givenName": "David", 
            "id": "sg:person.013052601043.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052601043.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa", 
              "id": "http://www.grid.ac/institutes/grid.11951.3d", 
              "name": [
                "Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mer", 
            "givenName": "Mervyn", 
            "id": "sg:person.01104732461.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104732461.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ispat General Hospital, Sundargarh, Rourkela, Odisha, India", 
              "id": "http://www.grid.ac/institutes/grid.440315.7", 
              "name": [
                "Ispat General Hospital, Sundargarh, Rourkela, Odisha, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohanty", 
            "givenName": "Sanjib", 
            "id": "sg:person.0610604105.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610604105.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "British Columbia Children\u2019s Hospital, Vancouver, Canada", 
              "id": "http://www.grid.ac/institutes/grid.414137.4", 
              "name": [
                "British Columbia Children\u2019s Hospital, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murthy", 
            "givenName": "Srinivas", 
            "id": "sg:person.0740103341.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740103341.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seattle Children\u2019s Hospital and University of Washington, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.240741.4", 
              "name": [
                "Seattle Children\u2019s Hospital and University of Washington, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Musa", 
            "givenName": "Ndidiamaka", 
            "id": "sg:person.0622142430.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622142430.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mulago National Referral Hospital, Kampala, Uganda", 
              "id": "http://www.grid.ac/institutes/grid.416252.6", 
              "name": [
                "Mulago National Referral Hospital, Kampala, Uganda"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakibuuka", 
            "givenName": "Jane", 
            "id": "sg:person.01261070640.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261070640.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil", 
              "id": "http://www.grid.ac/institutes/grid.413562.7", 
              "name": [
                "Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands", 
                "Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serpa Neto", 
            "givenName": "Ary", 
            "id": "sg:person.0603551123.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603551123.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam", 
              "id": "http://www.grid.ac/institutes/grid.412433.3", 
              "name": [
                "Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen Thi Hoang", 
            "givenName": "Mai", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Trung Vuong Hospital, Ho Chi Minh City, Vietnam", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Trung Vuong Hospital, Ho Chi Minh City, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen Thien", 
            "givenName": "Binh", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ispat General Hospital, Sundargarh, Rourkela, Odisha, India", 
              "id": "http://www.grid.ac/institutes/grid.440315.7", 
              "name": [
                "Ispat General Hospital, Sundargarh, Rourkela, Odisha, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pattnaik", 
            "givenName": "Rajyabardhan", 
            "id": "sg:person.01232635004.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232635004.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital, Singapore, Singapore", 
              "id": "http://www.grid.ac/institutes/grid.412106.0", 
              "name": [
                "National University Hospital, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Phua", 
            "givenName": "Jason", 
            "id": "sg:person.01345512332.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345512332.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.120073.7", 
              "name": [
                "Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Preller", 
            "givenName": "Jacobus", 
            "id": "sg:person.013716274643.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013716274643.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nova Medical School, CEDOC, New University of Lisbon and Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.414462.1", 
              "name": [
                "Nova Medical School, CEDOC, New University of Lisbon and Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Povoa", 
            "givenName": "Pedro", 
            "id": "sg:person.01167550047.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167550047.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Appolo Hospitals, Chennai, India", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Appolo Hospitals, Chennai, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ranjit", 
            "givenName": "Suchitra", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Talmor", 
            "givenName": "Daniel", 
            "id": "sg:person.0600270775.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600270775.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mzuzu Central Hospital, Mzuzu, Malawi", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Mzuzu Central Hospital, Mzuzu, Malawi"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thevanayagam", 
            "givenName": "Jonarthan", 
            "id": "sg:person.01105040674.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105040674.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thwaites", 
            "givenName": "C. Louise", 
            "id": "sg:person.0663401704.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663401704.10"
            ], 
            "type": "Person"
          }, 
          {}
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-015-4070-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020990665", 
              "https://doi.org/10.1007/s00134-015-4070-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc9410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009093304", 
              "https://doi.org/10.1186/cc9410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-016-4631-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051597939", 
              "https://doi.org/10.1007/s00134-016-4631-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-012-2627-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009233920", 
              "https://doi.org/10.1007/s00134-012-2627-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-12-146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042804359", 
              "https://doi.org/10.1186/1475-2875-12-146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-3174-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017840857", 
              "https://doi.org/10.1007/s00134-013-3174-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-010-2102-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012516702", 
              "https://doi.org/10.1007/s00134-010-2102-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-016-4415-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005830433", 
              "https://doi.org/10.1007/s00134-016-4415-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-003-1662-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038680632", 
              "https://doi.org/10.1007/s00134-003-1662-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-016-4347-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033562646", 
              "https://doi.org/10.1007/s00134-016-4347-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12098-016-2170-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034521275", 
              "https://doi.org/10.1007/s12098-016-2170-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-016-4222-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026714655", 
              "https://doi.org/10.1007/s00134-016-4222-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-012-2468-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014693845", 
              "https://doi.org/10.1007/s00134-012-2468-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-0500-5-475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006218037", 
