Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01

AUTHORS

Jacqueline M. Lankelma, Lonneke A. van Vught, Clara Belzer, Marcus J. Schultz, Tom van der Poll, Willem M. de Vos, W. Joost Wiersinga

ABSTRACT

PURPOSE: The intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the microbiota in critically ill patients may have a negative influence on key energy resources and immunity. We set out to characterize the fecal microbiota composition in critically ill patients both with and without sepsis and to explore the use of microbiota-derived markers for clinical outcome measurements in this setting. METHODS: In this prospective observational cohort study we analyzed the fecal microbiota of 34 patients admitted to the intensive care unit. Fifteen healthy subjects served as controls. The fecal microbiota was phylogenetically characterized by 16S rRNA gene sequencing, and associations with clinical outcome parameters were evaluated. RESULTS: A marked shift in fecal bacterial composition was seen in all septic and non-septic critically ill patients compared with controls, with extreme interindividual differences. In 13 of the 34 patients, a single bacterial genus made up >50% of the gut microbiota; in 4 patients this was even >75%. A significant decrease in bacterial diversity was observed in half of the patients. No associations were found between microbiota diversity, Firmicutes/Bacteroidetes ratio, or Gram-positive/Gram-negative ratio and outcome measurements such as complications and survival. CONCLUSIONS: We observed highly heterogeneous patterns of intestinal microbiota in both septic and non-septic critically ill patients. Nevertheless, some general patterns were observed, including disappearance of bacterial genera with important functions in host metabolism. More detailed knowledge of the short- and long-term health consequences of these major shifts in intestinal bacterial communities is needed. More... »

PAGES

59-68

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-016-4613-z

DOI

http://dx.doi.org/10.1007/s00134-016-4613-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012394698

