# Ventilator-related causes of lung injury: the mechanical power

Ontology type: schema:ScholarlyArticle

### Article Info

DATE

2016-09-12

AUTHORS ABSTRACT

PurposeWe hypothesized that the ventilator-related causes of lung injury may be unified in a single variable: the mechanical power. We assessed whether the mechanical power measured by the pressure–volume loops can be computed from its components: tidal volume (TV)/driving pressure (∆Paw), flow, positive end-expiratory pressure (PEEP), and respiratory rate (RR). If so, the relative contributions of each variable to the mechanical power can be estimated.MethodsWe computed the mechanical power by multiplying each component of the equation of motion by the variation of volume and RR: Powerrs=RR·ΔV2·12·ELrs+RR·1+I:E60·I:E·Raw+ΔV·PEEP,\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{Power}}_{\text{rs}} = {\text{RR}} \cdot \left\{ {\Delta V^{2} \cdot \left[ {\frac{1}{2} \cdot {\text{EL}}_{\text{rs}} + {\text{RR}} \cdot \frac{{\left( {1 + I:E} \right)}}{60 \cdot I:E} \cdot R_{\text{aw}} } \right] + \Delta V \cdot {\text{PEEP}}} \right\},$$\end{document}where ∆V is the tidal volume, ELrs is the elastance of the respiratory system, I:E is the inspiratory-to-expiratory time ratio, and Raw is the airway resistance. In 30 patients with normal lungs and in 50 ARDS patients, mechanical power was computed via the power equation and measured from the dynamic pressure–volume curve at 5 and 15 cmH2O PEEP and 6, 8, 10, and 12 ml/kg TV. We then computed the effects of the individual component variables on the mechanical power.ResultsComputed and measured mechanical powers were similar at 5 and 15 cmH2O PEEP both in normal subjects and in ARDS patients (slopes = 0.96, 1.06, 1.01, 1.12 respectively, R2 > 0.96 and p < 0.0001 for all). The mechanical power increases exponentially with TV, ∆Paw, and flow (exponent = 2) as well as with RR (exponent = 1.4) and linearly with PEEP.ConclusionsThe mechanical power equation may help estimate the contribution of the different ventilator-related causes of lung injury and of their variations. The equation can be easily implemented in every ventilator’s software. More... »

PAGES

1567-1575

### Journal

TITLE

Intensive Care Medicine

ISSUE

10

VOLUME

42

### Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-016-4505-2

DOI

http://dx.doi.org/10.1007/s00134-016-4505-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014545469

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27620287

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"description": "PurposeWe hypothesized that the ventilator-related causes of lung injury may be unified in a single variable: the mechanical power. We assessed whether the mechanical power measured by the pressure\u2013volume loops can be computed from its components: tidal volume (TV)/driving pressure (\u2206Paw), flow, positive end-expiratory pressure (PEEP), and respiratory rate (RR). If so, the relative contributions of each variable to the mechanical power can be estimated.MethodsWe computed the mechanical power by multiplying each component of the equation of motion by the variation of volume and RR: Powerrs=RR\u00b7\u0394V2\u00b712\u00b7ELrs+RR\u00b71+I:E60\u00b7I:E\u00b7Raw+\u0394V\u00b7PEEP,\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym}\n\t\t\t\t\\usepackage{amsfonts}\n\t\t\t\t\\usepackage{amssymb}\n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n\t\t\t\t\\setlength{\\oddsidemargin}{-69pt}\n\t\t\t\t\\begin{document}$${\\text{Power}}_{\\text{rs}} = {\\text{RR}} \\cdot \\left\\{ {\\Delta V^{2} \\cdot \\left[ {\\frac{1}{2} \\cdot {\\text{EL}}_{\\text{rs}} + {\\text{RR}} \\cdot \\frac{{\\left( {1 + I:E} \\right)}}{60 \\cdot I:E} \\cdot R_{\\text{aw}} } \\right] + \\Delta V \\cdot {\\text{PEEP}}} \\right\\},$$\\end{document}where \u2206V is the tidal volume, ELrs is the elastance of the respiratory system, I:E is the inspiratory-to-expiratory time ratio, and Raw is the airway resistance. In 30 patients with normal lungs and in 50 ARDS patients, mechanical power was computed via the power equation and measured from the dynamic pressure\u2013volume curve at 5 and 15\u00a0cmH2O PEEP and 6, 8, 10, and 12\u00a0ml/kg TV. We then computed the effects of the individual component variables on the mechanical power.ResultsComputed and measured mechanical powers were similar at 5 and 15\u00a0cmH2O PEEP both in normal subjects and in ARDS patients (slopes\u00a0=\u00a00.96, 1.06, 1.01, 1.12 respectively, R2\u00a0>\u00a00.96 and p\u00a0<\u00a00.0001 for all). The mechanical power increases exponentially with TV, \u2206Paw, and flow (exponent\u00a0=\u00a02) as well as with RR (exponent\u00a0=\u00a01.4) and linearly with PEEP.ConclusionsThe mechanical power equation may help estimate the contribution of the different ventilator-related causes of lung injury and of their variations. The equation can be easily implemented in every ventilator\u2019s software.",
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28 schema:description PurposeWe hypothesized that the ventilator-related causes of lung injury may be unified in a single variable: the mechanical power. We assessed whether the mechanical power measured by the pressure–volume loops can be computed from its components: tidal volume (TV)/driving pressure (∆Paw), flow, positive end-expiratory pressure (PEEP), and respiratory rate (RR). If so, the relative contributions of each variable to the mechanical power can be estimated.MethodsWe computed the mechanical power by multiplying each component of the equation of motion by the variation of volume and RR: Powerrs=RR·ΔV2·12·ELrs+RR·1+I:E60·I:E·Raw+ΔV·PEEP,\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{Power}}_{\text{rs}} = {\text{RR}} \cdot \left\{ {\Delta V^{2} \cdot \left[ {\frac{1}{2} \cdot {\text{EL}}_{\text{rs}} + {\text{RR}} \cdot \frac{{\left( {1 + I:E} \right)}}{60 \cdot I:E} \cdot R_{\text{aw}} } \right] + \Delta V \cdot {\text{PEEP}}} \right\},$$\end{document}where ∆V is the tidal volume, ELrs is the elastance of the respiratory system, I:E is the inspiratory-to-expiratory time ratio, and Raw is the airway resistance. In 30 patients with normal lungs and in 50 ARDS patients, mechanical power was computed via the power equation and measured from the dynamic pressure–volume curve at 5 and 15 cmH2O PEEP and 6, 8, 10, and 12 ml/kg TV. We then computed the effects of the individual component variables on the mechanical power.ResultsComputed and measured mechanical powers were similar at 5 and 15 cmH2O PEEP both in normal subjects and in ARDS patients (slopes = 0.96, 1.06, 1.01, 1.12 respectively, R2 > 0.96 and p < 0.0001 for all). The mechanical power increases exponentially with TV, ∆Paw, and flow (exponent = 2) as well as with RR (exponent = 1.4) and linearly with PEEP.ConclusionsThe mechanical power equation may help estimate the contribution of the different ventilator-related causes of lung injury and of their variations. The equation can be easily implemented in every ventilator’s software.
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