              "https://doi.org/10.1186/1756-0500-5-475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6963-13-140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011730801", 
              "https://doi.org/10.1186/1472-6963-13-140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026698708", 
              "https://doi.org/10.1038/ng.3548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-016-1325-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040821529", 
              "https://doi.org/10.1186/s13054-016-1325-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-016-4382-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044246187", 
              "https://doi.org/10.1007/s00134-016-4382-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc9294", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043956762", 
              "https://doi.org/10.1186/cc9294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00508-008-1064-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023956535", 
              "https://doi.org/10.1007/s00508-008-1064-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0897-866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019214768", 
              "https://doi.org/10.1038/nm0897-866"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-03-27", 
        "datePublishedReg": "2017-03-27", 
        "description": "BackgroundSepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome.AimTo describe differences between resource-poor and\u00a0resource-rich settings regarding the epidemiology, pathophysiology, economics and research aspects of sepsis. We restricted this manuscript to the ICU setting even knowing that many sepsis patients in LMICs are treated outside an ICU.FindingsAlthough many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can sometimes be more important than the response of the host. There are substantial and persisting differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs, but with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and the important differences in resources.ConclusionsAddressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for severe sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both at a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00134-017-4750-z", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1313639", 
            "issn": [
              "0342-4642", 
              "1432-1238"
            ], 
            "name": "Intensive Care Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "43"
          }
        ], 
        "keywords": [
          "resource-poor settings", 
          "sepsis management", 
          "intensive care unit admission", 
          "care unit admission", 
          "setting-specific factors", 
          "management of sepsis", 
          "cause of sepsis", 
          "resource-rich settings", 
          "resource-limited settings", 
          "direct damaging effect", 
          "individual LMICs", 
          "unit admission", 
          "severe sepsis", 
          "middle-income countries", 
          "sepsis patients", 
          "patient outcomes", 
          "critical care", 
          "high-income countries", 
          "sepsis", 
          "resistance patterns", 
          "ICU capacity", 
          "LMIC settings", 
          "ICUs", 
          "tropical diseases", 
          "LMICs", 
          "antimicrobial drugs", 
          "ICU", 
          "strong consideration", 
          "bacterial pathogens", 
          "rich countries", 
          "cost implications", 
          "damaging effects", 
          "setting", 
          "important heterogeneity", 
          "BackgroundSepsis", 
          "important differences", 
          "patients", 
          "admission", 
          "pathophysiology", 
          "pathogens", 
          "AimTo", 
          "management", 
          "countries", 
          "epidemiology", 
          "differences", 
          "important opportunity", 
          "disease", 
          "detailed evaluation", 
          "major reason", 
          "care", 
          "drugs", 
          "outcomes", 
          "cause", 
          "low capacity", 
          "economics", 
          "response", 
          "factors", 
          "levels", 
          "evaluation", 
          "frontier", 
          "training", 
          "current challenges", 
          "effect", 
          "improvement", 
          "heterogeneity", 
          "host", 
          "challenges", 
          "capacity", 
          "aspects", 
          "patterns", 
          "addition", 
          "implications", 
          "resources", 
          "reasons", 
          "manuscript", 
          "opportunities", 
          "initiatives", 
          "future", 
          "world", 
          "research aspects", 
          "suggestions", 
          "consideration", 
          "unexplored frontier", 
          "research", 
          "macro", 
          "products", 
          "implementation", 
          "performance", 
          "performance of ICUs", 
          "micro-economy level"
        ], 
        "name": "Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future", 
        "pagination": "612-624", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084018945"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00134-017-4750-z"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28349179"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00134-017-4750-z", 
          "https://app.dimensions.ai/details/publication/pub.1084018945"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_733.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00134-017-4750-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4750-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4750-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4750-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-017-4750-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    663 TRIPLES      22 PREDICATES      155 URIs      126 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00134-017-4750-z schema:about N0ea4abd7bf6349919be7ace835010dae
    2 N2d945f9875e848d8adec24668c94c58a
    3 N3b6cdc2850ae4c3d90f46d78ded2e4c7
    4 N42bc4024b3384aecb83b28b6310dfdf9
    5 N43b21c4d4bdb49e282c4bee79faef5e8
    6 N449567b48dc2455185b6ef7d87d1fecb
    7 N469cf4c7487543d680beddac0c7cb851
    8 N50aa8749990d4cfcb398a059f403434f
    9 N65a6fdde798c4646bf7cd7c87241bd6d
    10 N7013538e03784db68517759ce857fd30
    11 N728f2c7eaa1847238658b3c9555ad471
    12 N7b662766119741ad9c27ee5a929dc86b
    13 N81ccb53e21d9437583b68422be4f1799
    14 N9019942a478b43eeaf76db8772cca3af
    15 Na1867cd3c48e4b1d81bc64ef5568fa69
    16 Na7c3860c3eda445eaed34e1f6f465bce
    17 Nde254b2328d34b418c72580528c56f12
    18 Nf1c32108a68849818e1695d9ae411218
    19 anzsrc-for:11
    20 anzsrc-for:1103
    21 schema:author N106c9b35ea34493f990208a515b97e49
    22 schema:citation sg:pub.10.1007/s00134-003-1662-x
    23 sg:pub.10.1007/s00134-010-2102-3
    24 sg:pub.10.1007/s00134-012-2468-5
    25 sg:pub.10.1007/s00134-012-2627-8
    26 sg:pub.10.1007/s00134-013-3174-7
    27 sg:pub.10.1007/s00134-015-4070-0
    28 sg:pub.10.1007/s00134-016-4222-x
    29 sg:pub.10.1007/s00134-016-4347-y
    30 sg:pub.10.1007/s00134-016-4382-8
    31 sg:pub.10.1007/s00134-016-4415-3
    32 sg:pub.10.1007/s00134-016-4631-x
    33 sg:pub.10.1007/s00508-008-1064-8
    34 sg:pub.10.1007/s12098-016-2170-7
    35 sg:pub.10.1038/ng.3548
    36 sg:pub.10.1038/nm0897-866
    37 sg:pub.10.1186/1472-6963-13-140
    38 sg:pub.10.1186/1475-2875-12-146
    39 sg:pub.10.1186/1756-0500-5-475
    40 sg:pub.10.1186/cc9294
    41 sg:pub.10.1186/cc9410
    42 sg:pub.10.1186/s13054-016-1325-2
    43 schema:datePublished 2017-03-27
    44 schema:datePublishedReg 2017-03-27
    45 schema:description BackgroundSepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome.AimTo describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics and research aspects of sepsis. We restricted this manuscript to the ICU setting even knowing that many sepsis patients in LMICs are treated outside an ICU.FindingsAlthough many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can sometimes be more important than the response of the host. There are substantial and persisting differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs, but with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and the important differences in resources.ConclusionsAddressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for severe sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both at a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement.