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27837233


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Microbiome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Netherlands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lankelma", 
        "givenName": "Jacqueline M.", 
        "id": "sg:person.01151143363.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151143363.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Vught", 
        "givenName": "Lonneke A.", 
        "id": "sg:person.01003441765.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003441765.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wageningen University & Research", 
          "id": "https://www.grid.ac/institutes/grid.4818.5", 
          "name": [
            "Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belzer", 
        "givenName": "Clara", 
        "id": "sg:person.01203321731.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203321731.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schultz", 
        "givenName": "Marcus J.", 
        "id": "sg:person.01007146366.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146366.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands", 
            "Division of Infectious Diseases, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Poll", 
        "givenName": "Tom", 
        "id": "sg:person.01065476534.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065476534.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands", 
            "Research Programs Unit Immunobiology, Department of Bacteriology and Immunology, Helsinki University, Helsinski, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Vos", 
        "givenName": "Willem M.", 
        "id": "sg:person.01114225554.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114225554.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands", 
            "Division of Infectious Diseases, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiersinga", 
        "givenName": "W. Joost", 
        "id": "sg:person.0624001557.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624001557.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10620-015-4011-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001014933", 
          "https://doi.org/10.1007/s10620-015-4011-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-015-4011-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001014933", 
          "https://doi.org/10.1007/s10620-015-4011-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0101344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001642006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.101.6.1644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006971593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcc.0000000000000321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007440975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcc.0000000000000321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007440975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcc.0000000000000321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007440975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcc.0000000000000321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007440975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007512293", 
          "https://doi.org/10.1038/nature11550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007740093", 
          "https://doi.org/10.1038/nature11234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-02-554725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011557471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2009.1754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011684110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2014-307240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014629741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.5669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018033502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4441022a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018798093", 
          "https://doi.org/10.1038/4441022a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4441022a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018798093", 
          "https://doi.org/10.1038/4441022a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4441022a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018798093", 
          "https://doi.org/10.1038/4441022a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201503-0483oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021633610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1826-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022327044", 
          "https://doi.org/10.1007/s00134-010-1826-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1826-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022327044", 
          "https://doi.org/10.1007/s00134-010-1826-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.01361-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023214614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.2691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023592567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000200323.38139.c6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027768609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000200323.38139.c6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027768609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aad9358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030109643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc2872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031071552", 
          "https://doi.org/10.1186/cc2872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc2872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031071552", 
          "https://doi.org/10.1186/cc2872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mimet.2010.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031758556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032136570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032136570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.i1585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032982491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1205037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034655975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0039743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037818643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1574-6976.12075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039622540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2014.299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039645652", 
          "https://doi.org/10.1038/ajg.2014.299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.g2197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039657254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201507-1491oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041669694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aad9382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042002278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1469-0691.12418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044353759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ismej.2012.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045189531", 
