Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002–2010) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08-06

AUTHORS

Olivier Lortholary, Charlotte Renaudat, Karine Sitbon, Yoann Madec, Lise Denoeud-Ndam, Michel Wolff, Arnaud Fontanet, Stéphane Bretagne, Françoise Dromer, The French Mycosis Study Group

ABSTRACT

PurposeTo analyze trends in incidence and mortality of candidemia in intensive care units (ICUs) vs. non-ICU hospitalized patients and to determine risk factors for infection by specific species and for death.MethodsActive hospital-based surveillance program of incident episodes of candidemia due to common species in 24 tertiary care hospitals in the Paris area, France between October 2002 and September 2010.ResultsAmong 2,507 adult cases included, 2,571 Candida isolates were collected and species were C. albicans (56 %), C. glabrata (18.6 %), C. parapsilosis (11.5 %), C. tropicalis (9.3 %), C. krusei (2.9 %), and C. kefyr (1.8 %). Candidemia occurred in ICU in 1,206 patients (48.1 %). When comparing ICU vs. non-ICU patients, the former had significantly more frequent surgery during the past 30 days, were more often preexposed to fluconazole and treated with echinocandin, and were less frequently infected with C. parapsilosis. Risk factors and age remained unchanged during the study period. A significant increased incidence in the overall population and ICU was found. The odds of being infected with a given species in ICU was influenced by risk factors and preexposure to fluconazole and caspofungin. Echinocandins initial therapy increased over time in ICU (4.6 % first year of study, to 48.5 % last year of study, p < 0.0001). ICU patients had a higher day-30 death rate than non-ICU patients (odds ratio [OR] 2.12; 95 % confidence interval [CI] 1.66–2.72; p < 0.0001). The day-30 and early ( More... »

PAGES

1303-1312

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-014-3408-3

DOI

http://dx.doi.org/10.1007/s00134-014-3408-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019314988

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25097069


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    "description": "PurposeTo analyze trends in incidence and \nmortality of candidemia in intensive care units (ICUs) vs. non-ICU hospitalized patients and to determine risk factors for infection by specific species and for death.MethodsActive hospital-based surveillance program of incident episodes of candidemia due to common species in 24 tertiary care hospitals in the Paris area, France between October 2002 and September 2010.ResultsAmong 2,507 adult cases included, 2,571 Candida isolates were collected and species were C. albicans (56\u00a0%), C. glabrata (18.6\u00a0%), C. parapsilosis (11.5\u00a0%), C. tropicalis (9.3\u00a0%), C. krusei (2.9\u00a0%), and C. kefyr (1.8\u00a0%). Candidemia occurred in ICU in 1,206 patients (48.1\u00a0%). When comparing ICU vs. non-ICU patients, the former had significantly more frequent surgery during the past 30\u00a0days, were more often preexposed to fluconazole and treated with echinocandin, and were less frequently infected with C. parapsilosis. Risk factors and age remained unchanged during the study period. A significant increased incidence in the overall population and ICU was found. The odds of being infected with a given species in ICU was influenced by risk factors and preexposure to fluconazole and caspofungin. Echinocandins initial therapy increased over time in ICU (4.6\u00a0% first year of study, to 48.5\u00a0% last year of study, p\u00a0<\u00a00.0001). ICU patients had a higher day-30 death rate than non-ICU patients (odds ratio [OR] 2.12; 95\u00a0% confidence interval [CI] 1.66\u20132.72; p\u00a0<\u00a00.0001). The day-30 and early (
 

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26 schema:description PurposeTo analyze trends in incidence and mortality of candidemia in intensive care units (ICUs) vs. non-ICU hospitalized patients and to determine risk factors for infection by specific species and for death.MethodsActive hospital-based surveillance program of incident episodes of candidemia due to common species in 24 tertiary care hospitals in the Paris area, France between October 2002 and September 2010.ResultsAmong 2,507 adult cases included, 2,571 Candida isolates were collected and species were C. albicans (56 %), C. glabrata (18.6 %), C. parapsilosis (11.5 %), C. tropicalis (9.3 %), C. krusei (2.9 %), and C. kefyr (1.8 %). Candidemia occurred in ICU in 1,206 patients (48.1 %). When comparing ICU vs. non-ICU patients, the former had significantly more frequent surgery during the past 30 days, were more often preexposed to fluconazole and treated with echinocandin, and were less frequently infected with C. parapsilosis. Risk factors and age remained unchanged during the study period. A significant increased incidence in the overall population and ICU was found. The odds of being infected with a given species in ICU was influenced by risk factors and preexposure to fluconazole and caspofungin. Echinocandins initial therapy increased over time in ICU (4.6 % first year of study, to 48.5 % last year of study, p < 0.0001). ICU patients had a higher day-30 death rate than non-ICU patients (odds ratio [OR] 2.12; 95 % confidence interval [CI] 1.66–2.72; p < 0.0001). The day-30 and early (<day 8) death rates increased over time in ICU (from 41.5 % the first to 56.9 % the last year of study (p = 0.001) and 28.7–38.8 % (p = 0.0292), respectively). Independent risk factors for day-30 death in ICU were age, arterial catheter, Candida species, preexposure to caspofungin, and lack of antifungal therapy at the time of blood cultures results (p < 0.05).ConclusionsThe availability of new antifungals and the publication of numerous guidelines did not prevent an increase of candidemia and death in ICU patients in the Paris area.
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