    46 schema:genre article
    47 schema:inLanguage en
    48 schema:isAccessibleForFree true
    49 schema:isPartOf N9b3c8f31ee094fdb84942163f9d8a03f
    50 Nfe095b938e3c4627ab14ae207a803ac0
    51 sg:journal.1313639
    52 schema:keywords AimTo
    53 BackgroundSepsis
    54 ICU
    55 ICU capacity
    56 ICUs
    57 LMIC settings
    58 LMICs
    59 addition
    60 admission
    61 antimicrobial drugs
    62 aspects
    63 bacterial pathogens
    64 capacity
    65 care
    66 care unit admission
    67 cause
    68 cause of sepsis
    69 challenges
    70 consideration
    71 cost implications
    72 countries
    73 critical care
    74 current challenges
    75 damaging effects
    76 detailed evaluation
    77 differences
    78 direct damaging effect
    79 disease
    80 drugs
    81 economics
    82 effect
    83 epidemiology
    84 evaluation
    85 factors
    86 frontier
    87 future
    88 heterogeneity
    89 high-income countries
    90 host
    91 implementation
    92 implications
    93 important differences
    94 important heterogeneity
    95 important opportunity
    96 improvement
    97 individual LMICs
    98 initiatives
    99 intensive care unit admission
    100 levels
    101 low capacity
    102 macro
    103 major reason
    104 management
    105 management of sepsis
    106 manuscript
    107 micro-economy level
    108 middle-income countries
    109 opportunities
    110 outcomes
    111 pathogens
    112 pathophysiology
    113 patient outcomes
    114 patients
    115 patterns
    116 performance
    117 performance of ICUs
    118 products
    119 reasons
    120 research
    121 research aspects
    122 resistance patterns
    123 resource-limited settings
    124 resource-poor settings
    125 resource-rich settings
    126 resources
    127 response
    128 rich countries
    129 sepsis
    130 sepsis management
    131 sepsis patients
    132 setting
    133 setting-specific factors
    134 severe sepsis
    135 strong consideration
    136 suggestions
    137 training
    138 tropical diseases
    139 unexplored frontier
    140 unit admission
    141 world
    142 schema:name Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future
    143 schema:pagination 612-624
    144 schema:productId N0394ef657ac546909f044bb6112a4c12
    145 N785c13f953514458a51b2028181e4680
    146 Na31e0fe04bb4476e908d81cf203c1852
    147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084018945
    148 https://doi.org/10.1007/s00134-017-4750-z
    149 schema:sdDatePublished 2022-01-01T18:44
    150 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    151 schema:sdPublisher N4c72999f8a28450585a6062f44e08b63
    152 schema:url https://doi.org/10.1007/s00134-017-4750-z
    153 sgo:license sg:explorer/license/
    154 sgo:sdDataset articles
    155 rdf:type schema:ScholarlyArticle
    156 N011e8684973b41f48dbef1cfd9a48b97 schema:affiliation grid-institutes:None
    157 schema:familyName Nguyen Thien
    158 schema:givenName Binh
    159 rdf:type schema:Person
    160 N0394ef657ac546909f044bb6112a4c12 schema:name doi
    161 schema:value 10.1007/s00134-017-4750-z
    162 rdf:type schema:PropertyValue
    163 N0b637d2e3fe64f29b2d71a85d9e3699d rdf:first sg:person.01343754225.51
    164 rdf:rest N2f0da12e978f4aec9abebc298c88c6dd
    165 N0ea4abd7bf6349919be7ace835010dae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Drug Resistance
    167 rdf:type schema:DefinedTerm
    168 N0ec61b4085f84243b8d70db00ff992eb rdf:first sg:person.01013154627.14
    169 rdf:rest N13e0e786ed684f99a217bf630d434a37
    170 N106c9b35ea34493f990208a515b97e49 rdf:first N161c9e459a3c4e21b316238fcb3e2ae9
    171 rdf:rest N359e60ed945b4e729e1beccdf27c16f0
    172 N13e0e786ed684f99a217bf630d434a37 rdf:first sg:person.013070162407.02
    173 rdf:rest N9abc5e724f5141d8a3876eb834cb4496
    174 N152203825add42e19a194bc038b69b46 rdf:first sg:person.01051057723.31
    175 rdf:rest N19f3b76fc0ff42818f58a2cd6bf78eb3
    176 N161c9e459a3c4e21b316238fcb3e2ae9 schema:affiliation grid-institutes:grid.5650.6
    177 schema:familyName Schultz
    178 schema:givenName Marcus J.
    179 rdf:type schema:Person
    180 N193f3b9e432c409698a63335c6ca013d schema:affiliation grid-institutes:grid.239395.7
    181 schema:familyName Riviello
    182 schema:givenName Beth D.