          "https://doi.org/10.1038/ismej.2012.6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.0287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045696843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0738-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045768708", 
          "https://doi.org/10.1186/s13054-015-0738-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0738-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045768708", 
          "https://doi.org/10.1186/s13054-015-0738-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2016-312297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046209109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1753-4887.2012.00505.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049304867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-015-4009-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051686464", 
          "https://doi.org/10.1007/s00134-015-4009-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-015-4009-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051686464", 
          "https://doi.org/10.1007/s00134-015-4009-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ecco-jcc/jjw070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059495285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/ijs.0.000364-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060381856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/ijs.0.000364-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060381856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2016-312132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062813745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0885066615594344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063858230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0885066615594344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063858230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4291/wjgp.v2.i6.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072443400"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01", 
    "datePublishedReg": "2017-01-01", 
    "description": "PURPOSE: The intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the microbiota in critically ill patients may have a negative influence on key energy resources and immunity. We set out to characterize the fecal microbiota composition in critically ill patients both with and without sepsis and to explore the use of microbiota-derived markers for clinical outcome measurements in this setting.\nMETHODS: In this prospective observational cohort study we analyzed the fecal microbiota of 34 patients admitted to the intensive care unit. Fifteen healthy subjects served as controls. The fecal microbiota was phylogenetically characterized by 16S rRNA gene sequencing, and associations with clinical outcome parameters were evaluated.\nRESULTS: A marked shift in fecal bacterial composition was seen in all septic and non-septic critically ill patients compared with controls, with extreme interindividual differences. In 13 of the 34 patients, a single bacterial genus made up >50% of the gut microbiota; in 4 patients this was even >75%. A significant decrease in bacterial diversity was observed in half of the patients. No associations were found between microbiota diversity, Firmicutes/Bacteroidetes ratio, or Gram-positive/Gram-negative ratio and outcome measurements such as complications and survival.\nCONCLUSIONS: We observed highly heterogeneous patterns of intestinal microbiota in both septic and non-septic critically ill patients. Nevertheless, some general patterns were observed, including disappearance of bacterial genera with important functions in host metabolism. More detailed knowledge of the short- and long-term health consequences of these major shifts in intestinal bacterial communities is needed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00134-016-4613-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "43"
      }
    ], 
    "name": "Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study", 
    "pagination": "59-68", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3b0d4271a42913750b3eb6867cc0d88e466a6a0cb8f56fe855e9b40c487d184e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27837233"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704851"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-016-4613-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012394698"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-016-4613-z", 
      "https://app.dimensions.ai/details/publication/pub.1012394698"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87104_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00134-016-4613-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-016-4613-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-016-4613-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-016-4613-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-016-4613-z'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      84 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-016-4613-z schema:about N03c4c65ce186429297f0a20771813ce8
2 N1d6923c9da2d4555993ae42067f1ef61
3 N23cf0b568fc44df4a74c2d190e59b1d5
4 N353402a905434aa58285ef93a72d03f5
5 N3b241e8053434d0fbb66c5b7708a3dbe
6 N3c7a2f9b7bc34b83b2f41e2c78af32f2
7 N6fd167619ae940acb86f079f4ad485a9
8 N7f7a5b88e4cb4ce1b6d2205acb1ebecf
9 N88dfa2b4d5324d5c94b314f71e342a18
10 N8a36ff74d3ab4ff2b56a1541e3dc9418
11 N92610e1758094fe88d8ae3853f870d1c
12 Nab50159e3d1a489b97cafde9318e9d9c
13 Nbfc74d9a23d74334b5487bfac3c30e70
14 Ndce98e3dd53745b8a32f0c8aa095629d
15 Ned6227af0a784c1ab8ea7e47e95e86f2
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N31c67fc5252446e2bc10abf120c709fd
19 schema:citation sg:pub.10.1007/s00134-010-1826-4
20 sg:pub.10.1007/s00134-015-4009-5
21 sg:pub.10.1007/s10620-015-4011-3
22 sg:pub.10.1038/4441022a
23 sg:pub.10.1038/ajg.2014.299
24 sg:pub.10.1038/ismej.2012.6
25 sg:pub.10.1038/nature11234
26 sg:pub.10.1038/nature11550
27 sg:pub.10.1186/cc2872
28 sg:pub.10.1186/s13054-015-0738-7
29 https://doi.org/10.1001/jama.2009.1754
30 https://doi.org/10.1001/jama.2012.5669
31 https://doi.org/10.1001/jama.2016.0287
32 https://doi.org/10.1001/jama.2016.2691
33 https://doi.org/10.1016/j.mimet.2010.02.007
34 https://doi.org/10.1056/nejmoa1205037
35 https://doi.org/10.1093/ecco-jcc/jjw070
36 https://doi.org/10.1097/01.mib.0000200323.38139.c6
37 https://doi.org/10.1097/mcc.0000000000000321
38 https://doi.org/10.1099/ijs.0.000364-0
39 https://doi.org/10.1111/1469-0691.12418
40 https://doi.org/10.1111/1574-6976.12075
41 https://doi.org/10.1111/j.1753-4887.2012.00505.x
42 https://doi.org/10.1126/science.aad9358
43 https://doi.org/10.1126/science.aad9382
44 https://doi.org/10.1128/mbio.01361-14
45 https://doi.org/10.1136/bmj.g2197
46 https://doi.org/10.1136/bmj.i1585
47 https://doi.org/10.1136/gutjnl-2014-307240
48 https://doi.org/10.1136/gutjnl-2016-312132
49 https://doi.org/10.1136/gutjnl-2016-312297
50 https://doi.org/10.1164/rccm.201503-0483oc
51 https://doi.org/10.1164/rccm.201507-1491oc
52 https://doi.org/10.1172/jci43918
53 https://doi.org/10.1177/0885066615594344
54 https://doi.org/10.1182/blood-2014-02-554725
55 https://doi.org/10.1371/journal.pone.0039743
56 https://doi.org/10.1371/journal.pone.0101344
57 https://doi.org/10.1378/chest.101.6.1644
58 https://doi.org/10.4291/wjgp.v2.i6.138
59 schema:datePublished 2017-01
60 schema:datePublishedReg 2017-01-01
