Effect of the use of low and high potency statins and sepsis outcomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-05

AUTHORS

Shu-Yu Ou, Hsi Chu, Pei-Wen Chao, Shuo-Ming Ou, Yi-Jung Lee, Shu-Chen Kuo, Szu-Yuan Li, Chia-Jen Shih, Yung-Tai Chen

ABSTRACT

Introduction Although statins have been shown to have cholesterol-lowering effects, their pleiotropic benefits on sepsis remain a matter of debate. In addition, the influence of statin potency on sepsis-related mortality has never been explored. The aim of our study was to determine the sepsis outcomes of low- and high-potency statin users and non-users. MethodsThis nationwide, population-based, propensity score-matched analysis used data from the linked administrative databases of Taiwan’s National Health Insurance program. Patients were hospitalized for sepsis between 2000 and 2010. All-cause mortality and major adverse consequences of sepsis, such as in-hospital death, intensive care unit admission, shock events, and the use of mechanical ventilation, were assessed. Patients were divided into high-potency statin users (at least 10 mg rosuvastatin, at least 20 mg atorvastatin, or at least 40 mg simvastatin), low-potency statin users (all other statin treatments), and non-users.ResultsA propensity score-matched cohort of 27,792 statin users and 27,792 non-users was included. Of 27,792 statin users, 9,785 (35.2 %) were treated with high-potency statins and 18,007 (64.8 %) were treated with low-potency statins. The 1-year mortality risk was significantly lower among both low-potency [adjusted hazard ratio (aHR) 0.89, 95 % confidence interval (CI) 0.85–0.93] and high-potency (aHR 0.80, 95 % CI 0.75–0.86) statin users compared with non-users. The risks of mortality and adverse consequences of sepsis were lower among high-potency than among low-potency statin users.ConclusionsHigh-potency statin use is associated with a lower risk of sepsis-related mortality compared with low-potency statin use. More... »

PAGES

1509-1517

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-014-3418-1

DOI

http://dx.doi.org/10.1007/s00134-014-3418-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015962711

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25091791


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