    183 rdf:type schema:Person
    184 N19f3b76fc0ff42818f58a2cd6bf78eb3 rdf:first sg:person.013052601043.07
    185 rdf:rest N5ee8958789dc4321a728dfc8b0fe6672
    186 N20a2e3f9a6244364b0c649054ab3b5f5 rdf:first sg:person.0610604105.94
    187 rdf:rest N9e5cb6c2d1264228bc39898f83a8a0f5
    188 N289e47af11db44e987f97daa83adb73d rdf:first sg:person.01105040674.05
    189 rdf:rest N3ce05db62cca4fb6b3f920ddd298ac25
    190 N2d945f9875e848d8adec24668c94c58a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Health Care Costs
    192 rdf:type schema:DefinedTerm
    193 N2f0da12e978f4aec9abebc298c88c6dd rdf:first sg:person.01055636325.74
    194 rdf:rest Nda9790a863364cf28680958f1994ab0c
    195 N359e60ed945b4e729e1beccdf27c16f0 rdf:first sg:person.0661420277.42
    196 rdf:rest Neb0d0c6a213547ffb78e81d484297c2e
    197 N3b6cdc2850ae4c3d90f46d78ded2e4c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Sepsis
    199 rdf:type schema:DefinedTerm
    200 N3ce05db62cca4fb6b3f920ddd298ac25 rdf:first sg:person.0663401704.10
    201 rdf:rest Nb3c7603e00ea4eeb8e72492f93dd1392
    202 N3d9b70c3df744fd5a3f4d068f5a7ff82 rdf:first N011e8684973b41f48dbef1cfd9a48b97
    203 rdf:rest Nf0f55153426540dd9a66b645f8402a01
    204 N4074bffccde8407faf55ce27bc437f3a rdf:first sg:person.010522476441.05
    205 rdf:rest Ncf3d35dbf49749cd944931a12c8bf430
    206 N42bc4024b3384aecb83b28b6310dfdf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Practice Guidelines as Topic
    208 rdf:type schema:DefinedTerm
    209 N43b21c4d4bdb49e282c4bee79faef5e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Infant, Newborn
    211 rdf:type schema:DefinedTerm
    212 N449567b48dc2455185b6ef7d87d1fecb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Biomedical Research
    214 rdf:type schema:DefinedTerm
    215 N469cf4c7487543d680beddac0c7cb851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Middle Aged
    217 rdf:type schema:DefinedTerm
    218 N4bdcafc617d94c0c80e46d5516f5cc8b schema:affiliation grid-institutes:None
    219 schema:familyName Ranjit
    220 schema:givenName Suchitra
    221 rdf:type schema:Person
    222 N4c72999f8a28450585a6062f44e08b63 schema:name Springer Nature - SN SciGraph project
    223 rdf:type schema:Organization
    224 N4e350bb5b1ed45358f8d96702f2ff665 rdf:first sg:person.01205364112.01
    225 rdf:rest N9d1cb455ac244cddbe913adef0f64904
    226 N50aa8749990d4cfcb398a059f403434f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Intensive Care Units
    228 rdf:type schema:DefinedTerm
    229 N5af4bcaac20f4ccf97177c711df9e878 rdf:first sg:person.01167550047.55
    230 rdf:rest Ncfb84948059442569c28ba4e060adbf7
    231 N5ee8958789dc4321a728dfc8b0fe6672 rdf:first sg:person.01104732461.20
    232 rdf:rest N20a2e3f9a6244364b0c649054ab3b5f5
    233 N6005319eb3614732b9d8e285f0baedeb rdf:first sg:person.01075705652.42
    234 rdf:rest Nb759922f171941b58e865a7749a010bc
    235 N65a6fdde798c4646bf7cd7c87241bd6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Humans
    237 rdf:type schema:DefinedTerm
    238 N7013538e03784db68517759ce857fd30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Quality of Health Care
    240 rdf:type schema:DefinedTerm
    241 N728f2c7eaa1847238658b3c9555ad471 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Critical Care
    243 rdf:type schema:DefinedTerm
    244 N76b62b80092b40c8a0046c3c29b364c9 rdf:first sg:person.0600270775.23
    245 rdf:rest N289e47af11db44e987f97daa83adb73d
    246 N785c13f953514458a51b2028181e4680 schema:name pubmed_id
    247 schema:value 28349179
    248 rdf:type schema:PropertyValue
    249 N7b662766119741ad9c27ee5a929dc86b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    250 schema:name Cost-Benefit Analysis
    251 rdf:type schema:DefinedTerm
    252 N81ccb53e21d9437583b68422be4f1799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name Global Burden of Disease
    254 rdf:type schema:DefinedTerm
    255 N9019942a478b43eeaf76db8772cca3af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Infant
    257 rdf:type schema:DefinedTerm
    258 N90cea9bb78bb4e4d970344fe80edeab2 rdf:first sg:person.01345512332.33
    259 rdf:rest Nda51f108257c40ec810dc75b6f5b7483
    260 N9752d41ab5754fcc840f06d06b1fa9a5 rdf:first Na2385d5bc23c4e669e9a7424ae21036c
    261 rdf:rest N3d9b70c3df744fd5a3f4d068f5a7ff82
    262 N995873a65d1b42b1afabc46a9acfad64 rdf:first sg:person.01146723623.29
    263 rdf:rest Nbd10b7354f534f85af2f14f9f89ef3e3
    264 N9abc5e724f5141d8a3876eb834cb4496 rdf:first sg:person.01300325773.33
    265 rdf:rest N4074bffccde8407faf55ce27bc437f3a