61 schema:description PURPOSE: The intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the microbiota in critically ill patients may have a negative influence on key energy resources and immunity. We set out to characterize the fecal microbiota composition in critically ill patients both with and without sepsis and to explore the use of microbiota-derived markers for clinical outcome measurements in this setting. METHODS: In this prospective observational cohort study we analyzed the fecal microbiota of 34 patients admitted to the intensive care unit. Fifteen healthy subjects served as controls. The fecal microbiota was phylogenetically characterized by 16S rRNA gene sequencing, and associations with clinical outcome parameters were evaluated. RESULTS: A marked shift in fecal bacterial composition was seen in all septic and non-septic critically ill patients compared with controls, with extreme interindividual differences. In 13 of the 34 patients, a single bacterial genus made up >50% of the gut microbiota; in 4 patients this was even >75%. A significant decrease in bacterial diversity was observed in half of the patients. No associations were found between microbiota diversity, Firmicutes/Bacteroidetes ratio, or Gram-positive/Gram-negative ratio and outcome measurements such as complications and survival. CONCLUSIONS: We observed highly heterogeneous patterns of intestinal microbiota in both septic and non-septic critically ill patients. Nevertheless, some general patterns were observed, including disappearance of bacterial genera with important functions in host metabolism. More detailed knowledge of the short- and long-term health consequences of these major shifts in intestinal bacterial communities is needed.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N512a700b9d794f18a4f427f8ce9740ee
66 Naa3493866db34014a352f36e94c424e5
67 sg:journal.1313639
68 schema:name Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study
69 schema:pagination 59-68
70 schema:productId N1a294bedd3e64a7b9d44cd8a63b81990
71 N89e47ef65e78466d96e22acddacd5157
72 Nd64fb1a8aa0c444d8936c62a7bddc847
73 Ne9836dc60d95461ab336d51942832307
74 Nfa95f1663114440fb591626741f18999
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012394698
76 https://doi.org/10.1007/s00134-016-4613-z
77 schema:sdDatePublished 2019-04-11T12:25
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N35e0a166850e4e668b19f1c7b7d942c6
80 schema:url https://link.springer.com/10.1007%2Fs00134-016-4613-z
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N03c4c65ce186429297f0a20771813ce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Netherlands
86 rdf:type schema:DefinedTerm
87 N128e01141a314d358840196040c2663b schema:name Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands
88 Division of Infectious Diseases, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
89 rdf:type schema:Organization
90 N1a294bedd3e64a7b9d44cd8a63b81990 schema:name dimensions_id
91 schema:value pub.1012394698
92 rdf:type schema:PropertyValue
93 N1d6923c9da2d4555993ae42067f1ef61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Sepsis
95 rdf:type schema:DefinedTerm
96 N23cf0b568fc44df4a74c2d190e59b1d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Female
98 rdf:type schema:DefinedTerm
99 N31c67fc5252446e2bc10abf120c709fd rdf:first sg:person.01151143363.64
100 rdf:rest Ne10e4f0354594ce082e193545b105cd5
101 N353402a905434aa58285ef93a72d03f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Feces
103 rdf:type schema:DefinedTerm
104 N35e0a166850e4e668b19f1c7b7d942c6 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N3a76a0942c89447aa4ded8967cb46f65 rdf:first sg:person.0624001557.42
107 rdf:rest rdf:nil
108 N3b241e8053434d0fbb66c5b7708a3dbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Anti-Bacterial Agents
110 rdf:type schema:DefinedTerm
111 N3b7e4fcc4b744d64bdf930f20c4808cd rdf:first sg:person.01065476534.34
112 rdf:rest N69ce7a9df2af48ec88945414f87a8cc5
113 N3c46acd25bf0432691c6afd0eeba1bf3 schema:name Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands
114 rdf:type schema:Organization
115 N3c7a2f9b7bc34b83b2f41e2c78af32f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Aged
117 rdf:type schema:DefinedTerm
118 N512a700b9d794f18a4f427f8ce9740ee schema:issueNumber 1
119 rdf:type schema:PublicationIssue
120 N69ce7a9df2af48ec88945414f87a8cc5 rdf:first sg:person.01114225554.30
121 rdf:rest N3a76a0942c89447aa4ded8967cb46f65
122 N6fd167619ae940acb86f079f4ad485a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Humans
124 rdf:type schema:DefinedTerm
125 N7f7a5b88e4cb4ce1b6d2205acb1ebecf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Middle Aged
127 rdf:type schema:DefinedTerm
128 N839f7f2b7adb46c5b2bf1ff2f364abb1 schema:name Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands
129 rdf:type schema:Organization
130 N88dfa2b4d5324d5c94b314f71e342a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Male
132 rdf:type schema:DefinedTerm
133 N89e47ef65e78466d96e22acddacd5157 schema:name readcube_id
134 schema:value 3b0d4271a42913750b3eb6867cc0d88e466a6a0cb8f56fe855e9b40c487d184e
135 rdf:type schema:PropertyValue
136 N8a36ff74d3ab4ff2b56a1541e3dc9418 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Prospective Studies
138 rdf:type schema:DefinedTerm
139 N92610e1758094fe88d8ae3853f870d1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Biomarkers
141 rdf:type schema:DefinedTerm
142 Naa3493866db34014a352f36e94c424e5 schema:volumeNumber 43
143 rdf:type schema:PublicationVolume
144 Nab50159e3d1a489b97cafde9318e9d9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Gastrointestinal Microbiome
146 rdf:type schema:DefinedTerm
147 Nae786e43aefe46fca5f8ad42b66c3740 schema:name Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
148 rdf:type schema:Organization
149 Nbfc74d9a23d74334b5487bfac3c30e70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Pilot Projects
151 rdf:type schema:DefinedTerm
152 Nd57a6ecb18c34c7fa5657ed1ec194dc9 schema:name Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands
153 Division of Infectious Diseases, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
154 rdf:type schema:Organization
155 Nd64fb1a8aa0c444d8936c62a7bddc847 schema:name pubmed_id
156 schema:value 27837233
157 rdf:type schema:PropertyValue
158 Ndce98e3dd53745b8a32f0c8aa095629d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Critical Illness
160 rdf:type schema:DefinedTerm
161 Ne10e4f0354594ce082e193545b105cd5 rdf:first sg:person.01003441765.80
162 rdf:rest Nf6b1f32d27614fa2a5927fd452c683de
163 Ne9836dc60d95461ab336d51942832307 schema:name nlm_unique_id
164 schema:value 7704851
165 rdf:type schema:PropertyValue
166 Ned6227af0a784c1ab8ea7e47e95e86f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Aged, 80 and over
168 rdf:type schema:DefinedTerm
169 Nef7757a6c20f4e1da3f539bc96751999 rdf:first sg:person.01007146366.19
170 rdf:rest N3b7e4fcc4b744d64bdf930f20c4808cd
171 Nf6b1f32d27614fa2a5927fd452c683de rdf:first sg:person.01203321731.76
172 rdf:rest Nef7757a6c20f4e1da3f539bc96751999
173 Nfa95f1663114440fb591626741f18999 schema:name doi
174 schema:value 10.1007/s00134-016-4613-z
175 rdf:type schema:PropertyValue
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
180 schema:name Clinical Sciences
181 rdf:type schema:DefinedTerm
182 sg:journal.1313639 schema:issn 0342-4642
183 1432-1238
184 schema:name Intensive Care Medicine
185 rdf:type schema:Periodical
186 sg:person.01003441765.80 schema:affiliation N3c46acd25bf0432691c6afd0eeba1bf3
187 schema:familyName van Vught
188 schema:givenName Lonneke A.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003441765.80
190 rdf:type schema:Person
