Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of ... View Full Text


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Article Info

DATE

2015-09-14

AUTHORS

Sébastien Bailly, Olivier Leroy, Philippe Montravers, Jean-Michel Constantin, Hervé Dupont, Didier Guillemot, Olivier Lortholary, Jean-Paul Mira, Pierre-François Perrigault, Jean-Pierre Gangneux, Elie Azoulay, Jean-François Timsit

ABSTRACT

PurposeSystemic antifungal therapy (SAT) of invasive candidiasis needs to be initiated immediately upon clinical suspicion. Controversies exist about adequate time and potential harm of antifungal de-escalation (DE) in documented and suspected candidiasis in ICU patients. Our objective was to investigate whether de-escalation within 5 days of antifungal initiation is associated with an increase of the 28-day mortality in SAT-treated non-neutropenic adult ICU patients.MethodsFrom the 835 non-neutropenic adults recruited in the multicenter prospective observational AmarCAND2 study, we selected the patients receiving systemic antifungal therapy for a documented or suspected invasive candidiasis in the ICU and who were still alive 5 days after SAT initiation. They were included into two groups according to the occurrence of observed SAT de-escalation before day 6. The average causal SAT de-escalation effect on 28-day mortality was evaluated by using a double robust estimation.ResultsAmong the 647 included patients, early de-escalation at day 5 after antifungal initiation occurred in 142 patients (22 %), including 48 (34 %) patients whose SAT was stopped before day 6. After adjustment for the baseline confounders, early SAT de-escalation was the solely factor not associated with increased 28-day mortality (RR 1.12, 95 % CI 0.76–1.66).ConclusionIn non-neutropenic critically ill adult patients with documented or suspected invasive candidiasis, SAT de-escalation within 5 days was not related to increased day-28 mortality but it was associated with decreased SAT consumption. These results suggest for the first time that SAT de-escalation may be safe in these patients. More... »

PAGES

1931-1940

References to SciGraph publications

  • 2014-05-08. A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality in INTENSIVE CARE MEDICINE
  • 2014-04-09. Emergence of echinocandin-resistant Candida spp. in a hospital setting: a consequence of 10 years of increasing use of antifungal therapy? in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2015-06-24. What’s new in the quantification of causal effects from longitudinal cohort studies: a brief introduction to marginal structural models for intensivists in INTENSIVE CARE MEDICINE
  • 2014-06-17. Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later in INTENSIVE CARE MEDICINE
  • 2014-02-21. Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: results from an open-label trial in BMC INFECTIOUS DISEASES
  • 2007-02-27. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2014-04-08. Isolation of cholesterol-dependent, multidrug-resistant Candida glabratastrains from blood cultures of a candidemia patient in Kuwait in BMC INFECTIOUS DISEASES
  • 2014-08-06. Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002–2010) in INTENSIVE CARE MEDICINE
  • 2014-06-29. Presence of Candida cell wall derived polysaccharides in the sera of intensive care unit patients: relation with candidaemia and Candida colonisation in CRITICAL CARE
  • 2012-09-26. Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study in INTENSIVE CARE MEDICINE
  • Journal

    TITLE

    Intensive Care Medicine

    ISSUE

    11

    VOLUME

    41

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-015-4053-1

    DOI

    http://dx.doi.org/10.1007/s00134-015-4053-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003939917

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26370688


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