    266 N9b3c8f31ee094fdb84942163f9d8a03f schema:issueNumber 5
    267 rdf:type schema:PublicationIssue
    268 N9d1cb455ac244cddbe913adef0f64904 rdf:first sg:person.01362157550.77
    269 rdf:rest Nb18ac49c4e204654a37aa8017296dfc3
    270 N9e5cb6c2d1264228bc39898f83a8a0f5 rdf:first sg:person.0740103341.37
    271 rdf:rest Nb0a2963f1f7b4883b644ab9fe86ccba8
    272 Na1867cd3c48e4b1d81bc64ef5568fa69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    273 schema:name Health Resources
    274 rdf:type schema:DefinedTerm
    275 Na2385d5bc23c4e669e9a7424ae21036c schema:affiliation grid-institutes:grid.412433.3
    276 schema:familyName Nguyen Thi Hoang
    277 schema:givenName Mai
    278 rdf:type schema:Person
    279 Na31e0fe04bb4476e908d81cf203c1852 schema:name dimensions_id
    280 schema:value pub.1084018945
    281 rdf:type schema:PropertyValue
    282 Na61907aa0d2a498580d286e3c1803d2a rdf:first sg:person.0603551123.90
    283 rdf:rest N9752d41ab5754fcc840f06d06b1fa9a5
    284 Na7b54a4543aa4cc2b20654c4eecd29f8 rdf:first sg:person.01074734123.53
    285 rdf:rest Nd105f0b7b44542eab3c5f0ef4e1c6dad
    286 Na7c3860c3eda445eaed34e1f6f465bce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    287 schema:name Developing Countries
    288 rdf:type schema:DefinedTerm
    289 Nb0a2963f1f7b4883b644ab9fe86ccba8 rdf:first sg:person.0622142430.21
    290 rdf:rest Nced4e34caa524fc9962ef9a6e6162276
    291 Nb18ac49c4e204654a37aa8017296dfc3 rdf:first sg:person.01100610423.42
    292 rdf:rest Nf03375ca2e4b4d5a947f5edfb7570466
    293 Nb3c7603e00ea4eeb8e72492f93dd1392 rdf:first N509c900616bb4b5fa6bf8407c96fdc95
    294 rdf:rest rdf:nil
    295 Nb759922f171941b58e865a7749a010bc rdf:first sg:person.01366266562.86
    296 rdf:rest N152203825add42e19a194bc038b69b46
    297 Nbd10b7354f534f85af2f14f9f89ef3e3 rdf:first sg:person.0657017105.10
    298 rdf:rest Na7b54a4543aa4cc2b20654c4eecd29f8
    299 Nced4e34caa524fc9962ef9a6e6162276 rdf:first sg:person.01261070640.13
    300 rdf:rest Na61907aa0d2a498580d286e3c1803d2a
    301 Ncf3d35dbf49749cd944931a12c8bf430 rdf:first sg:person.0761337561.31
    302 rdf:rest N995873a65d1b42b1afabc46a9acfad64
    303 Ncfb84948059442569c28ba4e060adbf7 rdf:first N4bdcafc617d94c0c80e46d5516f5cc8b
    304 rdf:rest N76b62b80092b40c8a0046c3c29b364c9
    305 Nd105f0b7b44542eab3c5f0ef4e1c6dad rdf:first sg:person.014150672735.74
    306 rdf:rest N6005319eb3614732b9d8e285f0baedeb
    307 Nda51f108257c40ec810dc75b6f5b7483 rdf:first sg:person.013716274643.40
    308 rdf:rest N5af4bcaac20f4ccf97177c711df9e878
    309 Nda9790a863364cf28680958f1994ab0c rdf:first N193f3b9e432c409698a63335c6ca013d
    310 rdf:rest N0ec61b4085f84243b8d70db00ff992eb
    311 Nde254b2328d34b418c72580528c56f12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    312 schema:name Adult
    313 rdf:type schema:DefinedTerm
    314 Neb0d0c6a213547ffb78e81d484297c2e rdf:first sg:person.01162317707.88
    315 rdf:rest N4e350bb5b1ed45358f8d96702f2ff665
    316 Nf03375ca2e4b4d5a947f5edfb7570466 rdf:first sg:person.0772543414.88
    317 rdf:rest N0b637d2e3fe64f29b2d71a85d9e3699d
    318 Nf0f55153426540dd9a66b645f8402a01 rdf:first sg:person.01232635004.96
    319 rdf:rest N90cea9bb78bb4e4d970344fe80edeab2
    320 Nf1c32108a68849818e1695d9ae411218 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    321 schema:name Child, Preschool
    322 rdf:type schema:DefinedTerm
    323 Nfe095b938e3c4627ab14ae207a803ac0 schema:volumeNumber 43
    324 rdf:type schema:PublicationVolume
    325 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    326 schema:name Medical and Health Sciences
    327 rdf:type schema:DefinedTerm
    328 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    329 schema:name Clinical Sciences
    330 rdf:type schema:DefinedTerm
    331 sg:journal.1313639 schema:issn 0342-4642
    332 1432-1238
    333 schema:name Intensive Care Medicine
    334 schema:publisher Springer Nature
    335 rdf:type schema:Periodical
    336 sg:person.01013154627.14 schema:affiliation grid-institutes:grid.21925.3d
    337 schema:familyName Angus
    338 schema:givenName Derek C.
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013154627.14
    340 rdf:type schema:Person
    341 sg:person.01051057723.31 schema:affiliation grid-institutes:grid.444534.6
    342 schema:familyName Lundeg
    343 schema:givenName Ganbold
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051057723.31
    345 rdf:type schema:Person
    346 sg:person.010522476441.05 schema:affiliation grid-institutes:grid.17866.3e
    347 schema:familyName Diaz
    348 schema:givenName Janet V.