191 sg:person.01007146366.19 schema:affiliation Nae786e43aefe46fca5f8ad42b66c3740
192 schema:familyName Schultz
193 schema:givenName Marcus J.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146366.19
195 rdf:type schema:Person
196 sg:person.01065476534.34 schema:affiliation Nd57a6ecb18c34c7fa5657ed1ec194dc9
197 schema:familyName van der Poll
198 schema:givenName Tom
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065476534.34
200 rdf:type schema:Person
201 sg:person.01114225554.30 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
202 schema:familyName de Vos
203 schema:givenName Willem M.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114225554.30
205 rdf:type schema:Person
206 sg:person.01151143363.64 schema:affiliation N839f7f2b7adb46c5b2bf1ff2f364abb1
207 schema:familyName Lankelma
208 schema:givenName Jacqueline M.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151143363.64
210 rdf:type schema:Person
211 sg:person.01203321731.76 schema:affiliation https://www.grid.ac/institutes/grid.4818.5
212 schema:familyName Belzer
213 schema:givenName Clara
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203321731.76
215 rdf:type schema:Person
216 sg:person.0624001557.42 schema:affiliation N128e01141a314d358840196040c2663b
217 schema:familyName Wiersinga
218 schema:givenName W. Joost
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624001557.42
220 rdf:type schema:Person
221 sg:pub.10.1007/s00134-010-1826-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022327044
222 https://doi.org/10.1007/s00134-010-1826-4
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s00134-015-4009-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051686464
225 https://doi.org/10.1007/s00134-015-4009-5
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s10620-015-4011-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001014933
228 https://doi.org/10.1007/s10620-015-4011-3
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/4441022a schema:sameAs https://app.dimensions.ai/details/publication/pub.1018798093
231 https://doi.org/10.1038/4441022a
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/ajg.2014.299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039645652
234 https://doi.org/10.1038/ajg.2014.299
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/ismej.2012.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045189531
237 https://doi.org/10.1038/ismej.2012.6
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nature11234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007740093
240 https://doi.org/10.1038/nature11234
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature11550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007512293
243 https://doi.org/10.1038/nature11550
244 rdf:type schema:CreativeWork
245 sg:pub.10.1186/cc2872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031071552
246 https://doi.org/10.1186/cc2872
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/s13054-015-0738-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045768708
249 https://doi.org/10.1186/s13054-015-0738-7
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1001/jama.2009.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011684110
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1001/jama.2012.5669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018033502
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1001/jama.2016.0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045696843
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1001/jama.2016.2691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023592567
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.mimet.2010.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031758556
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1056/nejmoa1205037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034655975
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/ecco-jcc/jjw070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059495285
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/01.mib.0000200323.38139.c6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027768609
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/mcc.0000000000000321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007440975
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1099/ijs.0.000364-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060381856
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1111/1469-0691.12418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044353759
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1111/1574-6976.12075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039622540
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1753-4887.2012.00505.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049304867
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1126/science.aad9358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030109643
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1126/science.aad9382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042002278
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1128/mbio.01361-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023214614
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1136/bmj.g2197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039657254
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1136/bmj.i1585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032982491
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1136/gutjnl-2014-307240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014629741
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1136/gutjnl-2016-312132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062813745
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1136/gutjnl-2016-312297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046209109
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1164/rccm.201503-0483oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1021633610
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1164/rccm.201507-1491oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1041669694
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1172/jci43918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032136570
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1177/0885066615594344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063858230
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1182/blood-2014-02-554725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011557471
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1371/journal.pone.0039743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037818643
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1371/journal.pone.0101344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001642006
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1378/chest.101.6.1644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006971593
308 rdf:type schema:CreativeWork
309 https://doi.org/10.4291/wjgp.v2.i6.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072443400
310 rdf:type schema:CreativeWork
311 https://www.grid.ac/institutes/grid.4818.5 schema:alternateName Wageningen University & Research
312 schema:name Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
315 schema:name Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
316 Research Programs Unit Immunobiology, Department of Bacteriology and Immunology, Helsinki University, Helsinski, Finland
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...