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522476441.05
    350 rdf:type schema:Person
    351 sg:person.01055636325.74 schema:affiliation grid-institutes:grid.5650.6
    352 schema:familyName Pisani
    353 schema:givenName Luigi
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055636325.74
    355 rdf:type schema:Person
    356 sg:person.01074734123.53 schema:affiliation grid-institutes:grid.34477.33
    357 schema:familyName Jacob
    358 schema:givenName Shevin T.
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074734123.53
    360 rdf:type schema:Person
    361 sg:person.01075705652.42 schema:affiliation grid-institutes:grid.413618.9
    362 schema:familyName Lodha
    363 schema:givenName Rakesh
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075705652.42
    365 rdf:type schema:Person
    366 sg:person.01100610423.42 schema:affiliation grid-institutes:grid.416252.6
    367 schema:familyName Kwizera
    368 schema:givenName Arthur
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100610423.42
    370 rdf:type schema:Person
    371 sg:person.01104732461.20 schema:affiliation grid-institutes:grid.11951.3d
    372 schema:familyName Mer
    373 schema:givenName Mervyn
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104732461.20
    375 rdf:type schema:Person
    376 sg:person.01105040674.05 schema:affiliation grid-institutes:None
    377 schema:familyName Thevanayagam
    378 schema:givenName Jonarthan
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105040674.05
    380 rdf:type schema:Person
    381 sg:person.01146723623.29 schema:affiliation grid-institutes:grid.10223.32
    382 schema:familyName Haniffa
    383 schema:givenName Rashan
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146723623.29
    385 rdf:type schema:Person
    386 sg:person.01162317707.88 schema:affiliation grid-institutes:grid.5650.6
    387 schema:familyName Dondorp
    388 schema:givenName Arjen M.
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162317707.88
    390 rdf:type schema:Person
    391 sg:person.01167550047.55 schema:affiliation grid-institutes:grid.414462.1
    392 schema:familyName Povoa
    393 schema:givenName Pedro
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167550047.55
    395 rdf:type schema:Person
    396 sg:person.01205364112.01 schema:affiliation grid-institutes:grid.413104.3
    397 schema:familyName Adhikari
    398 schema:givenName Neill K. J.
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205364112.01
    400 rdf:type schema:Person
    401 sg:person.01232635004.96 schema:affiliation grid-institutes:grid.440315.7
    402 schema:familyName Pattnaik
    403 schema:givenName Rajyabardhan
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232635004.96
    405 rdf:type schema:Person
    406 sg:person.01261070640.13 schema:affiliation grid-institutes:grid.416252.6
    407 schema:familyName Nakibuuka
    408 schema:givenName Jane
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261070640.13
    410 rdf:type schema:Person
    411 sg:person.01300325773.33 schema:affiliation grid-institutes:grid.4714.6
    412 schema:familyName Baker
    413 schema:givenName Tim
    414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300325773.33
    415 rdf:type schema:Person
    416 sg:person.013052601043.07 schema:affiliation grid-institutes:grid.411192.e
    417 schema:familyName Misango
    418 schema:givenName David
    419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052601043.07
    420 rdf:type schema:Person
    421 sg:person.013070162407.02 schema:affiliation grid-institutes:grid.413471.4
    422 schema:familyName Azevedo
    423 schema:givenName Luciano C.
    424 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013070162407.02
    425 rdf:type schema:Person
    426 sg:person.01343754225.51 schema:affiliation grid-institutes:grid.411024.2
    427 schema:familyName Papali
    428 schema:givenName Alfred
    429 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343754225.51
    430 rdf:type schema:Person
    431 sg:person.01345512332.33 schema:affiliation grid-institutes:grid.412106.0
    432 schema:familyName Phua
    433 schema:givenName Jason
    434 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345512332.33
    435 rdf:type schema:Person
    436 sg:person.01362157550.77 schema:affiliation grid-institutes:grid.411681.b
    437 schema:familyName Iyer
    438 schema:givenName Shivakumar
    439 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362157550.77
    440 rdf:type schema:Person
    441 sg:person.01366266562.86 schema:affiliation grid-institutes:None
    442 schema:familyName Martin-Loeches
    443 schema:givenName Ignacio
    444 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366266562.86
    445 rdf:type schema:Person
    446 sg:person.013716274643.40 schema:affiliation grid-institutes:grid.120073.7
    447 schema:familyName Preller
    448 schema:givenName Jacobus
    449 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013716274643.40
    450 rdf:type schema:Person
    451 sg:person.014150672735.74 schema:affiliation grid-institutes:grid.414137.4
    452 schema:familyName Kissoon
    453 schema:givenName Niranjan
    454 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014150672735.74
    455 rdf:type schema:Person
    456 sg:person.0600270775.23 schema:affiliation grid-institutes:grid.239395.7
    457 schema:familyName Talmor
    458 schema:givenName Daniel
    459 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600270775.23
    460 rdf:type schema:Person
    461 sg:person.0603551123.90 schema:affiliation grid-institutes:grid.413562.7
    462 schema:familyName Serpa Neto
    463 schema:givenName Ary
    464 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603551123.90
    465 rdf:type schema:Person
    466 sg:person.0610604105.94 schema:affiliation grid-institutes:grid.440315.7
    467 schema:familyName Mohanty
    468 schema:givenName Sanjib
    469 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610604105.94
    470 rdf:type schema:Person
    471 sg:person.0622142430.21 schema:affiliation grid-institutes:grid.240741.4
    472 schema:familyName Musa
    473 schema:givenName Ndidiamaka
    474 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622142430.21
    475 rdf:type schema:Person
    476 sg:person.0657017105.10 schema:affiliation grid-institutes:grid.412695.d
    477 schema:familyName Jawa
    478 schema:givenName Randeep
    479 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657017105.10
    480 rdf:type schema:Person
    481 sg:person.0661420277.42 schema:affiliation grid-institutes:grid.439749.4
    482 schema:familyName Dunser
    483 schema:givenName Martin W.
    484 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661420277.42
    485 rdf:type schema:Person
    486 sg:person.0663401704.10 schema:affiliation grid-institutes:grid.4991.5
    487 schema:familyName Thwaites
    488 schema:givenName C. Louise
    489 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663401704.10
    490 rdf:type schema:Person
    491 sg:person.0740103341.37 schema:affiliation grid-institutes:grid.414137.4
    492 schema:familyName Murthy
    493 schema:givenName Srinivas
    494 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740103341.37
    495 rdf:type schema:Person
    496 sg:person.0761337561.31 schema:affiliation grid-institutes:grid.417467.7
    497 schema:familyName Festic
    498 schema:givenName Emir
    499 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761337561.31
    500 rdf:type schema:Person
    501 sg:person.0772543414.88 schema:affiliation grid-institutes:grid.5650.6
    502 schema:familyName Lubell
    503 schema:givenName Yoel
    504 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772543414.88
    505 rdf:type schema:Person
    506 sg:pub.10.1007/s00134-003-1662-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038680632
    507 https://doi.org/10.1007/s00134-003-1662-x
    508 rdf:type schema:CreativeWork
    509 sg:pub.10.1007/s00134-010-2102-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012516702
    510 https://doi.org/10.1007/s00134-010-2102-3
    511 rdf:type schema:CreativeWork
    512 sg:pub.10.1007/s00134-012-2468-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014693845
    513 https://doi.org/10.1007/s00134-012-2468-5
    514 rdf:type schema:CreativeWork
    515 sg:pub.10.1007/s00134-012-2627-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009233920
    516 https://doi.org/10.1007/s00134-012-2627-8
    517 rdf:type schema:CreativeWork
    518 sg:pub.10.1007/s00134-013-3174-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017840857
    519 https://doi.org/10.1007/s00134-013-3174-7
    520 rdf:type schema:CreativeWork
    521 sg:pub.10.1007/s00134-015-4070-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020990665
    522 https://doi.org/10.1007/s00134-015-4070-0
    523 rdf:type schema:CreativeWork
    524 sg:pub.10.1007/s00134-016-4222-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026714655
    525 https://doi.org/10.1007/s00134-016-4222-x
    526 rdf:type schema:CreativeWork
    527 sg:pub.10.1007/s00134-016-4347-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033562646
    528 https://doi.org/10.1007/s00134-016-4347-y
    529 rdf:type schema:CreativeWork
    530 sg:pub.10.1007/s00134-016-4382-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044246187
    531 https://doi.org/10.1007/s00134-016-4382-8
    532 rdf:type schema:CreativeWork
    533 sg:pub.10.1007/s00134-016-4415-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005830433
    534 https://doi.org/10.1007/s00134-016-4415-3
    535 rdf:type schema:CreativeWork
    536 sg:pub.10.1007/s00134-016-4631-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051597939
    537 https://doi.org/10.1007/s00134-016-4631-x
    538 rdf:type schema:CreativeWork
    539 sg:pub.10.1007/s00508-008-1064-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023956535
    540 https://doi.org/10.1007/s00508-008-1064-8
    541 rdf:type schema:CreativeWork
    542 sg:pub.10.1007/s12098-016-2170-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034521275
    543 https://doi.org/10.1007/s12098-016-2170-7
    544 rdf:type schema:CreativeWork
    545 sg:pub.10.1038/ng.3548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026698708
    546 https://doi.org/10.1038/ng.3548
    547 rdf:type schema:CreativeWork
    548 sg:pub.10.1038/nm0897-866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019214768
    549 https://doi.org/10.1038/nm0897-866
    550 rdf:type schema:CreativeWork
    551 sg:pub.10.1186/1472-6963-13-140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011730801
    552 https://doi.org/10.1186/1472-6963-13-140
    553 rdf:type schema:CreativeWork
    554 sg:pub.10.1186/1475-2875-12-146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042804359
    555 https://doi.org/10.1186/1475-2875-12-146
    556 rdf:type schema:CreativeWork
    557 sg:pub.10.1186/1756-0500-5-475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006218037
    558 https://doi.org/10.1186/1756-0500-5-475
    559 rdf:type schema:CreativeWork
    560 sg:pub.10.1186/cc9294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043956762
    561 https://doi.org/10.1186/cc9294
    562 rdf:type schema:CreativeWork
    563 sg:pub.10.1186/cc9410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009093304
    564 https://doi.org/10.1186/cc9410
    565 rdf:type schema:CreativeWork
    566 sg:pub.10.1186/s13054-016-1325-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040821529
    567 https://doi.org/10.1186/s13054-016-1325-2
    568 rdf:type schema:CreativeWork
    569 grid-institutes:None schema:alternateName Appolo Hospitals, Chennai, India
    570 Mzuzu Central Hospital, Mzuzu, Malawi
    571 St. James’s University Hospital, Dublin, Ireland
    572 Trung Vuong Hospital, Ho Chi Minh City, Vietnam
    573 schema:name Appolo Hospitals, Chennai, India
    574 Mzuzu Central Hospital, Mzuzu, Malawi
    575 St. James’s University Hospital, Dublin, Ireland
    576 Trung Vuong Hospital, Ho Chi Minh City, Vietnam
    577 rdf:type schema:Organization
    578 grid-institutes:grid.10223.32 schema:alternateName Mahidol University, Bangkok, Thailand
    579 schema:name Mahidol University, Bangkok, Thailand
    580 rdf:type schema:Organization
    581 grid-institutes:grid.11951.3d schema:alternateName Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
    582 schema:name Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
    583 rdf:type schema:Organization
    584 grid-institutes:grid.120073.7 schema:alternateName Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    585 schema:name Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    586 rdf:type schema:Organization
    587 grid-institutes:grid.17866.3e schema:alternateName California Pacific Medical Center, San Francisco, CA, USA
    588 schema:name California Pacific Medical Center, San Francisco, CA, USA
    589 rdf:type schema:Organization
    590 grid-institutes:grid.21925.3d schema:alternateName University of Pittsburgh, Pittsburgh, PA, USA
    591 schema:name University of Pittsburgh, Pittsburgh, PA, USA
    592 rdf:type schema:Organization
    593 grid-institutes:grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    594 schema:name Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    595 rdf:type schema:Organization
    596 grid-institutes:grid.240741.4 schema:alternateName Seattle Children’s Hospital and University of Washington, Seattle, WA, USA
    597 schema:name Seattle Children’s Hospital and University of Washington, Seattle, WA, USA
    598 rdf:type schema:Organization
    599 grid-institutes:grid.34477.33 schema:alternateName University of Washington, Seattle, WA, USA
    600 schema:name University of Washington, Seattle, WA, USA
    601 rdf:type schema:Organization
    602 grid-institutes:grid.411024.2 schema:alternateName University of Maryland School of Medicine, Baltimore, MD, USA
    603 schema:name University of Maryland School of Medicine, Baltimore, MD, USA
    604 rdf:type schema:Organization
    605 grid-institutes:grid.411192.e schema:alternateName Aga Khan University Hospital, Nairobi, Kenya
    606 schema:name Aga Khan University Hospital, Nairobi, Kenya
    607 rdf:type schema:Organization
    608 grid-institutes:grid.411681.b schema:alternateName Bharati Vidyapeeth Deemed University Medical College, Pune, India
    609 schema:name Bharati Vidyapeeth Deemed University Medical College, Pune, India
    610 rdf:type schema:Organization
    611 grid-institutes:grid.412106.0 schema:alternateName National University Hospital, Singapore, Singapore
    612 schema:name National University Hospital, Singapore, Singapore
    613 rdf:type schema:Organization
    614 grid-institutes:grid.412433.3 schema:alternateName Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    615 schema:name Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    616 rdf:type schema:Organization
    617 grid-institutes:grid.412695.d schema:alternateName Stony Brook University Medical Center, Stony Brook, NY, USA
    618 schema:name Stony Brook University Medical Center, Stony Brook, NY, USA
    619 rdf:type schema:Organization
    620 grid-institutes:grid.413104.3 schema:alternateName Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada
    621 schema:name Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada
    622 rdf:type schema:Organization
    623 grid-institutes:grid.413471.4 schema:alternateName Hospital Sirio-Libanes, Saõ Paulo, Brazil
    624 schema:name Hospital Sirio-Libanes, Saõ Paulo, Brazil
    625 rdf:type schema:Organization
    626 grid-institutes:grid.413562.7 schema:alternateName Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    627 schema:name Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    628 Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    629 rdf:type schema:Organization
    630 grid-institutes:grid.413618.9 schema:alternateName All India Institute of Medical Science, Delhi, India
    631 schema:name All India Institute of Medical Science, Delhi, India
    632 rdf:type schema:Organization
    633 grid-institutes:grid.414137.4 schema:alternateName British Columbia Children’s Hospital, Vancouver, Canada
    634 schema:name British Columbia Children’s Hospital, Vancouver, Canada
    635 rdf:type schema:Organization
    636 grid-institutes:grid.414462.1 schema:alternateName Nova Medical School, CEDOC, New University of Lisbon and Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
    637 schema:name Nova Medical School, CEDOC, New University of Lisbon and Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
    638 rdf:type schema:Organization
    639 grid-institutes:grid.416252.6 schema:alternateName Mulago National Referral Hospital, Kampala, Uganda
    640 schema:name Mulago National Referral Hospital, Kampala, Uganda
    641 rdf:type schema:Organization
    642 grid-institutes:grid.417467.7 schema:alternateName Mayo Clinic, Jacksonville, FL, USA
    643 schema:name Mayo Clinic, Jacksonville, FL, USA
    644 rdf:type schema:Organization
    645 grid-institutes:grid.439749.4 schema:alternateName University College of London Hospital, London, UK
    646 schema:name University College of London Hospital, London, UK
    647 rdf:type schema:Organization
    648 grid-institutes:grid.440315.7 schema:alternateName Ispat General Hospital, Sundargarh, Rourkela, Odisha, India
    649 schema:name Ispat General Hospital, Sundargarh, Rourkela, Odisha, India
    650 rdf:type schema:Organization
    651 grid-institutes:grid.444534.6 schema:alternateName Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
    652 schema:name Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
    653 rdf:type schema:Organization
    654 grid-institutes:grid.4714.6 schema:alternateName Karolinska Institute, Stockholm, Sweden
    655 schema:name Karolinska Institute, Stockholm, Sweden
    656 rdf:type schema:Organization
    657 grid-institutes:grid.4991.5 schema:alternateName Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
    658 schema:name Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
    659 rdf:type schema:Organization
    660 grid-institutes:grid.5650.6 schema:alternateName Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    661 schema:name Department of Intensive Care, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    662 Mahidol University, Bangkok, Thailand
    663 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...